|
1 |
(none) |
Hepatitis delta virus |
S-HDAg |
HDAg, LHDAg, P24, Small delta antigen |
P0C6L3 |
SHDAG_HDVD3 |
A0A0P0KG82,A0A185QEB0,A0A185QEB2,A0A185QEV2,A0A185QEW3,A0A185QEX3,A0A190LCH6,A0A190LCI6,A0A190LCJ6,A0A190LCL2,A0A190LCM2,A0A190LCN4,A0A190LCP3,A0A221S7Z0,A0A221S7Z2,A0A221S7Z5,A0A221S872,A0A221S875,A4ZN24,A4ZN28,A4ZN30,A4ZN32,A4ZN33,A4ZN34,A4ZN37,A4ZN38,A4ZN41,A4ZN42,A4ZN43,A4ZN44,A4ZN52,A4ZN66,A4ZN69,A4ZN70,A4ZN71,A4ZN72,A4ZN77,A4ZN79,A4ZN80,A4ZN81,A4ZN85,A4ZN86,A4ZN91,A4ZN96,A4ZN97,A4ZN98,A4ZN99,A4ZNA0,A4ZNA3,A4ZNA5,A4ZNA6,A4ZNB1,A4ZNB3,A4ZNB8,A4ZNC1,A4ZNC4,A4ZNH4,A5A0U5,A5A0U6,A5A0U9,D7RA49,P06934,P25880,P25881,P25882,P25989,P29833,P29997,Q6DUC3,Q6QT49,Q71DP5,Q81835,Q9E925,Q9E926 |
ssRNA |
TR, Rep |
S |
N |
N |
N |
D(18653455) |
N |
D(30153423, RNA-binding protein pull-down assay),
D(18653455) |
24198831.0 |
|
Promotes both transcription and replication of genomic
RNA. Following virus entry into host cell, provides nuclear
import of HDV RNPs thanks to its nuclear localization signal.
May interact with host RNA polymerase II thereby changing its
template requirement from DNA to RNA. RNA pol II complex
would then acts as an RNA-directed RNA polymerase, and
transcribe and replicate HDV genome (By similarity). |
|
2 |
Adenoviridae |
Human adenovirus A |
E1A |
Early E1A 29.5 kDa protein, Early E1A protein |
P03259 |
E1A_ADE12 |
A0A3G1HCH6,D0Z5R8,Q6JGG5,Q6JGG8 |
indirect/unknown |
TR |
P |
I(19129215, 21715488) |
N |
N |
D(7951410) |
D(7951410) |
D(7951410) |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to
efficiently use the cellular DNA replicating machinery to
achieve viral genome replication. E1A protein has both
transforming and trans-activating activities. Induces the
disassembly of the E2F1 transcription factor from RB1 by
direct competition for the same binding site on RB1, with
subsequent transcriptional activation of E2F1-regulated
S-phase genes and of the E2 region of the adenoviral genome.
Release of E2F1 leads to the ARF-mediated inhibition of MDM2
and causes TP53/p53 to accumulate because it is not targeted
for degradation by MDM2-mediated ubiquitination anymore. This
increase in TP53, in turn, would arrest the cell
proliferation and direct its death but this effect is
counteracted by the viral protein E1B-55K. Inactivation of
the ability of RB1 to arrest the cell cycle is critical for
cellular transformation, uncontrolled cellular growth and
proliferation induced by viral infection. Interaction with
RBX1 and CUL1 inhibits ubiquitination of the proteins
targeted by SCF(FBXW7) ubiquitin ligase complex, and may be
linked to unregulated host cell proliferation. The
tumorigenesis-restraining activity of E1A may be related to
the disruption of the host CtBP-CtIP complex through the CtBP
binding motif. Interaction with host TMEM173/STING impairs
the ability of TMEM173/STING to sense cytosolic DNA and
promote the production of type I interferon (IFN-alpha and
IFN-beta). |
|
3 |
Adenoviridae |
Human adenovirus A |
E2A |
DBP, DNA-binding protein, Early 2A protein, Early E2A
DNA-binding protein |
P04498 |
DNB2_ADE12 |
A0A3G8WIW6,D0Z5T4,D3JIT2 |
dsDNA |
TR, Rep |
S |
N |
N |
N |
I(11581372) |
I(12502807, 8039495) |
N |
Fields Virology |
|
Plays a role in the elongation phase of viral strand
displacement replication by unwinding the template in an
ATP-independent fashion, employing its capacity to form
multimers. Also enhances the rate of initiation. Released
from template upon second strand synthesis. Assembles in
complex with viral pTP, viral pol, host NFIA and host
POU2F1/OCT1 on viral origin of replication. Covers the whole
ssDNA genome during synthesis. The complementary strand
synthesis induces its relese from DNA template. May inhibit
cellular transcription mediated by the interaction between
host SRCAP and CBP. |
|
4 |
Adenoviridae |
Human adenovirus A |
E3 |
14.7 kDa protein, E3 14.7K, E3 14.7K homologue protein,
E3B 14.7 KD protein |
D0Z5U4 |
D0Z5U4_ADE31 |
D3JIU2,Q65288 |
indirect/unknown |
TR, other |
S |
N |
N |
N |
I(16423054) |
I(16423054, 11991979) |
N |
Fields Virology |
Q65288 is inferred from Human adenovirus C protein
P68976 |
mitigation of host defenses by virus |
|
5 |
Adenoviridae |
Human adenovirus A |
E4 |
E4 ORF6 protein, Early E4 34 kDa protein |
P36710 |
E434_ADE12 |
A0A3G8W3L7 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(8633237, 1832724, 2137929) |
I(1832724, 2137929) |
N |
Fields Virology |
P36710 is inferred from Human adenovirus C protein
P03238 |
Modulates viral and host transcriptional activity to
promote viral genome replication. Stimulates viral E2a
promoter activity by binding and inducing dimerization of
host E2F. During viral infection E1A protein binds to
cellular retinablastoma (RB) family members and disociates
these repressors from a complex with E2F proteins. Free E2F
is then bound to E4orf6/7 which leads to transactivation of
viral E2 promoter, and cellular promoters such as E2F-1
promoter. Activation of cellular E2F targets promote cell
cycle S phase and thereby possibly favorises viral DNA
replication process. |
|
6 |
Adenoviridae |
Human adenovirus A |
IVa2 |
Packaging protein 1, Packaging protein IVa2 |
P12540 |
PKG1_ADE12 |
A0A3G8WBN6,D0Z5S2,D3JIS0 |
dsDNA |
TR, NAP |
S |
I(15681437) |
N |
N |
I(8627656, 15327897) |
I(22884292, 8627656, 15681437) |
I(15780869, DNA-binding protein pull-down assay) |
Fields Virology |
|
Component of the packaging machinery which encapsidates
the viral DNA into preformed capsids and transcriptional
activator of the viral major late promoter (MLP). Binds,
along with packaging proteins 2 and 3, to the specific
packaging sequence on the left end of viral genomic DNA and
displays ATPase activity thereby providing the power stroke
of the packaging machinery. The activity of packaging protein
IVa2 is stimulated by protein 33K which acts as a terminase.
May be the protein that pumps DNA into the capsid powered by
ATP hydrolysis. Specifically binds to the 5'-CG-3'
nucleotides of the repeats making up the packaging sequence.
Component of the DEF-A and DEF-B transcription factors that
bind downstream elements of the major late promoter (MLP),
and stimulate transcription from the MLP after initiation of
viral DNA replication. DEF-A is a heterodimer packaging
proteins 1 and 2 and DEF-B is a homodimer of packaging
protein 1. |
|
7 |
Adenoviridae |
Human adenovirus A |
L2 |
L2 protein pVII, L2 protein VII, Major core protein pVII,
Pre-core protein VII, Pre-histone-like nucleoprotein, Protein
VII, pVII, PVII |
D0Z5S8 |
D0Z5S8_ADE31 |
|
dsDNA |
TR, NAP |
S |
N |
N |
N |
N |
I(6828374, 27362237) |
I(15780869, DNA-binding protein pull-down assay) |
Fields Virology |
D0Z5S8 is inferred from Human adenovirus C protein
P68950 |
Plays a role in the inhibition of host immune response
within the nucleus. Interacts with cellular nucleosomes and
immobilizes the host immune danger signal HMGB1 on chromatin.
In turn, prevents HMGB1 release out of the cell and thus
decreases inflammation. Plays also a role in the wrapping and
condensation of the viral DNA. May also promote viral genome
import into the nucleus. |
|
8 |
Adenoviridae |
Human adenovirus B |
E1A |
Early E1A 28 kDa protein, Early E1A protein |
P03256 |
E1A_ADE07 |
A0A0A7DXW5,A0A0A7DY38,A0A1U9ALF8,A0A1U9ALG4,A0A219PC17,A0A386NAE6,A0A386NAK0,A0A386NCD8,A0A386NCU0,D2DM82,D6BP20,Q2KRU4,Q2KS74,Q2KS76,Q2KS77,Q2KSL5,Q2KSL6,Q4JEQ5,Q4JEQ6,Q5EY85,Q5EY86,Q5YKW5,Q5YKX2,Q6JGG9,Q6RK99,Q7T953,Q7T954,Q8JSK3,Q8JSK4,R4HLK4,R4HMJ7 |
indirect/unknown |
TR |
P |
I(19129215, 21715488) |
N |
N |
I(19129215, 10446138) |
I(10446138) |
N |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to
efficiently use the cellular DNA replicating machinery to
achieve viral genome replication. E1A protein has both
transforming and trans-activating activities. Induces the
disassembly of the E2F1 transcription factor from RB1 by
direct competition for the same binding site on RB1, with
subsequent transcriptional activation of E2F1-regulated
S-phase genes and of the E2 region of the adenoviral genome.
Release of E2F1 leads to the ARF-mediated inhibition of MDM2
and causes TP53/p53 to accumulate because it is not targeted
for degradation by MDM2-mediated ubiquitination anymore. This
increase in TP53, in turn, would arrest the cell
proliferation and direct its death but this effect is
counteracted by the viral protein E1B-55K. Inactivation of
the ability of RB1 to arrest the cell cycle is critical for
cellular transformation, uncontrolled cellular growth and
proliferation induced by viral infection. Interaction with
RBX1 and CUL1 inhibits ubiquitination of the proteins
targeted by SCF(FBXW7) ubiquitin ligase complex, and may be
linked to unregulated host cell proliferation. The
tumorigenesis-restraining activity of E1A may be related to
the disruption of the host CtBP-CtIP complex through the CtBP
binding motif. Interaction with host TMEM173/STING impairs
the ability of TMEM173/STING to sense cytosolic DNA and
promote the production of type I interferon (IFN-alpha and
IFN-beta). |
|
9 |
Adenoviridae |
Human adenovirus B |
E2A |
DBP, DNA-binding protein, Early 2A protein, Early E2A
DNA-binding protein |
P04497 |
DNB2_ADE07 |
A0A219PC53,A0A219PC79,D0EF47,D2DMA0,Q2KRW8,Q2KS36,Q2KSI4,Q2Y0H2,Q5EY61,Q6RK85,Q6YL70,Q7T934,R4HLE7 |
dsDNA |
TR, Rep |
S |
N |
N |
N |
I(11581372) |
I(12502807, 8039495) |
N |
Fields Virology |
|
Plays a role in the elongation phase of viral strand
displacement replication by unwinding the template in an
ATP-independent fashion, employing its capacity to form
multimers. Also enhances the rate of initiation. Released
from template upon second strand synthesis. Assembles in
complex with viral pTP, viral pol, host NFIA and host
POU2F1/OCT1 on viral origin of replication. Covers the whole
ssDNA genome during synthesis. The complementary strand
synthesis induces its relese from DNA template. May inhibit
cellular transcription mediated by the interaction between
host SRCAP and CBP. |
|
10 |
Adenoviridae |
Human adenovirus B |
E3 |
14 kDa protein, 14.7 kDa protein, 15.3 kDa protein, E3
14.7 kDa protein, E3B, Early E3 15.3 kDa protein, ORF 15.3
kDa |
P11315 |
E3145_ADE03 |
D2DMA9,P15135,Q2KSH2,Q2Y0F9,Q5EY47,Q67732,Q83121,Q91CJ8,Q9PX47,R4HML9 |
indirect/unknown |
TR, other |
S |
N |
N |
N |
I(16423054) |
I(16423054, 11991979) |
N |
Fields Virology |
D2DMA9 is inferred from Human adenovirus C protein
P68976 |
Protects virus-infected cells from TNF-induced
cytolysis. |
|
11 |
Adenoviridae |
Human adenovirus B |
E4 |
299 aa, 32 kDa protein, 33.2 kDa protein, 34 kDa protein,
E4 33.2 kDa protein, E4 33 kDa protein, E4 ORF6 34.7 kDa
protein, E4 ORF6/7, E4 ORF6 protein, E4 ORF (Fragment), ORF
6/7, Orf6/7 protein, ORF6/7 |
D0EF64 |
D0EF64_ADE07 |
A0A096XFF7,D2DMB1,I1V198,K7SXT6,Q2KRV1,Q2KS47,Q2KSJ0,Q2Y0F6,Q4JEL5,Q5EY43,Q7T924,R4HLG5 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(8633237, 1832724, 2137929) |
I(1832724, 2137929) |
N |
Fields Virology |
D0EF64 is inferred from Human adenovirus C protein
P03238 |
Modulates viral and host transcriptional activity to
promote viral genome replication. Stimulates viral E2a
promoter activity by binding and inducing dimerization of
host E2F. During viral infection E1A protein binds to
cellular retinablastoma (RB) family members and disociates
these repressors from a complex with E2F proteins. Free E2F
is then bound to E4orf6/7 which leads to transactivation of
viral E2 promoter, and cellular promoters such as E2F-1
promoter. Activation of cellular E2F targets promote cell
cycle S phase and thereby possibly favorises viral DNA
replication process. |
|
12 |
Adenoviridae |
Human adenovirus B |
IVa2 |
E2B, Packaging protein 1, Packaging protein IVa2 |
P03273 |
PKG1_ADE07 |
A0A0A7DXV0,D2DM86,I1V164,Q2KRY3,Q2KS70,Q2KSL0,Q2Y0J0,Q5EY79,Q6RK95,Q7T948,R4HMK1 |
dsDNA |
TR, NAP |
S |
I(15681437) |
N |
N |
I(8627656, 15327897) |
I(22884292, 8627656, 15681437) |
I(15780869, DNA-binding protein pull-down assay) |
Fields Virology |
|
Component of the packaging machinery which encapsidates
the viral DNA into preformed capsids and transcriptional
activator of the viral major late promoter (MLP). Binds,
along with packaging proteins 2 and 3, to the specific
packaging sequence on the left end of viral genomic DNA and
displays ATPase activity thereby providing the power stroke
of the packaging machinery. The activity of packaging protein
IVa2 is stimulated by protein 33K which acts as a terminase.
May be the protein that pumps DNA into the capsid powered by
ATP hydrolysis. Specifically binds to the 5'-CG-3'
nucleotides of the repeats making up the packaging sequence.
Component of the DEF-A and DEF-B transcription factors that
bind downstream elements of the major late promoter (MLP),
and stimulate transcription from the MLP after initiation of
viral DNA replication. DEF-A is a heterodimer packaging
proteins 1 and 2 and DEF-B is a homodimer of packaging
protein 1. |
|
13 |
Adenoviridae |
Human adenovirus B |
L2 |
L2 protein pVII, L2 protein VII, Major core protein pVII,
Pre-core protein VII, Pre-histone-like nucleoprotein, Protein
VII, pVII, PVII |
D0EF42 |
D0EF42_ADE07 |
D2DM94,Q2KRX4,Q2KS41,Q2KSJ8,Q2Y0H8,Q5EY66,Q6RK90,Q7T940,R4HLK6 |
dsDNA |
TR, NAP |
S |
N |
N |
N |
N |
I(6828374, 27362237) |
I(3743550, cross-linking), I(15163739,
Immunofluorescence) |
Fields Virology |
D0EF42 is inferred from Human adenovirus C protein
P68950 |
Plays a role in the inhibition of host immune response
within the nucleus. Interacts with cellular nucleosomes and
immobilizes the host immune danger signal HMGB1 on chromatin.
In turn, prevents HMGB1 release out of the cell and thus
decreases inflammation. Plays also a role in the wrapping and
condensation of the viral DNA. May also promote viral genome
import into the nucleus. |
|
14 |
Adenoviridae |
Human adenovirus C |
E1A |
Early E1A 32 kDa protein, Early E1A protein |
P03255 |
E1A_ADE05 |
A0A1U9ALK2,A0A3G1HBN7,E1U5L3,E1U5L4,E7DY80,P03254,P03254-2,P03255-2,Q2KS29,Q6JGH2,Q6JGH3,Q6VGV9,Q6VGW0,Q71BY7,Q71BY8,W8VTN3 |
indirect/unknown |
TR |
P |
D(19129215, 21715488) |
N |
2KJE, 2R7G |
D(19129215, 10446138) |
D(10446138) |
N |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to
efficiently use the cellular DNA replicating machinery to
achieve viral genome replication. E1A protein has both
transforming and trans-activating activities. Induces the
disassembly of the E2F1 transcription factor from RB1 by
direct competition for the same binding site on RB1, with
subsequent transcriptional activation of E2F1-regulated
S-phase genes and of the E2 region of the adenoviral genome.
Release of E2F1 leads to the ARF-mediated inhibition of MDM2
and causes TP53/p53 to accumulate because it is not targeted
for degradation by MDM2-mediated ubiquitination anymore. This
increase in TP53, in turn, would arrest the cell
proliferation and direct its death but this effect is
counteracted by the viral protein E1B-55K. Inactivation of
the ability of RB1 to arrest the cell cycle is critical for
cellular transformation, uncontrolled cellular growth and
proliferation induced by viral infection. Interaction with
RBX1 and CUL1 inhibits ubiquitination of the proteins
targeted by SCF(FBXW7) ubiquitin ligase complex, and may be
linked to unregulated host cell proliferation. The
tumorigenesis-restraining activity of E1A may be related to
the disruption of the host CtBP-CtIP complex through the CtBP
binding motif. Interaction with host TMEM173/STING impairs
the ability of TMEM173/STING to sense cytosolic DNA and
promote the production of type I interferon (IFN-alpha and
IFN-beta) (PubMed:26405230). |
|
15 |
Adenoviridae |
Human adenovirus C |
E2A |
DBP, DNA-binding protein, Early 2A protein, Early E2A
DNA-binding protein, Early E2A DNA-binding
protein,,E2a_1 |
P03264 |
DNB2_ADE02 |
A0A0U5C455,A0A1U9ALL4,E1U5P2,E7DY93,P03265,Q2KS06,Q6VGU4,Q71BW6,W8VNG9 |
dsDNA |
TR, Rep |
S |
N |
N |
N |
D(11581372) |
D(12502807, 8039495) |
N |
Fields Virology |
|
Plays a role in the elongation phase of viral strand
displacement replication by unwinding the template in an
ATP-independent fashion, employing its capacity to form
multimers. Also enhances the rate of initiation. Released
from template upon second strand synthesis. Assembles in
complex with viral pTP, viral pol, host NFIA and host
POU2F1/OCT1 on viral origin of replication. Covers the whole
ssDNA genome during synthesis. The complementary strand
synthesis induces its release from DNA template. May inhibit
cellular transcription mediated by the interaction between
host SRCAP and CBP. |
|
16 |
Adenoviridae |
Human adenovirus C |
E3 |
E3-14.7k, Early 3 14.7 kDa protein |
P68976 |
E3145_ADE02 |
A0A0U5BYW0,A0A127WKD0,A0A3G8W4Y8 |
indirect/unknown |
TR, other |
S |
N |
N |
N |
D(16423054) |
D(16423054, 11991979) |
D(16423054) |
Fields Virology |
|
May prevent Nf-kappaB activation by immune signals like
Tumor necrosis factor, presumably by inhibiting NFKB1 dimer
DNA-binding. May act directly at the TNF receptor to inhibit
signaling. |
|
17 |
Adenoviridae |
Human adenovirus C |
E4 |
E4-ORF6/7, Early 4 ORF6/7 control protein, Early E4 17
kDa protein |
P03238 |
E4RF5_ADE02 |
A0A0U4XAB1,A0A0U5BPW3,A0A0U5CNF1,A0A127WK23,A0A1U9ALN2,A0A3G8WH84,E1U5Q6 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(8633237, 1832724, 2137929) |
D(1832724, 2137929) |
D(8035503) |
Fields Virology |
|
Modulates viral and host transcriptional activity to
promote viral genome replication. Stimulates viral E2a
promoter activity by binding and inducing dimerization of
host E2F. During viral infection E1A protein binds to
cellular retinablastoma (RB) family members and dissociates
these repressors from a complex with E2F proteins. Free E2F
is then bound to E4orf6/7 which leads to transactivation of
viral E2 promoter, and cellular promoters such as E2F-1
promoter. Activation of cellular E2F targets promote cell
cycle S phase and thereby possibly favorises viral DNA
replication process. |
|
18 |
Adenoviridae |
Human adenovirus C |
IVa2 |
Packaging protein 1, Packaging protein IVa2, pIVa2 |
P03272 |
PKG1_ADE02 |
A0A0U5BYH2,A0A0U5BZK4,A0A127WJS4,A0A1U9ALL6,A0A3G8W3U4,A8D0L0,E1U5M2,E7DY84,Q6VGV5 |
dsDNA |
TR, NAP |
S |
D(15681437) |
N |
N |
D(8627656, 15327897) |
D(22884292, 8627656, 15681437) |
D(15780869, DNA-binding protein pull-down assay) |
Fields Virology |
|
Component of the packaging machinery which encapsidates
the viral DNA into preformed capsids and transcriptional
activator of the viral major late promoter (MLP). Binds,
along with packaging proteins 2 and 3, to the specific
packaging sequence on the left end of viral genomic DNA and
displays ATPase activity thereby providing the power stroke
of the packaging machinery. The activity of packaging protein
IVa2 is stimulated by protein 33K which acts as a terminase.
May be the protein that pumps DNA into the capsid powered by
ATP hydrolysis. Specifically binds to the 5'-CG-3'
nucleotides of the repeats making up the packaging sequence.
Component of the DEF-A and DEF-B transcription factors that
bind downstream elements of the major late promoter (MLP),
and stimulate transcription from the MLP after initiation of
viral DNA replication. DEF-A is a heterodimer packaging
proteins 1 and 2 and DEF-B is a homodimer of packaging
protein 1. |
|
19 |
Adenoviridae |
Human adenovirus C |
L2 |
L2 protein pVII, L2 protein VII, Major core protein pVII,
ppVII, Pre-core protein VII, Pre-histone-like nucleoprotein,
Protein VII, pro-VII, pVII, PVII |
P68950 |
NP_ADE02 |
A8D0L7,E1U5N6,P68951,Q71BX2 |
dsDNA |
TR, NAP |
S |
N |
N |
N |
N |
D(6828374, 27362237) |
D(3743550, cross-linking), D(15163739,
Immunofluorescence) |
Fields Virology |
|
Plays a role in the inhibition of host immune response
within the nucleus. Interacts with cellular nucleosomes and
immobilizes the host immune danger signal HMGB1 on chromatin.
In turn, prevents HMGB1 release out of the cell and thus
decreases inflammation. Plays also a role in the wrapping and
condensation of the viral DNA. May also promote viral genome
import into the nucleus. |
|
20 |
Adenoviridae |
Human adenovirus D |
E1A |
21 kDa protein, 21.2 kDa protein, E1A 12S, E1A 12S
protein, Early E1A 12s, Early E1A 12S, Early E1A protein |
Q9YLA0 |
Q9YLA0_ADE09 |
A0A1B1W8K3,A0A1P7YXD4,A0A1P7YXL4,A0A1P7YY79,A0A1Y1C2A5,B2VQE2,B9A5A6,B9A5E2,B9A5H8,E1CII9,F1DT55,K7ZRT6,M0QU00,Q9YLA1 |
indirect/unknown |
TR |
P |
I(19129215, 21715488) |
N |
N |
I(19129215, 10446138) |
I(10446138) |
N |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. |
|
21 |
Adenoviridae |
Human adenovirus D |
E2A |
DBP, DNA binding protein, DNA-binding protein, Early 2A
protein, Early E2A DNA-binding protein |
B2VQF8 |
B2VQF8_9ADEN |
A0A1B1W8H7,A0A1P7YXH3,A0A1P7YYU8,B9A5C2,E1CIK5,F1DT72,K7ZJX4,M0QU16,Q5TJ02 |
dsDNA |
TR, Rep |
S |
N |
N |
N |
I(11581372) |
I(12502807, 8039495) |
N |
Fields Virology |
B2VQF8 is inferred from Human adenovirus B protein
P04497 |
Plays a role in the elongation phase of viral strand
displacement replication by unwinding the template in an
ATP-independent fashion, employing its capacity to form
multimers. Also enhances the rate of initiation. Released
from template upon second strand synthesis. Assembles in
complex with viral pTP, viral pol, host NFIA and host
POU2F1/OCT1 on viral origin of replication. Covers the whole
ssDNA genome during synthesis. The complementary strand
synthesis induces its relese from DNA template. May inhibit
cellular transcription mediated by the interaction between
host SRCAP and CBP. |
|
22 |
Adenoviridae |
Human adenovirus D |
E3 |
14.7K protein, 14.7kDa protein, Early E3B 14.7 kDa
protein |
Q9JFM0 |
Q9JFM0_ADE08 |
Q76C83,Q76EL2,Q7TBG6,Q9JFM3 |
indirect/unknown |
TR, other |
S |
N |
N |
N |
I(16423054) |
I(16423054, 11991979) |
N |
Fields Virology |
Q9JFM0 is inferred from Human adenovirus C protein
P68976 |
mitigation of host defenses by virus |
|
23 |
Adenoviridae |
Human adenovirus D |
E4 |
31 kDa protein, 34 kDa, 34 kDa protein, 34.1 kDa protein,
34kDa protein, Early E4 34 kDa protein |
P89083 |
E434_ADE09 |
A0A1B1W7J1,B2VQH1,B9A5D5,B9A5H1,B9A5K7,E1CIL8,F1DT87,K7ZLM0,M0QU32 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(8633237, 1832724, 2137929) |
I(1832724, 2137929) |
N |
Fields Virology |
F1DT87 is inferred from Human adenovirus C protein
P03238 |
Modulates viral and host transcriptional activity to
promote viral genome replication. Stimulates viral E2a
promoter activity by binding and inducing dimerization of
host E2F. During viral infection E1A protein binds to
cellular retinablastoma (RB) family members and disociates
these repressors from a complex with E2F proteins. Free E2F
is then bound to E4orf6/7 which leads to transactivation of
viral E2 promoter, and cellular promoters such as E2F-1
promoter. Activation of cellular E2F targets promote cell
cycle S phase and thereby possibly favorises viral DNA
replication process. |
|
24 |
Adenoviridae |
Human adenovirus D |
IVa2 |
Packaging protein 1, Packaging protein IVa2, pIVa2,
PIVa2, PIVa2 protein |
F1DT60 |
F1DT60_ADE17 |
A0A1P8C866,A0A2Z5WHY4,B2VQE6,B9A5B0,B9A5E6,E1CIJ3,K7ZQ22,M0QU04,Q5TJ14 |
dsDNA |
TR, NAP |
S |
I(15681437) |
N |
N |
I(8627656, 15327897) |
I(22884292, 8627656, 15681437) |
I(15780869, DNA-binding protein pull-down assay) |
Fields Virology |
F1DT60 is inferred from Human adenovirus C protein
P03272 |
Component of the packaging machinery which encapsidates
the viral DNA into preformed capsids and transcriptional
activator of the viral major late promoter (MLP). Binds,
along with packaging proteins 2 and 3, to the specific
packaging sequence on the left end of viral genomic DNA and
displays ATPase activity thereby providing the power stroke
of the packaging machinery. The activity of packaging protein
IVa2 is stimulated by protein 33K which acts as a terminase.
May be the protein that pumps DNA into the capsid powered by
ATP hydrolysis. Specifically binds to the 5'-CG-3'
nucleotides of the repeats making up the packaging sequence.
Component of the DEF-A and DEF-B transcription factors that
bind downstream elements of the major late promoter (MLP),
and stimulate transcription from the MLP after initiation of
viral DNA replication. DEF-A is a heterodimer packaging
proteins 1 and 2 and DEF-B is a homodimer of packaging
protein 1. |
|
25 |
Adenoviridae |
Human adenovirus D |
L2 |
L2 protein pVII, L2 protein VII, Major core protein pVII,
Pre-core protein VII, Pre-histone-like nucleoprotein, Protein
VII, pVII, PVII |
B9A5B6 |
B9A5B6_ADE08 |
B9A5F2,E1CIJ9,F1DT66,K7ZRT8,M0QU10 |
dsDNA |
TR, NAP |
S |
N |
N |
N |
N |
I(6828374, 27362237) |
I(3743550, cross-linking), I(15163739,
Immunofluorescence) |
Fields Virology |
B9A5B6 is inferred from Human adenovirus C protein
P68950 |
Plays a role in the inhibition of host immune response
within the nucleus. Interacts with cellular nucleosomes and
immobilizes the host immune danger signal HMGB1 on chromatin.
In turn, prevents HMGB1 release out of the cell and thus
decreases inflammation. Plays also a role in the wrapping and
condensation of the viral DNA. May also promote viral genome
import into the nucleus. |
|
26 |
Adenoviridae |
Human adenovirus E |
E1A |
Early E1A 28 kDa protein, Early E1A protein |
P10407 |
E1A_ADE04 |
A0A1U9AL55,A0A1W2KFI9,Q2KSG8,Q2KSH0,Q2KSH1,Q4JEV1,Q5GFD1,Q5VHC6,Q5YKX0,Q64835,Q64836,T1SQR0,T1SRS7,T1STJ3 |
indirect/unknown |
TR |
P |
I(19129215, 21715488) |
N |
N |
I(19129215, 10446138) |
I(10446138) |
N |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to
efficiently use the cellular DNA replicating machinery to
achieve viral genome replication. E1A protein has both
transforming and trans-activating activities. Induces the
disassembly of the E2F1 transcription factor from RB1 by
direct competition for the same binding site on RB1, with
subsequent transcriptional activation of E2F1-regulated
S-phase genes and of the E2 region of the adenoviral genome.
Release of E2F1 leads to the ARF-mediated inhibition of MDM2
and causes TP53/p53 to accumulate because it is not targeted
for degradation by MDM2-mediated ubiquitination anymore. This
increase in TP53, in turn, would arrest the cell
proliferation and direct its death but this effect is
counteracted by the viral protein E1B-55K. Inactivation of
the ability of RB1 to arrest the cell cycle is critical for
cellular transformation, uncontrolled cellular growth and
proliferation induced by viral infection. Interaction with
RBX1 and CUL1 inhibits ubiquitination of the proteins
targeted by SCF(FBXW7) ubiquitin ligase complex, and may be
linked to unregulated host cell proliferation. The
tumorigenesis-restraining activity of E1A may be related to
the disruption of the host CtBP-CtIP complex through the CtBP
binding motif. Interaction with host TMEM173/STING impairs
the ability of TMEM173/STING to sense cytosolic DNA and
promote the production of type I interferon (IFN-alpha and
IFN-beta). |
|
27 |
Adenoviridae |
Human adenovirus E |
E2A |
DBP, DNA-binding protein, Early 2A protein, Early E2A
DNA-binding protein |
P06500 |
DNB2_ADE04 |
A0A1W2KFE2,A0A1W2KFI6,Q2KSE6,Q5GFA6 |
dsDNA |
TR, Rep |
S |
N |
N |
N |
I(11581372) |
I(12502807, 8039495) |
N |
Fields Virology |
|
Plays a role in the elongation phase of viral strand
displacement replication by unwinding the template in an
ATP-independent fashion, employing its capacity to form
multimers. Also enhances the rate of initiation. Released
from template upon second strand synthesis. Assembles in
complex with viral pTP, viral pol, host NFIA and host
POU2F1/OCT1 on viral origin of replication. Covers the whole
ssDNA genome during synthesis. The complementary strand
synthesis induces its relese from DNA template. May inhibit
cellular transcription mediated by the interaction between
host SRCAP and CBP. |
|
28 |
Adenoviridae |
Human adenovirus E |
E3 |
14.7 kDa protein, Control protein E3 14.7K, E3 14.7 kDa
protein |
Q2KSD4 |
Q2KSD4_ADE04 |
Q8BEK9 |
indirect/unknown |
TR, other |
S |
N |
N |
N |
I(16423054) |
I(16423054, 11991979) |
N |
Fields Virology |
Q8BEK9 is inferred from Human adenovirus C protein
P68976 |
mitigation of host defenses by virus |
|
29 |
Adenoviridae |
Human adenovirus E |
E4 |
15.9 kDa protein, E4 15.9 kDa protein |
Q5GF91 |
Q5GF91_ADE04 |
Q2KSD2 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(8633237, 1832724, 2137929) |
I(1832724, 2137929) |
N |
Fields Virology |
Q5GF91 is inferred from Human adenovirus C protein
P03238 |
Modulates viral and host transcriptional activity to
promote viral genome replication. Stimulates viral E2a
promoter activity by binding and inducing dimerization of
host E2F. During viral infection E1A protein binds to
cellular retinablastoma (RB) family members and disociates
these repressors from a complex with E2F proteins. Free E2F
is then bound to E4orf6/7 which leads to transactivation of
viral E2 promoter, and cellular promoters such as E2F-1
promoter. Activation of cellular E2F targets promote cell
cycle S phase and thereby possibly favorises viral DNA
replication process. |
|
30 |
Adenoviridae |
Human adenovirus E |
IVa2 |
IVa2 protein, Maturation protein IVa2, Packaging protein
1, Packaging protein IVa2 |
Q5GFC2 |
Q5GFC2_ADE04 |
A0A1W2KF59,Q2KSG1 |
dsDNA |
TR, NAP |
S |
I(15681437) |
N |
N |
I(8627656, 15327897) |
I(22884292, 8627656, 15681437) |
I(15780869, DNA-binding protein pull-down assay) |
Fields Virology |
Q5GFC2 is inferred from Human adenovirus C protein
P03272 |
Component of the packaging machinery which encapsidates
the viral DNA into preformed capsids and transcriptional
activator of the viral major late promoter (MLP). Binds,
along with packaging proteins 2 and 3, to the specific
packaging sequence on the left end of viral genomic DNA and
displays ATPase activity thereby providing the power stroke
of the packaging machinery. The activity of packaging protein
IVa2 is stimulated by protein 33K which acts as a terminase.
May be the protein that pumps DNA into the capsid powered by
ATP hydrolysis. Specifically binds to the 5'-CG-3'
nucleotides of the repeats making up the packaging sequence.
Component of the DEF-A and DEF-B transcription factors that
bind downstream elements of the major late promoter (MLP),
and stimulate transcription from the MLP after initiation of
viral DNA replication. DEF-A is a heterodimer packaging
proteins 1 and 2 and DEF-B is a homodimer of packaging
protein 1. |
|
31 |
Adenoviridae |
Human adenovirus E |
L2 |
L2 protein pVII, L2 protein VII, Major core protein pVII,
Pre-core protein VII, Pre-histone-like nucleoprotein, Protein
VII, pVII, PVII |
Q2KSF2 |
Q2KSF2_ADE04 |
|
dsDNA |
TR, NAP |
S |
N |
N |
N |
N |
I(6828374, 27362237) |
I(3743550, cross-linking), I(15163739,
Immunofluorescence) |
Fields Virology |
Q2KSF2 is inferred from Human adenovirus C protein
P68950 |
Plays a role in the inhibition of host immune response
within the nucleus. Interacts with cellular nucleosomes and
immobilizes the host immune danger signal HMGB1 on chromatin.
In turn, prevents HMGB1 release out of the cell and thus
decreases inflammation. Plays also a role in the wrapping and
condensation of the viral DNA. May also promote viral genome
import into the nucleus. |
|
32 |
Adenoviridae |
Human adenovirus F |
E1A |
Early E1A 27 kDa protein, Early E1A protein |
P10541 |
E1A_ADE40 |
A0A142G3J1,A0A1S6ELR7,A0A3G4WBK4,A0A3G8WC02,B5SNR0,F4ZCJ7,P10542,Q64824,Q64881,W0RYQ2 |
indirect/unknown |
TR |
P |
I(19129215, 21715488) |
N |
N |
I(19129215, 10446138) |
I(10446138) |
N |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to
efficiently use the cellular DNA replicating machinery to
achieve viral genome replication. E1A protein has both
transforming and trans-activating activities. Induces the
disassembly of the E2F1 transcription factor from RB1 by
direct competition for the same binding site on RB1, with
subsequent transcriptional activation of E2F1-regulated
S-phase genes and of the E2 region of the adenoviral genome.
