Human virus transcriptional regulators
*Contributed
equally
#Co-corresponding
authors:
Matthew.Weirauch@cchmc.org;
fuxman@bu.edu
1Biology Department,
Boston University, Boston, Massachusetts, USA, 02215.
2Center for Autoimmune
Genomics and Etiology, Cincinnati Children’s Hospital Medical Center,
Cincinnati, Ohio, USA, 45229.
3Graduate program in
Systems Biology and Physiology, University of Cincinnati College of
Medicine, Cincinnati, Ohio, USA, 45267.
4Department of
Microbiology, Mount Sinai Hospital Icahn School of Medicine, New York,
NY, 10029-5674.
5Divisions of Biomedical
Informatics and Developmental Biology, Cincinnati Children’s Hospital
Medical Center, Cincinnati, Ohio, USA, 45229.
6Department of Pediatrics,
University of Cincinnati College of Medicine, Cincinnati, Ohio, USA,
45267.
Abstract
Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and functions. Here, we provide a comprehensive catalog of 419 vTRs belonging to 20 different virus families. Using this catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by particular vTRs, and discuss the role of vTRs in human disease pathogenesis. Our study provides a unique and valuable resource for the fields of virology, genomics, and human disease genetics.
How to cite
Please cite this article as: Liu et al., Human Virus Transcriptional Regulators, Cell (2020), https://doi.org/10.1016/j.cell.2020.06.023
Feedback
Have feedback on how we can make this resource better? Let us know.