Release of E2F1 leads to the ARF-mediated inhibition of MDM2
and causes TP53/p53 to accumulate because it is not targeted
for degradation by MDM2-mediated ubiquitination anymore. This
increase in TP53, in turn, would arrest the cell
proliferation and direct its death but this effect is
counteracted by the viral protein E1B-55K. Inactivation of
the ability of RB1 to arrest the cell cycle is critical for
cellular transformation, uncontrolled cellular growth and
proliferation induced by viral infection. Interaction with
RBX1 and CUL1 inhibits ubiquitination of the proteins
targeted by SCF(FBXW7) ubiquitin ligase complex, and may be
linked to unregulated host cell proliferation. The
tumorigenesis-restraining activity of E1A may be related to
the disruption of the host CtBP-CtIP complex through the CtBP
binding motif. Interaction with host TMEM173/STING impairs
the ability of TMEM173/STING to sense cytosolic DNA and
promote the production of type I interferon (IFN-alpha and
IFN-beta). |
|
33 |
Adenoviridae |
Human adenovirus F |
E2A |
DBP, DNA-binding protein, Early 2A protein, Early E2A
DNA-binding protein |
P11806 |
DNB2_ADE40 |
A0A060ILQ0,A0A060ILW5,A0A142G3K6,A0A1S6ELQ0,A0A1S6ELU3,A0A1S6ELX1,A0A3G4WEW3,A0A3G8W3Y9,B5SNS7,E2IJY9,P11807,W0RYE2 |
dsDNA |
TR, Rep |
S |
N |
N |
N |
I(11581372) |
I(12502807, 8039495) |
N |
Fields Virology |
|
Plays a role in the elongation phase of viral strand
displacement replication by unwinding the template in an
ATP-independent fashion, employing its capacity to form
multimers. Also enhances the rate of initiation. Released
from template upon second strand synthesis. Assembles in
complex with viral pTP, viral pol, host NFIA and host
POU2F1/OCT1 on viral origin of replication. Covers the whole
ssDNA genome during synthesis. The complementary strand
synthesis induces its relese from DNA template. May inhibit
cellular transcription mediated by the interaction between
host SRCAP and CBP. |
|
34 |
Adenoviridae |
Human adenovirus F |
E3 |
Control protein E3 14.7K, E3 14.0 kDa protein (Homologous
to Ad2 E3 14.7 kDa protein), E3 14.0 kd protein, E3 14.7K, E3
14.7K protein |
Q98817 |
Q98817_ADE41 |
|
indirect/unknown |
TR, other |
S |
N |
N |
N |
I(16423054) |
I(16423054, 11991979) |
N |
Fields Virology |
Q98817 is inferred from Human adenovirus C protein
P68976 |
mitigation of host defenses by virus |
|
35 |
Adenoviridae |
Human adenovirus F |
E4 |
E4 ORF6/7, ORF6/7 |
Q64857 |
Q64857_ADE40 |
A0A142G3L9,A0A3G8W5U1 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(8633237, 1832724, 2137929) |
I(1832724, 2137929) |
N |
Fields Virology |
Q64857 is inferred from Human adenovirus C protein
P03238 |
Modulates viral and host transcriptional activity to
promote viral genome replication. Stimulates viral E2a
promoter activity by binding and inducing dimerization of
host E2F. During viral infection E1A protein binds to
cellular retinablastoma (RB) family members and disociates
these repressors from a complex with E2F proteins. Free E2F
is then bound to E4orf6/7 which leads to transactivation of
viral E2 promoter, and cellular promoters such as E2F-1
promoter. Activation of cellular E2F targets promote cell
cycle S phase and thereby possibly favorises viral DNA
replication process. |
|
36 |
Adenoviridae |
Human adenovirus F |
IVa2 |
Packaging protein 1, Packaging protein IVa2 |
P48752 |
PKG1_ADE40 |
A0A142G3J5,B5SNR4 |
dsDNA |
TR, NAP |
S |
I(15681437) |
N |
N |
I(8627656, 15327897) |
I(22884292, 8627656, 15681437) |
I(15780869, DNA-binding protein pull-down assay) |
Fields Virology |
P48752 is inferred from Human adenovirus C protein
P03272 |
Component of the packaging machinery which encapsidates
the viral DNA into preformed capsids and transcriptional
activator of the viral major late promoter (MLP). Binds,
along with packaging proteins 2 and 3, to the specific
packaging sequence on the left end of viral genomic DNA and
displays ATPase activity thereby providing the power stroke
of the packaging machinery. The activity of packaging protein
IVa2 is stimulated by protein 33K which acts as a terminase.
May be the protein that pumps DNA into the capsid powered by
ATP hydrolysis. Specifically binds to the 5'-CG-3'
nucleotides of the repeats making up the packaging sequence.
Component of the DEF-A and DEF-B transcription factors that
bind downstream elements of the major late promoter (MLP),
and stimulate transcription from the MLP after initiation of
viral DNA replication. DEF-A is a heterodimer packaging
proteins 1 and 2 and DEF-B is a homodimer of packaging
protein 1. |
|
37 |
Adenoviridae |
Human adenovirus F |
L2 |
L2 protein pVII, L2 protein VII, Major core protein pVII,
Pre-core protein VII, Pre-histone-like nucleoprotein, Protein
VII, pVII, PVII |
Q89532 |
NP_ADE40 |
A0A142G3K1,A0A1S6ELN7,B5SNS1,E2IJY3 |
dsDNA |
TR, NAP |
S |
N |
N |
N |
N |
I(6828374, 27362237) |
I(3743550, cross-linking), I(15163739,
Immunofluorescence) |
Fields Virology |
Q89532 is inferred from Human adenovirus C protein
P68950 |
Plays a role in the inhibition of host immune response
within the nucleus. Interacts with cellular nucleosomes and
immobilizes the host immune danger signal HMGB1 on chromatin.
In turn, prevents HMGB1 release out of the cell and thus
decreases inflammation. Plays also a role in the wrapping and
condensation of the viral DNA. May also promote viral genome
import into the nucleus. |
|
38 |
Arenaviridae |
Junin mammarenavirus |
N |
Nucleocapsid protein, Nucleoprotein, Protein N |
P14239 |
NCAP_JUNIN |
A0A0M4MQK9,C1K9K0,C1K9K4,C5MKK3,D1GI65,D2CFM2,D2CFM5,D2CFR6,D2CFR8,D2CFS0,D2CFS2,D2CFS4,D2CFS6,D2CFS8,D2CFT0,D2CFT2,O10431,O10432,O10433,Q2XP54,Q6IVU2,Q6UY72 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
4K7E |
I(21085117, 21262835) |
N |
D(20007272), I(22084115, RNA complex structure) |
30123198.0 |
|
Encapsidates the genome, protecting it from nucleases.
The encapsidated genomic RNA is termed the nucleocapsid (NC).
Serves as template for viral transcription and replication.
The increased presence of protein N in host cell does not
seem to trigger the switch from transcription to replication
as observed in other negative strain RNA viruses. Through the
interaction with host IKBKE, strongly inhibits the
phosphorylation and nuclear translocation of host IRF3, a
protein involved in interferon activation pathway, leading to
the inhibition of interferon-beta and IRF3-dependent
promoters activation. Encodes also a functional 3'-5'
exoribonuclease that degrades preferentially dsRNA substrates
and thereby participates in the suppression of interferon
induction. |
|
39 |
Arenaviridae |
Lassa virus |
N |
Nucleocapsid protein, Nucleoprotein, Protein N |
P13699 |
NCAP_LASSJ |
Q6GWS1 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
3MWP, 3MWT, 3MX2, 3MX5, 3Q7B, 3Q7C, 4FVU, 4G9Z, 4GV3,
4GV6, 4GV9 |
D(21085117, 21262835) |
N |
D(23553456), D(22084115, RNA complex structure) |
29596412.0 |
|
Encapsidates the genome, protecting it from nucleases.
The encapsidated genomic RNA is termed the nucleocapsid (NC).
Serves as template for viral transcription and replication.
The increased presence of protein N in host cell does not
seem to trigger the switch from transcription to replication
as observed in other negative strain RNA viruses. Through the
interaction with host IKBKE, strongly inhibits the
phosphorylation and nuclear translocation of host IRF3, a
protein involved in interferon activation pathway, leading to
the inhibition of interferon-beta and IRF3-dependent
promoters activation. Encodes also a functional 3'-5'
exoribonuclease that degrades preferentially dsRNA substrates
and thereby participates in the suppression of interferon
induction. |
|
40 |
Arenaviridae |
Lujo mammarenavirus |
N |
Nucleocapsid protein, Nucleoprotein |
C5ILC2 |
C5ILC2_9VIRU |
|
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(21085117, 21262835) |
N |
I(22084115, RNA complex structure) |
30123198.0 |
C5ILC2 is inferred from Lassa virus protein P13699 |
viral nucleocapsid |
|
41 |
Arenaviridae |
Lymphocytic choriomeningitis virus |
N |
Nucleocapsid protein, Nucleoprotein, Protein N |
P07400 |
NCAP_LYCVW |
A0A218M2F8,P09992 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
D(12610166, 10729120) |
N |
D(10729120), I(22084115, RNA complex structure) |
22889536.0 |
|
Encapsidates the genome, protecting it from nucleases.
The encapsidated genomic RNA is termed the nucleocapsid (NC).
Serves as template for viral transcription and replication.
The increased presence of protein N in host cell does not
seem to trigger the switch from transcription to replication
as observed in other negative strain RNA viruses. Through the
interaction with host IKBKE, strongly inhibits the
phosphorylation and nuclear translocation of host IRF3, a
protein involved in interferon activation pathway, leading to
the inhibition of interferon-beta and IRF3-dependent
promoters activation. Encodes also a functional 3'-5'
exoribonuclease that degrades preferentially dsRNA substrates
and thereby participates in the suppression of interferon
induction. |
|
42 |
Arenaviridae |
Machupo virus |
N |
NP, Nucleocapsid protein, Nucleoprotein, Nucleoprotein
(Fragment), Protein N |
P26578 |
NCAP_MACHU |
A0A1U8ZS29,A0A1U8ZS66,A0A1U8ZS72,A0A1U8ZS90,A0A1U8ZSD0,A0A1U8ZSR6,A9JR11,A9JR13,A9JR15,A9JR19,A9JR21,C7AZ57,C7AZ59,C7AZ61,C7AZ63,C7AZ65,G9J1N3,Q6IUF6,Q6IVT4,Q6PXP5,Q8AZ68 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(21085117, 21262835) |
N |
D(20007272), I(22084115, RNA complex structure) |
22607481.0 |
|
Encapsidates the genome, protecting it from nucleases.
The encapsidated genomic RNA is termed the nucleocapsid (NC).
Serves as template for viral transcription and replication.
The increased presence of protein N in host cell does not
seem to trigger the switch from transcription to replication
as observed in other negative strain RNA viruses. Through the
interaction with host IKBKE, strongly inhibits the
phosphorylation and nuclear translocation of host IRF3, a
protein involved in interferon activation pathway, leading to
the inhibition of interferon-beta and IRF3-dependent
promoters activation. Encodes also a functional 3'-5'
exoribonuclease that degrades preferentially dsRNA substrates
and thereby participates in the suppression of interferon
induction. |
|
43 |
Arenaviridae |
Sabia mammarenavirus |
N |
Nucleocapsid protein, Nucleoprotein, Protein N |
Q90038 |
NCAP_SABVB |
H6V7J3 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(21085117, 21262835) |
N |
D(20007272), I(22084115, RNA complex structure) |
30123198.0 |
|
Encapsidates the genome, protecting it from nucleases.
The encapsidated genomic RNA is termed the nucleocapsid (NC).
Serves as template for viral transcription and replication.
The increased presence of protein N in host cell does not
seem to trigger the switch from transcription to replication
as observed in other negative strain RNA viruses. Through the
interaction with host IKBKE, strongly inhibits the
phosphorylation and nuclear translocation of host IRF3, a
protein involved in interferon activation pathway, leading to
the inhibition of interferon-beta and IRF3-dependent
promoters activation. Encodes also a functional 3'-5'
exoribonuclease that degrades preferentially dsRNA substrates
and thereby participates in the suppression of interferon
induction. |
|
44 |
Arenaviridae |
Whitewater Arroyo mammarenavirus |
N |
NP, Nucleocapsid protein, Nucleoprotein, Protein N |
Q91PB2 |
NCAP_WWAVU |
Q8BDE2,V9LTH7,V9LTK9,V9LTM7 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(21085117, 21262835) |
N |
I(22084115, RNA complex structure) |
28736175.0 |
Q91PB2 is inferred from Lassa virus protein P13699 |
Encapsidates the genome, protecting it from nucleases.
The encapsidated genomic RNA is termed the nucleocapsid (NC).
Serves as template for viral transcription and replication.
The increased presence of protein N in host cell does not
seem to trigger the switch from transcription to replication
as observed in other negative strain RNA viruses. Through the
interaction with host IKBKE, strongly inhibits the
phosphorylation and nuclear translocation of host IRF3, a
protein involved in interferon activation pathway, leading to
the inhibition of interferon-beta and IRF3-dependent
promoters activation. Encodes also a functional 3'-5'
exoribonuclease that degrades preferentially dsRNA substrates
and thereby participates in the suppression of interferon
induction. |
|
45 |
Bornaviridae |
Borna disease virus 1 |
P |
P protein, p23, p24, Phosphoprotein, P/X |
P0C799 |
PHOSP_BDVV |
A4D837,A5A7J0,O10393,O10402,O10404,O10405,O10406,Q1HVJ9,Q1L311,Q53WV0,Q53WV1,Q5GLA5,Q5GLB1,Q5GLC9,Q5XWT9,Q5XWU0,Q5XWU1,Q5XWU2,Q5XWU3,Q65456,Q65457,Q65458,Q76RA4,Q774E4,Q80G14,Q80G15,Q9DRF2,Q9DRF3,Q9E7S5,Q9E7S8,Q9IV61,Q9IV62,Q9IW59,Q9JGP3,Q9Q4W4,X2D1D2,X2D1D5 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
D(15509569, 14581561) |
N |
D(14581561, 15509569) |
14581561.0 |
|
Essential component of the RNA polymerase transcription
and replication complex. Acts as a scaffold which brings L in
close proximity to the N-RNA complex. Plays a role in the
segregation of the viral genome in host daughter cells during
mitosis by interacting with host HMGB1, a host
chromatin-remodeling DNA architectural protein, thereby
stabilizing RNP on chromosomes. Interacts with host TBK1 and
thus interferes with activation of cellular antiviral state.
Inhibits cellular histone acetyltransferase activities. |
|
46 |
Bornaviridae |
Borna disease virus 2 |
P |
Phosphoprotein, P protein |
Q9Q9U9 |
Q9Q9U9_9MONO |
|
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
D(15509569, 14581561) |
N |
D(14581561, 15509569) |
14581561.0 |
|
Viral nucleocapsid |
|
47 |
Coronaviridae |
Human coronavirus 229E (HCoV-229E) |
E |
E protein, Envelope small membrane protein, sM, sM
protein |
P19741 |
VEMP_CVH22 |
A0A059SEL9,A0A384L4F1,J9VDX2,S5YAG7,S5YGS8 |
indirect/unknown |
TR, Other |
S |
N |
N |
N |
N |
N |
I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) |
32006468.0 |
|
Plays a central role in virus morphogenesis and assembly.
Acts as a viroporin and self-assembles in host membranes
forming pentameric protein-lipid pores that allow ion
transport. Also plays a role in the induction of
apoptosis. |
|
48 |
Coronaviridae |
Human coronavirus 229E (HCoV-229E) |
N |
NC, Nucleocapsid protein, Nucleoprotein, Protein N |
P15130 |
NCAP_CVH22 |
A0A059SGB0,A0A097ZMN8,A0A097ZMN9,A0A097ZMP1,A0A097ZMP2,A0A097ZMP3,A0A097ZMR3,A0A127ATI4,A0A127ATI5,A0A127ATI6,A0A127ATI8,A0A127ATJ0,A0A127ATJ4,A0A127ATJ5,A0A127ATJ6,A0A127ATJ8,A0A127ATM6,A0A127ATM8,A0A127ATP2,A0A127AU31,A0A127AU35,A0A127AUT5,A0A127AUU5,A0A127AWS1,A0A127AWT0,A0A193BL28,A0A1B3TN93,A0A1L7B914,A0A1L7B917,A0A1L7B932,A0A1L7B959,A0A1V0BZ85,A0A1V0E0Z0,A0A1W6DZN2,A0A1Z1R303,A0A223FUI1,A0A384QXL5,A0A384QXL7,A0A384QXY0,A0A384QZB4,A0A384R2K5,A0A384R2L0,A0A384RBS5,A0A384RBS7,A0A384RHP2,J9V7P0,J9V7P5,Q1HVM7,Q1HVM8,Q1HVM9,Q1HVN3,Q1HVN6,Q1HVN7,Q1HVN9,Q1HVP0,Q1HVP1,Q1HVP2,Q1HVP3,Q1HVP5,Q1HVP6,Q1HVP8,Q1HVP9,Q1HVQ0,S5YAG2,S5Z1H9,S5ZJ09,U3PTJ0,U3PUD7 |
ssRNA, dsDNA |
TR, Rep, NAP |
S |
I(16546436;18055455) |
N |
N |
D(15890900) |
I(16546436;15759315;25700263) |
I(14623261;29793506) |
32006468.0 |
P15130 is inferred from Human SARS coronavirus protein
P59595 |
Packages the positive strand viral genome RNA into a
helical ribonucleocapsid (RNP) and plays a fundamental role
during virion assembly through its interactions with the
viral genome and membrane protein M. Plays an important role
in enhancing the efficiency of subgenomic viral RNA
transcription as well as viral replication. |
|
49 |
Coronaviridae |
Human coronavirus HKU1 |
E |
E protein, Envelope small membrane protein, sM, sM
protein |
Q5MQC8 |
VEMP_CVHN1 |
A0A224ANC8,Q0ZJ83,Q0ZJ91,Q0ZJB5,Q0ZJD1,Q0ZME5,Q14EA8,S5YA38,S5YTP7 |
indirect/unknown |
TR, Other |
S |
N |
N |
N |
N |
N |
I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) |
32006468.0 |
|
Plays a central role in virus morphogenesis and assembly.
Acts as a viroporin and self-assembles in host membranes
forming pentameric protein-lipid pores that allow ion
transport. Also plays a role in the induction of
apoptosis. |
|
50 |
Coronaviridae |
Human coronavirus HKU1 |
N |
NC, Nucleocapsid protein, Nucleoprotein, Protein N |
Q5MQC6 |
NCAP_CVHN1 |
A0A0C5PN53,A0A0C5PWK5,A0A0C5PXY9,A0A0C5Q0N4,A0A0C5Q9E2,A0A127ASV7,A0A127ASV8,A0A127ASW6,A0A127ASW7,A0A127ASY7,A0A127ASZ8,A0A127AT27,A0A127AT34,A0A127AT49,A0A127AT59,A0A127AT66,A0A127AT73,A0A127ATF0,A0A127ATF4,A0A127ATT6,A0A127ATU5,A0A127ATV4,A0A127AUB1,A0A127AUC1,A0A127AW89,A0A127AWE0,A0A1Y0EV09,A0A3Q9JNH6,E0YJ48,Q0PRK0,Q0ZJD7,Q0ZJE5,Q0ZJH7,Q0ZME3,Q14EA6,Q19U24,Q19U25,Q19U26,Q19U29,Q19U34,Q19U36,S5ZBQ7,U3NAH8 |
ssRNA, dsDNA |
TR, Rep, NAP |
S |
I(16546436;18055455) |
N |
N |
I(16546436;14623261;18055455;17108024;15890900) |
I(16546436;15759315;25700263) |
I(14623261;29793506) |
32006468.0 |
|
Packages the positive strand viral genome RNA into a
helical ribonucleocapsid (RNP) and plays a fundamental role
during virion assembly through its interactions with the
viral genome and membrane protein M. Plays an important role
in enhancing the efficiency of subgenomic viral RNA
transcription as well as viral replication. |
|
51 |
Coronaviridae |
Human coronavirus NL63 (HCoV-NL63) |
E |
Envelope small membrane protein, NC, Nucleocapsid
protein, Nucleoprotein, Protein N |
Q6Q1S0 |
VEMP_CVHNL |
Q5SBN7 |
indirect/unknown |
TR, Other |
S |
N |
N |
N |
N |
N |
I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) |
32006468.0 |
|
Plays a central role in virus morphogenesis and assembly.
Acts as a viroporin and self-assembles in host membranes
forming pentameric protein-lipid pores that allow ion
transport. Also plays a role in the induction of
apoptosis. |
|
52 |
Coronaviridae |
Human coronavirus NL63 (HCoV-NL63) |
N |
NC, Nucleocapsid protein, Nucleoprotein, Protein N |
Q6Q1R8 |
NCAP_CVHNL |
A0A127ATP0,A0A127ATQ0,A0A127ATQ1,A0A127ATQ4,A0A127ATQ7,A0A127ATQ8,A0A127ATR0,A0A127ATR3,A0A127ATR6,A0A127ATR7,A0A127ATS0,A0A127ATS3,A0A127ATS5,A0A127ATS6,A0A127ATS9,A0A127ATT3,A0A127ATT5,A0A127ATT9,A0A127ATU8,A0A127ATV6,A0A127ATV7,A0A127ATW2,A0A127ATW4,A0A127ATX3,A0A127ATX8,A0A127ATY1,A0A127ATY7,A0A127ATY8,A0A127AU18,A0A127AU23,A0A127AU27,A0A127AU68,A0A127AU79,A0A127AU90,A0A127AUA1,A0A127AV25,A0A127AV38,A0A127AV50,A0A127AV68,A0A127AX00,A0A127AX15,A0A127AX50,A0A127AX58,A0A1Y0EV18,A0A2L0WQF7,A0A2P1E938,A0A2P1E945,A0A2P1E948,A0A2P1E959,A0A2P1E971,A0A2U8JDM2,A0A384R2N5,A0A384RBU9,A0A384RBV1,A0T2T5,H9EJ20,H9EJ69,H9EJ76,H9EJA4,I7DJE7,Q06XQ0,Q06XQ1,Q06XQ2,Q06XQ3,Q06XQ4,Q06XQ5,Q06XQ6,Q06XQ7,Q06XQ8,Q06Y12,Q0GMF2,U3M6A0,U3M7G3 |
ssRNA, dsDNA |
TR, Rep, NAP |
S |
I(16546436;18055455) |
N |
5EPW |
I(16546436;14623261;18055455;17108024;15890900) |
D(25700263) |
I(14623261;29793506) |
32006468.0 |
|
Packages the positive strand viral genome RNA into a
helical ribonucleocapsid (RNP) and plays a fundamental role
during virion assembly through its interactions with the
viral genome and membrane protein M. Plays an important role
in enhancing the efficiency of subgenomic viral RNA
transcription as well as viral replication. |
|
53 |
Coronaviridae |
Human coronavirus OC43 (HCoV-OC43) |
E |
E protein, Envelope small membrane protein, sM, sM
protein |
Q04854 |
VEMP_CVHOC |
A0A140E067,Q4VID3,Q4VIE2,U3M6J8,U3M6Q3,U3M6Z1,U3M6Z8,U3M703,U3M734 |
indirect/unknown |
TR, Other |
S |
N |
N |
N |
N |
N |
I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) |
32006468.0 |
|
Plays a central role in virus morphogenesis and assembly.
Acts as a viroporin and self-assembles in host membranes
forming pentameric protein-lipid pores that allow ion
transport. Also plays a role in the induction of
apoptosis. |
|
54 |
Coronaviridae |
Human coronavirus OC43 (HCoV-OC43) |
N |
NC, Nucleocapsid protein, Nucleoprotein, Protein N |
P33469 |
NCAP_CVHOC |
A0A0A0YP48,A0A0B4N5U7,A0A0B4N5V5,A0A0B4N684,A0A0B4N6G5,A0A0B4N6G8,A0A0B4N6W6,A0A0B4N7F3,A0A0B4N7G3,A0A0B4N7G5,A0A0B4Q800,A0A0B4Q8L7,A0A0B4UEK7,A0A0B4UFS5,A0A0C5PN59,A0A0C5PN66,A0A0C5PN72,A0A0C5PWL1,A0A0C5PWL5,A0A0C5PWM1,A0A0C5PWM6,A0A0C5PXZ8,A0A0C5PY00,A0A0C5PY04,A0A0C5Q0P0,A0A0C5Q0P6,A0A0C5Q0Q2,A0A0C5Q9E8,A0A0C5Q9F4,A0A0C5Q9G1,A0A0G2RC60,A0A0G2RC64,A0A0G2RC66,A0A0G2RC68,A0A0G2RC70,A0A0G2RC83,A0A0G2RC86,A0A0G2RC94,A0A0G2RCA8,A0A0G2RCB5,A0A0G2RCY1,A0A0G2RCZ3,A0A0K0KPA1,A0A0K0KPA2,A0A0K0KPB1,A0A0K0KPQ5,A0A0K0KQ87,A0A0K0KQA8,A0A0K0L8G1,A0A0K0L9S6,A0A127AT13,A0A127AT23,A0A127AT26,A0A127AT35,A0A127AT45,A0A127AT53,A0A127AT99,A0A127ATA3,A0A127ATA6,A0A127ATA7,A0A127ATA9,A0A127ATB4,A0A127ATB6,A0A127ATC1,A0A127ATJ2,A0A127ATK0,A0A127ATZ8,A0A127AU02,A0A127AUL9,A0A127AUM9,A0A127AWJ2,A0A127AWK6,A0A127AWL7,A0A140E069,A0A1C8Z4S7,A0A1L7H9A3,A0A1S5VG93,A0A1S5VGD1,A0A1S5VGI5,A0A1S5VGJ0,A0A1V0BZ77,A0A1W6DZM9,A0A1W6DZV4,A0A1W6DZW0,A0A1W6DZX0,A0A1Y0EV19,A0A2D1CLX3,A0A2D1QW28,A0A385H5N1,A0A385H5Q3,A0A385H5U7,A0A385H5X1,A0A385H5Z4,A0A385H6E5,A0A385H6Q1,A0A385H6V0,G5CJB5,G5CJC3,Q4VID1,Q4VIE0,Q696P4,Q6SA23,U3M6V0,U3M6V7,U3M7I5,U3M7J7,U3M7K1,U3M7Z4,U3M7Z6,U3M7Z8,U3M804,U3M816,U3M820,U3M822,U3M826,U3M828 |
ssRNA, dsDNA |
TR, Rep, NAP |
S |
I(16546436;18055455) |
N |
N |
I(16546436;14623261;18055455;17108024;15890900) |
I(16546436;15759315;25700263) |
I(14623261;29793506) |
32006468.0 |
|
Packages the positive strand viral genome RNA into a
helical ribonucleocapsid (RNP) and plays a fundamental role
during virion assembly through its interactions with the
viral genome and membrane protein M. Plays an important role
in enhancing the efficiency of subgenomic viral RNA
transcription as well as viral replication. |
|
55 |
Coronaviridae |
Human SARS coronavirus |
3b |
Accessory protein 3b, Non-structural protein 3b, ns3b,
ORF3b,SARSCoVgp06, ORF4, Protein X2 |
P59633 |
NS3B_CVHSA |
A0A0U2PTX6,A0A3G5BIZ2,B8Q8Q5,B8Q8R6,B8Q8S8,B8Q8T9,B8Q8V0,B8Q8W1,C4P6Q9,D2DJW6,D2E1D4,D2E1E9,D2E223,D2E252,D2E267,D2E2F4,D2E2T6,D3KDM7,J9T0L3,Q19QW8,Q1EFN0,Q1EFP3,Q1T6X4,Q3S2C3,Q3ZTC3,Q3ZTD8,Q4JDQ2,Q4JDR5,Q5DIC3,Q692E2,Q6GYQ9,Q6JH36,Q6JH44,Q6R7Y4,Q6RCW3,Q6RCX4,Q6RCY5,Q6RCZ6,Q6RD07,Q6RD18,Q6RD29,Q6RD40,Q6RD51,Q6RD62,Q6S8D5,Q6T1E1,Q6TPE6,Q6VA76,Q6VA87,Q6VA98,Q6WGN1,U5WHZ3,U5WI10,U5WLA7 |
indirect/unknown |
TR, Rep, Other |
S |
D(22253733) |
N |
N |
D(22253733) |
N |
N |
27344959.0 |
|
Induces host cell G0/G1 arrest and apoptosis. |
|
56 |
Coronaviridae |
Human SARS coronavirus |
E |
E protein, Envelope small membrane protein, sM, sM
protei, sM protein |
P59637 |
VEMP_CVHSA |
A0A0K1Z002,A0A0K1Z029,A0A0U2PTJ4,A0A3G5BJ03,A2TGS2,B8Q8Q6,B8Q8R7,B8Q8S9,B8Q8U0,B8Q8V1,B8Q8W2,C4P6R0,D2DJW7,D2E1D5,D2E1F0,D2E224,D2E253,D2E268,D2E2J8,D2E2M8,D2E2S3,D2E2T7,D3KDM8,D3KDQ6,D5HJQ3,D5HJR4,D5HJS5,D5HJT6,D5HJW0,D5HJX1,D5HJY2,D5HJZ3,D5HK04,J9TE86,Q19QW7,Q1EFM9,Q1EFP2,Q1T6X3,Q3LZU0,Q3LZV1,Q3S2C2,Q3ZTC2,Q3ZTD7,Q4JDQ1,Q4JDR4,Q5DIC2,Q5Y298,Q692E1,Q6GYQ8,Q6JH35,Q6JH43,Q6QJ39,Q6R7Y3,Q6RCW2,Q6RCX3,Q6RCY4,Q6RCZ5,Q6RD06,Q6RD17,Q6RD28,Q6RD39,Q6RD50,Q6RD61,Q6S8D4,Q6SRI1,Q6SRI5,Q6SRI9,Q6SRJ3,Q6SRJ7,Q6SRK1,Q6SRK5,Q6SRK9,Q6SRL3,Q6SRL7,Q6SRM1,Q6SRM5,Q6SRM9,Q6SRN3,Q6SRN7,Q6SRP1,Q6SRP5,Q6SRP9,Q6T1D9,Q6TPE5,Q6VA75,Q6VA86,Q6VA97,Q6WGP2,U5WI28,U5WI54,U5WLL8 |
indirect/unknown |
TR, Other |
S |
N |
N |
N |
N |
N |
I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) |
27344959.0 |
|
Plays a central role in virus morphogenesis and assembly.
Acts as a viroporin and self-assembles in host membranes
forming pentameric protein-lipid pores that allow ion
transport. Also plays a role in the induction of apoptosis
(By similarity). Activates the host NLRP3 inflammasome,
leading to IL-1beta overproduction. |
|
57 |
Coronaviridae |
Human SARS coronavirus |
N |
NC, Nucleocapsid protein, Nucleoprotein, Protein N |
P59595 |
NCAP_CVHSA |
A0A0K1YZZ7,A0A0K1Z0P8,A0A0U2NR12,A0A3G5BJ14,A2TGS3,B8Q8R0,B8Q8S2,B8Q8T3,B8Q8U4,B8Q8V5,B8Q8W6,C4P6R7,D2DJX3,D2E1E2,D2E1F7,D2E216,D2E230,D2E275,D2E2E7,D2E2N5,D3KDN4,D5HJQ9,D5HJS0,D5HJT1,D5HJU2,D5HJV5,D5HJW6,D5HJX7,D5HJY8,D5HJZ9,D5HK10,Q19QW0,Q1EFM2,Q1EFN5,Q1T6X0,Q3I5K0,Q3I5K3,Q3LZU2,Q3LZV6,Q3S2B5,Q3ZTB6,Q3ZTD1,Q4JDP5,Q4JDQ8,Q5DIB8,Q692D7,Q6GYQ2,Q6JH33,Q6JH41,Q6QHB3,Q6QHB4,Q6QHB5,Q6QJ37,Q6R7X9,Q6RCV8,Q6RCW9,Q6RCY0,Q6RCZ1,Q6RD02,Q6RD13,Q6RD35,Q6RD46,Q6RD57,Q6S8C7,Q6S8E1,Q6T1D2,Q6TPE0,Q6UPD4,Q6UUW1,Q6UZE8,Q6UZF2,Q6V583,Q6VA71,Q6VA82,Q6VA93,U5WIP0,U5WLA2,U5WLN3 |
ssRNA, dsDNA |
TR, Rep,NAP |
S |
D(16546436;18055455) |
N |
2OFZ |
D(16546436;14623261;18055455;17108024) |
D(16546436;15759315) |
D(14623261, TransFactor analysis assay) |
27344959.0 |
|
Packages the positive strand viral genome RNA into a
helical ribonucleocapsid (RNP) and plays a fundamental role
during virion assembly through its interactions with the
viral genome and membrane protein M. Plays an important role
in enhancing the efficiency of subgenomic viral RNA
transcription as well as viral replication. |
|
58 |
Coronaviridae |
Middle East respiratory syndrome-related coronavirus;
Human coronavirus EMC |
E |
E protein, Envelope small membrane protein, M, sM
protein |
R9UQN1 |
R9UQN1_9BETC |
A0A075E1D8,A0A0G3VM72,A0A0G3VM78,A0A0S3IVQ1,A0A0U2GLG8,A0A0U2GP61,A0A1D6Y7S6,K0BRH1,K9N5R3,M4SQZ1,R9WYQ9,T2BBC7,T2BBI3 |
indirect/unknown |
TR, Other |
S |
N |
N |
N |
N |
N |
I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) |
27344959.0 |
|
Plays a central role in virus morphogenesis and assembly.
Acts as a viroporin and self-assembles in host membranes
forming pentameric protein-lipid pores that allow ion
transport. Also plays a role in the induction of
apoptosis. |
|
59 |
Coronaviridae |
Middle East respiratory syndrome-related coronavirus;
Human coronavirus EMC |
N |
NC, Nucleocapsid protein, Nucleoprotein, Protein N |
K9N4V7 |
NCAP_CVEMC |
A0A023NFV4,A0A023VZL1,A0A023VZM0,A0A024E1L1,A0A068FIZ3,A0A068FM93,A0A068FR27,A0A0A0QHI8,A0A0A7E7L7,A0A0A7KVQ1,A0A0D3MU51,A0A0D3MU65,A0A0G2UKT0,A0A0G3KE78,A0A0R7E423,A0A0U2GLA1,A0A0U2GM98,A0A0U2GMX8,A0A0U2GPN9,A0A0U2GQM3,A0A0U2GQX0,A0A0U4BQZ8,A0A140AZ32,A0A141LLD8,K0BVN3,M1S193,M4SRY6,R9UM87,T2B9H8,T2B9R0,T2BBB8,T2BBK0,V9TXP8,W5ZZJ8,W5ZZL9,W5ZZM7,W5ZZP8,W5ZZV0,W6A8J1,W8NMH3 |
ssRNA, dsDNA |
TR, Rep, NAP |
S |
I(16546436;18055455) |
N |
N |
I(16546436;14623261;18055455;17108024;15890900) |
I(16546436;15759315;25700263) |
D(29793506, Filter binding assay ) |
27344959.0 |
K9N4V7 is inferred from Human SARS coronavirus protein
P59595 |
Packages the positive strand viral genome RNA into a
helical ribonucleocapsid (RNP) and plays a fundamental role
during virion assembly through its interactions with the
viral genome and membrane protein M. Plays an important role
in enhancing the efficiency of subgenomic viral RNA
transcription as well as viral replication. |
|
60 |
Coronaviridae |
Human SARS coronavirus 2 |
E |
E protein, Envelope small membrane protein, ORF4, sM
protein, structural protein |
P0DTC4 |
VEMP_SARS2 |
|
indirect/unknown |
TR, Other |
S |
N |
N |
N |
N |
N |
D(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) |
32072569.0 |
|
Plays a central role in virus morphogenesis and assembly.
Acts as a viroporin and self-assembles in host membranes
forming pentameric protein-lipid pores that allow ion
transport. Also plays a role in the induction of apoptosis
(By similarity). Activates the host NLRP3 inflammasome,
leading to IL-1beta overproduction. |
|
61 |
Coronaviridae |
Human SARS coronavirus 2 |
N |
NC, Nucleocapsid protein, Nucleoprotein, Protein N |
P0DTC9 |
NCAP_SARS2 |
|
ssRNA, dsDNA |
TR, Rep, NAP |
S |
I(16546436;18055455) |
N |
N |
I(16546436;14623261;18055455;17108024;15890900) |
I(16546436;15759315;25700263) |
I(14623261;29793506) |
32072569.0 |
YP_009724397.2_11 is inferred from Human SARS coronavirus
protein P59595 |
Packages the positive strand viral genome RNA into a
helical ribonucleocapsid (RNP) and plays a fundamental role
during virion assembly through its interactions with the
viral genome and membrane protein M. Plays an important role
in enhancing the efficiency of subgenomic viral RNA
transcription as well as viral replication. |
|
62 |
Filoviridae |
Bundibugyo ebolavirus |
NP |
Nucleocapsid protein, Nucleoprotein |
B8XCM7 |
B8XCM7_9MONO |
R4QJ68 |
ssRNA |
NAP, TR, Rep |
S |
N |
N |
5VKD |
I(31952352; 9971816) |
I(28566377) |
I(28593988) |
21987745.0 |
|
RNA binding,viral RNA genome packaging,helical viral
capsid,host cell cytoplasm,viral nucleocapsid |
|
63 |
Filoviridae |
Bundibugyo ebolavirus |
VP30 |
Minor nucleoprotein, Minor nucleoprotein VP30 |
B8XCN3 |
B8XCN3_9MONO |
R4QUH9 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(27279615, 23493393, 27755595) |
I(27279615) |
I(12163572) |
21987745.0 |
R4QUH9 is inferred from Zaire ebolavirus protein
Q05323 |
Metal ion binding,viral nucleocapsid |
|
64 |
Filoviridae |
Bundibugyo ebolavirus |
VP35 |
Polymerase cofactor VP35, Polymerase complex protein |
B8XCM8 |
B8XCM8_9MONO |
R4QGV8 |
dsRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(9971816, 11027311, 12829834, 19557165) |
I(27642076) |
I(19557165) |
21987745.0 |
R4QGV8 is inferred from Zaire ebolavirus protein
Q05127 |
Plays an essential role in viral RNA synthesis and also a
role in suppressing innate immune signaling. |
|
65 |
Filoviridae |
Ebola virus |
NP |
Nucleocapsid protein, Nucleoprotein |
A0A2Z2FMG9 |
A0A2Z2FMG9_9MONO |
A0A0E3H7K1,A0A0E3KX27,A0A141BR54,A0A1C4HD05,A0A2Z2FIR4,A0A2Z2FJ72,A0A2Z2FJB7,A0A2Z2FJH7,A0A2Z2FNR0,A0A2Z2FWI4 |
ssRNA |
NAP, TR, Rep |
S |
N |
N |
N |
D(31952352; 9971816) |
I(28566377) |
D(28593988) |
Fields Virology |
|
RNA binding,viral RNA genome packaging,helical viral
capsid,host cell cytoplasm,viral nucleocapsid |
|
66 |
Filoviridae |
Ebola virus |
VP30 |
Minor nucleoprotein VP30 |
A0A0E3KX28 |
A0A0E3KX28_9MONO |
A0A2Z2FME8 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
D(27279615, 23493393, 27755595) |
D(27279615; 27315567) |
D(12163572, 27279615) |
Fields Virology |
|
metal ion binding,viral nucleocapsid |
|
67 |
Filoviridae |
Ebola virus |
VP35 |
Polymerase cofactor VP35 |
A0A1C4HDK9 |
A0A1C4HDK9_9MONO |
A0A0E3N983 |
dsRNA |
TR, NAP, Rep |
S |
N |
N |
N |
D(9971816, 11027311, 12829834, 19557165) |
D(27642076) |
D(19557165) |
Fields Virology |
|
Plays an essential role +U68:U85in viral RNA synthesis
and also a role in suppressing innate immune signaling. |
|
68 |
Filoviridae |
Lake Victoria marburgvirus |
NP |
NC, Nucleocapsid protein, Nucleoprotein, Protein N |
P27588 |
NCAP_MABVM |
A9Q1G5,A9Q1H2,C0IT76,C0IT83,G9HWE2,P35263,Q1PD53,Q1PD74,Q1PDA9,Q1PDB6,Q1PDD0,Q6UY69 |
ssRNA |
NAP, TR, Rep |
S |
N |
N |
6APP |
I(31952352; 9971816) |
I(28566377) |
I(28593988) |
31131088.0 |
|
Encapsidates the genome, protecting it from nucleases.
The encapsidated genomic RNA is termed the nucleocapsid and
serves as template for transcription and replication. During
replication, encapsidation by NP is coupled to RNA synthesis
and all replicative products are resistant to nucleases (By
similarity). |
|
69 |
Filoviridae |
Lake Victoria marburgvirus |
VP30 |
Minor nucleoprotein VP30, Transcription activator
VP30 |
P35258 |
VP30_MABVM |
P41326,Q1PD49,Q1PD56,Q1PDA5,Q1PDB2,Q1PDB9,Q1PDC6,Q6UY65 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
5T3W |
I(27279615, 23493393, 27755595) |
I(27279615) |
I(12163572) |
31131088.0 |
|
Acts as a transcription anti-termination factor
immediately after transcription initiation, but does not
affect transcription elongation. This function has been found
to be dependent on the formation of an RNA secondary
structure at the transcription start site of the first gene
(By similarity). |
|
70 |
Filoviridae |
Lake Victoria marburgvirus |
VP35 |
Marburg VP35, mVP35, Polymerase cofactor VP35 |
P35259 |
VP35_MABVM |
Q03039,Q1PD52,Q1PDA8,Q1PDB5,Q1PDC9,Q6UY68 |
dsRNA |
TR, NAP, Rep |
S |
N |
N |
4GH9, 4GHA, 5TOH, 5TOI |
I(9971816, 11027311, 12829834, 19557165) |
I(27642076) |
I(19557165) |
31131088.0 |
|
Plays an essential role in viral RNA synthesis and also a
role in suppressing innate immune signaling. |
|
71 |
Filoviridae |
Marburg marburgvirus |
NP |
Nucleocapsid protein, Nucleoprotein |
C7B276 |
C7B276_9MONO |
A0A077D355,A0A0U2M3H8,A0A385L0K9,C7B248,C7B269,C7B283,E0X0Z7,E0X111,K4MQ25,K4MQC5,K4MQF4,K4MQY0,K4MR07,K4MR89,K4MRA8,K4MSQ7,K4MSZ0,K4MT16,K4N3C7,K4N3K2,K4N3V7 |
ssRNA |
NAP, TR, Rep |
S |
N |
N |
N |
D(9971816;9765419) |
D(28566377) |
I(28593988) |
31146800.0 |
|
RNA binding,viral RNA genome packaging,helical viral
capsid,host cell cytoplasm,viral nucleocapsid |
|
72 |
Filoviridae |
Marburg marburgvirus |
VP30 |
Minor nucleoprotein VP30, Viral protein 30, VP30 minor
nucleoprotein |
C7B280 |
C7B280_9MONO |
A0A077CZD4,A0A1U8ZSA8,A0A385L0L3,C7B252,C7B273,E0X101,K4MQ93,K4MQB7,K4MQE5,K4MR00,K4MSM3,K4MSU4,K4MSY4,K4MSZ1,K4MT90,K4N3J5,K4N3M2 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
D(9765419) |
I(27279615) |
I(12163572) |
31146800.0 |
|
metal ion binding,viral nucleocapsid |
|
73 |
Filoviridae |
Marburg marburgvirus |
VP35 |
Polymerase cofactor VP35 |
C7B270 |
C7B270_9MONO |
A0A077CY87,A0A0B4WUN1,A0A0B4WW37,A0A0E3NAG7,A0A1L6C7S2,A0A2H4CAK4,C7B277,E0X0Z8,O36427 |
dsRNA |
TR, NAP, Rep |
S |
N |
N |
N |
D(9765419) |
I(27642076) |
I(19557165) |
31146800.0 |
|
Plays an essential role in viral RNA synthesis and also a
role in suppressing innate immune signaling. |
|
74 |
Filoviridae |
Reston ebolavirus |
NP |
Nucleocapsid protein, Nucleoprotein, Protein N, Reston
NP, rNP |
Q8JPY1 |
NCAP_EBORR |
A0A1I9VT52,A0A1Y0K5B8,A0A1Y0K5E1,A0A1Y0K5E6,A0A343J1N2,A0A343J1P1,C6G8D3,C6G8E1,C6G8E9,L7RI74,Q91DE1 |
ssRNA |
NAP, TR, Rep |
S |
N |
N |
5W2B |
I(31952352; 9971816) |
I(28566377) |
I(28593988) |
28542463, 24699737 |
|
Oligomerizes into helical capsid to encapsidate the viral
genome, protecting it from nucleases and the cellular innate
immune response. VP35 binds to and stabilizes monomeric NP,
keeping it soluble. Upon virus replication, NP is recruited
to bind cooperatively viral genomic RNA and VP35 is released.
The encapsidated genomic RNA is termed the nucleocapsid and
serves as template for transcription and replication. The
nucleocapsid is helical with a pitch of 10.81 NP per turn and
a diameter of about 22nm. Each NP binds to six nucleotides of
viral genomic RNA, three being exposed to the solvant and
three hidden into the nucleocapsid. Recruits also host
PPP2R5C phosphatase to dephosphorylate VP30 and thereby
promote viral transcription. Upon virion assembly and
budding, NP binds to VP24 and possibly host STAU1. |
|
75 |
Filoviridae |
Reston ebolavirus |
VP30 |
Minor nucleoprotein VP30, Transcription activation factor
VP30, Transcription activator VP30, Truncated transcription
activation factor VP30 |
Q8JPX6 |
VP30_EBORR |
A0A1I9VT58,A0A1Y0K5D8,A0A343J1N8,C6G8D8,C6G8E6,C6G8F4,L7RFD4,L7RI71,Q91DD6 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(27279615, 23493393, 27755595) |
I(27279615) |
I(12163572) |
28542463, 24699737 |
Q8JPX6 is inferred from Zaire ebolavirus protein
Q05323 |
Acts as a transcription anti-termination factor
immediately after transcription initiation, but does not
affect transcription elongation. This function has been found
to be dependent on the formation of an RNA stem-loop at the
transcription start site of the first gene. Binds to RNA (By
similarity). |
|
76 |
Filoviridae |
Reston ebolavirus |
VP35 |
Polymerase cofactor VP35, Polymerase complex protein
VP35 |
Q8JPY0 |
VP35_EBORR |
A0A1I9VT53,A0A343J1P2,C6G8D4,C6G8E2,C6G8F0,L7RF08,L7RFC8,Q91DE0 |
dsRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(9971816, 11027311, 12829834, 19557165) |
I(27642076) |
I(19557165) |
28542463, 24699737 |
Q8JPY0 is inferred from Zaire ebolavirus protein
Q05127 |
Acts as a polymerase cofactor in the RNA polymerase
transcription and replication complex. Prevents establishment
of cellular antiviral state by blocking virus-induced
phosphorylation and activation of interferon regulatory
factor 3 (IRF3), a transcription factor critical for the
induction of interferons alpha and beta. This blockage is
produced through the interaction with and inhibition host
IKBKE and TBK1 producing a strong inhibition of the
phosphorylation and activation of IRF3. Also inhibits the
antiviral effect mediated by the interferon-induced,
double-stranded RNA-activated protein kinase EIF2AK2/PKR (By
similarity). |
|
77 |
Filoviridae |
Sudan ebolavirus |
NP |
Nucleocapsid protein, Nucleoprotein, Protein N |
Q5XX08 |
NCAP_EBOSU |
A0A0E3N979,A0A0N9QTI0,A0A1L7B8B1,A0A2U8KL52,A0A2U8KLA7,B0LPL4,C4PK55,I7FUR1,M4J9H3,Q9QP77,R4QTJ0 |
ssRNA |
NAP, TR, Rep |
S |
N |
N |
6OAF |
I(31952352; 9971816) |
I(28566377) |
I(28593988) |
28545034.0 |
|
Oligomerizes into helical capsid to encapsidate the viral
genome, protecting it from nucleases and the cellular innate
immune response. VP35 binds to and stabilizes monomeric NP,
keeping it soluble. Upon virus replication, NP is recruited
to bind cooperatively viral genomic RNA and VP35 is released.
The encapsidated genomic RNA is termed the nucleocapsid and
serves as template for transcription and replication. The
nucleocapsid is helical with a pitch of 10.81 NP per turn and
a diameter of about 22nm. Each NP binds to six nucleotides of
viral genomic RNA, three being exposed to the solvant and
three hidden into the nucleocapsid. Recruits also host
PPP2R5C phosphatase to dephosphorylate VP30 and thereby
promote viral transcription. Upon virion assembly and
budding, NP binds to VP24 and possibly host STAU1. |
|
78 |
Filoviridae |
Sudan ebolavirus |
VP30 |
Minor nucleoprotein, Minor nucleoprotein VP30,
Transcription activator VP30, Viral protein 30 |
Q5XX03 |
VP30_EBOSU |
A0A0E3NAE6,B0LPL9,I7FWC9,M4J9H6,R4P2H0,R4QUF0 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(27279615, 23493393, 27755595) |
I(27279615) |
I(12163572) |
28545034.0 |
Q5XX03 is inferred from Zaire ebolavirus protein
Q05323 |
Acts as a transcription anti-termination factor
immediately after transcription initiation, but does not
affect transcription elongation. This function has been found
to be dependent on the formation of an RNA stem-loop at the
transcription start site of the first gene. Binds to RNA (By
similarity). |
|
79 |
Filoviridae |
Sudan ebolavirus |
VP35 |
Polymerase cofactor VP35, Viral protein 35 |
Q5XX07 |
VP35_EBOSU |
A0A0E3N5D2,A0A0N9Q7A6,B0LPL5,C4PK56,I7FLL9,R4NUK7,R4QGR7 |
dsRNA |
TR, NAP, Rep |
S |
N |
N |
N |
I(9971816, 11027311, 12829834, 19557165) |
I(27642076) |
I(19557165) |
28545034.0 |
Q5XX07 is inferred from Zaire ebolavirus protein
Q05127 |
Acts as a polymerase cofactor in the RNA polymerase
transcription and replication complex. Prevents establishment
of cellular antiviral state by blocking virus-induced
phosphorylation and activation of interferon regulatory
factor 3 (IRF3), a transcription factor critical for the
induction of interferons alpha and beta. This blockage is
produced through the interaction with and inhibition host
IKBKE and TBK1 producing a strong inhibition of the
phosphorylation and activation of IRF3. Also inhibits the
antiviral effect mediated by the interferon-induced,
double-stranded RNA-activated protein kinase EIF2AK2/PKR (By
similarity). |
|
80 |
Filoviridae |
Zaire ebolavirus |
NP |
Ebola NP, eNP, Nucleocapsid protein, Nucleoprotein,
Protein N |
P18272 |
NCAP_EBOZM |
A0A068J945,A0A068J9B9,A0A075W933,A0A075WG99,A0A096YGX0,A0A0A7PCE0,A0A0D4D8I2,A0A0D5W848,A0A0D5W865,A0A0D5W876,A0A0D5W897,A0A0D5W8E5,A0A0D5W8K5,A0A0D5W8N2,A0A0D5W8N9,A0A0D5W8U8,A0A0D5W957,A0A0D5W989,A0A0D5W9A2,A0A0D5W9C4,A0A0E3GLU4,A0A0E3TL09,A0A0E3TL91,A0A0E3TLB3,A0A0E3TLI7,A0A0E3TLJ4,A0A0E3TLM0,A0A0E3TLN8,A0A0E3TLR4,A0A0E3TLU1,A0A0E3TLU2,A0A0E3TLW5,A0A0E3TLZ1,A0A0E3TM18,A0A0E3TM19,A0A0E3TMF2,A0A0E3TMH8,A0A0E3TMK2,A0A0E3TMK6,A0A0E3TMN6,A0A0E3TMR4,A0A0E3TMS8,A0A0E3TMW3,A0A0E3TMX8,A0A0E3TMZ7,A0A0E3TN27,A0A0E3TN97,A0A0E3TNH7,A0A0E3TNK0,A0A0E3TNX9,A0A0E3X8E1,A0A0E3XJA0,A0A0E3XJB4,A0A0E3XJS6,A0A0E3XJW0,A0A0E3XJY7,A0A0E3XJZ8,A0A0E3XK34,A0A0E3XK48,A0A0E3XK58,A0A0E3XKU6,A0A0E3XKW4,A0A0E3XL13,A0A0E3XL94,A0A0E3XLF1,A0A0E3XLG4,A0A0E3XLG8,A0A0E3XLL9,A0A0E3XLQ1,A0A0E3XLR5,A0A0E3XLX7,A0A0E3XM43,A0A0F6PCY0,A0A0F6PD20,A0A0F6PDL5,A0A0F6PDL7,A0A0F6PE43,A0A0F6PE50,A0A0F6PEB1,A0A0F6PFN6,A0A0F6PG50,A0A0F6PGB6,A0A0F6PGL9,A0A0F6PGT9,A0A0F6PHL7,A0A0F7DDS0,A0A0F7DDT8,A0A0F7DDX4,A0A0F7IMS2,A0A0F7IMW8,A0A0F7ING0,A0A0F7IQ00,A0A0F7IQT2,A0A0F7IRF1,A0A0G2Y8P8,A0A0G2Y8U2,A0A0G2Y8W8,A0A0G2YAC4,A0A0G2YAP4,A0A0G2YAR8,A0A0G2YAT2,A0A0G2YB39,A0A0G2YCG7,A0A0G2YD31,A0A0G2YDZ4,A0A0G2YEH7,A0A0G2YGJ1,A0A0G2YGK1,A0A0G2YHE2,A0A0G2YHH9,A0A0G2YIW8,A0A0H3VU44,A0A0H3VUH4,A0A0H3VV97,A0A0H3VVT3,A0A0H3VXA2,A0A0H3VYJ4,A0A0H3VYM0,A0A0H3VYM9,A0A0K1NXJ4,A0A0K1NXX0,A0A0K1NY14,A0A0K1NYC4,A0A0K1NYD3,A0A0K1NYE8,A0A0K1NYH3,A0A0K1NYT7,A0A0K1NZA3,A0A0M4RGV8,A0A0N9BE19,A0A0N9QXB6,A0A0N9QXW1,A0A0S0GAE9,A0A0S0GAT9,A0A0S0GBJ7,A0A0S0H198,A0A0S0H215,A0A0S0H2Q7,A0A0S0H2R5,A0A0S0H2S9,A0A0S0H383,A0A0S0H385,A0A0S0H3C5,A0A0S0H3D3,A0A0S0H430,A0A0S0H572,A0A0S0HC67,A0A0S0HDV6,A0A0S2RN13,A0A0U3MRZ4,A0A0U3V214,A0A0U3V2G4,A0A0U3V4C0,A0A0U3V6V7,A0A0U3VB98,A0A0U3VJA1,A0A0U4CUH6,A0A0U4D4X6,A0A0U4DB33,A0A0U4DBA8,A0A0U4DCH1,A0A0U4DD37,A0A0U4DGL1,A0A0U4DGS4,A0A0U4E4B3,A0A0U4E4X5,A0A0U4EBG4,A0A0U4EBR7,A0A0U4EBZ4,A0A0U4EES8,A0A0U4EGH6,A0A0U4EGX9,A0A0U4ENR9,A0A0U4EP82,A0A0U4EPI4,A0A0U4EPQ5,A0A0U4EQU8,A0A0U4ESJ8,A0A0U4ET89,A0A0U4ETP8,A0A0U4EW56,A0A0U4EWH3,A0A0U4EXV0,A0A0U4EYY3,A0A0U4F6D6,A0A141LL89,A0A165Q9F3,A0A172QC61,A0A172QC79,A0A172QC87,A0A1L2BID6,A0A1L2BIG9,A0A1L2BIR4,A0A1L2BIY4,A0A1L2BJ48,A0A1L2BJD9,A0A1L2BJG4,A0A1L7B882,A0A1L7B8E4,A0A1X9IXM9,A0A288QU69,A0A2I4PDK8,A0A2I4PDT9,A0A2I4PE21,A0A2I4PED3,A0A2I4Q526,A0A2I4Q545,A0A2I4SAN4,A0A2I4SAT9,A0A2I4SAU6,A0A2U8KL40,A0A2U9QPQ7,A0A345BF59,A0A345BF77,A0A345BFD1,A0A3G1S963,A0A3G1TWY2,A0A3G2LM13,A0A3G2LM48,A0A3G2LM81,A0A3G2XD84,A0A3G2XE25,A0A3G2XE33,A0A3G2XEF7,A0A3G2XEP4,A0A3G2XG98,A0A3G2XH51,A0A3Q8HGW6,A0A3Q8HHE4,A0A3Q8HHH5,A0A3Q8HHT0,A0A3Q8HI48,A0A3Q8HIF8,A0A3Q8HII1,A0A3Q8HIZ0,A0A3Q8HJA9,A0A3Q8HK17,A0A3Q8HQL2,A8TSK5,A8TSL1,A8TSL7,A8TSM3,A8TSM9,A8TSN5,A8TSP1,A8TSP9,A8TSQ5,A8TSR2,A8TSR7,A8TSS3,A9QPL6,G8DB37,I0DHA6,L7QHT6,L7QHU5,L7QI42,L7QI51,L7QIA8,O72142,Q913A5,Q9QCE9,X5GXS8,X5HMY5 |
ssRNA |
NAP, TR, Rep |
S |
N |
N |
4ZTA |
D(31516086) |
I(28566377) |
D(20421407) |
20957152.0 |
|
Oligomerizes into helical capsid to encapsidate the viral
genome, protecting it from nucleases and the cellular innate
immune response (PubMed:26119732, PubMed:25865894,
PubMed:30333622, PubMed:16719918). VP35 binds to and
stabilizes monomeric NP, keeping it soluble (PubMed:26119732,
PubMed:25865894). Upon virus replication, NP is recruited to
bind cooperatively viral genomic RNA and VP35 is released
(PubMed:29144446). The encapsidated genomic RNA is termed the
nucleocapsid and serves as template for transcription and
replication. The nucleocapsid is helical with a pitch of
10.81 NP per turn and a diameter of about 22nm
(PubMed:22247782). Each NP binds to six nucleotides of viral
genomic RNA, three being exposed to the solvant and three
hidden into the nucleocapsid (PubMed:30333622). Recruits also
host PPP2R5C phosphatase to dephosphorylate VP30 and thereby
promote viral transcription (PubMed:29290611,
PubMed:27755595). Upon virion assembly and budding, NP binds
to VP24 and possibly host STAU1 (PubMed:28794491,
PubMed:30301857). |
|
81 |
Filoviridae |
Zaire ebolavirus |
VP30 |
Ebola VP30, eVP30, Hexameric zinc-finger protein VP30,
Minor nucleoprotein VP30, Transcription activator VP30 |
Q05323 |
VP30_EBOZM |
A0A0A7P6S7,A0A0D4D8P9,A0A0D5W867,A0A0D5W881,A0A0D5W8K4,A0A0D5W8L5,A0A0D5W8P3,A0A0D5W8Q0,A0A0D5W8S4,A0A0D5W9G0,A0A0E3TKV3,A0A0E3TLF2,A0A0E3TLT1,A0A0E3TNA7,A0A0E3XJ86,A0A0E3XKF2,A0A0E3XL58,A0A0F6PD42,A0A0F6PD98,A0A0F6PDF6,A0A0F6PE67,A0A0F6PGB0,A0A0F7IMJ5,A0A0F7IML9,A0A0F7IMR4,A0A0G2YEA1,A0A0G2YEX8,A0A0G2YGG0,A0A0K1NXF0,A0A0K1NY74,A0A0K1NY97,A0A0K1NYB8,A0A0K1NYX1,A0A0K1NZ17,A0A0N9BE47,A0A0S0G9Y9,A0A0S0H3V9,A0A0S0H5G2,A0A0S0H693,A0A0S0HCI9,A0A0S0HCX3,A0A0U3MQS2,A0A0U3MRQ2,A0A0U3V2Q4,A0A0U3V2T6,A0A0U3V4I1,A0A0U3V9C5,A0A0U3VJZ0,A0A0U4CS06,A0A0U4D596,A0A0U4D5B5,A0A0U4E233,A0A0U4E3T0,A0A0U4E6R5,A0A0U4EJT4,A0A0U4ENB6,A0A0U4F7Q3,A0A144INH8,A0A165Q6Y8,A0A165Q9K2,A0A1L2BIG8,A0A1X9ITK5,A0A1X9IWG5,A0A2I4PDJ3,A0A2I4PEA3,A0A2I4Q549,A0A2I4Q575,A0A3G2LMC4,A0A3Q8HH29,A0A3Q8HQ01,L7QHS4,L7QI14,L7QI23 |
ssRNA |
TR, NAP, Rep |
S |
N |
N |
5DVW, 5T3T |
D(18829754, 27279615, 9971816) |
D(27279615) |
D(20421407) |
20957152.0 |
|
Multifunctional protein that acts as a viral
transcriptional activator. Promotes read-through of an RNA
hairpin in the NP open reading frame to enhance viral
transcription. Mechanistically, nonphosphorylated VP30
hexamers form a ternary complex with the viral leader RNA. In
turn, clamps the RNA template and the complex VP35-polymerase
L together, thereby increasing the polymerase affinity for
the RNA template to increase transcription initiation despite
the presence of RNA secondary structures. Assists also
stop-start transcription at gene junctions to promote
transcription of downstream genes. |
|
82 |
Filoviridae |
Zaire ebolavirus |
VP35 |
Ebola VP35, eVP35, Polymerase cofactor VP35 |
Q05127 |
VP35_EBOZM |
A0A096YGW9,A0A0A0UG55,A0A0A7P6T2,A0A0D4D9D7,A0A0D5W860,A0A0D5W888,A0A0D5W8A6,A0A0D5W8D3,A0A0D5W8F8,A0A0D5W8I0,A0A0D5W8K1,A0A0D5W8L0,A0A0D5W8L3,A0A0D5W8P1,A0A0D5W8P9,A0A0D5W8S0,A0A0D5W8Y3,A0A0D5W907,A0A0D5W910,A0A0D5W932,A0A0D5W967,A0A0D5W9C3,A0A0D5W9F6,A0A0E3JNL8,A0A0E3TL62,A0A0E3TLJ9,A0A0E3TLL9,A0A0E3TN58,A0A0E3TND3,A0A0E3TP51,A0A0E3XJ79,A0A0E3XL17,A0A0E3XLC2,A0A0F6PCZ9,A0A0F6PD95,A0A0F6PDS1,A0A0F6PDT0,A0A0F6PE53,A0A0F6PEA2,A0A0F6PEB0,A0A0F6PEX9,A0A0F6PG67,A0A0F6PGM5,A0A0F6PGU9,A0A0F6PH54,A0A0F7IM75,A0A0F7IMK4,A0A0G2YA07,A0A0G2YB97,A0A0G2YCE4,A0A0G2YCW0,A0A0G2YD36,A0A0G2YFC9,A0A0G2YGH5,A0A0G2YGK9,A0A0G2YGN0,A0A0G2YH23,A0A0G2YI78,A0A0G2YIT8,A0A0K1NXW9,A0A0K1NY24,A0A0K1NY41,A0A0K1NY91,A0A0K1NY92,A0A0K1NYD4,A0A0K1NYD6,A0A0K1NYW6,A0A0K1NZ58,A0A0K1NZE7,A0A0N7E4U0,A0A0N7E4U2,A0A0S0GA68,A0A0S0GBT2,A0A0S0GCF5,A0A0S0H1F0,A0A0S0H2X8,A0A0S0H3D9,A0A0S0H3X8,A0A0S0H3Y5,A0A0S0H453,A0A0S0H4A9,A0A0S0H4M9,A0A0S0H4P4,A0A0S0H6B4,A0A0S0HAT4,A0A0S0HBA9,A0A0S0HCX5,A0A0S0HDX3,A0A0S0HEE4,A0A0S0HEH4,A0A0U3MI82,A0A0U3MLC1,A0A0U4D7K3,A0A0U4DBV4,A0A0U4E017,A0A0U4E4W0,A0A0U4EJL2,A0A0U4EJR8,A0A0U4EPG5,A0A0U4FDH1,A0A141LKX3,A0A165Q6T7,A0A165Q7K3,A0A172QC54,A0A172QC60,A0A1L2BI43,A0A1L2BIB3,A0A1L2BIE6,A0A1L7B886,A0A1L7B8N5,A0A2I4PDK5,A0A2I4PEH1,A0A2I4PEM7,A0A2I4SAM2,A0A2I4SAS7,A0A2I4SAT1,A0A2U9QPQ6,A0A345K436,A0A3G2LLZ4,A0A3G2LM16,A0A3G2XDA3,A0A3G2XDB5,A0A3G2XDD1,A0A3G2XDD3,A0A3G2XDY9,A0A3G2XGG3,A9QPL7,I0DHA7,L7QI13,L7QI22,L7QI35,V9TIA7 |
dsRNA |
TR, NAP, Rep |
S |
N |
N |
3FKE, 3L25, 3L26, 3L27, 3L28, 3L29, 4IBB, 4IBC, 4IBD,
4IBE, 4IBF, 4IBG, 4IBI, 4IBJ, 4IBK, 4IJE, 4IJF, 4YPI, 4ZTA,
4ZTG, 4ZTI, 6GBO, 6GBP |
D(9971816, 11027311, 12829834, 19557165) |
I(27642076) |
D(20421407) |
20957152.0 |
|
Plays an essential role in viral RNA synthesis and also a
role in suppressing innate immune signaling. Acts as a
polymerase cofactor in the RNA polymerase transcription and
replication complexes. Serves as nucleoprotein/NP monomer
chaperone prior to the formation of the large oligomeric
RNA-bound complexes. Prevents establishment of cellular
antiviral state, thereby suppressing host DC maturation
(PubMed:26962215). Acts by inhibiting host DDX58/RIG-I
activation both by shielding dsRNA from detection and by
preventing PRKRA binding to DDX58 (PubMed:23870315). Blocks
virus-induced phosphorylation and activation of interferon
regulatory factor 3/IRF3, a transcription factor critical for
the induction of interferons alpha and beta. This blockage is
produced through the interaction with and inhibition of host
IKBKE and TBK1, producing a strong inhibition of the
phosphorylation and activation of IRF3. Also inhibits the
antiviral effect mediated by the host interferon-induced,
double-stranded RNA-activated protein kinase EIF2AK2/PKR
(PubMed:17065211). |
|
83 |
Flaviviridae |
Hepatitis C virus |
Genome polyprotein |
Cleaved into the following 11 chains-Core protein
p21 |
P27958 |
POLG_HCVH |
A0A1X9Q776,A0A1X9Q782,A0A1X9Q784,A0A1X9Q787,A0A1X9Q788,A0A1X9Q790,A0A1X9Q798,A0A1X9Q7A4,A0A1X9Q7A5,A0A1X9Q7A7,A0A1X9Q7A8,A0A1X9Q7B3,A0A1X9Q7B5,A0A1X9Q7B6,A0A1X9Q7F9,A0A1X9Q7G7,A0A1X9Q7G8,A0A1X9Q7H0,A0A1X9Q7H1,A0A1X9Q7H2,A0A1X9Q7H4,A0A1X9Q7H6,A0A1X9Q7I0,A0A1X9Q7I2,A0A1X9Q7I6,A0A1X9Q7I8,A0A1X9Q7M9,A0A1X9Q7N5,A0A1X9Q7P0,A0A1X9Q7P4,A0A1X9Q7P8,A0A1X9Q7T5,A0A1X9Q809,A0A1X9Q843,A0A1X9Q844,A0A1X9Q845,A0A1X9Q860,A0A1X9Q868,A6N8C5,A8DEQ3,A8DER9,A8DES5,A8DF52,A8DF65,A8DF80,A8DF92,A8DFA3,A8DFB2,A8DFB8,A8DFC4,A8DFD0,A8DFD6,A8DFE3,A8DFF0,A8DFF3,A8DFF5,A8DFG4,A8DFP3,A8DFQ2,A8DFR2,A8DFS1,A8DFT0,A8DFT8,A8DFU5,A8DFV3,A8DFW2,A8DFW9,A8DFX7,A8DFY4,A8DFY6,A8DFZ1,A8DG21,A8DG30,A8DG50,A8DG59,A8DG69,A8DG81,A8DG88,A8DG98,A8DGA7,A8DGB7,A8DGC9,A8DGD8,A8DGF9,A8DGH0,A8DGI0,A8DGN1,A8DGP0,A8DGP9,A8DGQ7,A8DGR6,A8DGS6,A8DGV7,A8DGW5,A8DGX1,A8DGX9,A8DH64,A8DH72,A8DH77,A8DH84,A8DH90,A8DH96,A8DHA2,A8DHB9,A8DHE5,A8DHE9,A8DHF6,A8DHH1,A8DHV8,A8DHW9,A8QIN1,A8QIN2,A8QIN3,A8QIN4,A8QIN5,A8QIN7,A8QIN8,A8QIP8,A8WE32,A8WE34,A8WE36,A8WEV8,A8WFA4,A8WFA6,A9LLG7,A9LLH0,A9LLH2,B1PPI0,B1PPI5,B1PPI7,B1PPI9,B1PPJ1,B1PPJ3,B1PPJ6,B1PPJ8,B1PPK0,B1PPK2,B1PPK6,B1PPL0,B1PPL2,B1PPL5,B1PPL7,B1PPL9,B1PPM3,B1PPM5,B1PPM9,B1PPN4,B1PPN6,B1PPN8,B1PPP0,B1PPP2,B1PPP4,B1PPP6,B1PPP8,B1PPQ0,B1PPQ2,B1PPQ4,B1PPQ8,B1PPR2,B1PPR5,B1PPS1,B1PPS4,B1PPT0,B2CNA8,B2CNB0,B2CNB4,B2CNB6,B2CNB8,B2D1G7,B2D1G9,B2LXT0,B2ZGC3,B2ZGC5,B2ZTK5,B2ZTK7,B2ZTK9,B3TKD8,B3TKE0,B3TKE4,B3TKE6,B3TKE8,B3TKF0,B3TKF2,B3TKF4,B3TKF8,B3TKG0,B3TKG2,B3TKG4,B3TKG6,B3TKG8,B3TKH2,B3TKH4,B3TKH6,B3TKI6,B3TKI8,B3TKJ4,B3TKJ5,B3TKJ7,B3TKJ9,B3TKK3,B3TKK5,B3TKK7,B3TKK9,B3TKL1,B3TKL3,B3TKL5,B3TKL7,B3TKM0,B3TKM2,B3TKM4,B3TKM6,B3TKM8,B3TKN0,B3TKN2,B3TKN4,B3TKN6,B3TKN8,B3TKP0,B3TKP2,B3TKP3,B3TKP5,B3TKP7,B3TKP9,B3TKQ1,B3TKQ3,B3TKQ5,B3TKQ7,B3TKQ9,B3TKR1,B3TKR7,B3TKR9,B3TKS1,B3TKS5,B3TKS7,B3TKS8,B3TKT0,B3TKT2,B3TKT6,B3TKT8,B3TKU0,B3TKU2,B3TKU4,B3TKU6,B3TKU8,B3TKV0,B3TKV2,B3TKV4,B3TKV6,B3TKV8,B3TKW0,B3TKW2,B3TKW4,B3TKW6,B3TKW8,B3TKX0,B3TKX2,B3TKX4,B3TKX6,B3TKX8,B3TKY0,B3TKY2,B3TKY4,B3TKY6,B3TKY8,B3TKZ0,B3TKZ2,B3TKZ4,B3TKZ6,B3TKZ8,B3TL00,B3TL02,B3TL05,B3TL07,B3TL10,B3TL12,B3TL14,B3TL16,B3TL18,B3TL20,B3TL22,B3TL27,B3TL29,B3TL31,B3TL33,B3TL36,B3TL43,B3TL49,B3TL51,B3TL53,B3TL56,B3TL69,B3TL71,B3TL79,B3TL81,B3TL83,B3TL85,B3TL93,B3TL95,B5M916,B5M920,B5M922,B5M925,B5M928,B5M930,B5M932,B5TBA9,B5TBB2,B5TBB4,B5U654,B5U658,B5U6M7,B5U6M9,B5U6N1,B6VGD0,B6VGD2,B6VGD7,B6VJ19,C4MR37,C4MR38,C4MR39,C4MR40,C4MR41,C4MR42,C4MR43,C4MR44,C4MR45,C4MR46,C4MR47,C4MR49,C4MR50,C4MR51,C4MR52,C4MR53,C4MR54,C4MR55,C4MR56,C4MR57,C4MR58,C4MR59,C4MR60,C4MR61,C4MR62,C4MR63,C4MR64,C4MR65,C4MR66,C4MR67,C4MR68,C4MR69,C4MR70,C4MR71,C4MR72,C4MR73,C4MR74,C4MR75,C4MR76,C4MR77,C4MR78,C4MR79,C4MR80,C4MR81,C4MR82,C4MR83,C4MR84,C4MR85,C4MR86,C4MR87,C4MR88,C4MR89,C4MR90,C4MR91,C4MR92,C4MR93,C4MR94,C4MR95,C4MR97,C4MR99,C4MRA0,C4MRA1,C4MRA2,C4MRA3,C4MRA4,C4MRA5,C4MRA6,C4MRA7,C4MRA8,C4MRA9,C4MRB0,C4MRB1,C4MRB2,C4MRB3,C4MRB4,C7G539,D2CVL5,H6TCE5,H6TCE7,H6TCE8,H6TCE9,H6TCF0,H6TCF1,Q03463,Q9ELS8,S4UXY5,S4UXY7,S4UXY9,S4UXZ3,S4UXZ6,S4UXZ8,S4UXZ9,S4UY00,S4UY01,S4UY02,S4UY03,S4UY04,S4UY05,S4UY06,S4UY08,S4UY10,S4UY14,S4UY17,S4UY19,S4UYB5,S4UYB9,S4UYC1,S4UYC2,S4UYC4,S4UYC6,S4UYC7,S4UYC8,S4UYD0,S4UYD2,S4UYD4,S4UYD5,S4UYD7,S4UYE1,S4UYE2,S4UYE4,S4UYE5,S4UYE9,S4UYF0,S4UYF1,S4UYQ2,S4UYQ7,S4UYQ9,S4UYR2,S4UYR5,S4UYR9,S4UYS2,S4UYS4,S4UYS6,S4UYS8,S4UYT0,S4UYT1,S4UYT2,S4UYT4,S4UYT5,S4UYT6,S4UYT8,S4UZ41,S4UZ44,S4UZ47,S4UZ50,S4UZ54,S4UZ58,S4UZ60,S4UZ61,S4UZ62,S4UZ63,S4UZ64,S4UZ67,S4UZ68,S4UZ69,S4UZ71,S4UZ73,S4UZ76,S4UZ78,S4UZ79,S4UZG4,S4UZG5,S4UZG6,S4UZG7,S4UZG9,S4UZH0,S4UZH2,S4UZH3,S4UZH5,S4UZH6,S4UZH7,S4UZH9,S4UZI0,S4UZI1,S4UZI2,S4UZI3,S4UZI4,S4UZI5,S4UZI6 |
dsRNA |
TR, NAP, Other |
S |
N |
N |
1A1R, 1A1V, 1CWX, 1HEI, 1JR6, 1N1L |
D(10544138) |
D(10924497) |
D(10544138) |
Fields Virology |
|
Core protein p21: Packages viral RNA to form a viral
nucleocapsid, and promotes virion budding. Modulates viral
translation initiation by interacting with HCV IRES and 40S
ribosomal subunit. Also regulates many host cellular
functions such as signaling pathways and apoptosis. Prevents
the establishment of cellular antiviral state by blocking the
interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma
signaling pathways and by inducing human STAT1 degradation
(PubMed:23799612). Interacts with, and activates STAT3
leading to cellular transformation. Represses cell cycle
negative regulating factor CDKN1A, thereby interrupting an
important check point of normal cell cycle regulation.
Targets transcription factors involved in the regulation of
inflammatory responses and in the immune response: suppresses
NK-kappaB activation, and activates AP-1. Enhances TRAIL
mediated apoptosis, suggesting that it might play a role in
immune-mediated liver cell injury. Seric core protein is able
to bind C1QR1 at the T-cell surface, resulting in
down-regulation of T-lymphocytes proliferation
(PubMed:11086025). Alters lipid metabolism by interacting
with hepatocellular proteins involved in lipid accumulation
and storage. Induces up-regulation of FAS promoter activity,
and thereby contributes to the increased triglyceride
accumulation in hepatocytes (steatosis) (PubMed:14602201).
Envelope glycoprotein E1: Forms a heterodimer with envelope
glycoprotein E2 that mediates virus attachment to the host
cell, virion internalization through clathrin-dependent
endocytosis and fusion with host membrane. E1/E2 heterodimer
binds to host LDLR, CD81 and SCARB1/SR-BI receptors
(PubMed:12615904). However, additional liver specific
cofactors may be required for entry. The fusion function is
carried by E1 (PubMed:14990718, PubMed:15371595,
PubMed:16894197, PubMed:16533059). Envelope glycoprotein E2:
Forms a heterodimer with envelope glycoprotein E1 that
mediates virus attachment to the host cell, virion
internalization through clathrin-dependent endocytosis and
fusion with host membrane. E1/E2 heterodimer binds to host
LDLR, CD81 and SCARB1/SR-BI receptors (PubMed:12615904), but
additional liver specific cofactors may be required for
entry. E2 inhibits human EIF2AK2/PKR activation, preventing
the establishment of an antiviral state. E2 is a viral ligand
for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively
found on dendritic cells (DCs), and on liver sinusoidal
endothelial cells and macrophage-like cells of lymph node
sinuses. These interactions allow capture of circulating HCV
particles by these cells and subsequent transmission to
permissive cells. DCs act as sentinels in various tissues
where they entrap pathogens and convey them to local lymphoid
tissue or lymph node for establishment of immunity. Capture
of circulating HCV particles by these SIGN+ cells may
facilitate virus infection of proximal hepatocytes and
lymphocyte subpopulations and may be essential for the
establishment of persistent infection. Viroporin p7: Plays an
essential role in the virus replication cycle by acting as a
viroporin. Creates a pore in the host reticulum endoplasmic
and as a consequence releases Ca2+ in the cytoplasm of
infected cell. Targets also host mitochondria and induces
mitochondrial depolarization (PubMed:29039530). In turn, high
levels of cyctoplasmic calcium may trigger membrane
trafficking and transport of viral ER-associated proteins to
viroplasms, sites of viral genome replication. In addition of
its role as a viroporin, acts as a lipid raft adhesion factor
(PubMed:27320856). Protease NS2-3: Cysteine protease
responsible for the autocatalytic cleavage of NS2-NS3. Seems
to undergo self-inactivation following maturation. Serine
protease NS3: Displays three enzymatic activities: a serine
protease with a chymotrypsin-like fold, a NTPase and a RNA
helicase. NS3 serine protease, in association with NS4A, is
responsible for the cleavages of NS3-NS4A, NS4A-NS4B,
NS4B-NS5A and NS5A-NS5B (PubMed:8189513). NS3/NS4A complex
also prevents phosphorylation of host IRF3, thus preventing
the establishment of dsRNA induced antiviral state. NS3 RNA
helicase binds to RNA and unwinds dsRNA in the 3' to 5'
direction, and likely RNA stable secondary structure in the
template strand. Cleaves and inhibits the host antiviral
protein MAVS (PubMed:16301520). Non-structural protein 4A:
Peptide cofactor which forms a non-covalent complex with the
N-terminal of NS3 serine protease. Non-structural protein 4B:
Induces a specific membrane alteration that serves as a
scaffold for the virus replication complex. This membrane
alteration gives rise to the so-called ER-derived membranous
web that contains the replication complex. NS4B
polymerization or in protein-protein interactions activity
may contribute to its function in membranous web formation
(PubMed:23868571). Plays also a role in the inhibition of
host innate response by inhibiting host TLR3-mediated
interferon signaling. Mechanistically, promotes host TRIF
protein degradation in a caspase8-dependent manner
(PubMed:29782532). Non-structural protein 5A: Component of
the replication complex involved in RNA-binding. Its
interaction with host VAPB may target the viral replication
complex to vesicles. Down-regulates viral IRES translation
initiation. Mediates interferon resistance, presumably by
interacting with and inhibiting human EIF2AK2/PKR. The
hyperphosphorylated form of NS5A is an inhibitor of viral
replication. RNA-directed RNA polymerase: Plays an essential
role in the virus replication. |
|
84 |
Hepadnaviridae |
Hepatitis B virus |
HBx |
Peptide X, Protein X, Px, X |
P0C686 |
X_HBVC1 |
A0A060A215,A0A060A625,A0A060A691,A0A060A6W8,A0A060AAM5,A0A060AB18,A0A060AB60,A0A060CJH4,A0A060CNF3,A0A060CP25,A0A067YSC9,A0A067YSG3,A0A067YST1,A0A067YSX0,A0A067YSZ4,A0A067YTH8,A0A067YTM9,A0A067YTS0,A0A067YU08,A0A067YU73,A0A067YUA7,A0A067YUE2,A0A067YUG9,A0A067YUJ1,A0A067YUP6,A0A067YUR5,A0A067YUT6,A0A067YUT9,A0A067YUW7,A0A067YV23,A0A067YV25,A0A067YV34,A0A067YV61,A0A067YVH3,A0A067YVP5,A0A067YVT2,A0A067YVV0,A0A067YVW2,A0A067YVX6,A0A067YWL3,A0A067YWN2,A0A067YWQ7,A0A067YWT4,A0A067YWU4,A0A067YWV9,A0A067YWX6,A0A067YWZ6,A0A067YX24,A0A067YXB4,A0A067YXH9,A0A067YXU2,A0A067YY49,A0A067YYA1,A0A075D8X9,A0A075D922,A0A075D983,A0A075D9Y3,A0A075DA09,A0A075DA55,A0A075DA67,A0A075DA80,A0A075DAP3,A0A075DAT4,A0A075DAW9,A0A075DAZ2,A0A075DB43,A0A075DBT5,A0A075DBU1,A0A075T6J6,A0A077EQB3,A0A0A0V835,A0A0A0V8W4,A0A0G2QWQ5,A0A0G2QWY8,A0A0G3EXJ8,A0A0G3EYX8,A0A0G3EZ59,A0A0G3EZQ6,A0A0G3F0M2,A0A0G3F1C1,A0A0G3F1E9,A0A0G3F1V7,A0A0G3F256,A0A0G3F2A3,A0A0G3F2V3,A0A0G3F2W2,A0A0G3F311,A0A0G3F376,A0A0G3F3N8,A0A0G3F4D1,A0A0G3F4Y2,A0A0G3F549,A0A0G3F559,A0A0G3F5R7,A0A0G3F666,A0A0G3F6R7,A0A0K0K6H8,A0A0K0K6I8,A0A0K0K6J9,A0A0K0K6M2,A0A0K0K6M5,A0A0K0K6N2,A0A0K0K6R4,A0A0K0WRU8,A0A0K0WZ59,A0A0S1RTH5,A0A0U3LF26,A0A1B1LVD7,A0A1B3SNS0,A0A1W5XAX3,A0A249JRC5,A0A286QXF4,A0A290G3R8,A0A290G413,A0A2H4NKA4,A0A2H4NKH4,A0A2H4NL94,A0A2H4NLA4,A0A2H4NLA6,A0A2H4NLF6,A0A2H4NLF8,A0A2H4NLH4,A0A2H4NLL5,A0A2H4NLM7,A0A2H4NLP1,A0A2H4NM06,A0A2H4NM11,A0A2H4NM90,A0A2H4NMB6,A0A2H4NMD0,A0A2H4NMS1,A0A2H4NN58,A0A2H4NNA6,A0A2H4NNB2,A0A2H4NNE7,A0A2H4NNG5,A0A2H4NNI4,A0A2Z6DS46,A0A346RSZ9,A0A346RT27,A0A346RT31,A0A346RT35,A0A346RT39,A0A346RT99,A0A3Q9HHF8,A0A3S5ICN4,A0FDK1,A5GZG6,A5GZH1,A5GZI2,A5GZJ0,A5GZK1,A5GZK9,A5GZL6,A5GZN2,A5GZN6,A5HKP8,A5HKQ4,A5LG64,A5LG76,A5LG84,A5LG92,A5LGB6,A6MG24,A6MG36,A7M682,A7M686,A8J461,A8J478,A8J5I3,A8R7F4,B0FCC1,B0FD21,B0FD41,B0FD94,B1B5L8,B1Q2W8,B2CY06,B2CY33,B2CZW0,B2LWA4,B2LWD7,B3V3R9,B4YT99,B5A2H5,B5ASU1,B5ASW3,B5B482,B5B494,B5B4B1,B5B4C4,B5B4G1,B5B4H9,B5B4J0,B5B4J7,B5B4P8,B5BPH9,B5BPK7,B5BPN1,B5BPR3,B5BPS1,B5BPT6,B5BPU0,B5BPU4,B5BPV6,B5BPW5,B5BPX6,B5BPY8,B5M520,B5M573,B5M576,B5M582,B5M5A9,B5M5B2,B5M5J9,B5M5K2,B5M5K6,B5M5L7,B5M5P4,B5M5V6,B5M5V9,B5M5X4,B5TXI5,B5TXK2,B5TXL1,B5TY06,B5TY09,B6EUP5,B7TTN0,B7TU29,B7TU66,B7TUB0,B7TUB9,B7TUE5,B7TUW8,B9VK29,B9VK45,B9VKC0,B9VKD1,B9VKG2,B9VKK5,B9VKP0,B9VKQ5,B9VKY1,B9VL15,B9VL31,B9VL35,C0SVX4,C0SVX6,C1K177,C1K1B6,C1K1C8,C1K1G7,C1K1K6,C1K1N4,C1K1Z2,C1K1Z8,C1K220,C5WK20,C5WK24,C5WK28,C7G2Z1,D0E579,D0E590,D0E5A5,D0E5B5,D0E5D1,D0E5F5,D0E5G7,D0E5I4,D0E5K5,D0E5P0,D0E5Q1,D0E5W6,D0E5X0,D0E643,D0E677,D0E684,D0E696,D0E6A4,D0E6A8,D0ESR9,D0UDN6,D0UDP1,D0UDQ6,D0UDR1,D0UDT1,D0UDT6,D0UDX9,D0UDY9,D0UE09,D0UE46,D0UE60,D0UE84,D0UE93,D0UE97,D0UEA9,D0VXG7,D2CGU5,D2JMN8,D2JMT5,D3Y5S0,D6QVP4,D8VB84,D9U5A9,D9U5H4,E5RD27,E5RD43,E5RD55,F5C7K1,F5C7K8,F5C7Q7,G1EIE8,G1EIF2,G1EIF4,G1EIF8,G1EIG3,G3XGU2,G3XGU6,G3XLB5,G4XMC5,G4XMG5,G9HVE4,G9HZX0,G9HZX1,G9HZX2,G9HZX4,G9HZX5,G9HZY5,G9HZY7,G9HZZ2,G9HZZ9,G9I018,G9I019,G9I021,G9M9Q7,H1ACW6,H1ACY2,H1AE16,H1AE19,H1AE20,H1AE26,H1AE33,H1AE34,H1AE40,H1AE44,H1AE49,H1AE50,H1AE52,H1AE53,H1AE59,H1AE61,H1AE66,H1AE68,H1AE74,H1AE78,H1AE79,H2ERA7,H3K3E8,H3K3L8,I0DH59,I0DH70,I0DH71,I0DH81,I0DH84,I0DH85,I0DH87,I0DH90,I3RTG2,I6XQK3,I6YLZ5,I6YM12,J7IFV6,J7INA2,K0F4R2,K0F4Y6,K0FBC6,K0FBH3,K0FCI9,K0FGT3,K4N0Z4,K4N2P0,K4N2U9,K7QG64,K7QGH7,K7QGZ9,K7QH35,L0HAK4,L0HBS8,O42033,O42065,O91520,O91550,P12936,Q04288,Q06AN6,Q0PVA4,Q1XHE0,Q2EIE9,Q2V2L4,Q3V642,Q4FD63,Q4FD75,Q4FDH3,Q58W10,Q5DW04,Q5KR13,Q5KR29,Q5KR37,Q5KR41,Q5R2M1,Q5R2N7,Q5SDK3,Q5SDK7,Q5SDL4,Q69027,Q7TDA7,Q7TDA8,Q7TDA9,Q805R6,Q80GZ0,Q80IS2,Q80JB9,Q80JC0,Q80JC1,Q80JC2,Q80JC8,Q80MQ6,Q80MR2,Q81109,Q81133,Q8BCI3,Q8JVC7,Q8JXA9,Q8QY54,Q8V1I7,Q8V1J3,Q8V1M6,Q910W8,Q91IN9,Q91IP3,Q91R65,Q91S91,Q99HU6,Q99HV1,Q9DH55,Q9DKR3,Q9DKR4,Q9DKS7,Q9E935,Q9PX27,Q9PX52,Q9QMJ9,Q9QMK2,Q9QN50,Q9WMC0,Q9YZR0,Q9YZR1,Q9YZR6,Q9YZS5,Q9YZT6,Q9YZU4,Q9YZU7,Q9YZU9,Q9YZV1,S4WC30,S4WD77,S4WEV9,S4WIB4,S4WIH4,T1YVH2,V5LDL0,V9P3T8,V9P494,W8E0P8,X4YQZ5,X4YR22,X4YRB2,X4YSM4,X4YXY3,X4YY13,X4YY84,X4YYT9,X4YZ76,X4YZQ5,X4YZY0,X4Z047,X4Z061,X4Z170,X4Z1A9,X4ZCP4,X4ZCY8,X4ZE40,X4ZEJ8,X4ZEL4,X4ZEN0,X4ZES8,X4ZFE0,X4ZFX8 |
dsDNA |
TR, Other |
P |
D(27302019) |
D(28212627, 29933745) |
N |
D(11604508, 28102638) |
D(11604508) |
D(1602534) |
Fields Virology |
|
Multifunctional protein that plays a role in silencing
host antiviral defenses and promoting viral transcription.
Does not seem to be essential for HBV infection. May be
directly involved in development of cirrhosis and liver
cancer (hepatocellular carcinoma). Most of cytosolic
activities involve modulation of cytosolic calcium. The
effect on apoptosis is controversial depending on the cell
types in which the studies have been conducted. May induce
apoptosis by localizing in mitochondria and causing loss of
mitochondrial membrane potential. May also modulate apoptosis
by binding host CFLAR, a key regulator of the death-inducing
signaling complex (DISC). Promotes viral transcription by
using the host E3 ubiquitin ligase DDB1 to target the
SMC5-SMC6 complex to proteasomal degradation. This host
complex would otherwise bind to viral episomal DNA, and
prevents its transcription. Moderately stimulates
transcription of many different viral and cellular
transcription elements. Promoters and enhancers stimulated by
HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2,
c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. |
|
85 |
Herpesviridae |
Cercopithecine alphaherpesvirus 2 |
RL2 |
Immediate early protein ICP0 |
Q5Y0P4 |
Q5Y0P4_9ALPH |
|
dsDNA |
TR, Other |
S |
N |
N |
N |
I(18539148, 15494213, 2552142, 2820720, 20686034) |
I(15494213) |
I(6098466; 25497088) |
12603998.0 |
ICP0 homolog |
Evades nuclear antiviral defenses triggered by dsDNA
viruses. Acts during the initial stages of lytic infection
and the reactivation of latent viral genome. Prevents the
antiviral effect of nuclear bodies by degrading host PML and
SP100. Prevents antiviral response to viral DNA induced by
IFI16 by degrading it. Additionally, inhibits host IRF3
nuclear signaling to prevent interferon production by the
infected cells. Interestingly, the E3 ubiquitin ligase
activity associated with the RING finger domain does not seem
to be directly required to inhibit the activation of IRF3 but
instead plays a critical role in modulating the cellular
localization of ICP0. Upon reactivation of latent genome,
suppresses the silencing of viral DNA by dissociating either
HDAC1 or HDAC2 from the HDAC-RCOR1-REST-KDM1A complex
localized at the ND10 structures and causes their dispersal.
Two cellular histone ubiquitin ligases RNF8 and RNF168 are
also targeted by ICP0 for degradation, leading to a loss of
ubiquitinated forms of H2A, a relief of transcriptional
repression, and the activation of latent viral genomes.
Enhances the localization of host CCND3 to ND10 bodies that
serve as precursors of replication compartments to enable
efficient viral replication. Like many RING-finger E3
ubiquitin ligases, ICP0 can induce its own ubiquitination, an
activity that promotes its instability due to its targeting
to the 26S proteasome for degradation. ICP0 restricts this
process by recruiting the cellular ubiquitin-specific
protease USP7 that cleaves the anchored ubiquitin chains from
ICP0, thereby promoting its stabilization. |
|
86 |
Herpesviridae |
Cercopithecine alphaherpesvirus 2 |
RS1 |
ICP4, Immediate early protein ICP4 |
Q5Y0M9 |
Q5Y0M9_9ALPH |
|
dsDNA |
TR |
P |
I(26984403) |
I(28611249) |
N |
I(26984403) |
I(22496239, 26984403) |
I(28505309) |
12603998.0 |
|
host cell nucleus;positive regulation of transcription,
DNA-templated |
|
87 |
Herpesviridae |
Cercopithecine alphaherpesvirus 2 |
UL29 |
DBP, Major DNA-binding protein, Single-strand DNA-binding
protein |
Q5Y0S3 |
Q5Y0S3_9ALPH |
|
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
I(20585571) |
I(26676794, 30598436) |
I(2987527) |
12603998.0 |
|
Plays several crucial roles in viral infection.
Participates in the opening of the viral DNA origin to
initiate replication by interacting with the origin-binding
protein. May disrupt loops, hairpins and other secondary
structures present on ssDNA to reduce and eliminate pausing
of viral DNA polymerase at specific sites during elongation.
Promotes viral DNA recombination by performing
strand-transfer, characterized by the ability to transfer a
DNA strand from a linear duplex to a complementary
single-stranded DNA circle. Can also catalyze the
renaturation of complementary single strands. Additionally,
reorganizes the host cell nucleus, leading to the formation
of prereplicative sites and replication compartments. This
process is driven by the protein which can form
double-helical filaments in the absence of DNA. |
|
88 |
Herpesviridae |
Cercopithecine alphaherpesvirus 2 |
UL48 |
Major tegument protein VP16, Tegument protein,
Transactivating tegument protein VP16 |
Q5Y0Q4 |
Q5Y0Q4_9ALPH |
|
dsDNA |
TR |
P |
I(19321615) |
N |
N |
I(2538647) |
I(11416146, 2538647) |
I(11416146) |
12603998.0 |
|
DNA binding;regulation of transcription,
DNA-templated |
|
89 |
Herpesviridae |
Cercopithecine alphaherpesvirus 2 |
UL54 |
Immediate early protein ICP27 |
Q5Y0P7 |
Q5Y0P7_9ALPH |
|
dsDNA, ssDNA, ssRNA, dsRNA |
TR, TNA |
P |
N |
N |
N |
I(25712217) |
I(19783816) |
I(19783816, Yeast three-hybrid analysis, NMR) |
12603998.0 |
ICP27 homolog |
regulation of transcription, DNA-templated |
|
90 |
Herpesviridae |
Cercopithecine alphaherpesvirus 2 |
US1 |
Immediate early protein ICP22, Regulatory protein
ICP22 |
Q5Y0P2 |
Q5Y0P2_9ALPH |
|
indirect/unknown |
TR |
P |
I(25233083, 23029222) |
N |
N |
I(25712217, 30863402) |
N |
I(25712217) |
12603998.0 |
|
Functions as a general transcriptional regulator of
cellular and viral mRNAs mainly by mediating changes on the
host RNA polymerase II. One change, which is UL13
independent, is the rapid loss of Pol II forms bearing Ser-2
phosphorylation. A second change, which is UL13 dependent, is
the appearance of an intermediate form of Pol II that differs
from the normal hypo- and hyperphosphorylated forms. These
Pol II modifications immediately inhibit host genome
transcription, leading to cell cycle deregulation and loss of
efficient antiviral response. |
|
91 |
Herpesviridae |
Cercopithecine herpesvirus 1 |
RL2 |
Immediate early protein ICP0, Ubiquitin E3 ligase
ICP0 |
A0A059WI18 |
A0A059WI18_CHV1 |
0A059WDD4 |
dsDNA |
TR, Other |
S |
N |
N |
N |
I(18539148, 15494213, 2552142, 2820720, 20686034) |
I(15494213) |
I(6098466; 25497088) |
12603998.0 |
ICP0 homolog |
Evades nuclear antiviral defenses triggered by dsDNA
viruses. Acts during the initial stages of lytic infection
and the reactivation of latent viral genome. Prevents the
antiviral effect of nuclear bodies by degrading host PML and
SP100. Prevents antiviral response to viral DNA induced by
IFI16 by degrading it. Additionally, inhibits host IRF3
nuclear signaling to prevent interferon production by the
infected cells. Interestingly, the E3 ubiquitin ligase
activity associated with the RING finger domain does not seem
to be directly required to inhibit the activation of IRF3 but
instead plays a critical role in modulating the cellular
localization of ICP0. Upon reactivation of latent genome,
suppresses the silencing of viral DNA by dissociating either
HDAC1 or HDAC2 from the HDAC-RCOR1-REST-KDM1A complex
localized at the ND10 structures and causes their dispersal.
Two cellular histone ubiquitin ligases RNF8 and RNF168 are
also targeted by ICP0 for degradation, leading to a loss of
ubiquitinated forms of H2A, a relief of transcriptional
repression, and the activation of latent viral genomes.
Enhances the localization of host CCND3 to ND10 bodies that
serve as precursors of replication compartments to enable
efficient viral replication. Like many RING-finger E3
ubiquitin ligases, ICP0 can induce its own ubiquitination, an
activity that promotes its instability due to its targeting
to the 26S proteasome for degradation. ICP0 restricts this
process by recruiting the cellular ubiquitin-specific
protease USP7 that cleaves the anchored ubiquitin chains from
ICP0, thereby promoting its stabilization. |
|
92 |
Herpesviridae |
Cercopithecine herpesvirus 1 |
RS1 |
ICP4, Immediate early protein ICP4 |
Q7T401 |
Q7T401_CHV1 |
A0A059WI86,A0A1X9WFW5,A0A1X9WG45,A0A1X9WG88,A0A1X9WG94,A0A1X9WHE3,A0A1X9WI28,A0A1X9WIB5,A0A1X9WIH6,A0A1X9WIL9,A0A1X9WIS4 |
dsDNA |
TR |
P |
I(26984403) |
I(28611249) |
N |
I(26984403) |
I(22496239, 26984403) |
I(28505309) |
12603998.0 |
|
positive regulation of transcription, DNA-templated,host
cell nucleus |
|
93 |
Herpesviridae |
Cercopithecine herpesvirus 1 |
UL29 |
DBP, Major DNA-binding protein, Single-strand DNA-binding
protein |
Q805Z9 |
Q805Z9_CHV1 |
A0A1X9WF78,A0A1X9WFT8,A0A1X9WFU2,A0A1X9WG66,A0A1X9WHS8,A0A1X9WIW2 |
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
I(20585571) |
I(26676794, 30598436) |
I(2987527) |
12603998.0 |
Q805Z9 is inferred from Cercopithecine alphaherpesvirus 2
protein Q5Y0S3 |
Plays several crucial roles in viral infection.
Participates in the opening of the viral DNA origin to
initiate replication by interacting with the origin-binding
protein. May disrupt loops, hairpins and other secondary
structures present on ssDNA to reduce and eliminate pausing
of viral DNA polymerase at specific sites during elongation.
Promotes viral DNA recombination by performing
strand-transfer, characterized by the ability to transfer a
DNA strand from a linear duplex to a complementary
single-stranded DNA circle. Can also catalyze the
renaturation of complementary single strands. Additionally,
reorganizes the host cell nucleus, leading to the formation
of prereplicative sites and replication compartments. This
process is driven by the protein which can form
double-helical filaments in the absence of DNA. |
|
94 |
Herpesviridae |
Cercopithecine herpesvirus 1 |
UL48 |
Major tegument protein VP16, Tegument protein,
Transactivating tegument protein VP16 |
Q805Y1 |
Q805Y1_CHV1 |
A0A059WDC4,A0A1X9WFH9,A0A1X9WGD5,A0A1X9WHR9,A0A1X9WI32,A0A1X9WIY8 |
dsDNA |
TR |
P |
I(19321615) |
N |
N |
I(2538647) |
I(11416146, 2538647) |
I(11416146) |
12603998.0 |
|
DNA binding;regulation of transcription,
DNA-templated |
|
95 |
Herpesviridae |
Cercopithecine herpesvirus 1 |
UL54 |
Immediate early protein, Immediate early protein ICP27,
Multifunctional expression regulator |
Q805X4 |
Q805X4_CHV1 |
A0A059WP42,A0A1X9WF94,A0A1X9WFD7,A0A1X9WGK1,A0A1X9WHQ3,A0A1X9WI66,A0A1X9WIB1 |
dsDNA, ssDNA, ssRNA, dsRNA |
TR, TNA |
P |
N |
N |
N |
I(25712217) |
I(19783816) |
I(19783816, Yeast three-hybrid analysis, NMR) |
12603998.0 |
ICP27 homolog |
regulation of transcription, DNA-templated |
|
96 |
Herpesviridae |
Cercopithecine herpesvirus 1 |
US1 |
Immediate early protein ICP22, Regulatory protein
ICP22 |
Q7T5C5 |
Q7T5C5_CHV1 |
A0A059WP48,A0A1X9WFA0,A0A1X9WFD9,A0A1X9WFQ7,A0A1X9WHH9,A0A1X9WHY3,A0A1X9WIJ4,A0A1X9WIR3 |
indirect/unknown |
TR |
P |
I(25233083, 23029222) |
N |
N |
I(25712217, 30863402) |
N |
I(25712217) |
12603998.0 |
|
Functions as a general transcriptional regulator of
cellular and viral mRNAs mainly by mediating changes on the
host RNA polymerase II. One change, which is UL13
independent, is the rapid loss of Pol II forms bearing Ser-2
phosphorylation. A second change, which is UL13 dependent, is
the appearance of an intermediate form of Pol II that differs
from the normal hypo- and hyperphosphorylated forms. These
Pol II modifications immediately inhibit host genome
transcription, leading to cell cycle deregulation and loss of
efficient antiviral response. |
|
97 |
Herpesviridae |
Human herpesvirus 1; Herpes simplex virus 1 |
ICP0 |
Alpha-0 protein, E3 ubiquitin-protein ligase ICP0, IE110,
Immediate-early protein IE110, RING-type E3 ubiquitin
transferase ICP0, Trans-acting transcriptional protein ICP0,
Trans-acting transcriptional protein ICP0 , VMW110 |
P08393 |
ICP0_HHV11 |
A0A0F6TMA8,A0A0F7CWV0,A0A0F7CX66,A0A0F7CXM5,A0A0F7CXT2,A0A0F7CXW1,A0A0F7CY33,A0A0F7CY77,A0A0F7CYD5,A0A0F7GQZ5,A0A0F7GR62,A0A0F7GRM9,A0A0F7GS15,A0A0F7GSK5,A0A0F7GSQ3,A0A0F7GT05,A0A0F7GTF5,A0A0F7GTH7,A0A0F7GTR3,A0A0F7GU10,A0A0F7GU88,A0A0F7GV83,A0A0F7GVF0,A0A0F7GW03,A0A0F7GW86,A0A0F7GX28,A0A0F7GXE2,A0A0F7MZW1,A0A0S1TJG0,A0A0S1TJU7,A0A0S1TL48,A0A0S2I6L3,A0A181ZG35,A0A181ZG46,A0A193GSD7,A0A193GSS8,A0A193GT95,A0A193GTE7,A0A193GTH4,A0A193GTN4,A0A193GTW0,A0A193GTW3,A0A193GU35,A0A193GUI9,A0A193GUJ6,A0A193GUP1,A0A193GUR4,A0A193GUX0,A0A193GV30,A0A193GVR5,A0A193GW67,A0A193GW73,A0A193GWM3,A0A193GWV3,A0A193GXB0,A0A1C3J693,A0A1C3J6C6,A0A1C3J6E2,A0A1C3J6E4,A0A1C3J6N4,A0A1C3J716,A0A1C3J749,A0A1C3J7K9,A0A1C3J7Q4,A0A1C3J7X0,A0A1C3J7Z9,A0A1C3K9E0,A0A1D9CK31,A0A1V0E4Z7,A0A290Y1F5,A0A2U9A3L9,A0A2U9AAR9,A0A2U9ABP7,A0A2U9ABT1,A0A2Z4GZE1,A0A2Z4H0U7,A0A2Z4H1E3,A0A2Z4H1P0,A0A2Z4H1Y3,A0A2Z4H2C8,A0A2Z4H2N9,A0A2Z4H2V1,A0A2Z4H2V5,A0A2Z4H3G6,A0A2Z4H3U3,A0A2Z4H4P0,A0A2Z4H4X5,A0A2Z4H5E2,A0A2Z4H5P4,A0A2Z4H5W9,A0A2Z4H614,A0A2Z4H6U6,A0A2Z4H6Y6,A0A2Z4H8C0,A0A2Z4H9C0,A0A2Z4HAC0,A0A2Z4HAK7,A0A2Z4HAT8,A0A2Z4HAY7,A0A2Z4HBW8,A0A2Z4HBY4,A0A2Z4HCB2,A0A2Z4HCC6,A0A2Z4HE50,A0A2Z4HEE5,A0A2Z4HEQ7,A0A2Z4HFF6,A0A3G1LC33,B9VQC7,D3YPC2,D3YPF7,F8RCI7,F8RCS6,F8RDF7,F8RDN3,F8RE37,F8REB3,F8REI9,F8REZ2,F8RF66,F8RFE3,F8RFX1,F8RG89,G8H5J4,G8H854,G8H8C3,G8H8P9,G8H8X1,G8H8Y7,G8H957,G8HBH2,H9E965,I3TC55,I3TC56,J7GUK9,J7H0H8,Q09I79,U5TMT3 |
dsDNA |
TR, Other |
S |
N |
N |
5C56 |
D(18539148, 15494213, 2552142, 2820720, 20686034) |
D(15494213) |
D(6098466; 25497088) |
Fields Virology |
|
Evades nuclear antiviral defenses triggered by dsDNA
viruses. Acts during the initial stages of lytic infection
and the reactivation of latent viral genome. Prevents the
antiviral effect of nuclear bodies by degrading host PML and
SP100. Prevents antiviral response to viral DNA induced by
IFI16 by degrading it. Additionally, inhibits host IRF3
nuclear signaling to prevent interferon production by the
infected cells. Interestingly, the E3 ubiquitin ligase
activity associated with the RING finger domain does not seem
to be directly required to inhibit the activation of IRF3 but
instead plays a critical role in modulating the cellular
localization of ICP0. Upon reactivation of latent genome,
suppresses the silencing of viral DNA by dissociating either
HDAC1 or HDAC2 from the HDAC-RCOR1-REST-KDM1A complex
localized at the ND10 structures and causes their dispersal.
Two cellular histone ubiquitin ligases RNF8 and RNF168 are
also targeted by ICP0 for degradation, leading to a loss of
ubiquitinated forms of H2A, a relief of transcriptional
repression, and the activation of latent viral genomes.
Enhances the localization of host CCND3 to ND10 bodies that
serve as precursors of replication compartments to enable
efficient viral replication. Like many RING-finger E3
ubiquitin ligases, ICP0 can induce its own ubiquitination, an
activity that promotes its instability due to its targeting
to the 26S proteasome for degradation. ICP0 restricts this
process by recruiting the cellular ubiquitin-specific
protease USP7 that cleaves the anchored ubiquitin chains from
ICP0, thereby promoting its stabilization. |
|
98 |
Herpesviridae |
Human herpesvirus 1; Herpes simplex virus 1 |
RS1 |
Alpha-4 protein, ICP4, IE175, Infected cell protein 4,
Major viral transcription factor ICP4, Major viral
transcription factor ICP4 RS1, RS1.2, Transcriptional
activator IE175, Transcriptional regulator ICP4 |
P08392 |
ICP4_HHV11 |
A0A0B5E5S4,A0A0B5EBZ6,A0A0F6TMP9,A0A0F7CX08,A0A0F7CXB0,A0A0F7CXL0,A0A0F7CY62,A0A0F7GR69,A0A0F7GS44,A0A0F7GVD0,A0A0F7GVQ1,A0A0F7GWJ5,A0A0S1TJ69,A0A0S1TJB1,A0A0X8E9W1,A0A193GSU1,A0A193GT76,A0A193GTA0,A0A193GTY9,A0A193GUC1,A0A193GV99,A0A193GVK4,A0A193GW58,A0A193GWU4,A0A193GX28,A0A193GXR6,A0A1C3J777,A0A1C3J7A4,A0A1C3J7I7,A0A1C3J7R6,A0A1C3J7T6,A0A1C3J7V9,A0A1C3J807,A0A1C3J815,A0A1C3K9I9,A0A1D9CK53,A0A1V0E590,A0A290Y188,A0A290Y1F8,A0A2U9ABK0,A0A2Z4GZD9,A0A2Z4GZG8,A0A2Z4GZN3,A0A2Z4H0A9,A0A2Z4H0B3,A0A2Z4H1V7,A0A2Z4H250,A0A2Z4H2C3,A0A2Z4H2W5,A0A2Z4H2Y6,A0A2Z4H2Z8,A0A2Z4H4F0,A0A2Z4H4K9,A0A2Z4H4P5,A0A2Z4H559,A0A2Z4H5Q1,A0A2Z4H6S2,A0A2Z4H6V6,A0A2Z4H7F9,A0A2Z4H7P9,A0A2Z4H7U3,A0A2Z4H986,A0A2Z4HAX0,A0A2Z4HB37,A0A2Z4HB72,A0A2Z4HBC0,A0A2Z4HBK8,A0A2Z4HBR2,A0A2Z4HCI3,A0A2Z4HCS0,A0A2Z4HCS6,A0A2Z4HDY8,A0A2Z4HEG2,A0A2Z4HEH1,A0A2Z4HEZ5,A0A2Z4HFA5,A0A2Z4HFJ4,A0A2Z4LE53,A0A2Z4LFE8,B9VQC5,D3YPC4,D3YPL8,F8RCC6,F8RCI9,F8RCS9,F8RD83,F8RDF9,F8RDN6,F8RDW3,F8RE39,F8REJ2,F8RER9,F8REZ4,F8RF68,F8RFE5,F8RFL6,F8RG91,F8RGG8,G8H8J2,G8H943,G8HBH4,H9E981,I1UYM4,I3TCD6,J7GV28,Q09I77,U5TQG7 |
dsDNA |
TR |
P |
D(26984403) |
D(28611249) |
5MHJ |
D(26984403; 21998580; 18539148) |
D(22496239, 26984403; 21998580) |
D(28505309) |
Fields Virology |
|
Plays an essential role in the regulation of viral gene
expression by both activating and repressing host RNA
polymerase II-mediated transcription. Binds with high
affinity to the sequence 5'-ATCGTC-3'. Activates
transcription by recruiting a form of the host TFIID to
promoters and stabilizing the pre-initiation complex
formation. Negatively regulates its own transcription. This
immediate early (IE) protein is absolutely necessary for the
transition from IE transcription to later viral gene
transcription. |
|
99 |
Herpesviridae |
Human herpesvirus 1; Herpes simplex virus 1 |
UL29 |
DBP, ICP8, Major DNA-binding protein |
P04296 |
DNBI_HHV11 |
A0A0B5E506,A0A0B5EAK3,A0A0B5ED26,A0A0S1TES2,A0A0S1TIP6,A0A181ZGK5,A0A181ZGT1,A0A181ZHM5,A0A290Y1C7,A0A2U9A559,A0A2U9A5G9,A0A2U9A5R4,A0A2U9A614,A0A2U9A670,A0A2U9A6Q7,A0A2U9A7J1,A0A2U9A994,A0A2U9A9S5,A0A2U9ABP2,A0A2Z2D682,A0A2Z4H192,A0A2Z4H1V4,A0A2Z4H2S6,A0A2Z4H493,A0A2Z4H5K9,A0A2Z4H6I9,A0A2Z4H705,A0A2Z4H7A8,A0A2Z4H7J3,A0A2Z4H8N3,A0A2Z4H9Z2,A0A2Z4HBR6,A0A2Z4HBU1,A0A2Z4HD21,A0A2Z4HED3,A0A2Z4HEQ2,G8H881,G8H8M0,G8H8U2,I3TC88,P17469,P17470,Q2MGU6,Q2MGU7,Q2MGV1 |
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
1URJ |
I(20585571) |
D(26676794, 30598436) |
D(2987527) |
Fields Virology |
|
Plays several crucial roles in viral infection.
Participates in the opening of the viral DNA origin to
initiate replication by interacting with the origin-binding
protein. May disrupt loops, hairpins and other secondary
structures present on ssDNA to reduce and eliminate pausing
of viral DNA polymerase at specific sites during elongation.
Promotes viral DNA recombination by performing
strand-transfer, characterized by the ability to transfer a
DNA strand from a linear duplex to a complementary
single-stranded DNA circle. Can also catalyze the
renaturation of complementary single strands. Additionally,
reorganizes the host cell nucleus, leading to the formation
of prereplicative sites and replication compartments. This
process is driven by the protein which can form
double-helical filaments in the absence of DNA. |
|
100 |
Herpesviridae |
Human herpesvirus 1; Herpes simplex virus 1 |
UL48 |
Alpha trans-inducing protein, Alpha-TIF, ICP25, Tegument
protein VP16, Vmw65, VP16 |
P06492 |
VP16_HHV11 |
A0A0B5EBV9,A0A0F7GRN8,A0A0X8EA31,A0A109R0Q6,A0A110AV46,A0A110AX28,A0A140GKG8,A0A181ZFV5,A0A181ZGY2,A0A181ZHC6,A0A193GUI5,A0A1C3J6Y6,A0A1C3J7F2,A0A1C3J7F6,A0A1D9CK22,A0A1V0E561,A0A2U9A5R5,A0A2U9A645,A0A2U9A6S4,A0A2U9A847,A0A2U9A8N0,A0A2U9ABI7,A0A2U9AC12,A0A2Z2D2L3,A0A2Z4H418,A0A2Z4H451,A0A2Z4H850,A0A2Z4HC21,A0A2Z4HC83,A0A2Z4HEG6,D3YPB2,D3YPK6,F8RCZ3,F8RDE7,F8REY2,F8RF56,F8RG79,G8H933,G8HBG2,I3TCA8,J7GUJ5,U5TMS3 |
dsDNA |
TR |
P |
D(19321615) |
N |
16VP, 2PHE, 2PHG |
D(2538647) |
D(11416146, 2538647) |
D(11416146) |
Fields Virology |
Binds to DNA with host TFs |
Transcriptional activator of immediate-early (IE) gene
products (alpha genes). Acts as a key activator of lytic
infection by initiating the lytic program through the
assembly of the transcriptional regulatory VP16-induced
complex composed of VP16 and two cellular factors, HCFC1 and
POU2F 1. VP16-induced complex represents a regulatory switch:
when it is on, it promotes IE-gene expression and thus lytic
infection, and when it is off, it limits IE-gene
transcription favoring latent infection. |
|
101 |
Herpesviridae |
Human herpesvirus 1; Herpes simplex virus 1 |
UL54 |
ICP27, Immediate-early protein IE63, Infected cell
protein 27, mRNA export factor, VMW63 |
P10238 |
ICP27_HHV11 |
A0A076N1M8,A0A089WX37,A0A181ZFZ5,A0A181ZG53,A0A290Y181,A0A2U9A4C7,A0A2U9A6X5,A0A2U9A8Q3,A0A2U9A975,A0A2U9ABC8,A0A2Z4H1C0,A0A2Z4H2L7,A0A2Z4H3W4,A0A2Z4H4C4,A0A2Z4H541,A0A2Z4H661,A0A2Z4H7A3,A0A2Z4H805,A0A2Z4H871,A0A2Z4H937,A0A2Z4HBG5,A0A2Z4HCG4,A0A2Z4HEX6,A0A2Z4HF86,A0A2Z4HF92,A0A2Z4LF63,G8H8A5,G8H8P6,G8H8W8,G8H940,P36295 |
dsDNA, ssDNA, ssRNA, dsRNA |
TR, TNA |
P |
N |
N |
2KT5, 4YXP, 5BQK |
D(18539148) |
D(19783816; 1853914) |
D(19783816, Yeast three-hybrid analysis, NMR) |
Fields Virology |
|
Multifunctional regulator of the expression of viral
genes that contributes to the shutoff of host protein
synthesis and mediates nuclear export of viral intronless
mRNAs. Early in infection, this immediate early (EI) protein
mediates the inhibition of cellular splicing. This results in
the accumulation of unprocessed 3'end pre-mRNAs which can't
be exported from the nucleus. Cellular protein synthesis is
thereby shut off early after virus infection. Later in the
infection, it helps recruit cellular RNA polymerase II to
viral replication sites and promotes the nuclear export of
viral intronless mRNAs by interacting with mRNAs and host
NXF1/TAP. ICP27 binds to NUP62 which may provide facilitated
viral mRNA export and may indirectly compete with some host
cell transport receptors for binding and inhibit cellular
nucleocytoplasmic transport pathways (PubMed:22334672). Also
stimulates translation of viral transcripts. Repression of
host gene expression blocks the cell cycle at the G1 phase
and prevents apoptosis. Seems to silence the 3' splice site
of the promyelocytic leukemia (PML) intron 7a, thereby
switching PML isoforms from PML-II to PML-V. This could be
linked to the accelerated mRNA export induced by ICP27 which
might not provide sufficient time for PML pre-mRNA to be
spliced in the nucleus. |
|
102 |
Herpesviridae |
Human herpesvirus 1; Herpes simplex virus 1 |
US1 |
ICP22, Immediate-early protein IE68, Infected cell
protein 22, Transcriptional regulator ICP22 |
P04485 |
ICP22_HHV11 |
A0A089YQP5,A0A0B5E4A8,A0A0S1TKF2,A0A181ZFQ8,A0A181ZFX4,A0A181ZG17,A0A181ZH58,A0A181ZHB1,A0A181ZHL3,A0A290Y190,A0A2U9A3V9,A0A2U9A473,A0A2U9A612,A0A2U9A653,A0A2U9A738,A0A2U9A8A8,A0A2U9A8H3,A0A2U9A988,A0A2Z4GZP5,A0A2Z4GZY6,A0A2Z4H1M5,A0A2Z4H668,A0A2Z4H8Q8,A0A2Z4H9C8,A0A2Z4HAC1,A0A2Z4HBP6,A0A2Z4HBT9,A0A2Z4HCT0,A0A2Z4HCU3,A0A2Z4HCZ9,A0A2Z4HDW9,A0A2Z4HE75,A0A2Z4HF25,Q09I76 |
indirect/unknown |
TR |
P |
D(25233083, 23029222) |
N |
N |
D(19535441) |
N |
I(25712217) |
Fields Virology |
|
Functions as a general transcriptional regulator of
cellular and viral mRNAs mainly by mediating changes on the
host RNA polymerase II. One change, which is UL13
independent, is the rapid loss of Pol II forms bearing Ser-2
phosphorylation. A second change, which is UL13 dependent, is
the appearance of an intermediate form of Pol II that differs
from the normal hypo- and hyperphosphorylated forms. These
Pol II modifications immediately inhibit host genome
transcription, leading to cell cycle deregulation and loss of
efficient antiviral response. |
|
103 |
Herpesviridae |
Human herpesvirus 2; Herpes simplex virus 2 |
RL2 |
E3 ubiquitin-protein ligase ICP0, RING-type E3 ubiquitin
transferaseICP0, VMW118 protein |
P28284 |
ICP0_HHV2H |
A0A290D0A4,A0A290DJM1,A0A290DPU6,A0A290DQ85,A0A290DQC7,A0A290Y3R4,A0A290Y3T1,A0A290Y453,A0A290Y4M0,A0A290Y4T0,A0A2U9DUX7,A0A2X0RYZ6,D6PUZ2,D6PUZ3,D6PUZ4,D6PUZ5,D6PUZ6,D6PUZ7,G9I221,G9I280,P89473,W0NW81 |
dsDNA |
TR, Other |
S |
N |
N |
N |
D(25712217) |
I(15494213) |
I(20106921, 11333917 |
Fields Virology |
|
Evades nuclear antiviral defenses triggered by dsDNA
viruses. Acts during the initial stages of lytic infection
and the reactivation of latent viral genome. Prevents the
antiviral effect of nuclear bodies by degrading host PML and
SP100. Prevents antiviral response to viral DNA induced by
IFI16 by degrading it. Additionally, inhibits host IRF3
nuclear signaling to prevent interferon production by the
infected cells. |
|
104 |
Herpesviridae |
Human herpesvirus 2; Herpes simplex virus 2 |
RS1 |
Alpha-4 protein, ICP4, IE175, Infected cell protein 4,
Major viral transcription factor ICP4 homolog,
Transcriptional activator IE175 |
P90493 |
ICP4_HHV2H |
A0A290DJV7,A0A290DQ87,A0A290DQD8,A0A290Y3U5,A0A290Y4N5,A0A290Y4U9,A0A2H4PJL5,A0A2U9DVR1,A0A2U9DWA7,A0A2X0TFV2,G9I282 |
dsDNA |
TR |
P |
I(26984403) |
I(28611249) |
N |
D(25712217, 25673716) |
I(22496239, 26984403) |
I(28505309) |
Fields Virology |
|
Plays an essential role in the regulation of viral gene
expression by both activating and repressing host RNA
polymerase II-mediated transcription. Binds with high
affinity to the sequence 5'-ATCGTC-3'. Activates
transcription by recruiting a form of the host TFIID to
promoters and stabilizing the pre-initiation complex
formation. Negatively regulates its own transcription. This
immediate early (IE) protein is absolutely necessary for the
transition from IE transcription to later viral gene
transcription. |
|
105 |
Herpesviridae |
Human herpesvirus 2; Herpes simplex virus 2 |
UL29 |
DBP, DNA binding protein ICP8, ICP8, Major DNA-binding
protein, Single-stranded DNA-binding protein |
P36384 |
DNBI_HHV2 |
A0A0E3U2R9,A0A0E3Y6D1,A0A0Y0R3K0,A0A0Y0RPP0,A0A0Y0RQH2,A0A109R1L2,A0A1D8M9D0,A0A1U9ZCS9,A0A1U9ZD80,A0A1U9ZDS2,A0A1U9ZDY0,A0A1U9ZFU3,A0A1U9ZGK2,A0A1U9ZGZ7,A0A1U9ZHX5,A0A1U9ZJ89,A0A1U9ZJG3,A0A1U9ZK04,A0A1U9ZKU7,A0A1U9ZLW5,A0A1U9ZM30,A0A218KLT5,A0A218KLU4,A0A290D402,A0A290D687,A0A290Y3N1,A0A290Y3X5,A0A290Y4D4,A0A290Y4L1,A0A290Y4Y4,A0A2U9DUT8,A0A2U9DVR8,G9I251,I6U4X4,P89452,Q69101,W0NSF6 |
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
I(20585571) |
I(26676794, 30598436) |
I(2987527) |
Fields Virology |
Q69101 is inferred from Cercopithecine alphaherpesvirus 2
protein Q5Y0S3 |
Single-stranded DNA-binding protein required for DNA
replication. |
|
106 |
Herpesviridae |
Human herpesvirus 2; Herpes simplex virus 2 |
UL48 |
Transactivating tegument protein VP16, VP16, VP16
protein |
Q69113 |
Q69113_HHV2 |
A0A0Y0QTX6,A0A0Y0RIG1,A0A0Y0RUC4,A0A109R1E4,A0A120I2I5,A0A1U9ZDH2,A0A1U9ZE81,A0A1U9ZEL1,A0A1U9ZFX0,A0A1U9ZJL0,A0A1U9ZK94,A0A1U9ZKX9,A0A1U9ZLF9,G9I270,I6TLV8 |
dsDNA |
TR |
P |
I(19321615) |
N |
N |
I(2538647) |
I(11416146, 2538647) |
I(11416146) |
Fields Virology |
|
DNA binding,regulation of transcription,
DNA-templated |
|
107 |
Herpesviridae |
Human herpesvirus 2; Herpes simplex virus 2 |
UL54 |
ICP27, Immediate-early protein IE63, Infected cell
protein 27, mRNA export factor, VMW63 |
P28276 |
ICP27_HHV2H |
A0A1D8M9A7,A0A290D5Z7,A0A290DPS4,A0A290Y4K6,A0A2U9DVV4 |
dsDNA, ssDNA, ssRNA, dsRNA |
TR+J84, TNA |
P |
N |
N |
N |
D(25712217) |
I(19783816) |
I(19783816, Yeast three-hybrid analysis, NMR) |
Fields Virology |
ICP27 homolog |
Multifunctional regulator of the expression of viral
genes that contributes to the shutoff of host protein
synthesis and mediates nuclear export of viral intronless
mRNAs. Early in infection, this immediate early (EI) protein
mediates the inhibition of cellular splicing. This results in
the accumulation of unprocessed 3'end pre-mRNAs which can't
be exported from the nucleus. Cellular protein synthesis is
thereby shut off early after virus infection. Later in the
infection, it helps recruit cellular RNA polymerase II to
viral replication sites and promotes the nuclear export of
viral intronless mRNAs by interacting with mRNAs and host
NXF1/TAP. ICP27 binds to NUP62 which may provide facilitated
viral mRNA export and may compete with some host cell
transport receptors for binding and inhibit cellular
nucleocytoplasmic transport pathways. Also stimulates
translation of viral transcripts. Repression of host gene
expression blocks the cell cycle at the G1 phase and prevents
apoptosis (By similarity). Seems to silence the 3' splice
site of the promyelocytic leukemia (PML) intron 7a, thereby
switching PML isoforms from PML-II to PML-V. This could be
linked to the accelerated mRNA export induced by ICP27 which
might not provide sufficient time for PML pre-mRNA to be
spliced in the nucleus. |
|
108 |
Herpesviridae |
Human herpesvirus 2; Herpes simplex virus 2 |
US1 |
|
P89474 |
ICP22_HHV2H |
A0A0E3U2V3,A0A0Y0R3N1,A0A0Y0RAR6,A0A0Y0RPR1,A0A0Y0RQK2,A0A0Y0RQR5,A0A109R0Y3,A0A110B8A0,A0A1U9ZDA4,A0A1U9ZDI2,A0A1U9ZDV1,A0A1U9ZEP9,A0A1U9ZF54,A0A1U9ZFY2,A0A1U9ZGL3,A0A1U9ZH77,A0A1U9ZH85,A0A1U9ZII6,A0A1U9ZJK5,A0A1U9ZJQ9,A0A1U9ZK70,A0A1U9ZLG9,A0A1U9ZLK1,A0A1U9ZLR4,A0A1U9ZM71,A0A1U9ZMI5,A0A290DCW2,A0A290Y3Z3,A0A290Y411,A0A290Y505,A0A2U9DVE6,A0A2U9DVM7,A0A2U9DX76,A0A2X0SBG7,G9I283 |
indirect/unknown |
TR |
P |
D(25712217) |
N |
N |
D(25712217, 30863402) |
N |
D(25712217) |
Fields Virology |
|
Functions as a general transcriptional regulator of
cellular and viral mRNAs mainly by mediating changes on the
host RNA polymerase II. One change, which is UL13
independent, is the rapid loss of Pol II forms bearing Ser-2
phosphorylation. A second change, which is UL13 dependent, is
the appearance of an intermediate form of Pol II that differs
from the normal hypo- and hyperphosphorylated forms. These
Pol II modifications immediately inhibit host genome
transcription, leading to cell cycle deregulation and loss of
efficient antiviral response. |
|
109 |
Herpesviridae |
Human herpesvirus 3; Varicella-zoster virus |
IE61 |
Immediate-early protein 61,E3 ubiquitin-protein ligase
IE61, Modulator of cell state and gene expression, ORF61,
ORF62-2, Ring-finger protein, Transactivator, Transcription
regulator, Ubiquitin E3 ligase ICP0 |
Q6QCJ5 |
Q6QCJ5_HHV3 |
A0A0F7CWE3,A0A1B1JGJ2,G9IWI5,I7EJ31,Q0Q9A7,Q0Q9Q3,U5NTS2 |
dsDNA (20225013,table1) |
TR |
P |
N |
N |
N |
D(19457996, 22090112) |
N |
N |
Fields Virology |
ICP0 homolog |
ligase activity,metal ion binding |
|
110 |
Herpesviridae |
Human herpesvirus 3; Varicella-zoster virus |
IE62 |
ICP4, Immediate-early protein 62, Major viral
transcription factor ICP4 homolog, ORF62, ORF71 |
P09310 |
ICP4_VZVD |
A0A076N2G9,A0A0F7CV41,A0A0F7CVI7,A0A0F7CW41,A0A0F7GJ31,A0A0F7GL21,A0A0F7GMV1,A0A1B1JEY7,A0A1B1JFB3,A0A1B1JFK7,A0A1B1JG10,A0A1B1JG79,A0A1B1JGD9,A0A1B1JGP6,A0A1B1JGU1,A0A1B1JGX5,A0A3G2KR87,G0ZLH3,I2CNT9,I7EJ42,Q6X674,Q80AB9,Q80AC0,Q80AC2,Q80AC4,Q8AZM1,Q993S8,Q99BU9,Q99BW7,Q9DK02,Q9DWX9,U5NPD5,U5NQ74,U5NQE5,U5NQJ5,U5NR65,U5NRF1,U5NS27,U5NSM0,U5NSM7,U5NTS8,U5NUT7,W5RSN1 |
dsDNA |
TR |
P |
I(26984403) |
I(28611249) |
N |
D(20631144, 15936796, 2556848, 21937644, 8230477,
19457996) |
D(21937644) |
I(28505309) |
Fields Virology |
|
Transcriptional transactivator. May interact with and
recruit specific components of the general transcription
machinery to viral promoters and stabilize their formation
for transcription initiation. Negatively regulates its own
transcription. This immediate early (EI) protein may be
necessary in virion for viral pathogenesis. |
|
111 |
Herpesviridae |
Human herpesvirus 3; Varicella-zoster virus |
IE63 |
Immediate-early protein 63, ORF63, ORF70, Transcriptional
regulator ICP22 homolog, Transcriptional regulator IE63 |
P09255 |
ICP22_VZVD |
A0A1B1JGF9,A0A1B1JGW2,A0A2Z5BRN6,A0A2Z5BRP5,A0A2Z5BRQ4,A0A2Z5BRQ9,A0A2Z5BRS1,A0A2Z5BRT2,A0A2Z5BSR7,A0A2Z5BSS5,A0A2Z5BTS0,A0A2Z5BTS7,A0A2Z5BUH2,A0A2Z5BUI1,A0A2Z5BUI9,A0A2Z5BUK8,A0A2Z5BUL5,A0A2Z5BV47,A0A2Z5BV56,A0A2Z5BV63,A0A2Z5BWY5,A0A2Z5BWY7,A0A2Z5BX41,A0A2Z5BX44,G3LF46,Q77NN7 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(15843171, 11912195, 1316489, 15936796, 15936796,
21937644, 19457996) |
N |
D(15843171) |
Fields Virology |
|
Immediate early (EI) protein that functions as a
transcriptional regulator of cellular and viral mRNAs mainly
by interacting with several general transcription factors
thereby disorganizing the preinitiation complex at certain
promoters. May additionally help to regulate levels of
histones in virus-infected cells by interacting with host
ASF1. By inhibiting host transcriptional program, IE63 plays
a major role in the ability of VZV to overcome the innate
immune response to the virus. |
|
112 |
Herpesviridae |
Human herpesvirus 3; Varicella-zoster virus |
ORF10 |
Alpha trans-inducing protein, Alpha-TIF, ORF10 protein,
ORF-10, Tegument protein 10, Tegument protein VP16 homolog,
VP16 |
P09265 |
VP16_VZVD |
A0A0F7CW89,A0A1B1JG98,Q2PJ54,Q4JQW5,Q6QCP5 |
indirect/unknown |
TR |
P |
I(19321615) |
N |
N |
D(15522876, 8386275) |
I(11416146, 2538647) |
I(11416146) |
Fields Virology |
|
Transcriptional activator of immediate-early (IE) gene
products (alpha genes). Acts as a key activator of lytic
infection by initiating the lytic program through the
assembly of the transcriptional regulatory VP16-induced
complex composed of VP16 and two cellular factors, HCFC1 and
POU2F1. VP16-induced complex represents a regulatory switch:
when it is on, it promotes IE-gene expression and thus lytic
infection, and when it is off, it limits IE-gene
transcription favoring latent infection (By similarity). |
|
113 |
Herpesviridae |
Human herpesvirus 3; Varicella-zoster virus |
ORF29 |
DBP, Major DNA-binding protein |
P09246 |
DNBI_VZVD |
A0A0F7CVJ5,A0A0F7CWJ5,A0A0F7GIL1,A0A0F7GKY5,I7D9F2,Q4JQU6,U5NU18,U5NU72 |
ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
I(20585571) |
D(21937644) |
I(2987527) |
Fields Virology |
|
Plays several crucial roles in viral infection.
Participates in the opening of the viral DNA origin to
initiate replication by interacting with the origin-binding
protein. May disrupt loops, hairpins and other secondary
structures present on ssDNA to reduce and eliminate pausing
of viral DNA polymerase at specific sites during elongation.
Promotes viral DNA recombination by performing
strand-transfer, characterized by the ability to transfer a
DNA strand from a linear duplex to a complementary
single-stranded DNA circle. Can also catalyze the
renaturation of complementary single strands. Additionally,
reorganizes the host cell nucleus, leading to the formation
of prereplicative sites and replication compartments. This
process is driven by the protein which can form
double-helical filaments in the absence of DNA. |
|
114 |
Herpesviridae |
Human herpesvirus 3; Varicella-zoster virus |
ORF4 |
Gene expression post-transcriptional regulator, ICP27,
Multifunctional expression regulator, Post-transcriptional
regulator, Post-transcriptional regulator of gene expression,
Transactivator, UL54 |
Q6QCQ2 |
Q6QCQ2_HHV3 |
A0A075X2D8,A0A0F7CVL9,A0A0F7CWE6,A0A1B1JFU7,U5NPR6 |
dsDNA, ssDNA, ssRNA, dsRNA |
TR, TNA |
P |
N |
N |
N |
D(8389935, 9261438, 17634217, 2556848, 19457996) |
I(19783816) |
I(19783816, Yeast three-hybrid analysis, NMR) |
Fields Virology |
ICP27 homolog |
regulation of transcription, DNA-templated |
|
115 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
BALF2 |
DBP, Major DNA-binding protein, Major DNA-binding
protein,DBP |
P03227 |
DNBI_EBVB9 |
A0A0C7TMQ4,A0A0C7TUF9,A0A0C7U097,A0A0S2YRG9,A0A0U3K2Q9,A0A0U3TGP5,A0A0U3TMI4,A0A0U3U8D7,A0A120GXZ4,A0A191T7N2,A0A1W7HH80,A0A1W7HHM5,A0A2D1LY71,A0A2D1LYV2,A0A2D1LZI4,A0A2D1M0K1,A0A2D1M0T4,A0A2S1MKR8,A0A2S1MLV4,A0A2S1MNV2,A0A2S1MPZ1,A0A2S1MQH8,A0A2S1MSX2,A0A2S1MUL4,A0A2S1MUV4,A0A2S1MV65,A0A2S1MWF2,A0A2S1MWR1,A0A2S1MX72,A0A2S1MX94,A0A2S1MY55,A0A2S1MYS1,A0A2S1N124,A0A2S1N1E3,A0A2S1N1K4,A0A2S1N246,A0A2S1N3C7,A0A2S1N3Z9,A0A2S1N521,A0A385J8J4,A0A385J8S6,A0A385J9A1,A0A385J9M3,A0A385J9X3,A0A385JAK5,A0A385JAS1,A0A385JAX3,K9UTM4,Q1HVB8,Q3KSN9,R4R989,V5KTZ5 |
ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
N |
N |
D(9434720, 8806519) |
Fields Virology |
|
Plays several crucial roles in viral infection.
Participates in the opening of the viral DNA origin to
initiate replication by interacting with the origin-binding
protein. May disrupt loops, hairpins and other secondary
structures present on ssDNA to reduce and eliminate pausing
of viral DNA polymerase at specific sites during elongation.
Promotes viral DNA recombination by performing
strand-transfer, characterized by the ability to transfer a
DNA strand from a linear duplex to a complementary
single-stranded DNA circle. Can also catalyze the
renaturation of complementary single strands. Additionally,
reorganizes the host cell nucleus, leading to the formation
of prereplicative sites and replication compartments. This
process is driven by the protein which can form
double-helical filaments in the absence of DNA. |
|
116 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
BcRF1 |
TBP-like protein BcRF1 |
P25215 |
UL87_EBVB9 |
A0A0C7T247,A0A0X8WTD9,K9URF1 |
dsDNA |
TR |
P |
N |
N |
N |
D(22457524, 25165108) |
D(22457524) |
N |
Fields Virology |
vPIC homologs |
DNA-binding protein that is required for viral late gene
expression. |
|
117 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
BDLF3.5 |
BDLF3, BDLF3 protein, BDLF3.5 protein |
I1YP44 |
I1YP44_EBVG |
|
indirect/unknown |
TR |
P |
N |
N |
N |
D(25165108) |
N |
D(25165108) |
Fields Virology |
vPIC homologs |
Not annotated |
|
118 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
BDLF4 |
Uncharacterized protein BDLF4 |
P0CK56 |
UL92_EBVB9 |
G3CKS0,P0CK57 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(25165108) |
N |
D(25165108) |
Fields Virology |
vPIC homologs |
host cell nucleus;DNA binding;DNA-binding transcription
factor activity;protein dimerization
activity;sequence-specific DNA binding;modulation by virus of
host G0/G1 transition checkpoint;positive regulation of
transcription, DNA-templated;regulation of transcription,
DNA-templated;release from viral latency;suppression by virus
of host IRF7 activity |
|
119 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
BFRF2 |
Uncharacterized protein BFRF2 |
P14347 |
BFRF2_EBVB9 |
A0A0B6VKS2 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(25165108) |
N |
D(25165108) |
Fields Virology |
vPIC homologs |
viral process,viral tegument |
|
120 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
BGLF3 |
Protein BGLF3 |
P03220 |
UL95_EBVB9 |
A0A0B6VJ43,A0A0B6VMR4,A0A0C7NU37,A0A0C7SZ89,A0A0C7T510,A0A0C7T6N5,A0A0C7T892,A0A0C7T8Y5,A0A0C7TBC9,A0A1P7TZK4,A0A2D1LY20,A0A2S1MNR9,A0A2S1MR69,A0A2S1MRS3,A0A2S1MRX8,A0A2S1MUP2,A0A2S1MYJ5,A0A2S1N2D8,A0A2S1N2L3,A0A2S1N4W5,A0A385J8Q1,A0A385JAF2,A0A385JAM3,A0A3R5TNR6,A0A3R5U7A5,A0A3R5VQ48,A0A3R5WKF6,A0A3R5WKP5,A0A3R5XW44,A0A3R5YGK7,G3CKR7,K9USY2,Q3KSR4,V5KTY2 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(25165108) |
N |
D(25165108) |
Fields Virology |
vPIC homologs |
viral tegument;viral process |
|
121 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
BMRF1 |
DNA polymerase processivity factor BMRF1, EA-D, Early
antigen protein D, Polymerase accessory subunit |
P03191 |
EAD_EBVB9 |
K9UR48,P0C6Z0 |
dsDNA |
TR, Rep |
S |
N |
N |
N |
D(31462557) |
D(31462557) |
D(19801550, Nitrocellulose Filter Binding Assay) |
Fields Virology |
|
Plays an essential role in the viral lytic DNA
replication by acting as the polymerase accessory subunit.
Stimulates the viral DNA polymerase activity and appears to
function with it as a holoenzyme. Increases the processivity
of the viral polymerase, probably by acting as a sliding
clamp that prevents dissociation of the polymerase from the
active template. In addition, BMRF1 transcriptionally
activates the early BHLF1 promoter. |
|
122 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
BVLF1 |
Protein BVLF1 |
Q2MG95 |
Q2MG95_EBVB9 |
I1YP55 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(25165108) |
N |
D(25165108) |
Fields Virology |
vPIC homologs |
host cell nucleus;viral tegument;DNA
binding;bidirectional double-stranded viral DNA
replication |
|
123 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
EBNA1 |
BKRF1, EBNA-1, EBV nuclear antigen 1, Epstein-Barr
nuclear antigen 1 |
P03211 |
EBNA1_EBVB9 |
A0A0U3AZS7,A0A2D1LZQ0,Q1HVF7 |
dsDNA |
TR, Rep |
P |
D(20929547) |
D(20929547, 26468528,29142137) |
1B3T, 1VHI, 1YY6, 2FYY, 2FZ3, 3MV7, 3MV8, 3MV9, 4PRA,
4PRE, 4PRI, 4PRP, 5WMF, 5WUM, 5WUN, 6NPI, 6NPM, 6NPP,
6PW2 |
D(10799567) |
D(20929547, 10799567) |
|
Fields Virology |
|
Plays an essential role in replication and partitioning
of viral genomic DNA during latent viral infection. During
this phase, the circular double-stranded viral DNA undergoes
replication once per cell cycle and is efficiently
partitioned to the daughter cells. EBNA1 activates the
initiation of viral DNA replication through binding to
specific sites in the viral latent origin of replication,
oriP. Additionally, it governs the segregation of viral
episomes by mediating their attachment to host cell metaphase
chromosomes. Also activates the transcription of several
viral latency genes. Finally, it can counteract the
stabilization of host p53/TP53 by host USP7, thereby
decreasing apoptosis and increasing host cell survival. |
|
124 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
EBNA2 |
BYRF1, EBNA-2, EBV nuclear antigen 2, Epstein-Barr
nuclear antigen 2 |
P12978 |
EBNA2_EBVB9 |
A0A075FCH9,A0A075FCI7,A0A075FDA7,A0A075FDG8,A0A075FFC3,A0A075FFL0,A0A075FFX2,A0A075FGL9,A0A0A8IKS3,A0A0B6VHM4,A0A0C7NTX7,A0A0C7SZP2,A0A0C7T066,A0A0C7T1F2,A0A0C7T2F0,A0A0C7T426,A0A0C7T5P8,A0A0C7T5T4,A0A0C7T687,A0A0C7TCF1,A0A0C7TCX1,A0A0C7TEL7,A0A0C7TI73,A0A0C7TIT1,A0A0C7TKT1,A0A0C7TL19,A0A0C7TLJ0,A0A0C7TMR9,A0A0C7TN88,A0A0C7TNR8,A0A0C7TSE2,A0A0C7TUG9,A0A0C7TV69,A0A0C7TX39,A0A0C7TYV8,A0A0C7TZP5,A0A0C7U0A2,A0A0C7U0N0,A0A0E4D790,A0A0E4HQQ5,A0A0F6QKC9,A0A0S2YQC3,A0A0S2YR23,A0A0U2VT93,A0A0U3J1F9,A0A0U3J5M7,A0A0U3K2E3,A0A0U3SB38,A0A0U3SCD4,A0A0U3TM83,A0A0U3TY67,A0A0U3UKE0,A0A0X8W0J3,A0A0X8W0W5,A0A0X8XBT9,A0A0X8Z1K9,A0A125T0U7,A0A125T130,A0A191T6S4,A0A191T710,A0A191T790,A0A191T7H0,A0A1W5LUS2,A0A2D1LXX3,A0A2D1LY86,A0A2D1LYD8,A0A2D1LYN4,A0A2D1LYW2,A0A2D1LZ30,A0A2D1LZB0,A0A2D1M071,A0A2D1M0L5,A0A3R5TN76,A0A3R5TNW6,A0A3R5TRP0,A0A3R5TTM1,A0A3R5TU90,A0A3R5TUU2,A0A3R5TV00,A0A3R5TVV4,A0A3R5U305,A0A3R5U329,A0A3R5U471,A0A3R5U4S0,A0A3R5U5P5,A0A3R5U808,A0A3R5UAV2,A0A3R5UBI8,A0A3R5UCF3,A0A3R5UCS0,A0A3R5UD40,A0A3R5UDT7,A0A3R5UGT2,A0A3R5VW62,A0A3R5VZT8,A0A3R5W0Z1,A0A3R5W616,A0A3R5W7U3,A0A3R5W866,A0A3R5WD22,A0A3R5WKC0,A0A3R5WQ14,A0A3R5WQP7,A0A3R5WU22,A0A3R5WUM5,A0A3R5WWB4,A0A3R5WWE7,A0A3R5WWI4,A0A3R5WX09,A0A3R5WXB8,A0A3R5WY79,A0A3R5WYI2,A0A3R5WYN4,A0A3R5WZW6,A0A3R5X0F9,A0A3R5X0S5,A0A3R5X1P2,A0A3R5X4D5,A0A3R5X6P1,A0A3R5X741,A0A3R5X8A5,A0A3R5X9K2,A0A3R5XD17,A0A3R5XDF6,A0A3R5XDK0,A0A3R5XFA1,A0A3R5XIC4,A0A3R5XMU8,A0A3R5XR67,A0A3R5YDU1,A0A3R5YEE6,A0A3R5ZGU7,A0A3R5ZZ51,A0A3R6A0M6,A0A3R6A337,A0A3R6A9X6,I1YNZ9,K9UR36,K9URA4,Q3KSV2,R4QYS0,U5YU33 |
indirect/unknown |
TR |
P |
D(26845565, 24068937) |
D(21746931, 24068937, 26883634) |
2MKR, 2N2J, 5HDA |
D(26845565) |
D(21710493, 9445037) |
N |
Fields Virology |
|
Plays a key role in the activation of the host resting
B-cell and stimulation of B-cell proliferation. Acts by
up-regulating the expression of viral EBNA1-6, LMP1, LMP2A
and LMP2B genes, as well as several host genes including
CD21, CD23 and MYC. Activates transcription by acting as an
adapter molecule that binds to cellular sequence-specific
DNA-binding proteins such as host CBF1, SMARCB1 and SPI1.
Once EBNA2 is near promoter sites, its acidic activating
domain recruits basal and activation-associated transcription
factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and
CBP in order to promote transcription. Alternatively, EBNA2
can affect activities of cell cycle regulators and retard
cell cycle progression at G2/M phase. It also induces
chromosomal instability, by disrupting mitotic checkpoints,
multi-nucleation and formation of micronuclei in infected
cells. |
|
125 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
EBNA3A |
BLRF3-BERF1, EBNA3, EBNA-3, EBNA-3A, EBV nuclear antigen
3, EBV nuclear antigen 3A, Epstein-Barr nuclear antigen 3,
Epstein-Barr nuclear antigen 3A |
P12977 |
EBNA3_EBVB9 |
A0A075FCV9,A0A075FCW4,A0A075FFK6,A0A075FGE2,A0A0A8IN05,A0A0B6VPX8,A0A0C7P0X9,A0A0C7SX58,A0A0C7SZG8,A0A0C7T019,A0A0C7T0J9,A0A0C7T1N7,A0A0C7T3A9,A0A0C7T3S7,A0A0C7T5I8,A0A0C7T6Q6,A0A0C7T6Z1,A0A0C7T8F1,A0A0C7T9C3,A0A0C7T9D1,A0A0C7TAY3,A0A0C7TBQ7,A0A0C7TD44,A0A0C7TFN4,A0A0C7TIG9,A0A0C7TKB3,A0A0C7TLT1,A0A0C7TLW3,A0A0C7TN30,A0A0C7TNK3,A0A0C7TPP7,A0A0C7TPQ7,A0A0C7TPS6,A0A0C7TQD5,A0A0C7TR83,A0A0C7TRR5,A0A0C7TSA1,A0A0C7TSL0,A0A0C7TSM3,A0A0C7TTD0,A0A0C7TU38,A0A0C7TUC1,A0A0C7TVT3,A0A0C7TVZ9,A0A0C7TWE5,A0A0C7TWV3,A0A0C7TYQ1,A0A0C7TZ60,A0A0C7TZJ3,A0A0C7U0I2,A0A0C7U378,A0A0F6QK09,A0A191T7B4,A0A191T7J2,A0A1W5LUA3,A0A1W5LUF8,A0A2D1LXZ8,A0A2D1LYG7,A0A2D1LYX5,A0A2D1LZ53,A0A2D1M0F9,A0A2S1MLI0,A0A3R5TLU3,A0A3R5TQC1,A0A3R5TU26,A0A3R5TUK3,A0A3R5TUX6,A0A3R5TX13,A0A3R5TXM2,A0A3R5TY93,A0A3R5TZE0,A0A3R5U0J0,A0A3R5U3V1,A0A3R5U4Q0,A0A3R5U5C4,A0A3R5U5V3,A0A3R5U6R9,A0A3R5U851,A0A3R5UBX8,A0A3R5UBZ5,A0A3R5UFL7,A0A3R5W1K4,A0A3R5W2D1,A0A3R5WDB0,A0A3R5WHZ1,A0A3R5WJQ0,A0A3R5WME6,A0A3R5WT39,A0A3R5WTU4,A0A3R5WXL4,A0A3R5WYV7,A0A3R5X5D7,A0A3R5XA97,A0A3R5XE13,A0A3R5XG85,A0A3R5XHM9,A0A3R5ZJQ4,A0A3R5ZMQ3,A0A3R6A954,A0A3R6ADF3,I1YP19,K9USU8,K9UT27,Q3KST2,Q69138,V5KUF0 |
indirect/unknown |
TR |
P |
D(26719268) |
D(26719268, 27903901, 24068937) |
1M05, 1XR8, 5WMO |
D(12372828, 9499037, 8709211) |
D(8709211) |
D(12372828, 9499037) |
Fields Virology |
|
Plays an essential role for activation and
immortalization of human B-cells. Represses transcription of
viral promoters TP1 and Cp through interaction with host
RBPJ, and inhibits EBNA2-mediated activation of these
promoters. Since Cp is the promoter for all EBNA mRNAs,
EBNA3A probably contributes to a negative autoregulatory
control loop. |
|
126 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
EBNA3B |
BERF2A-BERF2B, EBNA-3B, EBNA4, EBNA-4, EBV nuclear
antigen 3B, EBV nuclear antigen 4, Epstein-Barr nuclear
antigen 3B, Epstein-Barr nuclear antigen 4 |
P03203 |
EBNA4_EBVB9 |
A0A075FCS4,A0A075FDV6,A0A075FFW1,A0A075FGX8,A0A0B6VHN8,A0A0C7T689,A0A0F6QJ13,A0A0S2YQI6,A0A0S2YQL8,A0A0S2YQZ5,A0A0S2YR40,A0A0S2YRH7,A0A0S2YRK7,A0A0U3SNH2,A0A0U3SPQ3,A0A0U3TMR1,A0A0U3TXD3,A0A0U3U0Q9,A0A0U3UK97,A0A0X8WSM4,A0A0X8XBD6,A0A0X9A8U7,A0A0X9A9Q5,A0A109NQL8,A0A125T0X2,A0A125T156,A0A191T6V0,A0A191T735,A0A191T7J5,A0A2D1LY00,A0A2D1LYF8,A0A2D1LYQ0,A0A2D1LYY5,A0A2D1LZ71,A0A2D1LZD7,A0A2D1LZV8,A0A2D1M014,A0A2D1M0F4,A0A3R5TNF9,A0A3R5TP59,A0A3R5TPG0,A0A3R5TPS0,A0A3R5TQG9,A0A3R5TSJ0,A0A3R5TTM5,A0A3R5TUK0,A0A3R5TXL1,A0A3R5TZH9,A0A3R5TZN1,A0A3R5U7Y1,A0A3R5U9C9,A0A3R5UB62,A0A3R5UBE0,A0A3R5UBT5,A0A3R5UD37,A0A3R5UEB9,A0A3R5UF10,A0A3R5UFR7,A0A3R5VSI4,A0A3R5VTK1,A0A3R5W2X0,A0A3R5W7M9,A0A3R5WB92,A0A3R5WCP8,A0A3R5WLR6,A0A3R5WLT6,A0A3R5WPT2,A0A3R5WUM4,A0A3R5WUT6,A0A3R5WVA4,A0A3R5X152,A0A3R5X4L7,A0A3R5X4W3,A0A3R5X809,A0A3R5XAT0,A0A3R5XR04,A0A3R5XX02,A0A3R5XZ10,A0A3R5Y0F1,A0A3R5Y4K2,A0A3R5Y5B4,A0A3R5Y901,A0A3R5YB68,A0A3R5ZUB9,A0A3R5ZWY8,A0A3R5ZXN2,A0A3R6A7Y7,A0A3R6ACM8,G3CKQ8,I1YP20,K9URU7,K9US25,Q1HVG4,Q3KST1,Q69139,R4R679,U5YU54,V5KU13 |
indirect/unknown |
TR |
P |
D(26719268) |
D(26719268, 24068937, 27903901) |
N |
D(7975264) |
N |
N |
Fields Virology |
|
May be involved in transcriptional regulation of both
viral and cellular genes by interacting with the host
DNA-binding protein RBPJ. |
|
127 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
EBNA3C |
BERF3-BERF4, EBNA-3C, EBNA-4B, EBNA6, EBNA-6, EBV nuclear
antigen 3C, EBV nuclear antigen 4B, EBV nuclear antigen 6,
Epstein-Barr nuclear antigen 3C, Epstein-Barr nuclear antigen
4B, Epstein-Barr nuclear antigen 6 |
P03204 |
EBNA6_EBVB9 |
A0A0A8IMR0,A0A0B6VJ05,A0A0F6QLY8,A0A0S2YQE3,A0A0S2YQM8,A0A0S2YQU4,A0A0S2YR37,A0A0S2YRI8,A0A0U2IVT5,A0A0U3K2A9,A0A0U3SSI4,A0A0U3THE3,A0A0U3TY20,A0A0X8W0H0,A0A0X8W0R4,A0A0X8Z1G7,A0A109NNY9,A0A120GXX6,A0A120GY11,A0A125T0X3,A0A125T157,A0A191T6V5,A0A191T734,A0A191T7I9,A0A1W5LUG5,A0A1W5LUK3,A0A1W5LUQ5,A0A2D1LXZ6,A0A2D1LY82,A0A2D1LYF3,A0A2D1LYP4,A0A2D1LYY0,A0A2D1LZ65,A0A2D1LZD8,A0A2D1LZP5,A0A2D1LZW5,A0A2D1M0I0,Q3KST0,Q69140 |
indirect/unknown |
TR |
P |
D(24068937, 22357270, 26719268) |
D(24068937, 22357270, 26719268, 24344258, 27903901) |
1CG9, 2BSR, 3DX6, 3DX7, 3DX8, 3DXA |
D(7745710, 11739688, 10799590) |
D(10799590, 8709211) |
D(11739688) |
Fields Virology |
|
Plays an essential role for the activation and
immortalization of human B-cells. Represses transcription of
viral promoters TP1 and Cp through interaction with host
RBPJ, and inhibits EBNA2-mediated activation of these
promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA6
probably contributes to a negative autoregulatory control
loop. Alternatively, EBNA6 also regulates the transcription
of the EBV oncogene LMP1 in a cell cycle-dependent manner.
Modulates the activity of several host proteins involved in
cell cycle regulation including host cyclin A, MYC, RB, p21
and p27 mainly through binding to the host SCF(SKP2) complex.
Inhibits the promoter of host H2AX and targets H2AX to
proteasomal degradation in order to promote latency and cell
proliferation. |
|
128 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
EBNA-LP |
EBNA5, EBNA-5, EBNALP, EBNA-LP protein, EBV nuclear
antigen 5, EBV nuclear antigen leader protein, Epstein-Barr
62-kDa polypeptide RNA from clone IB4WY-1, Epstein-Barr
nuclear antigen 5, Epstein-Barr nuclear antigen leader
protein, Epstein-Barr virus Ir1/U2 region protein T1
(Fragment), Latency protein, Leader protein |
Q8AZK7 |
EBNA5_EBVB9 |
A0A0A7DK99,A0A0S2YQH1,A0A0S2YQX5,A0A0S2YRB1,A0A0S2YRQ2,A0A0X8YIJ7,A0A125T0U6,A0A2D1LYW5,K9US68,K9USE8,P0C732,Q1HVI8,Q69125,Q69136,Q69147 |
indirect/unknown |
TR |
P |
N |
D(29467311, 24167291) |
5X8N |
D(29467311) |
N |
D(29467311) |
Fields Virology |
|
Plays an important role in the establishment of B-cell
immortalization by acting as an EBNA2 coactivator. This
transcriptional activation preferentially enhances the
expression of the major viral protein LMP1. The interaction
between EBNA-LP and host SP100 correlates with coactivation
of EBNA2 and the relocalization of SP100 from PML nuclear
bodies into nucleoplasm. |
|
129 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
Rta |
BRLF1, Immediate-early protein Rta, Replication and
transcription activator, RTA |
P03209 |
RTA_EBVB9 |
A0A075FGE7,A0A0A8IL74,A0A0B6VHK7,A0A0B6VMK6,A0A0B6VP67,A0A0B6VPY0,A0A0C7SX63,A0A0C7SZH5,A0A0C7T024,A0A0C7T3T2,A0A0C7T5J1,A0A0C7T650,A0A0C7TFN7,A0A0C7TI29,A0A0C7TI76,A0A0C7TMI1,A0A0C7TN35,A0A0C7TNL3,A0A0C7TR86,A0A0C7TRS0,A0A0C7TS97,A0A0C7TZJ8,A0A0C7U0I6,A0A0U3J154,A0A0U3TX69,A0A1W7HHU5,A0A2D1LYE8,A0A2D1M0G7,A0A2D1M0N6,A0A2S1MKD6,A0A2S1MQS6,A0A2S1MR54,A0A2S1MRJ6,A0A2S1MSH1,A0A2S1MTZ3,A0A2S1MUD3,A0A2S1MUN1,A0A2S1MUU8,A0A2S1MUY5,A0A2S1MVQ3,A0A2S1MVZ5,A0A2S1MXG7,A0A2S1MZE3,A0A2S1MZL7,A0A2S1N122,A0A2S1N1H8,A0A2S1N1T8,A0A2S1N2Q2,A0A2S1N3I5,A0A2S1N441,A0A2S1N4M4,A0A385J7S9,G3CKR1,K9UT49,Q1HVG0,Q3KSS7,V5KU06 |
dsDNA |
TR |
P |
D(17301127, 22379087) |
D(22379087) |
N |
D(17301127, 22379087) |
D(17301127, 22379087) |
N |
Fields Virology |
|
Immediate-early transcription factor that controls the
initiation of viral lytic gene expression and lytic
reactivation from latency. Triggers lytic replication, and
initiates a cellular senescence program in epithelial cells.
Upregulates human DCR3/TNFRSF6B by directly binding to its
receptor. |
|
130 |
Herpesviridae |
Human herpesvirus 4; Epstein-Barr virus |
Zta |
BZLF1, EB1, Trans-activator protein BZLF1, Z, Zebra,
ZEBRA, ZTA |
P03206 |
BZLF1_EBVB9 |
A0A060A1H7,A0A060A1R5,A0A060A624,A0A060A629,A0A0B6VMG6,A0A0C7T7Z0,A0A0C7TGZ2,A0A0C7TIV5,A0A0C7TJ79,A0A0C7TJC8,A0A0C7TLE1,A0A0C7TNH9,A0A0C7TP04,A0A0C7TST0,A0A0C7TUL0,A0A0U3K1L7,A0A0U3SKG1,A0A1W5LUA9,A0A2D1LYB2,A0A2D1M030,A0A2D1M0N0,A0A3R5TL42,A0A3R5TWW0,A0A3R5U420,A0A3R5VRE2,A0A3R5W4V8,A0A3R5WXE1,A0A3R5X5L7,A0A3R5X6C8,A0A3R5XWF5,G3CKR0,K9URC5,Q1HVG1,Q3KSS8,Q69115,Q69123,V5KU67 |
dsDNA |
TR |
P |
D(23015699) |
D(23015699, 25779048, 29142137) |
1ZSD, 2AK4, 2AXF, 2AXG, 2C9L, 2C9N, 2NX5, 3KWW, 3KXF,
3SPV, 3VFN, 3VFO, 3VFP, 3VFR, 5SZX |
D(2157874) |
D(2157874, 2159531) |
D(2157874, 2159531) |
Fields Virology |
ICP0 homolog |
Plays a key role in the switch from latent infection to
lytic cycle producing new virions. Acts as a transcription
factor, inducing early lytic cycle genes, and as a origin
binding protein for genome replication. BZLF1 activates the
promoter of another EBV gene (BSLF2+BMLF1). |
|
131 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
IE1 |
55 kDa immediate-early protein 1, UL123 |
P03169 |
VIE1_HCMVT |
A0A0A7CGH8,A0A0A7CH45,A0A0G2T6P9,A0A0G2T717,A0A0G2T934,A0A0G2T9V0,A0A0G2TB17,A0A0G2TCU8,A0A0G2TFI8,A0A0G2TFM5,A0A0G2TIG1,A0A0G2TJG7,A0A0G2TKF7,A0A0G2TMB8,A0A0G2TQM8,A0A0G2TR65,A0A0G2TT45,A0A0G2TTN7,A0A0G2TTY5,A0A0G2TUY9,A0A0G2TVN3,A0A0G2TVV8,A0A0G2TWD2,A0A0G2TZN5,A0A0G2U0L5,A0A0G2U0P4,A0A0G2U107,A0A0G2U5F3,A0A0G2U6D3,A0A0G2U775,A0A0G2U789,A0A0G2U9Y0,A0A0G2UA46,A0A0G2UB54,A0A0G2UB64,A0A0G2UBY0,A0A0G2UCW7,A0A0G2UF68,A0A0G2UFS7,A0A0G2UGT4,A0A0R5E2Q2,A0A0R5E3W7,A0A0R5E6M7,A0A0R5E7P5,A0A0R5E9Q8,A0A0R5E9Z2,A0A0R5EB18,A0A0R5EGD5,A0A126N8Q0,A0A126N954,A0A126N9K7,A0A126NAR7,A0A126NBL2,A0A126NC20,A0A126NCL1,A0A126NCY3,A0A126NDE2,A0A126NIT2,A0A140D1E4,A0A140IIR2,A0A140IJ80,A0A159B136,A0A159B2R2,A0A159B4L6,A0A159B5S3,A0A161C1V5,A0A191SCH8,A0A1L3IX30,A0A1L3IYI0,A0A2H4GFT1,A0A2H4GJ43,A0A2H4GK92,A0A2H4GLV7,A0A2H4GNL9,A0A2I2MMP9,B8YED9,C5MKW0,C8BLJ1,C8CFF3,C8CFW8,D2K3S2,D2K507,D2W9F5,D2W9H9,D2W9M7,D2W9Q1,D2W9S5,D2W9X3,D2W9Z7,E7DVQ4,P13202,Q6RXC2,Q6SWJ1,Q6SWL8,Q6SWP6,Q6SWS4,Q6SWV2,Q6SX10,Q6SX39,R4S3N7,V9LM41,V9LMP3,V9LP50,V9LPA5,V9LPS2,V9LRP7,V9LS79,V9PU14,V9PU19,V9PV04,X4YAG1 |
dsDNA |
TR |
P |
D(27733551) |
N |
4QRU, 5E5A |
D(19776115, 27733551) |
N |
N |
Fields Virology |
ICP0 homolog |
Plays an important role in transactivating viral early
genes as well as activating its own promoter. Targets and
disrupts host PML/nuclear domain 10 (ND10). Promotes
efficient viral growth by interacting with and directing host
SP100 to degradation, leading to enhanced acetylation level
of histones. In addition, functions in counteracting the host
innate antiviral response. Inhibits the type I interferon
pathway by directly interacting with and sequestrating host
STAT2. Alters host cell cycle progression, probably through
its interaction with host E2F1 or RB1 that overcomes the
RB1-mediated repression of E2F-responsive promoters. |
|
132 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
IE2 |
Protein UL122, UL122, Viral transcription factor IE2 |
P19893 |
VIE2_HCMVA |
A0A0A0PU13,A0A0A7CFM1,A0A0A7CHB3,A0A0G2T7B8,A0A0G2T8I7,A0A0G2T9H8,A0A0G2T9P9,A0A0G2TAW2,A0A0G2TC19,A0A0G2TD78,A0A0G2TE28,A0A0G2TGN0,A0A0G2TI14,A0A0G2TIF9,A0A0G2TJ39,A0A0G2TLE4,A0A0G2TN04,A0A0G2TN92,A0A0G2TNS1,A0A0G2TPC1,A0A0G2TR93,A0A0G2TTK4,A0A0G2TVE6,A0A0G2TXS8,A0A0G2TYR3,A0A0G2TZ60,A0A0G2U2J8,A0A0G2U314,A0A0G2U3E1,A0A0G2U3Y8,A0A0G2U7G8,A0A0G2U7T0,A0A0G2UAC5,A0A0G2UC28,A0A0G2UCV3,A0A0G2UD10,A0A0G2UDJ2,A0A0G2UEQ5,A0A0G2UID8,A0A0G2UJ44,A0A0R5E660,A0A0R5E733,A0A0R5EB52,A0A0R5ECK4,A0A0R5ECZ5,A0A0R5EHA7,A0A126N9K6,A0A126NDW2,A0A126NF63,A0A126NGT3,A0A140D1E3,A0A140IIR1,A0A159AZC8,A0A159B0U1,A0A162DRE1,A0A191SBK7,A0A1L3IX19,A0A2H4GFS6,A0A2H4GHA4,A0A2H4GHN8,A0A2H4GL85,A0A2H4GP31,A0A2H4GQK7,B8YED8,C5MKV9,C8BLJ0,C8CFF2,D2IG93,D2K4M9,D2K506,D2K5K9,D2W9M6,D2W9S4,D2W9X2,D2W9Z6,D5LXA9,E7DVQ3,F5HE22,Q6RXC5,Q6SW29,Q6SWJ2,Q6SWL9,Q6SWP7,Q6SWS5,Q6SWV3,Q6SWY2,Q6SX11,Q6SX40,R4SHW1,V9LNF7,V9LQ15,V9LRJ7,V9LSG0,V9PUG0,V9PUQ9 |
dsDNA |
TR |
P |
D(27733551, 15479808) |
N |
N |
D(9875333, 27733551, 15479808, 28161581) |
D(10225210, 9875333) |
|
Fields Virology |
|
Stimulates viral early and late gene expression and thus
play a crucial role in the regulation of productive
infection. In addition, activates quiescent cells to reenter
the cell cycle and upregulates several E2F-responsive genes,
which are responsible for pushing the cell into S phase. In
S-phase, inhibits cellular DNA synthesis and blocks further
cell cycle progression. |
|
133 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL29 |
Protein UL29/UL28 |
C0H677 |
UL298_HCMVA |
A0A0A7CFZ0,A0A0A7CGC5,A0A0G2T6M0,A0A0G2T800,A0A0G2TD10,A0A0G2TJD6,A0A0G2TLM9,A0A0G2TPJ7,A0A0G2TQE9,A0A0G2TSX7,A0A0G2TZ11,A0A0G2U0G4,A0A0G2U0K1,A0A0G2U0V6,A0A0G2U2S6,A0A0G2U5N3,A0A0G2U760,A0A0G2UFK8,A0A0G2UGK9,A0A0G2UHH1,A0A0R5E240,A0A0R5E2Z4,A0A0R5E4G4,A0A0R5E6C3,A0A0R5EA67,A0A0R5EC46,A0A0R5EDP6,A0A0U2Q734,A0A126N9C9,A0A126NDN5,A0A126NFE8,A0A140III8,A0A159B0Q9,A0A159B4J9,A0A162DUP8,A0A2H4GFP4,A0A2H4GH35,A0A2H4GI26,A0A2H4GJW2,A0A2H4GKT9,A0A2H4GPE8,A8T794,B8YE64,B9VXJ9,D2K5D5,D3YRW8,D5LX41,E7DVH9,F5HIG2,P16764,Q6SWA3,Q6XNK8,S5FXY3,V9LME7,V9LN39,V9LQ33,V9LS16,V9LSI1,V9PSW3,V9PUS9,V9PV83 |
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
D(20585571) |
I(26676794, 30598436) |
I(2987527) |
Fields Virology |
|
Contributes to activation of immediate-early gene
expression. |
|
134 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL34 |
Transcriptional regulator UL34 |
P16812 |
UL34_HCMVA |
A0A0A7CFS9,A0A0A7CFU8,A0A0A7CFZ2,A0A0A7CGD1,A0A0G2T6M2,A0A0G2T6X8,A0A0G2T8U9,A0A0G2T9R9,A0A0G2T9V2,A0A0G2TAW7,A0A0G2TBG1,A0A0G2TD15,A0A0G2TJE0,A0A0G2TK87,A0A0G2TKN5,A0A0G2TKP7,A0A0G2TM42,A0A0G2TTS1,A0A0G2TV84,A0A0G2TW58,A0A0G2TZ16,A0A0G2TZG7,A0A0G2U0E2,A0A0G2U0H0,A0A0G2U700,A0A0G2U9Y1,A0A0G2UAW6,A0A0G2UCD9,A0A0G2UCR1,A0A0G2UD52,A0A0G2UDU7,A0A0G2UGL3,A0A0G2UHH5,A0A0R5E3K5,A0A0R5E3P5,A0A0R5E443,A0A0R5E5U6,A0A0R5E6Z8,A0A0R5E8J6,A0A0R5E9J3,A0A126N8Y5,A0A126N9E3,A0A140D0Q8,A0A159AZ79,A0A159B019,A0A159B132,A0A191SBA6,A0A1I9XCP6,A0A1I9XDE2,A0A1L3IXT5,A0A2H4GDQ8,A0A2H4GG19,A0A2H4GKH8,A0A2H4GLN9,A0A2H4GNF1,A0A2I2MMI6,A0A3G6XL13,A8T7A1,B8YE70,C8BKY8,C8BLC1,C8CF83,C8CFP8,C8CPD5,D2K5A2,D3YRX3,D5LX46,E7DVI4,F5HC16,Q6VNV0,R4S5N4,V9LMF4,V9LMN6,V9LN29,V9PTQ8,V9PUT4,X4YA79 |
dsDNA |
TR |
P |
N |
D(29626748) |
N |
D(11390608) |
D(11390608) |
N |
Fields Virology |
|
Acts as a transcriptional repressor of the US3 gene
expression through a specific DNA sequence named the
transcriptional repressive element (tre). |
|
135 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL49 |
Protein HFLF5, Uncharacterized protein UL49,
Uncharacterized protein UL49,Protein HFLF5 |
P16786 |
UL49_HCMVA |
A0A0A0PIG0,A0A0A7CFW2,A0A0G2T6Y6,A0A0G2T7U5,A0A0G2TAX3,A0A0G2TD27,A0A0G2TFD1,A0A0G2TKA2,A0A0G2TPR1,A0A0G2TR21,A0A0G2TUT5,A0A0G2TW75,A0A0G2TXM7,A0A0G2TZY1,A0A0G2U0G0,A0A0G2U0V5,A0A0G2U4N6,A0A0G2U5C7,A0A0G2U5Q4,A0A0G2U679,A0A0G2U779,A0A0G2UAY1,A0A0G2UCF0,A0A0G2UD66,A0A0G2UFM8,A0A0G2UFN4,A0A0G2UG25,A0A0R5EA71,A0A0R5EC84,A0A0U2JPK2,A0A126NBX2,A0A126NCU9,A0A126ND93,A0A140D0S3,A0A159B0S4,A0A159B4B2,A0A162DZ71,A0A1L3IYU1,A0A2H4GDS4,A0A2H4GFN2,A0A2H4GIN6,A8T7C6,B8YE85,B9VXL8,C5MKQ5,C8BKK6,C8BLD6,C8CFR3,C8CPF0,D2K5F5,D3YRY8,D5LX61,E7DVJ9,F5HEF7,Q6RXG9,Q6SW82,R4S5P9,V9HX93,V9LMH3,V9LNW1,V9LQW8,V9LSI8,V9PSX2,V9PTS4 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(25165108) |
N |
N |
Fields Virology |
vPIC homologs |
viral process,viral tegument |
|
136 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL57 |
DBP, Major DNA-binding protein |
P17147 |
DNBI_HCMVA |
A0A0R5EAX5,A0A1L3IXF9,A0A1L3IXW0,A0A1L3IYC5,A0A2H4GDT7,A0A2H4GET4,A0A2H4GKC4,A0A2H4GP02,A0A2S0DCR9,A0A3G6XKQ2,A8T7D7,A9YU24,A9YU25,A9YU26,A9YU27,A9YU31,Q6RXG4,Q80MY8,V9LM77 |
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
N |
N |
D(9426445) |
Fields Virology |
|
Plays several crucial roles in viral infection.
Participates in the opening of the viral DNA origin to
initiate replication by interacting with the origin-binding
protein (PubMed:8230421). May disrupt loops, hairpins and
other secondary structures present on ssDNA to reduce and
eliminate pausing of viral DNA polymerase at specific sites
during elongation. Promotes viral DNA recombination by
performing strand-transfer, characterized by the ability to
transfer a DNA strand from a linear duplex to a complementary
single-stranded DNA circle. Can also catalyze the
renaturation of complementary single strands. Additionally,
reorganizes the host cell nucleus, leading to the formation
of prereplicative sites and replication compartments. This
process is driven by the protein which can form
double-helical filaments in the absence of DNA. |
|
137 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL69 |
mRNA export factor ICP27 homolog |
Q6SW73 |
ICP27_HCMVM |
A0A3G6XL32 |
dsDNA, ssDNA, ssRNA, dsRNA |
TR, TNA |
P |
N |
N |
N |
D(8189530, 16478985) |
N |
N |
Fields Virology |
ICP27 homolog |
Immediate early (EI) protein that plays many roles during
productive infection including regulation of host cell cycle
progression, regulation of viral gene expression or nuclear
export of intronless viral RNAs. Acts as a transcriptional
transactivator via interaction with the cellular
transcription elongation factor SUPT6H and as a nuclear RNA
export factor via interaction with UAP56, a component of the
cellular mRNA export machinery (By similarity). |
|
138 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL79 |
Protein UL79 |
P16752 |
UL79_HCMVA |
A0A0A0PKK4,A0A0A7CF34,A0A0A7CGG1,A0A0G2T6N3,A0A0G2T910,A0A0G2T9T2,A0A0G2TAY7,A0A0G2TBJ1,A0A0G2U0K7,A0A0G2U5D9,A0A0G2UB12,A0A0G2UG47,A0A0R5E690,A0A0R5E943,A0A126NDS7,A0A126NEP6,A0A159B014,A0A159B138,A0A1I9XCS0,A0A1L3IWY8,A0A2H4GK38,A0A2H4GN24,A0A2H4GNQ9,A0A2H4GPI2,A0A2I2MML7,A0A3G6XL37,A8T7F6,B8YEA4,B9VXN7,C5MKS5,C8BLF6,C8CFB8,C8CFT3,D2K5H5,D3YS03,D5LX75,F5HFM1,Q6SW63,V9LM10,V9LQ09,V9LQM3,V9LS53,V9PTX7,V9PTY8,V9PUX0 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
D(21367901) |
Fields Virology |
vPIC homologs |
Plays a role in the expression of late transcripts
bridging viral DNA replication and late gene expression
during infection. |
|
139 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL82 |
71 kDa upper matrix phosphoprotein, Phosphoprotein UL82,
pp71, ppUL82, Protein pp71, Tegument protein UL82 |
P06726 |
PP71_HCMVA |
A0A0A7CGS9,A0A0G2TA12,A0A0G2TE35,A0A0G2TFG8,A0A0G2TLV2,A0A0G2TVB4,A0A0G2U825,A0A0G2U8I2,A0A0G2U9L4,A0A0G2UA33,A0A0G2UAJ0,A0A0G2UKQ3,A0A0R5E8M4,A0A140D1B2,A0A140D1S9,A0A159B0K5,A0A1L3IYE9,A0A2H4GFA1,A0A2H4GJN7,A0A2H4GK52,A0A2I2MM68,A0A3G6XKT7,A8T7G0,B8YEA7,B9VXP0,C8BKM9,C8BL26,C8CFC1,C8CPH3,D3YS06,R4SH92,V9LLY2,V9LNL7,V9LQC3,V9PTH3,V9PTY5,V9PUF9 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(28132838, 1318413) |
N |
D(12610120) |
Fields Virology |
|
Stimulates viral immediate-early (IE) transcription.
Plays a role in the inhibition of the host innate repsonse by
targeting STING and thus the cGAS-STING pathway
(PubMed:28132838). Counteracts also the DAXX-mediated
repression of viral transcription. Displaces a DAXX-binding
protein, ATRX, from nuclear domain 10 sites (ND10) shortly
after infection. Increases the basal level of SUMOylated DAXX
in infected cells. May also play a role in the progression of
the host cell cycle through the G1 phase. |
|
140 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL84 |
Initiator protein, Protein UL84, UL84 protein |
P29839 |
UL84_HCMVT |
A0A076JUV4,A0A0A0PKK9,A0A0A7CGG2,A0A0A7CH25,A0A0G2T6N5,A0A0G2T701,A0A0G2T913,A0A0G2TA27,A0A0G2TAZ0,A0A0G2TBJ3,A0A0G2TCR6,A0A0G2TD50,A0A0G2TG34,A0A0G2TH07,A0A0G2TI36,A0A0G2TJB4,A0A0G2TJD7,A0A0G2TJH9,A0A0G2TJI0,A0A0G2TN73,A0A0G2TQJ7,A0A0G2TR45,A0A0G2TRN3,A0A0G2TS06,A0A0G2TXQ2,A0A0G2TZ57,A0A0G2U0L2,A0A0G2U0P1,A0A0G2U105,A0A0G2U3Z0,A0A0G2U6A5,A0A0G2U960,A0A0G2UA21,A0A0G2UBV3,A0A0G2UCH0,A0A0G2UCU0,A0A0G2UD93,A0A0G2UFP7,A0A0G2UFQ2,A0A0G2UG52,A0A0G2UGQ0,A0A0R5E867,A0A0R5E9Q2,A0A0R5EA57,A0A0R5EAZ3,A0A0R5ECN0,A0A0R5EDV8,A0A126N924,A0A126NBJ0,A0A126NBZ0,A0A126NIL7,A0A140D0U8,A0A140D1B4,A0A159B2N6,A0A159B4L0,A0A161BXL4,A0A1I9XC23,A0A1L3IXH8,A0A2H4GEC9,A0A2H4GJ14,A0A2H4GJ70,A0A2H4GKM2,A0A2H4GQ12,A0A2H4GQI0,A8T7G3,A9YU44,A9YU45,A9YU46,A9YU47,A9YU48,A9YU49,A9YU51,B8YEA9,B9VXP2,C5MKT0,C8BLG1,C8CFC3,C8CPH5,D2K4K0,D2K4X7,D2K5I0,D3YS08,D5LX80,E7DVM4,P16727,Q6RXF3,R4S3J6,V9LM14,V9LMH2,V9LML4,V9LP17,V9LP67,V9LPN9,V9LRM2,V9LRU9,V9LS58,V9PTZ2,V9PUX5 |
ssRNA |
Rep, TNA, TR |
S |
N |
N |
N |
D(9261435) |
N |
D(20573826) |
Fields Virology |
|
Plays an essential role in viral DNA replication. May
participate in the DNA replication initiation by interacting
with the origin of lytic replication, oriLyt and subsequently
recruiting other viral/cellular factors. Additionally,
interacts with and shuttles IRS1 viral mRNA from the host
nucleus to the cytoplasm (By similarity). |
|
141 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL87 |
Protein UL87 |
P16730 |
UL87_HCMVA |
A0A0A7CGT1,A0A0A7CH46,A0A0G2T6S1,A0A0G2T7C6,A0A0G2T8L6,A0A0G2TA16,A0A0G2TA67,A0A0G2TAE2,A0A0G2TBC7,A0A0G2TCR3,A0A0G2TDF1,A0A0G2TE40,A0A0G2TE80,A0A0G2TFH3,A0A0G2TIF5,A0A0G2TJT9,A0A0G2TN44,A0A0G2TNU9,A0A0G2TQ45,A0A0G2TQ79,A0A0G2TY67,A0A0G2TZN0,A0A0G2U036,A0A0G2U4U8,A0A0G2U8A3,A0A0G2U9J7,A0A0G2UAJ6,A0A0G2UB23,A0A0G2UC04,A0A0G2UDG5,A0A0G2UKQ8,A0A0R5E2I0,A0A0R5E8Z4,A0A0R5ECI5,A0A0R5EFR1,A0A126N941,A0A126NAB8,A0A126NAM9,A0A126NBX7,A0A126NDT6,A0A140D1T4,A0A159B023,A0A159B0T6,A0A159B283,A0A159B4A0,A0A159B5D5,A0A191SC79,A0A1I9XC25,A0A1I9XEZ1,A0A1L3IXY1,A0A1L3IYY9,A0A2H4GMD9,A0A2H4GPJ5,A0A2H4GRL2,B8YEB2,B9VXP5,C8BKN4,C8BLG4,C8CFC6,C8CFU1,D2K4K3,D3YS11,D5LX83,F5HIL1,Q6SW55,S5ZY95,V9LLY7,V9LMW9,V9PUG3,V9PV44 |
dsDNA |
TR |
P |
N |
N |
N |
D(25165108) |
I(24403583) |
D(21507978) |
Fields Virology |
vPIC homologs |
Not annotated |
|
142 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL91 |
Protein UL91 |
P16797 |
UL91_HCMVA |
A0A076JQV0,A0A0G2TFZ4,A0A0G2TTF4,A0A0G2TVC5,A0A0G2TYZ8,A0A0G2U7V6,A0A0G2UEE4,A0A0R5E5N9,A0A0R5E608,A0A159B1K2,A0A2H4GKW5,A8T7H4,B8YEB5,B9VXP8,C8CFU4,D2K4K6,D2K5V2,D5LX86,E7DVN0,F5HFJ8,S6A6A7,V9LML0,V9LSJ5,V9PUH7 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(25165108) |
N |
D(23720731) |
Fields Virology |
vPIC homologs |
Not annotated |
|
143 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL92 |
Protein UL92 |
P16798 |
UL92_HCMVA |
A0A076JW34,A0A0A7CFH5,A0A0G2TF71,A0A0G2U868,A0A1L3IXZ5,A0A2H4GQI1,B9VXP9,C8CFU5,D3YS15,E7DVN1,F5HAS7,Q6RXE7,S5ZAG0,V9LLV3 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(25165108) |
N |
D(24131715) |
Fields Virology |
vPIC homologs |
Not annotated |
|
144 |
Herpesviridae |
Human herpesvirus 5; Human cytomegalovirus |
UL95 |
Protein UL95 |
P16801 |
UL95_HCMVA |
A0A0A0PKL9,A0A0A7CG46,A0A0G2T6N9,A0A0G2T707,A0A0G2T826,A0A0G2T9T8,A0A0G2TAZ9,A0A0G2TBK3,A0A0G2TCS8,A0A0G2TFG7,A0A0G2TG53,A0A0G2TI46,A0A0G2TJE7,A0A0G2TJI8,A0A0G2TKT4,A0A0G2TLT4,A0A0G2TLT6,A0A0G2TM98,A0A0G2TMC3,A0A0G2TQK8,A0A0G2TR53,A0A0G2TUX1,A0A0G2TVC3,A0A0G2TVL3,A0A0G2TVT4,A0A0G2TXR1,A0A0G2TZ69,A0A0G2U0Y6,A0A0G2U2Y6,A0A0G2U3Z5,A0A0G2U4S4,A0A0G2U5T9,A0A0G2U6B4,A0A0G2UA30,A0A0G2UFQ6,A0A0G2UH47,A0A0G2UHL8,A0A0R5E486,A0A0R5E5G7,A0A0R5E5I6,A0A0R5E8J7,A0A0R5E8V4,A0A0R5EC08,A0A126NAD0,A0A126NC00,A0A126NE98,A0A140D1C4,A0A140D1U1,A0A140IIP2,A0A159AZJ9,A0A159AZP6,A0A159B123,A0A159B4K0,A0A162DTW9,A0A1L3IX11,A0A2H4GG66,A0A2H4GJ23,A0A2H4GKN2,A0A2H4GM46,A0A2H4GQ22,A0A2H4GQI7,B8YEB9,C8BLH1,C8CFD3,C8CPI5,D2K4L0,D2K4Y7,D2K5V6,D5LX90,F5HB20,R4S3K7,S5ZGL2,V9LM21,V9LMI2,V9LP79,V9LPP8,V9LQN8,V9LRV9,V9PSZ3,V9PU01,V9PUY4,V9PVC5,X4YAD5 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(25165108) |
N |
D(21507978) |
Fields Virology |
vPIC homologs |
Participates in the expression of late viral mRNAs.
Expressed before viral DNA replication, UL95 assembles at the
viral pre-replication complexes (pre-RCs) containing the
early viral protein UL44. |
|
145 |
Herpesviridae |
Human herpesvirus 6A |
DR7L |
DR7R, Uncharacterized protein DR7 |
Q89743 |
DR7_HHV6U |
|
indirect/unknown |
TR |
P |
N |
N |
N |
D(8178493) |
N |
D(8178493) |
Fields Virology |
|
Involved in transactivation (Probable). Displays
transforming activity. |
|
146 |
Herpesviridae |
Human herpesvirus 6A |
IE2 |
Immediate-early protein 2, U90/U86 |
Q8BB47 |
IE2_HHV6G |
|
dsDNA |
TR |
P |
N |
N |
N |
D(17005699, 12068008, 16884756) |
N |
D(16884756) |
Fields Virology |
|
Transcriptional transactivator. |
|
147 |
Herpesviridae |
Human herpesvirus 6A |
U33 |
Protein U33, UL49, XILF3 |
P52441 |
UL49_HHV6U |
A0A140AK60,M9TG08 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
N |
Fields Virology |
vPIC homologs |
viral process,viral tegument |
|
148 |
Herpesviridae |
Human herpesvirus 6A |
U41 |
DBP, Major DNA-binding protein |
P52338 |
DNBI_HHV6U |
|
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
I(20585571) |
I(26676794, 30598436) |
D(30469324) |
Fields Virology |
U41 is an ortholog of HSV-1 ICP8 (30469324) |
Single-stranded DNA-binding protein required for DNA
replication. |
|
149 |
Herpesviridae |
Human herpesvirus 6A |
U42 |
ICP27, mRNA export factor ICP27 homolog, UL69 |
P52354 |
ICP27_HHV6U |
A0A0A7RNQ1 |
dsDNA, ssDNA, ssRNA, dsRNA |
TR, TNA |
P |
N |
N |
N |
I(8189530, 16478985) |
N |
N |
Fields Virology |
ICP27 homolog |
Immediate early (EI) protein that plays many roles during
productive infection including regulation of viral gene
expression and nuclear export of intronless viral RNAs. |
|
150 |
Herpesviridae |
Human herpesvirus 6A |
U52 |
Protein U52, UL79, XKLF1 |
P52469 |
UL79_HHV6U |
M9TG20 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(21367901) |
Fields Virology |
vPIC homologs |
Not annotated |
|
151 |
Herpesviridae |
Human herpesvirus 6A |
U58 |
5R, Protein U58, UL87 |
P24437 |
UL87_HHV6U |
A0A140AK87,M9TM32 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
I(24403583) |
I(21507978) |
Fields Virology |
vPIC homologs |
Not annotated |
|
152 |
Herpesviridae |
Human herpesvirus 6A |
U62 |
8R, Protein U62, Protein UL91, UL91 |
P24439 |
UL91_HHV6U |
A0A140AK90 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
I(23720731) |
Fields Virology |
vPIC homologs |
Not annotated |
|
153 |
Herpesviridae |
Human herpesvirus 6A |
U63 |
9R, Protein U63, UL92 |
P24440 |
UL92_HHV6U |
M9TNG7 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
I(24131715) |
Fields Virology |
vPIC homologs |
Not annotated |
|
154 |
Herpesviridae |
Human herpesvirus 6A |
U67 |
13R, Protein U67, UL95 |
P24444 |
UL95_HHV6U |
M9TIH4 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
I(21507978) |
Fields Virology |
vPIC homologs |
Not annotated |
|
155 |
Herpesviridae |
Human herpesvirus 6A |
IE1 |
Immediate-early protein 1, pRF2/pRF3/pRF4, RF4,
U90/U89 |
Q69567 |
IE1_HHV6U |
|
indirect/unknown |
TR |
P |
N |
N |
N |
D(17376932) |
D(17376932) |
N |
Fields Virology |
|
host cell cytoplasm;host cell nucleus;viral
tegument;metal ion binding;regulation of transcription,
DNA-templated |
|
156 |
Herpesviridae |
Human herpesvirus 6B |
DR7R |
DR7, Transactivator, Transforming transactivat |
Q9W9H8 |
Q9W9H8_HHV6H |
|
indirect/unknown |
TR |
P |
N |
N |
N |
D(8178493) |
N |
D(8178493) |
Fields Virology |
|
Transforming transactivator |
|
157 |
Herpesviridae |
Human herpesvirus 6B |
IE2 |
Immediate-early protein 2, U86, U90/U86 |
Q9QJ16 |
IE2_HHV6Z |
A0A219XVN1,A0A219XW25,A0A219XWE5,A0A219XWM9,A0A219XWU0,A0A219XXA5,A0A219XXU4,A0A219XY21,A0A219XYM7,A0A219XYW1,A0A219XZ48,A0A219Y0C1,A0A219Y0K1 |
dsDNA |
TR |
P |
N |
N |
N |
I(17005699, 12068008, 16884756) |
N |
N |
Fields Virology |
|
Transcriptional transactivator. |
|
158 |
Herpesviridae |
Human herpesvirus 6B |
U33 |
Capsid Protein, Protein U33, UL49 |
Q9QJ36 |
UL49_HHV6Z |
A0A219Y0F6,A0A2L2QCE9,Q9WT31 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
N |
Fields Virology |
vPIC homologs |
viral process,host cell membrane,integral component of
membrane,viral tegument |
|
159 |
Herpesviridae |
Human herpesvirus 6B |
U41 |
DBP, Major DNA binding protein, Major DNA-binding
protein, Single-stranded DNA-binding protein, U41
protein |
Q785N4 |
Q785N4_HHV6H |
A0A219XV25,P52538 |
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
I(20585571) |
I(26676794, 30598436) |
I(30469324) |
Fields Virology |
U41 is an ortholog of HSV-1 ICP8 (30469324) |
Plays several crucial roles in viral infection.
Participates in the opening of the viral DNA origin to
initiate replication by interacting with the origin-binding
protein. May disrupt loops, hairpins and other secondary
structures present on ssDNA to reduce and eliminate pausing
of viral DNA polymerase at specific sites during elongation.
Promotes viral DNA recombination by performing
strand-transfer, characterized by the ability to transfer a
DNA strand from a linear duplex to a complementary
single-stranded DNA circle. Can also catalyze the
renaturation of complementary single strands. Additionally,
reorganizes the host cell nucleus, leading to the formation
of prereplicative sites and replication compartments. This
process is driven by the protein which can form
double-helical filaments in the absence of DNA. |
|
160 |
Herpesviridae |
Human herpesvirus 6B |
U42 |
ICP27, KA3L, mRNA export factor ICP27 homolog |
P52539 |
ICP27_HHV6Z |
|
dsDNA, ssDNA, ssRNA, dsRNA |
TR, TNA |
P |
N |
N |
N |
I(8189530, 16478985) |
N |
N |
Fields Virology |
ICP27 homolog |
Immediate early (EI) protein that plays many roles during
productive infection including regulation of viral gene
expression and nuclear export of intronless viral RNAs. |
|
161 |
Herpesviridae |
Human herpesvirus 6B |
U52 |
KA13L, Protein U52, U52 Protein, UL79 |
P52548 |
UL79_HHV6Z |
Q9WT21 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(21367901) |
Fields Virology |
vPIC homologs |
Not annotated |
|
162 |
Herpesviridae |
Human herpesvirus 6B |
U58 |
Protein U58, UL87 |
Q9QJ25 |
UL87_HHV6Z |
A0A219XWH2,A0A219XWU2,A0A219XXB8,A0A219Y0Y3,A0A2L2Q8X7,A0A2P1E573,A0A2P1E5H2,Q9WT15 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
I(24403583) |
I(21507978) |
Fields Virology |
vPIC homologs |
Not annotated |
|
163 |
Herpesviridae |
Human herpesvirus 6B |
U62 |
Protein U62, UL91 |
Q9QJ22 |
UL91_HHV6Z |
A0A219XV46,A0A2L2Q8Y5,A0A2L2QCH6,A0A2L2QEC4,Q9WT11 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
I(23720731) |
Fields Virology |
vPIC homologs |
Not annotated |
|
164 |
Herpesviridae |
Human herpesvirus 6B |
U63 |
Protein U63, UL92 |
Q9QJ21 |
UL92_HHV6Z |
A0A219Y0A0,A0A2L2Q8Z1,A0A2L2QE97,Q9WT10 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
I(24131715) |
Fields Virology |
vPIC homologs |
Not annotated |
|
165 |
Herpesviridae |
Human herpesvirus 6B |
U67 |
Protein U67, UL95 |
Q9WT06 |
UL95_HHV6Z |
A0A219Y007,A0A2L2Q907,A0A2P1E660 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
I(21507978) |
Fields Virology |
vPIC homologs |
Not annotated |
|
166 |
Herpesviridae |
Human herpesvirus 6B |
IE1 |
IE1 Protein, Immediate-early protein 1, U90 |
Q6XA69 |
Q6XA69_HHV6H |
A0A291ID66,A0A291ID67,A0A291ID73,A0A291ID74,A0A291ID75,A0A291ID93,A0A291IDA0,A0A291IDC1,Q6XA64,Q6XA65,Q6XA66,Q6XA67,Q6XA68,Q6XA70,Q6XA72,Q6XA73,Q77PU6,Q9QJ15 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(17376932) |
D(17376932) |
N |
Fields Virology |
|
host cell nucleus;DNA binding;regulation of
transcription, DNA-templated;viral process |
|
167 |
Herpesviridae |
Human herpesvirus 7 |
DR7' |
DR7, DR7 protein, DR7' protein |
Q89478 |
Q89478_HHV7J |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8178493) |
N |
N |
Fields Virology |
|
host cell cytoplasm;host cell nucleus;viral
tegument;metal ion binding;regulation of transcription,
DNA-templated |
|
168 |
Herpesviridae |
Human herpesvirus 7 |
U33 |
Protein U33, UL49 |
P52442 |
UL49_HHV7J |
Q77Y75 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
N |
Fields Virology |
vPIC homologs |
Not annotated |
|
169 |
Herpesviridae |
Human herpesvirus 7 |
U41 |
DBP, Major DNA-binding protein |
O56282 |
O56282_9BETA |
|
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
I(20585571) |
I(26676794, 30598436) |
I(30469324) |
Fields Virology |
O56282 is inferred from Human herpesvirus 5; Human
cytomegalovirus protein P17147 |
Plays several crucial roles in viral infection.
Participates in the opening of the viral DNA origin to
initiate replication by interacting with the origin-binding
protein. May disrupt loops, hairpins and other secondary
structures present on ssDNA to reduce and eliminate pausing
of viral DNA polymerase at specific sites during elongation.
Promotes viral DNA recombination by performing
strand-transfer, characterized by the ability to transfer a
DNA strand from a linear duplex to a complementary
single-stranded DNA circle. Can also catalyze the
renaturation of complementary single strands. Additionally,
reorganizes the host cell nucleus, leading to the formation
of prereplicative sites and replication compartments. This
process is driven by the protein which can form
double-helical filaments in the absence of DNA. |
|
170 |
Herpesviridae |
Human herpesvirus 7 |
U42 |
ICP27, mRNA export factor ICP27 homolog |
P52355 |
ICP27_HHV7J |
O56283 |
dsDNA, ssDNA, ssRNA, dsRNA |
TR, TNA |
P |
N |
N |
N |
I(8189530, 16478985) |
N |
N |
Fields Virology |
ICP27 homolog |
Immediate early (EI) protein that plays many roles during
productive infection including regulation of viral gene
expression and nuclear export of intronless viral RNAs. |
|
171 |
Herpesviridae |
Human herpesvirus 7 |
U52 |
Protein U52, UL79 |
P52470 |
UL79_HHV7J |
O56286,T2C8Y1 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(21367901) |
Fields Virology |
vPIC homologs |
regulation of transcription, DNA-templated |
|
172 |
Herpesviridae |
Human herpesvirus 7 |
U58 |
Protein U58, UL87 |
P52363 |
UL87_HHV7J |
T2C969 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
I(24403583) |
I(21507978) |
Fields Virology |
vPIC homologs |
Not annotated |
|
173 |
Herpesviridae |
Human herpesvirus 7 |
U62 |
Protein U62, UL91 |
P52365 |
UL91_HHV7J |
Q77Y59 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
I(23720731) |
Fields Virology |
vPIC homologs |
Not annotated |
|
174 |
Herpesviridae |
Human herpesvirus 7 |
U63 |
Protein U63, UL92 |
P52471 |
UL92_HHV7J |
Q77Y58 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
I(24131715) |
Fields Virology |
vPIC homologs |
Not annotated |
|
175 |
Herpesviridae |
Human herpesvirus 7 |
U67 |
Protein U67, UL95 |
P52472 |
UL95_HHV7J |
Q77Y57 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(25165108) |
N |
I(21507978) |
Fields Virology |
vPIC homologs |
Not annotated |
|
176 |
Herpesviridae |
Human herpesvirus 7 |
U86 |
U86 protein |
Q69513 |
Q69513_HHV7J |
O56300 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(17005699, 12068008, 16884756) |
N |
N |
Fields Virology |
|
regulation of transcription, DNA-templated |
|
177 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
K8 |
E3 SUMO-protein ligase K-bZIP, E3 SUMO-protein
transferase K-bZIP, KIE-1, RAP |
Q2HR82 |
KBZIP_HHV8P |
A0A0N9RNL1,A0A0N9RP86,A0A0N9RPS7,A0A0N9S314,A0A0N9S4U8,A0A0N9SDG5,A0A0N9SDK7,A0A0N9SDQ8,A0A0N9SFS2,A0A0N9SFT9,A0A193PN17,A0A2Z5TGL2,A0A2Z5TGX0,A0A2Z5TK66,D0UZR3,E5LBX3,K0FC23,O92597,P88939,Q77UV1,Q9WRJ7 |
dsDNA |
TR |
P |
D(12885907, 30998737) |
D(30998737) |
N |
D(12885907, 30998737) |
D(12885907, 30998737) |
N |
Fields Virology |
|
Plays a role in viral gene regulation and seems to be
essential for KSHV reactivation. Disrupts host G1 cell cycle
control thus allowing viral transcription and translation to
proceed at the early stages of infection. Catalyzes its own
SUMO modification as well as that of its interacting partners
such as host TP53 AND RB1. |
|
178 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
LANA |
ORF73 |
E5LC01 |
E5LC01_HHV8 |
A0A0N9S387,A0A0N9S3L8,A0A0N9SCV1,A0A0N9SCV5,A0A0N9SEW3,A0A0N9SF30,A0A0N9SF93,A0A0N9SNQ9,A0A193PND8,A0A2Z5THC2,A0A2Z5TRA4,D0UZU1,Q91LX9 |
dsDNA |
TR |
P |
D(30682185, 24696474, 22419807) |
D(24696474, 22419807, 25033463) |
4UZC, 4UZB |
D(30682185) |
D(25947153, 22419807, 12015325) |
D(25947153, 12015325) |
Fields Virology |
|
DNA binding,nucleosome binding,host cell nucleus |
|
179 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
ORF18 |
Protein UL79 homolog, UL79 |
Q2HRB4 |
UL79_HHV8P |
A0A0N9RN23,A0A0N9S3E8,A0A0N9SD38,A0A0N9SGT1,D0UZN0,J9QSB8 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(30305361;26468530) |
N |
N |
Fields Virology |
A specialized complex of viral transcriptional
activators (vTAs) coordinate to direct expression of
virus-encoded late genes. The vTAs in Kaposi’s
sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24,
ORF30, ORF31, ORF34, and ORF66. |
Plays a role in the expression of late transcripts
bridging viral DNA replication and late gene expression
during infection. |
|
180 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
ORF24 |
Gene 24 protein, ORF24 Protein, Protein ORF24 |
F5HFD2 |
ORF24_HHV8P |
Q98140 |
dsDNA |
TR |
P |
N |
N |
N |
D(30305361;26468530) |
Y(25544563) |
N |
Fields Virology |
A specialized complex of viral transcriptional
activators (vTAs) coordinate to direct expression of
virus-encoded late genes. The vTAs in Kaposi’s
sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24,
ORF30, ORF31, ORF34, and ORF66. |
Not annotated |
|
181 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
ORF30 |
Protein ORF30 |
F5HES7 |
ORF30_HHV8P |
A0A0N7GET6,A0A2Z5U063 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(30305361;26468530) |
N |
N |
Fields Virology |
A specialized complex of viral transcriptional
activators (vTAs) coordinate to direct expression of
virus-encoded late genes. The vTAs in Kaposi’s
sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24,
ORF30, ORF31, ORF34, and ORF66. |
Regulates the expression of late genes |
|
182 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
ORF31 |
Gene 31 protein, ORF 31, Protein ORF31, UL92 |
Q2HRA1 |
UL92_HHV8P |
E5LBV4,Q98135 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(30305361;26468530) |
N |
N |
Fields Virology |
A specialized complex of viral transcriptional
activators (vTAs) coordinate to direct expression of
virus-encoded late genes. The vTAs in Kaposi’s
sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24,
ORF30, ORF31, ORF34, and ORF66. |
May play a role in viral replication. |
|
183 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
ORF34 |
Protein UL95 homolog, UL95 |
Q2HR98 |
UL95_HHV8P |
|
indirect/unknown |
TR |
P |
D(31095645) |
D(31095645) |
N |
D(30305361;26468530; 31095645) |
N |
N |
Fields Virology |
A specialized complex of viral transcriptional
activators (vTAs) coordinate to direct expression of
virus-encoded late genes. The vTAs in Kaposi’s
sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24,
ORF30, ORF31, ORF34, and ORF66. |
Participates in the expression of late viral mRNAs.
Expressed before viral DNA replication, protein ORF34
assembles at the viral pre-replication complexes (pre-RCs)
(By similarity). |
|
184 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
ORF49 |
ORF49 Protein, Protein ORF49 |
Q2HR83 |
ORF49_HHV8P |
A0A0N9SE29,A0A0N9SF04,E5LBX2 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(16501115) |
N |
D(16501115) |
Fields Virology |
|
Plays a role in the activation the host JNK/p38 pathways
necessary for KSHV reactivation from latency and for viral
replication. Induces transcriptional activation through host
JUN of several ORF50-responsive promoters. |
|
185 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
ORF52 |
ORF52 Protein |
F5HBL8 |
F5HBL8_HHV8 |
A0A0N7GEV0,A0A0N9RMV2 |
indirect/unknown |
TR, Other |
S |
N |
N |
N |
N |
N |
D(26320998) |
Fields Virology |
|
host cell cytoplasm;viral tegument;DNA
binding;suppression by virus of host innate immune
response |
|
186 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
ORF6 |
Core gene UL29 family protein, DBP, Major DNA-binding
protein, ORF 6 |
K0FHU3 |
K0FHU3_HHV8 |
A0A0N9RNY3,A0A0N9RUK2,A0A0N9RV39,A0A0N9S3V6,A0A0N9SC72,A0A0N9SDM5,A0A0N9SFW6,A0A0N9SHS5,A0A2Z5TGV3,O40913 |
ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
N |
D(24850743) |
D(24850743, Fluorescence polarization analysis) |
Fields Virology |
|
single-stranded DNA binding,DNA replication,host cell
nucleus |
|
187 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
ORF66 |
ORF 66, Protein ORF66, UL49 |
F5HG20 |
UL49_HHV8P |
O40943 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(30305361;26468530) |
N |
N |
Fields Virology |
A specialized complex of viral transcriptional
activators (vTAs) coordinate to direct expression of
virus-encoded late genes. The vTAs in Kaposi’s
sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24,
ORF30, ORF31, ORF34, and ORF66. |
viral process,viral tegument |
|
188 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
Rta |
ORF50, Putative transcription activator ORF50 |
F5HCV3 |
ORF50_HHV8P |
A0A0N7GF04,A0A0N9RUU4,A0A0N9RVD9,A0A0N9RX80,A0A0N9S418,A0A0N9SDX6,A0A0N9SE53,A0A0N9SEG4,A0A193PN21,A0A2Z5TKP1,E5LBX1,K0FCG0,O92608 |
dsDNA |
TR |
P |
D(19233445) |
D(19233445, 29302027, 30541837) |
N |
D(12154127, 11435569, 19233445) |
D(12154127, 11435569, 19233445) |
N |
Fields Virology |
|
Transcription activation. |
|
189 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
vIRF-1 |
K9, Latent viral interferon regulatory factor, Lytic
viral interferon regulatory factor, ORF K9, vIRF, VIRF-1,
VIRF-1 protein |
Q77Q82 |
Q77Q82_HHV8 |
A0A0N9RX90,A0A0N9SEG2,A0A0N9SGV7,P88946 |
dsDNA |
TR |
P |
N |
N |
4HLX, 4YSI |
D(9365244, 11027294, 10438822) |
D(10438822, 17855527) |
D(23435230) |
Fields Virology |
|
DNA-binding transcription factor activity,transcription
regulatory region DNA binding |
|
190 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
vIRF-2 |
K11, ORF K11, Viral IRF2-like protein, VIRF2 |
Q2HR71 |
VIRF2_HHV8P |
A0A193PN34,A0A2Z5TUW0,F5H9G3,O40941,P88948 |
dsDNA |
TR |
P |
D(26537687) |
D(26537687) |
4P55 |
D(26537687) |
D(26537687) |
N |
Fields Virology |
|
Plays a role in the inhibition of host immune response.
Acts by interacting with host EIF2AK2/PKR and inhibiting its
activation. In turn, EIF2AK2/PKR substrates including EIF2S1
or histone H2A are not phosphorylated. |
|
191 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
vIRF-3 |
B-cell specific latent nuclear protein, Interferon
regulatory factor 3, K10.5, ORF K10.5, Viral IRF3-like
protein, VIRF-3 protein, VIRF-3 Viral IRF3-like protein |
Q9DUN1 |
Q9DUN1_HHV8 |
D0UZS3,K0FCD9,O40940,Q99AM3 |
indirect/unknown |
TR |
P |
D(17728244, 19129183) |
N |
N |
D(22453922, 17728244, 19129183, 10933732, 17522209) |
D(17522209) |
N |
Fields Virology |
|
DNA-binding transcription factor activity,transcription
regulatory region DNA binding |
|
192 |
Herpesviridae |
Human herpesvirus 8; Kaposi sarcoma-associated
herpesvirus |
vIRF-4 |
K10, Viral IRF4-like protein |
Q2HR73 |
VIRF4_HHV8P |
A0A193PN61,F5H9D8,O40939,P88947 |
dsDNA |
TR |
P |
D(24335298) |
N |
2XXN |
D(28342865, 20861242) |
N |
N |
Fields Virology |
|
Plays a role in host cell apoptosis modulation by
promoting TP53/p53 ubiquitination and subsequent degradation
and thus downregulating TP53/p53-mediated apoptosis. |
|
193 |
Herpesviridae |
Pseudorabies virus |
DBP |
ICP8, Major DNA-binding protein, UL29 |
P11870 |
DNBI_SUHVF |
|
dsDNA, ssDNA |
TR, Rep, DR |
S |
N |
N |
N |
I(20585571) |
I(26676794, 30598436) |
I(2987527) |
Fields Virology |
|
Plays several crucial roles in viral infection.
Participates in the opening of the viral DNA origin to
initiate replication by interacting with the origin-binding
protein. May disrupt loops, hairpins and other secondary
structures present on ssDNA to reduce and eliminate pausing
of viral DNA polymerase at specific sites during elongation.
Promotes viral DNA recombination by performing
strand-transfer, characterized by the ability to transfer a
DNA strand from a linear duplex to a complementary
single-stranded DNA circle. Can also catalyze the
renaturation of complementary single strands. Additionally,
reorganizes the host cell nucleus, leading to the formation
of prereplicative sites and replication compartments. This
process is driven by the protein which can form
double-helical filaments in the absence of DNA. |
|
194 |
Herpesviridae |
Pseudorabies virus |
EP0 |
E3 ubiquitin-protein ligase ICP0, Early protein 0, Early
Protein EP0, ICP0, RING-type E3 ubiquitin transferase ICP0,
RL2 |
P29129 |
ICP0_SUHVF |
A0A0B4ZUF5,A0A0S2MM93,A0A142I9X0,A0A172XDT2,A0A1B2G2G1,B0FL91,B8Y463,G3G917,G3G997,I1WX43,Q5PPD2,Q9DYB6,T2FKB8 |
dsDNA |
TR, Other |
S |
N |
N |
N |
D(10426211, 9850990, 7595399) |
I(15494213) |
D(10426211) |
Fields Virology |
|
Evades nuclear antiviral defenses triggered by dsDNA
viruses. Acts during the initial stages of lytic infection
and the reactivation of latent viral genome. Prevents the
antiviral effect of nuclear bodies by degrading host PML and
SP100. |
|
195 |
Herpesviridae |
Pseudorabies virus |
IE180 |
ICP4, IE, Immediate-early protein IE180, RS1 |
G3G929 |
G3G929_9ALPH |
A0A097I4Q1,A0A0B4ZXC3,A0A0B4ZXD4,A0A0D5C710,A0A0H4M3P1,A0A0S2MM72,A0A0X7ZX98,A0A140FAV4,A0A140FB14,A0A141B6X8,A0A172XDL4,A0A172XDM4,A0A1B2G2G2,B6UV86,G3G8V9,G3G918,P33479,Q5PP75,Q8JL63 |
dsDNA |
TR |
P |
N |
N |
N |
D(12881636, 9850990) |
D(12881636) |
D(2539489) |
Fields Virology |
|
positive regulation of transcription, DNA-templated,host
cell nucleus |
|
196 |
Herpesviridae |
Pseudorabies virus |
RSP40 |
Transcriptional regulator ICP22 homolog, Transcriptional
regulator ICP22 homolog， Immediate-early protein RSP40 |
P24827 |
ICP22_SUHVK |
|
indirect/unknown |
TR |
P |
I(25233083, 23029222) |
N |
N |
I(19535441) |
N |
N |
Fields Virology |
|
host cell nucleus;DNA binding;DNA-templated viral
transcription;positive regulation of transcription,
DNA-templated |
|
197 |
Herpesviridae |
Pseudorabies virus |
UL48 |
UL48 tegument protein |
Q8QXN6 |
Q8QXN6_SUHVK |
G3G8W8,Q5PP87,Q80KJ3 |
dsDNA |
TR |
P |
I(19321615) |
N |
N |
I(2538647) |
I(11416146, 2538647) |
I(11416146) |
Fields Virology |
|
host cell cytoplasm;host cell nucleus;metal ion
binding;RNA binding;regulation of transcription,
DNA-templated;viral process |
|
198 |
Herpesviridae |
Pseudorabies virus |
UL54 |
Early regulation protein UL54, ICP27, mRNA export factor
ICP27 homolog, Protein UL54 |
Q85232 |
ICP27_SUHVK |
A0A0D5C668,Q6K1M1,Q9DL70,T2FL56 |
dsDNA, ssDNA, ssRNA, dsRNA |
TR, TNA |
P |
N |
N |
N |
I(25712217) |
I(19783816) |
I(19783816, Yeast three-hybrid analysis, NMR) |
Fields Virology |
ICP27 homolog |
Multifunctional regulator of the expression of viral
genes that mediates nuclear export of viral intronless mRNAs.
This immediate early (EI) protein promotes the nuclear export
of viral intronless mRNAs by interacting with mRNAs and host
NXF1/TAP (By similarity). |
|
199 |
Orthomyxoviridae |
Influenza A |
NS1 |
Nonstructural Protein 1, Non-structural protein 1, NS,
NS1A |
P03496 |
NS1_I34A1 |
A0A075ETP1,A0A075ETS1,A0A075ETV2,A0A075EU06,A0A075EU11,A0A075EU57,A0A075EUA6,A0A075EUD3,A0A075EUU4,A0A075EV20,A0A075EV61,A0A075EVF3,A0A075EWN4,A0A075EWW8,A0A075EXF8,A0A075EXX0,A0A089H8R8,A0A0A7E4T1,A0A0A7E4W7,A0A0A7E4X0,A0A0A7E4Z7,A0A0A7E560,A0A0A7E699,A0A0A7E6A8,A0A0A7E6E6,A0A0C6DX30,A0A0D3RZY3,A0A0M3YVZ6,A0A1C9ZU70,A0A1D8EMU4,A0A1D8EMY9,A0A1L5LBA5,A0A1U9W4W5,A0A2I6B733,A0A2R4QPM2,A0A343VTP4,A0A343VTQ9,A0A343VTR4,A0A343VTR9,A0A385P538,A0A3G1GLA5,A0M7Z1,A0M802,A0M813,A0M824,A0M835,A0M846,A0M857,A0M868,A0RSE2,A0RSL9,A0RSN0,A0RSP1,A1BL03,A1BL14,A2CGG4,A2CGH5,A2CGI6,A3DRG9,A3DRJ1,A3DRK2,A3DRL3,A3DRM4,A3DSA5,A3DSB6,A3DSC7,A3DSD8,A4D6R9,A4D6T0,A4D6U1,A4D6V2,A4D6W3,A4D6X4,A4D6Y5,A4D6Z6,A4D707,A4GBF7,A4GBG8,A4GBH9,A4GBJ0,A4GBQ6,A4GBX2,A4GBY3,A4GC16,A4GC93,A4GCA4,A4GCJ2,A4GCK3,A4GCM5,A4GCN6,A4GCP7,A4JZ56,A4JZ89,A4JZA0,A4K0Z4,A4K116,A4K127,A4K149,A4K171,A4U6U7,A4U6V8,A4U6Y0,A4U6Z1,A4U768,A4U779,A4U790,A4U7A1,A4U7B2,A4Z3W0,A4Z3X1,A4Z404,A4ZNQ3,A4ZNR3,A5GX47,A5GX69,A5GXC3,A5GXD4,A6M5K9,A6N9H7,A6ZIX6,A6ZIY5,A9C4V7,A9C995,B0KVE4,B2VMN7,B2VMP8,B2VMS0,B3EUU5,B3EUW7,B3EUX8,B3EUY9,B3EV00,B3EV11,B3RDQ2,B4UPB2,B4UPD4,B4UPI5,B4UQV5,B4UR32,B4UR43,B4UR54,B4UR65,B4UR76,B4URE2,B6A6G5,B6A6Q3,B6A6S5,B6A6T6,B6A6V8,B6A723,B6A767,B6A778,B6A7B1,B7NZ26,B8K0Q2,B8K0R3,C0RSJ6,C3PQG2,C3PQH3,C4LP16,C7RWF6,C7RWK0,C7RWL1,C7RWM2,C7S1W6,C7S1X7,C7S1Y8,C7S221,C7S243,C7S254,C7S276,C7S287,C7S298,C8XP22,C8XP33,C9S2A3,C9S2C9,C9S2D8,C9S2E7,C9S2F7,C9S2G6,C9S2H4,C9S2J1,C9S2K0,D3J182,D5F1T6,D5F1U6,D5F1V6,D6R8P6,D8KQS4,E1AFU6,E4UFQ5,E4UFQ7,E5FF42,E6XTN1,E6XTN8,E6XTP9,E6XTR0,E6XTS0,E6XTT1,E6XTU2,E6XTV2,E6XTW3,E6XTX3,E6XTY4,E6XUC0,E6XUD1,E6XUE2,E6XUF2,E8Z3P7,E8Z4Y8,E8Z4Z0,F0TTA7,F0TTB8,F0TTC9,F0TTE0,F0TTF1,F0TTG2,F0TTH3,F0TTI4,F0TTJ5,F0TTK6,F0TTL7,F0TTM8,F0TTN9,F0TTQ0,F0TTR1,F0TTS2,F0TTT3,F0TTU4,F0TTV5,F0TTW6,F0TTX7,F0TTY8,F0TTZ9,F0TU10,F0TU21,F0TU32,F0TU43,F0TU54,F0TU65,F0TU76,F2P1A3,F2P1B4,F4MDL2,F5CGM8,F5CGN9,F5CGQ0,F5CU09,F6GLF7,G0KR79,G0KTU8,G0KTX4,G0KU08,G2TU06,G7WW33,G7WW47,G7X3X3,G7X407,G7X431,G7X486,G8JBY2,H2KIX8,H2KIZ8,H2KJ09,H6QNR4,H8PHK7,H8XZS5,H8XZT1,H8XZV5,H8XZW5,H9XI03,H9XJP7,I6S4N8,I6S507,I6S561,I6S5I7,I6S5K2,I6S5R7,I6S699,I6S6S7,I6S8B7,I6S8Z3,I6S927,I6S938,I6SGN6,I6SH48,I6SHB2,I6SHJ5,I6SI16,I6SIC0,I6SIT8,I6SJ14,I6SJ90,I6SK95,I6SKG6,I6SUD6,I6T2Q4,I6T342,I6T3J6,I6T444,I6T513,I6T525,I6T535,I6T550,I6T6Z8,I6TAB5,I6TAG8,I6TAN1,I6TB35,I6TBJ3,I6TBT2,I6TBV0,I6TC02,I6TCC8,I6TCJ2,I6TCQ6,I6TCX4,I6TDL1,I6TDV0,I6TE19,I6TEC5,I6TEG7,I6TEL7,I6TEZ1,I6TF77,I6TFJ0,I6TFV0,I6TG01,I6TG75,I6TGD2,I6TGJ1,I6TH83,I6THH9,I6THP0,I6THU6,I6TWM9,I7CY76,I7DBQ0,J7GXI7,K4P0X9,K4P1A0,K4P381,K4P399,M9Q862,M9Q876,M9Q888,M9Q974,M9Q982,M9QA98,M9QAA7,M9QAB7,M9QBB0,M9QBB4,M9QBB8,M9QBQ4,M9QBQ6,M9V1A0,M9V1A1,P03498,P11618,P17042,P69272,P69273,P69274,P69279,Q0A108,Q0A2W7,Q0HCS2,Q0HD44,Q0HD54,Q0PDM0,Q0R7K8,Q0R7L9,Q0R9C4,Q15ME2,Q15MF3,Q15MG4,Q194T2,Q194T3,Q1G0M3,Q1G0M5,Q1G0M6,Q1I1J9,Q1I1L0,Q1I1M1,Q1I1N2,Q1I1P3,Q1I1Q4,Q1I1R5,Q1I1S6,Q1I1T7,Q1I1U8,Q1I1V9,Q1I1X0,Q1I1Y1,Q1I1Z2,Q1I203,Q1I2B3,Q1K9K7,Q1K9P7,Q1WP03,Q1WP14,Q20MF1,Q20MG2,Q20MH3,Q20TN7,Q288T5,Q288U6,Q288V7,Q289A1,Q289B2,Q289C3,Q2IBH5,Q2Y206,Q30N15,Q4ZH89,Q67249,Q6LD08,Q6XSV8,Q6XSW8,Q6XSX2,Q6XSX4,Q6XSX6,Q6XSX8,Q6XSY2,Q6XSY4,Q6XSY6,Q6XSZ2,Q6XSZ4,Q6XTC4,Q6XTC6,Q6XTC8,Q6XTD0,Q6XTD6,Q6XTE2,Q6XTE4,Q6XTE6,Q6XTE8,Q6XTF2,Q6XTF4,Q6XTF6,Q6XTF8,Q6XTG2,Q6XTG4,Q6XTG8,Q6XTH0,Q6XTH2,Q6XTH4,Q6XTH6,Q6XTH8,Q6XTI0,Q6XTI2,Q6XTI4,Q6XTI6,Q6XTI8,Q6XTJ0,Q6XTJ2,Q6XTJ4,Q6XTJ6,Q6XTJ8,Q76MT8,Q82505,Q82506,Q84068,Q99AU3,Q9DUT8,R4PCK4,R9WJE6,R9WJT7,R9WK02,R9WKA5,R9WKG0,R9WKL2,R9WKN0,R9WKW2,R9WL34,R9WME5,R9WMK2,R9WND6,R9WNJ7,R9WNR4,S5FQH9,S5FR40,S5FRA4,S5FS10,S5FSD4,S5FSQ5,S5FT23,S5FTA2,S5FTD5,S5FTK0,S5FTR8,S5FZI2,S5G093,S5G297,S5G2D0,S5G2L6,S5G2T0,V5J5C4 |
ssRNA |
TR, other |
S |
D(29259342;23283961) |
N |
5NT2 |
D(23283961;11090154;11773396) |
D(23093596;21085662;11090154;29782795) |
D(23093596;Fluorescence anisotropy),
D(17376915;RNA-binding assay), D(29782795, Fluorescence
anisotropy;RNA-binding assay;In Vitro Transcription) |
27486731.0 |
|
Prevents the establishment of the cellular antiviral
state by inhibiting TRIM25-mediated DDX58 ubiquitination,
which normally triggers the antiviral transduction signal
that leads to the activation of type I IFN genes by
transcription factors IRF3 and IRF7. Prevents human
EIF2AK2/PKR activation, either by binding double-strand RNA,
or by interacting directly with EIF2AK2/PKR. This function
may be important at the very beginning of the infection, when
NS1 is mainly present in the cytoplasm. Also binds poly(A)
and U6 snRNA. |
|
200 |
Papillomaviridae |
Human papillomavirus type 116 |
E2 |
Regulatory protein E2 |
C7B7D5 |
C7B7D5_9PAPI |
|
dsDNA |
TR, Rep |
P |
I(14643661, 22031941, 12019268, 29142126) |
N |
N |
I(22210627, 7957111) |
I(14643661, 21482558, 7957111, 12239214) |
I(14643661, binding assay, DNA complex,
footprinting) |
Fields Virology |
|
Plays a role in the initiation of viral DNA replication.
A dimer of E2 interacts with a dimer of E1 in order to
improve specificity of E1 DNA binding activity. Once the
complex recognizes and binds DNA at specific sites, the E2
dimer is removed from DNA. E2 also regulates viral
transcription through binding to the E2RE response element
(5'-ACCNNNNNNGGT-3') present in multiple copies in the
regulatory regions of the viral genome. Activates or
represses transcription depending on E2RE's position with
regards to proximal promoter elements including the TATA-box.
Repression occurs by sterically hindering the assembly of the
transcription initiation complex. |
|
201 |
Papillomaviridae |
Human papillomavirus type 116 |
E6 |
Protein E6 |
C7B7D2 |
C7B7D2_9PAPI |
|
indirect/unknown |
TR, Other |
P |
I(15664194) |
N |
N |
I(31002735, 11275986, 22210627) |
I(11275986) |
N |
Fields Virology |
|
Plays a major role in the induction and maintenance of
cellular transformation. E6 associates with host UBE3A/E6-AP
ubiquitin-protein ligase and modulates its activity. Protects
host keratinocytes from apoptosis by mediating the
degradation of host BAK1. May also inhibit host immune
response. |
|
202 |
Papillomaviridae |
Human papillomavirus type 116 |
E7 |
Protein E7 |
C7B7D3 |
C7B7D3_9PAPI |
|
indirect/unknown |
TR, Other |
P |
I(22099967) |
N |
N |
I(22210627, 7933087, 9426463, 11039910) |
N |
N |
Fields Virology |
|
E7 protein has both transforming and trans-activating
activities. |
|
203 |
Papillomaviridae |
Human papillomavirus type 16 |
E2 |
Regulatory protein E2 |
P03120 |
VE2_HPV16 |
A0A0M4B738,A0A0M5I1R5,A0A140FB34,A0A141E6C6,A0A159DYJ1,A0A220NLS7,A0A220NM82,A0A220NM85,A0A220NMY5,A0A220NNA3,A0A220NNP4,A0A220NPB2,A0A220NPJ9,A0A220NPW4,A0A220NQ18,A0A291L508,A0A291L599,A0A291L5B6,A0A2P1HAL8,A0A2P1HAX9,A0A2P1HAZ0,A0A2P1HBJ1,A0A2P1HBK7,A0A2P1HBZ1,A0A2P1HC20,A0A2P1HCQ0,A0A2P1HCR3,A0A2P1HCR4,A0A2P1HCS0,A0A2P1HCX2,A0A2P1HCY1,A0A2P1HD20,A0A2P1HD25,A0A2P1HD43,A0A2P1HDC2,A0A2P1HDD2,A0A2P1HDS5,A0A2P1HDU8,A0A2P1HDW9,A0A2P1HE27,A0A2P1HE44,A0A2P1HEL7,A0A2P1HEM6,A0A2P1HES9,A0A2P1HEX6,A0A2P1HFE1,A0A2P1HFY5,A0A2P1HGA0,A0A2P1HGC9,A0A2P1HGE1,A0A2P1HGK3,A0A2P1HGQ9,A0A2P1HGV5,A0A2P1HH37,A0A2P1HH86,A0A2P1HH94,A0A2P1HHW6,A0A2P1HI17,A0A2P1HI38,A0A2P1HI44,A0A2P1HI84,A0A2P1HI91,A0A2P1HIA7,A0A2P1HIE3,A0A2P1HII1,A0A2P1HIQ3,A0A2P1HIV5,A0A2P1HIW5,A0A2P1HIY0,A0A2P1HJ67,A0A2P1HJA3,A0A2P1HJB1,A0A2P1HJB8,A0A2P1HJD0,A0A2P1HJG6,A0A2P1HJP9,A0A2P1HJS2,A0A2P1HK00,A0A2P1HK97,A0A2P1HKD8,A0A2P1HKI2,A0A2P1HKJ9,A0A2P1HKK3,A0A2P1HKL1,A0A2P1HKR6,A0A2P1HKT0,A0A2P1HL34,A0A2P1HLC9,A0A2P1HLK0,A0A2P1HLT4,A0A2P1HMF1,A0A2P1HMJ8,A0A2P1HMK4,A0A2P1HMP5,A0A2P1HMU0,A0A2P1HN06,A0A2P1HN27,A0A2P1HNB3,A0A2P1HND5,A0A2P1HNM5,A0A2P1HNU8,A0A2P1HNV4,A0A2P1HPG1,A0A2P1HPH7,A0A2P1HPS3,A0A2P1HPV0,A0A2P1HQ06,A0A2P1HQG6,A0A2P1HQR1,A0A2P1HQZ3,A0A2P1HQZ4,A0A2P1HQZ7,A0A2P1HR91,A0A2P1HRB4,A0A2P1HRL8,A0A2P1HRN8,A0A2P1HRP5,A0A2P1HRQ9,A0A2P1HRR6,A0A2P1HS03,A0A2P1HS26,A0A2P1HS42,A0A2P1HS76,A0A2P1HSA9,A0A2P1HSF4,A0A2P1HSP3,A0A2P1HSQ0,A0A2P1HSU6,A0A2P1HSW8,A0A2P1HSX8,A0A2P1HT05,A0A2P1HT52,A0A2P1HT60,A0A2P1HT76,A0A2P1HTC1,A0A2P1HTJ7,A0A2P1HTK2,A0A2P1HTK4,A0A2P1HTL0,A0A2P1HTN5,A0A2P1HTN8,A0A2P1HTZ3,A0A2P1HU04,A0A2P1HU15,A0A2P1HU23,A0A2P1HU81,A0A2P1HUG7,A0A2P1HUL7,A0A2P1HUN7,A0A2P1HUT3,A0A2P1HUV1,A0A2P1HV08,A0A2P1HV51,A0A2P1HV63,A0A2P1HVJ4,A0A2P1HVR1,A0A2P1HVU5,A0A2P1HW33,A0A2P1HW43,A0A2P1HW55,A0A2P1HW89,A0A2P1HWD2,A0A2P1HWF5,A0A2P1HWM1,A0A2P1HWR3,A0A2P1HWT1,A0A2P1HWT5,A0A2P1HWV9,A0A2P1HWW2,A0A2P1HWY5,A0A2P1HWY9,A0A2P1HX44,A0A2P1HX57,A0A2P1HX80,A0A2P1HXB2,A0A2P1HXJ6,A0A2P1HXJ8,A0A2P1HXK9,A0A2P1HXN5,A0A2P1HXT3,A0A2P1HXY6,A0A2P1HY15,A0A2P1HY36,A0A2P1HYS7,A0A2P1HZ11,A0A2P1HZ73,A0A2P1HZ74,A0A2P1HZF4,A0A2P1HZG3,A0A2P1HZH0,A0A2P1HZL0,A0A2P1HZS0,A0A2P1I011,A0A2P1I049,A0A2P1I080,A0A2P1I0E3,A0A2P1I0E5,A0A2P1I0J1,A0A2P1I0K7,A0A2P1I0M3,A0A2P1I0V9,A0A2P1I110,A0A2P1I114,A0A2P1I148,A0A2P1I176,A0A2P1I1A9,A0A2P1I1C0,A0A2P1I1C1,A0A2P1I1E1,A0A2P1I1G4,A0A2P1I1L0,A0A2P1I1N1,A0A2P1I1P3,A0A2P1I1R3,A0A2P1I1S1,A0A2P1I1U6,A0A2P1I1V2,A0A2P1I259,A0A2P1I2C0,A0A2P1I2D5,A0A2P1I2G5,A0A2P1I2K9,A0A2P1I2U5,A0A2P1I376,A0A2P1I3A1,A0A2P1I3A8,A0A2P1I3L7,A0A2P1I3P3,A0A2P1I3R0,A0A2P1I3R2,A0A2P1I3U6,A0A2P1I443,A0A2P1I444,A0A2P1I470,A0A2P1I4I8,A0A2P1I4M6,A0A2P1I4X1,A0A2P1I5I6,A0A2P1I5J7,A0A2P1I5N9,A0A2P1I5Q3,A0A2P1I5U4,A0A2P1I634,A0A2P1I655,A0A2P1I667,A0A2P1I686,A0A2P1I698,A0A2P1I6K3,A0A2P1I6K9,A0A2P1I6Q2,A0A2P1I6T7,A0A2P1I721,A0A2P1I744,A0A2P1I769,A0A2P1I773,A0A2P1I783,A0A2P1I7A6,A0A2P1I7D4,A0A2P1I7E7,A0A2P1I7H6,A0A2P1I7K2,A0A2P1I7M2,A0A2P1I7W3,A0A2P1I811,A0A2P1I872,A0A2P1I873,A0A2P1I878,A0A2P1I890,A0A2P1I894,A0A2P1I8I0,A0A2P1I8K4,A0A2P1I8M8,A0A2P1I8P0,A0A2P1I8T3,A0A2P1I950,A0A2P1I9C4,A0A2P1I9G8,A0A2P1I9J8,A0A2P1I9T0,A0A2P1I9X7,A0A2P1I9Y9,A0A2P1IAB5,A0A2P1IAK9,A0A2P1IAM9,A0A2P1IAU5,A0A2P1IAZ6,A0A2P1IB11,A0A2P1IB34,A0A2P1IB46,A0A2P1IB60,A0A2P1IB88,A0A2P1IBA1,A0A2P1IBF1,A0A2P1IBG1,A0A2P1IBH3,A0A2P1IBQ5,A0A2P1IBR3,A0A2P1IBV0,A0A2P1IBW3,A0A2P1IBZ1,A0A2P1ICD8,A0A2P1ICK7,A0A2P1ICM7,A0A2P1ICV0,A0A2P1ICX3,A0A2P1ID26,A0A2P1ID31,A0A2P1IDB5,A0A2P1IDD2,A0A2P1IDD9,A0A2P1IDG1,A0A2P1IDI0,A0A2P1IDJ2,A0A2P1IDK6,A0A2P1IDP1,A0A2P1IDT4,A0A2P1IDU6,A0A2P1IDW1,A0A2P1IE60,A0A2P1IE69,A0A2P1IEA0,A0A2P1IEI4,A0A2P1IEP9,A0A2P1IEQ8,A0A2P1IEY0,A0A2P1IEY4,A0A2P1IF70,A0A2P1IFB7,A0A2P1IFC5,A0A2P1IFQ2,A0A2P1IFT5,A0A2P1IFU1,A0A2P1IFY2,A0A2P1IG25,A0A2P1IG93,A0A2P1IGA1,A0A2P1IGE9,A0A2P1IGM0,A0A2P1IGM4,A0A2P1IGQ2,A0A2P1IGR6,A0A2P1IH19,A0A2P1IH21,A0A2P1IH35,A0A2P1IHA3,A0A2P1IHJ0,A0A2P1IHL9,A0A2P1IHN3,A0A2P1IHT0,A0A2P1IHW5,A0A2P1II20,A0A2P1II60,A0A2P1II66,A0A2P1IIF5,A0A2P1IIK4,A0A2P1IIW4,A0A2P1IJ92,A0A2P1IJ95,A0A2P1IJA7,A0A2P1IJH6,A0A2P1IJJ5,A0A2P1IJQ4,A0A2P1IJT5,A0A2P1IJY2,A0A2P1IKD0,A0A2P1IKE1,A0A2P1IKE7,A0A2P1IKL6,A0A2P1IKL7,A0A2P1IKR7,A0A2P1IKT3,A0A2P1IKV3,A0A2P1IKW8,A0A2P1IL29,A0A2P1IL50,A0A2P1IL94,A0A2P1ILC6,A0A2P1ILH3,A0A2P1ILI6,A0A2P1ILJ1,A0A2P1ILJ5,A0A2P1ILQ4,A0A2P1ILU5,A0A2Z5ZNE4,A0A2Z5ZNI2,A0A2Z5ZNJ8,A0A2Z5ZNL6,A0A2Z5ZNR3,A0A2Z5ZNU6,A0A2Z5ZNX6,A0A2Z5ZNY7,A0A2Z5ZP42,A0A2Z5ZP70,A0A2Z5ZP86,A0A2Z5ZPA8,A0A384K9A3,A0A384KLH2,A0A384KR39,A0A384L6H3,A0A384LBT8,A0A384LCN9,A0A384LIA5,A0A384LLD3,A0A384LN04,A0A384LPS7,B1A8W7,B1A8X5,B1A8Y3,B9UPB8,C6G868,C6G876,C6G884,D7RGN0,G0XRL3,I1SUZ8,I1SV00,J3SRD7,J3T1D1,J3T1F4,J3T1J6,J3T1Y4,J3UE95,J3XCG3,J3XCM3,J3XLP7,J3XLU0,J3XMC9,J7FME7,K4F2R3,K4F666,N0CFQ0,Q07D09,Q4VRP0,Q4VRP8,Q549Q0,Q71C70,Q8B5P3,Q8JQA8,Q918T0,Q918T5,Q918T8,Q918U1,Q918U3,Q918U5,Q918U7,Q9E839,Q9E840,Q9E841,Q9E842,Q9YIV0,Q9YV72,Q9YV73,Q9YV74,Q9YV75,Q9YV76,S4W1B0,S4W1C8,S4W1D1,S4W2B8,S4W2C7,S4W2D0,S4W2D4,S4W4I9,S4W4J3,S4W4J8,S4W4K3,S4W4K7,S4W7A5,S4W7A9,S4W7B3,S4W7B7,S4W7C0,S4W7C4,S4W8C4,S4W8C8,S4W8D0,S6AWR2,S6B2P1,S6BB15,S6BB53,S6BHC8 |
dsDNA |
TR, Rep |
P |
D(14643661, 22031941, 12019268, 29142126) |
N |
1BY9, 1DTO, 1R8P, 1ZZF, 2NNU, 2Q79, 3MI7 |
D(22210627, 7957111) |
D(14643661, 21482558, 7957111, 12239214) |
D(14643661, binding assay, DNA complex,
footprinting) |
Fields Virology |
|
Plays a role in the initiation of viral DNA replication.
A dimer of E2 interacts with a dimer of E1 in order to
improve specificity of E1 DNA binding activity. Once the
complex recognizes and binds DNA at specific sites, the E2
dimer is removed from DNA. E2 also regulates viral
transcription through binding to the E2RE response element
(5'-ACCNNNNNNGGT-3') present in multiple copies in the
regulatory regions of the viral genome. Activates or
represses transcription depending on E2RE's position with
regards to proximal promoter elements including the TATA-box.
Repression occurs by sterically hindering the assembly of the
transcription initiation complex. |
|
204 |
Papillomaviridae |
Human papillomavirus type 16 |
E6 |
Protein E6 |
P03126 |
VE6_HPV16 |
A0A059VIP8,A0A059VIQ1,A0A059VJK0,A0A059VNE0,A0A059VNE3,A0A059VNE7,A0A059VNM4,A0A059VNM8,A0A076G1E4,A0A076G284,A0A089N7R5,A0A089N7S9,A0A0C5FR62,A0A0C5FUK7,A0A0C5FUL8,A0A0C5G7Y2,A0A0C5G7Y5,A0A0D5CS67,A0A0D5ZYT6,A0A0M4AZY2,A0A0N9QU66,A0A0N9R7C8,A0A0S2E7X6,A0A0S2E831,A0A0U2QTF6,A0A0U2QTG8,A0A0U2QTK7,A0A0U2QTM0,A0A0U2YX27,A0A0U2YX58,A0A0U2ZNY5,A0A0U2ZPD7,A0A0U3AVN8,A0A0U3AVT2,A0A0U3I277,A0A0U3I8A2,A0A0U3IDX2,A0A0U3IE20,A0A0U3IE52,A0A0U3IE93,A0A0U3IEB5,A0A0U3IJH2,A0A0U3J8V8,A0A0U3J927,A0A0U3JAY8,A0A0U3JB52,A0A0U3JCG6,A0A0U3JCM7,A0A0U3JCQ7,A0A0U3JL94,A0A0U3JLC6,A0A0U3JLK2,A0A0U3JSW5,A0A0U3JWC6,A0A0U3JWG7,A0A0U3JWJ7,A0A0U3JWN1,A0A0U3K7C4,A0A0U3K7F7,A0A1B2AH91,A0A1B2AH95,A0A1B2AHB5,A0A1B2AHE3,A0A1B2AHE5,A0A1B2AHH7,A0A1C9HIX0,A0A1C9HIX9,A0A1D8V743,A0A1D8V772,A0A1D8V7D7,A0A1P8NVX0,A0A220NMJ5,A0A220NMS7,A0A220NMT0,A0A286LT27,A0A286LT38,A0A286R0Y2,A0A286R0Z6,A0A291L533,A0A291L5A1,A0A2D1LVN5,A0A2D1LVP3,A0A2D1LVP6,A0A2D1LVP7,A0A2D1LVP8,A0A2D1LVP9,A0A2D1LVQ0,A0A2D1LVQ5,A0A2D1LVQ7,A0A2D1LVR1,A0A2D1LVR3,A0A2D1LVR4,A0A2D1LVR6,A0A2D1LVR8,A0A2D1LVS2,A0A2D1LVS6,A0A2D1LVS8,A0A2D1LVT2,A0A2D1LVU2,A0A2D1LVU7,A0A2P0VG54,A0A2P0VGD5,A0A2P0VGY9,A0A2P0VHG1,A0A2P0VHX4,A0A2P0VIB7,A0A2P0VIU5,A0A2P0VIU9,A0A2P0VJB1,A0A2P0VJU1,A0A2P0VKB9,A0A2P0VKC2,A0A2P1HB01,A0A2P1HB02,A0A2P1HB15,A0A2P1HBA8,A0A2P1HBE1,A0A2P1HBH3,A0A2P1HBM3,A0A2P1HBR0,A0A2P1HBY2,A0A2P1HCG3,A0A2P1HCG9,A0A2P1HDE3,A0A2P1HE67,A0A2P1HEE5,A0A2P1HEF3,A0A2P1HEI2,A0A2P1HEJ9,A0A2P1HF36,A0A2P1HFT5,A0A2P1HFZ6,A0A2P1HG21,A0A2P1HGE7,A0A2P1HGM3,A0A2P1HGS9,A0A2P1HGX6,A0A2P1HHC8,A0A2P1HHQ0,A0A2P1HI11,A0A2P1HIG8,A0A2P1HIH1,A0A2P1HIR9,A0A2P1HJ72,A0A2P1HJF4,A0A2P1HJU7,A0A2P1HKA0,A0A2P1HKD0,A0A2P1HKP1,A0A2P1HKQ2,A0A2P1HKZ5,A0A2P1HL30,A0A2P1HL39,A0A2P1HL86,A0A2P1HLJ8,A0A2P1HLP0,A0A2P1HLP7,A0A2P1HM15,A0A2P1HM36,A0A2P1HM90,A0A2P1HME4,A0A2P1HMG4,A0A2P1HMG5,A0A2P1HMH9,A0A2P1HMJ0,A0A2P1HMQ1,A0A2P1HMT1,A0A2P1HMZ8,A0A2P1HN04,A0A2P1HN94,A0A2P1HNM9,A0A2P1HNV3,A0A2P1HNX7,A0A2P1HP96,A0A2P1HPQ3,A0A2P1HPX8,A0A2P1HQ86,A0A2P1HQE9,A0A2P1HQI1,A0A2P1HQJ9,A0A2P1HQK3,A0A2P1HQL5,A0A2P1HQL9,A0A2P1HR68,A0A2P1HRA2,A0A2P1HRC8,A0A2P1HRI0,A0A2P1HRR9,A0A2P1HS04,A0A2P1HS22,A0A2P1HS59,A0A2P1HSQ4,A0A2P1HSV1,A0A2P1HTP3,A0A2P1HTX2,A0A2P1HTZ5,A0A2P1HUS9,A0A2P1HUW9,A0A2P1HV39,A0A2P1HV98,A0A2P1HVX7,A0A2P1HW32,A0A2P1HX54,A0A2P1HXK4,A0A2P1HXQ6,A0A2P1HY06,A0A2P1HY11,A0A2P1HYJ5,A0A2P1HYN2,A0A2P1HZ06,A0A2P1HZ47,A0A2P1HZE4,A0A2P1HZX9,A0A2P1I0J5,A0A2P1I0M9,A0A2P1I102,A0A2P1I128,A0A2P1I1F2,A0A2P1I1I8,A0A2P1I1J9,A0A2P1I1X0,A0A2P1I1Z1,A0A2P1I1Z7,A0A2P1I2B1,A0A2P1I2B8,A0A2P1I2R1,A0A2P1I3F3,A0A2P1I3J7,A0A2P1I3Q5,A0A2P1I3X8,A0A2P1I3Z9,A0A2P1I419,A0A2P1I497,A0A2P1I4B0,A0A2P1I4E0,A0A2P1I4Z7,A0A2P1I4Z9,A0A2P1I543,A0A2P1I590,A0A2P1I5C9,A0A2P1I5D5,A0A2P1I5S2,A0A2P1I5X1,A0A2P1I643,A0A2P1I6U0,A0A2P1I704,A0A2P1I738,A0A2P1I741,A0A2P1I7I4,A0A2P1I7P4,A0A2P1I7P8,A0A2P1I7S1,A0A2P1I7Y6,A0A2P1I825,A0A2P1I830,A0A2P1I8M0,A0A2P1I8P9,A0A2P1I8Z1,A0A2P1I949,A0A2P1I9I0,A0A2P1I9T1,A0A2P1IA25,A0A2P1IA62,A0A2P1IA81,A0A2P1IAA7,A0A2P1IAG9,A0A2P1IB33,A0A2P1IB69,A0A2P1IBQ6,A0A2P1IBT0,A0A2P1IBW4,A0A2P1IBX1,A0A2P1IBY0,A0A2P1IC50,A0A2P1ICA0,A0A2P1ID20,A0A2P1IDC6,A0A2P1IDD8,A0A2P1IDN9,A0A2P1IDU8,A0A2P1IDV8,A0A2P1IDW3,A0A2P1IE23,A0A2P1IE68,A0A2P1IEA9,A0A2P1IEF5,A0A2P1IEX8,A0A2P1IFE8,A0A2P1IFG8,A0A2P1IFS0,A0A2P1IFV9,A0A2P1IFX6,A0A2P1IFY1,A0A2P1IG57,A0A2P1IG80,A0A2P1IG87,A0A2P1IGG0,A0A2P1IGW0,A0A2P1IGX6,A0A2P1IH24,A0A2P1IHC7,A0A2P1IHE2,A0A2P1IHI4,A0A2P1II23,A0A2P1IIF0,A0A2P1IIJ4,A0A2P1IIR6,A0A2P1IJK4,A0A2P1IJR0,A0A2P1IJR1,A0A2P1IK24,A0A2P1IK64,A0A2P1IK80,A0A2P1IK89,A0A2P1IKC0,A0A2P1IKF2,A0A2P1IKI0,A0A2P1IKJ2,A0A2P1IKU9,A0A2P1IL87,A0A2P1ILI8,A0A2P1ILK1,A0A2Z5DHD3,A0A2Z5DHF0,A0A384K9E7,A0A384K9Q3,A0A384KEH1,A0A384KKG5,A0A384KQK8,A0A384LDF5,A0A384LH07,A0A384LI46,A0A384LQE2,A0MPS4,A1YQC0,A1YT18,A1YT19,A3RM07,A3RM08,A4L2Z5,A4L2Z7,A4L313,A7LCD3,B1A8X8,B1N828,B1N831,B7T163,B7T167,B7T1G5,B7T1G7,B7T1H5,B7T1I2,B9UPB5,C0KXJ9,C0KXK0,C0KXK2,C0KXK3,C0KXK6,C0KXK7,C0KXK9,C0KXL0,C0KXL2,C0KXL4,C0KXL6,C0KXL9,C0KXM0,C0KXM1,C0KXM3,C0KXM5,C6G881,D5LNF2,D7RGM7,E1A4A4,G0WKQ5,G0WKQ6,G9HQC8,G9HQD8,G9HQE8,G9HQF1,H6VNE9,H6VNF0,H6VNF1,H6VNF2,H6VNF3,H6VNF4,H6VNF5,H6VNF6,H6VNF7,H6VNF8,H6VNF9,H6VNG0,H6VNG2,H6VNG4,H6VNG6,H6VNG7,H6VNG8,H6VNH0,H6VNH1,H6VNH2,H6VNH3,H6VNH4,H6VNH5,H6VNH7,H6VNH8,H6VNH9,H6VNI0,H6VNI2,H6VNI3,H6VNI4,H6VNI5,H6VNI6,H6VNI7,H6VNI8,H6VNI9,H6VNJ0,H6VNJ1,H6VNJ2,H6VNJ3,H6VNJ4,H6VNJ5,H6VNJ6,H6VNJ9,H6VNK0,H6VNK1,H6VNK3,H6VNK4,J3T208,J9ZYN7,J9ZYY5,J9ZZ15,J9ZZ21,K0A0D0,N0DLZ7,N0DM07,N0DRU0,N0DRU7,Q2PJN9,Q4VRN5,Q547J2,Q71BH9,Q778I6,Q77JC7,Q8JMU8,Q8QHN0,Q8QHP5,Q8QHT0,Q8QRD5,Q8QRD6,Q8QRD7,Q8QRD8,Q8QRD9,Q8QRE0,Q8QRE1,Q919A9,Q919B1,Q919C6,Q919D4,Q9QDH3,Q9QDH5,Q9QDH7,Q9QDH9,Q9W931,Q9WH13,S5TCK5,S5TDM3,S5TDR0,S5THQ0,S5THX6,S5TL73,S5TL98,S5TLA4,S5TQ97,S5U276,S5U2B7,S5U2Z7,S5U365,S5U371,S5U3B0,S5U3D5,S5U3E1,S5U7G7 |
indirect/unknown |
TR, Other |
P |
D(15664194) |
N |
1VZN, 2FK4, 2KPL, 2LJX, 2LJY, 2LJZ, 4GIZ, 4JOP, 4XR8,
6HKS, 6SIV, 6SJA |
D(31002735, 11275986, 22210627) |
D(11275986) |
N |
Fields Virology |
|
Plays a major role in the induction and maintenance of
cellular transformation. Acts mainly as an oncoprotein by
stimulating the destruction of many host cell key regulatory
proteins. E6 associates with host UBE3A/E6-AP
ubiquitin-protein ligase, and inactivates tumor suppressors
TP53 and TP73 by targeting them to the 26S proteasome for
degradation. In turn, DNA damage and chromosomal
instabilities increase and lead to cell proliferation and
cancer development. The complex E6/E6AP targets several other
substrates to degradation via the proteasome including host
DLG1 or NFX1, a repressor of human telomerase reverse
transcriptase (hTERT). The resulting increased expression of
hTERT prevents the shortening of telomere length leading to
cell immortalization. Other cellular targets including BAK1,
Fas-associated death domain-containing protein (FADD) and
procaspase 8, are degraded by E6/E6AP causing inhibition of
apoptosis. E6 also inhibits immune response by interacting
with host IRF3 and TYK2. These interactions prevent IRF3
transcriptional activities and inhibit TYK2-mediated JAK-STAT
activation by interferon alpha resulting in inhibition of the
interferon signaling pathway. |
|
205 |
Papillomaviridae |
Human papillomavirus type 16 |
E7 |
Protein E7 |
P03129 |
VE7_HPV16 |
A0A059PVS3,A0A059PVS5,A0A059PVS7,A0A059PVT2,A0A059PVT4,A0A059PVT6,A0A059PVU6,A0A059PVU7,A0A059PVU9,A0A059PVV2,A0A059PVW7,A0A059PVX1,A0A076G1E9,A0A076G292,A0A076G3A1,A0A076G7W8,A0A089N7T4,A0A0G2YFL8,A0A0G2YJI6,A0A0G2YL83,A0A0H4CN15,A0A0H4CQU3,A0A0M5I281,A0A159DWG2,A0A1B2AH93,A0A1B2AHI1,A0A1B2AHJ8,A0A289SF75,A0A289SFD2,A0A289SFF8,A0A289SFI7,A0A289SFR6,A0A289SFX4,A0A289SG08,A0A289SM88,A0A289SMC3,A0A289SME7,A0A289SMJ4,A0A289SMN5,A0A289SMS4,A0A289SMW3,A0A289SPS0,A0A289SPX7,A0A289SQ04,A0A289SQ43,A0A289SQA6,A0A289SQL8,A0A289SZM6,A0A289SZX7,A0A289T025,A0A289T0B9,A0A289T0E2,A0A289T0G1,A0A289TIL4,A0A289TIQ9,A0A289TIW2,A0A289TIZ2,A0A289TJ28,A0A289TJ61,A0A291S0D2,A0A291S0D3,A0A291S0D8,A0A291S0E0,A0A291S0E9,A0A291S0F0,A0A291S0F1,A0A291S0F3,A0A291S0F7,A0A291S0F8,A0A291S0G1,A0A291S0G3,A0A291S0G4,A0A291S0G5,A0A291S0G8,A0A291S0H0,A0A291S0H1,A0A291S0H3,A0A291S0H7,A0A291S0I0,A0A291S0I3,A0A2C9DJ22,A0A2C9DJ24,A0A2C9DJ25,A0A2C9DJ27,A0A2C9DJ29,A0A2C9DJ31,A0A2C9DJ33,A0A2C9DJ34,A0A2C9DJ36,A0A2C9DJ38,A0A2C9DJ40,A0A2C9DJ42,A0A2C9DJ43,A0A2C9DJ45,A0A2C9DJ47,A0A2C9DJ49,A0A2C9DJ51,A0A2C9DJ52,A0A2C9DJ54,A0A2C9DJ56,A0A2C9DJ58,A0A2C9DJ60,A0A2C9DJ61,A0A2C9DJ63,A0A2C9DJ65,A0A2C9DJ67,A0A2C9DJ69,A0A2C9DJ70,A0A2C9DJ72,A0A2C9DJ74,A0A2C9DJ76,A0A2C9DJ78,A0A2C9DJ79,A0A2C9DJ81,A0A2C9DJ83,A0A2C9DJ85,A0A2C9DJ87,A0A2C9DJ88,A0A2C9DJ90,A0A2C9DJ92,A0A2C9DJ94,A0A2C9DJ96,A0A2C9DJ97,A0A2C9DJ99,A0A2C9DJA1,A0A2C9DJA3,A0A2C9DJA5,A0A2C9DJA6,A0A2C9DJA8,A0A2C9DJB0,A0A2C9DJB2,A0A2C9DJB4,A0A2C9DJB5,A0A2C9DJB7,A0A2C9DJB9,A0A2C9DJC1,A0A2P0VGD6,A0A2P0VGD7,A0A2P0VGZ1,A0A2P0VHG2,A0A2P0VHG5,A0A2P0VHY0,A0A2P0VHY3,A0A2P0VIC2,A0A2P0VIV5,A0A2P0VJB3,A0A2P0VJU6,A0A2P0VKC6,A0A2P1HCE8,A0A2P1HF34,A0A2P1HG37,A0A2P1HIW7,A0A2P1HJR6,A0A2P1HJS5,A0A2P1HJZ9,A0A2P1HKE3,A0A2P1HKM2,A0A2P1HLI0,A0A2P1HME9,A0A2P1HMR8,A0A2P1HNA9,A0A2P1HNK2,A0A2P1HNX3,A0A2P1HPZ2,A0A2P1HRS5,A0A2P1HS38,A0A2P1HT93,A0A2P1HTU4,A0A2P1HTU6,A0A2P1HU85,A0A2P1HUE1,A0A2P1HUQ8,A0A2P1HV03,A0A2P1HV70,A0A2P1HWM3,A0A2P1HWX3,A0A2P1HXT8,A0A2P1HYA9,A0A2P1HYI5,A0A2P1HYV4,A0A2P1HZB6,A0A2P1HZJ7,A0A2P1HZQ7,A0A2P1HZY9,A0A2P1I050,A0A2P1I084,A0A2P1I1X1,A0A2P1I1Y2,A0A2P1I277,A0A2P1I2C5,A0A2P1I369,A0A2P1I3T1,A0A2P1I4H2,A0A2P1I589,A0A2P1I5V8,A0A2P1I5W2,A0A2P1I681,A0A2P1I752,A0A2P1I7N9,A0A2P1I898,A0A2P1I8U1,A0A2P1I8V3,A0A2P1I8Y6,A0A2P1I8Z6,A0A2P1I911,A0A2P1I9B3,A0A2P1I9B5,A0A2P1I9F6,A0A2P1I9K6,A0A2P1I9V6,A0A2P1IA20,A0A2P1IBS1,A0A2P1IBV2,A0A2P1ID77,A0A2P1IDR9,A0A2P1IDZ5,A0A2P1IE20,A0A2P1IE97,A0A2P1IHA0,A0A2P1IHZ3,A0A2P1II29,A0A2P1IJ05,A0A2P1IJ29,A0A2P1IJF7,A0A2P1IJW8,A0A2P1IK25,A0A2P1IKM7,A0A2P1ILF9,A0A2Z5DHM3,A0A384LCP1,A0A384LMA3,A0A384LNE6,A0MPS5,A0MPS6,A0MPS7,A1YQD4,A1YQD5,A1YQD6,A1YQD7,A1YQD8,A1YQD9,A1YQE0,A1YQE1,B7T164,B9UPB6,C0KXQ4,C0KXQ5,D7RGM8,G0WKQ8,J9Q2I8,J9Q2V6,J9Q2W0,J9Q391,J9Q3Y3,J9Q4N7,J9Q4P1,K0F2R1,K0F2S0,K0F2T0,K0F2T8,K0F2U7,K0F2V7,K0F2W6,K0F2X5,K0F2Y7,K0F300,K0F312,K0F9K7,K0F9L4,K0F9M5,K0F9N3,K0F9P2,K0F9Q2,K0F9Q8,K0F9Q9,K0F9R8,K0F9S1,K0F9S7,K0F9S9,K0F9T5,K0F9T8,K0F9U6,K0F9U7,K0F9V4,K0F9V8,K0F9W3,K0F9X1,K0F9X9,K0F9Y7,K0F9Z4,K0FA01,K0FAG8,K0FAH3,K0FAH8,K0FAI6,K0FAJ4,K0FAK5,K0FAL4,K0FAM6,K0FAN4,K0FAP2,K0FAQ5,K0FAR6,K0FFB1,K0FFC3,K0FFD3,K0FFE3,K0FFF2,K0FFG1,K0FFG8,K0FFH7,K0FFI7,K0FFJ6,K0FFK5,K0FFL4,O11650,O12337,O12338,Q2MJT4,Q547B8,Q778G4,Q778G6,Q778G8,Q778G9,Q778H1,Q778H2,Q778H3,Q778H5,Q778H7,Q778H9,Q778I0,Q778I1,Q778I3,Q778I5,Q77AI1,Q77GV7,Q8B5P6,Q8QRD2,Q8QRD3,Q8QRD4,Q8V1J0,Q9QDH2,Q9QDH4,Q9QDH6,Q9QDH8,R4UNR4,R4UNS0,R4UNS5,R4URG4,R4URH2,R4URH7,R4UZM3,R4UZM8,R4UZN4,R4V4T8,R4V4U3,R4V4U7,R4V4V0,R4V788,R4V795,R4V7A2,R9QVU4,S4S7U0,S4S7U2,S4S7U5,S4S7U9,S4S7V5,S4S7V7,S4S7V9,S4S7W1,S4S7W3,S4S7W5,S4S7W7,S4S7W9,S4S7X1,S4S7Y4,S4S868,S4S877,S4S884,S4S891,S4S895,S4S898,S4S8A1,S4S8A4,S4S8A6,S4S8A9,S4S8B1,S4S8B5,S4S8B8,S4S8M4,S4S8N2,S4S8N9,S4S8Q3,S4S8Q9,S4S8R3,S4S8R7,S4S8S1,S4S8S4,S4S8S8,S4S8T0,S4S8T4,S4S8T9,S4S8U0,S4S8U3,S4S8U4,S4S8V1,S4S8W3,S4S8X0,S4S8X6,S4S8Y0,S4S8Y3,S4S8Y7,S4S8Z1,S4S8Z4,S4S8Z7,S4S902,S4S9B2,S4S9B9,S4S9C6,S4S9D2,S4S9E0,S4S9E5,S4S9E8,S4S9F1,S4S9F4,S4S9F8,S4S9G0,S4S9G4,S4S9G8,S4S9H0,S4U723,S4U729,S4U736,S4U7T5,S4U7U0,S4U954,S4U959,S4UB75,S4UB84,S4UDF6,S4UDG0,T1R4E0,T1R4E3,T1R539 |
indirect/unknown |
TR, Other |
P |
D(22099967) |
N |
4YOZ, 6APN |
D(22210627, 7933087, 9426463, 11039910) |
N |
N |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to
efficiently use the cellular DNA replicating machinery to
achieve viral genome replication. E7 protein has both
transforming and trans-activating activities. Induces the
disassembly of the E2F1 transcription factor from RB1, with
subsequent transcriptional activation of E2F1-regulated
S-phase genes. Interferes with host histone deacetylation
mediated by HDAC1 and HDAC2, leading to transcription
activation. Plays also a role in the inhibition of both
antiviral and antiproliferative functions of host interferon
alpha. Interaction with host TMEM173/STING impairs the
ability of TMEM173/STING to sense cytosolic DNA and promote
the production of type I interferon (IFN-alpha and
IFN-beta). |
|
206 |
Papillomaviridae |
Human papillomavirus type 1a |
E2 |
Regulatory protein E2 |
P03118 |
VE2_HPV1 |
|
dsDNA |
TR, Rep |
P |
I(14643661, 22031941, 12019268, 29142126) |
N |
N |
I(22210627, 7957111) |
I(14643661, 21482558, 7957111, 12239214) |
I(14643661, binding assay, DNA complex,
footprinting) |
Fields Virology |
|
Plays a role in the initiation of viral DNA replication.
A dimer of E2 interacts with a dimer of E1 in order to
improve specificity of E1 DNA binding activity. Once the
complex recognizes and binds DNA at specific sites, the E2
dimer is removed from DNA. E2 also regulates viral
transcription through binding to the E2RE response element
(5'-ACCNNNNNNGGT-3') present in multiple copies in the
regulatory regions of the viral genome. Activates or
represses transcription depending on E2RE's position with
regards to proximal promoter elements including the TATA-box.
Repression occurs by sterically hindering the assembly of the
transcription initiation complex. |
|
207 |
Papillomaviridae |
Human papillomavirus type 1a |
E6 |
Protein E6 |
P06929 |
VE6_HPV1 |
|
indirect/unknown |
TR, Other |
P |
I(15664194) |
N |
N |
D(7933087) |
I(11275986) |
N |
Fields Virology |
|
Plays a major role in the induction and maintenance of
cellular transformation. E6 associates with host UBE3A/E6-AP
ubiquitin-protein ligase and modulates its activity. Protects
host keratinocytes from apoptosis by mediating the
degradation of host BAK1. May also inhibit host immune
response. |
|
208 |
Papillomaviridae |
Human papillomavirus type 1a |
E7 |
Protein E7 |
P06465 |
VE7_HPV1 |
|
indirect/unknown |
TR, Other |
P |
I(22099967) |
N |
2B9D |
D(7933087) |
N |
N |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to
efficiently use the cellular DNA replicating machinery to
achieve viral genome replication. E7 protein has both
transforming and trans-activating activities. Induces the
disassembly of the E2F1 transcription factor from RB1, with
subsequent transcriptional activation of E2F1-regulated
S-phase genes. Interferes with host histone deacetylation
mediated by HDAC1 and HDAC2, leading to transcription
activation. Plays also a role in the inhibition of both
antiviral and antiproliferative functions of host interferon
alpha. Interaction with host TMEM173/STING impairs the
ability of TMEM173/STING to sense cytosolic DNA and promote
the production of type I interferon (IFN-alpha and
IFN-beta). |
|
209 |
Papillomaviridae |
Human papillomavirus type 41 |
E2 |
Regulatory protein E2 |
P27552 |
VE2_HPV41 |
|
dsDNA |
TR, Rep |
P |
I(14643661, 22031941, 12019268, 29142126) |
N |
N |
I(22210627, 7957111) |
I(14643661, 21482558, 7957111, 12239214) |
I(14643661, binding assay, DNA complex,
footprinting) |
Fields Virology |
|
Plays a role in the initiation of viral DNA replication.
A dimer of E2 interacts with a dimer of E1 in order to
improve specificity of E1 DNA binding activity. Once the
complex recognizes and binds DNA at specific sites, the E2
dimer is removed from DNA. E2 also regulates viral
transcription through binding to the E2RE response element
(5'-ACCNNNNNNGGT-3') present in multiple copies in the
regulatory regions of the viral genome. Activates or
represses transcription depending on E2RE's position with
regards to proximal promoter elements including the TATA-box.
Repression occurs by sterically hindering the assembly of the
transcription initiation complex. |
|
210 |
Papillomaviridae |
Human papillomavirus type 41 |
E6 |
Protein E6 |
P27555 |
VE6_HPV41 |
|
indirect/unknown |
TR, Other |
P |
I(15664194) |
N |
N |
I(31002735, 11275986, 22210627) |
I(11275986) |
N |
Fields Virology |
|
Plays a major role in the induction and maintenance of
cellular transformation. E6 associates with host UBE3A/E6-AP
ubiquitin-protein ligase and modulates its activity. Protects
host keratinocytes from apoptosis by mediating the
degradation of host BAK1. May also inhibit host immune
response. |
|
211 |
Papillomaviridae |
Human papillomavirus type 41 |
E7 |
Protein E7 |
P27556 |
VE7_HPV41 |
|
indirect/unknown |
TR, Other |
P |
I(22099967) |
N |
N |
I(22210627, 7933087, 9426463, 11039910) |
N |
N |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to
efficiently use the cellular DNA replicating machinery to
achieve viral genome replication. E7 protein has both
transforming and trans-activating activities. Induces the
disassembly of the E2F1 transcription factor from RB1, with
subsequent transcriptional activation of E2F1-regulated
S-phase genes. Interferes with host histone deacetylation
mediated by HDAC1 and HDAC2, leading to transcription
activation. Plays also a role in the inhibition of both
antiviral and antiproliferative functions of host interferon
alpha. Interaction with host TMEM173/STING impairs the
ability of TMEM173/STING to sense cytosolic DNA and promote
the production of type I interferon (IFN-alpha and
IFN-beta). |
|
212 |
Papillomaviridae |
Human papillomavirus type 5 |
E2 |
Regulatory protein E2 |
P06921 |
VE2_HPV05 |
P26545 |
dsDNA |
TR, Rep |
P |
I(14643661, 22031941, 12019268, 29142126) |
N |
N |
I(22210627, 7957111) |
I(14643661, 21482558, 7957111, 12239214) |
I(14643661, binding assay, DNA complex,
footprinting) |
Fields Virology |
|
Plays a role in the initiation of viral DNA replication.
A dimer of E2 interacts with a dimer of E1 in order to
improve specificity of E1 DNA binding activity. Once the
complex recognizes and binds DNA at specific sites, the E2
dimer is removed from DNA. E2 also regulates viral
transcription through binding to the E2RE response element
(5'-ACCNNNNNNGGT-3') present in multiple copies in the
regulatory regions of the viral genome. Activates or
represses transcription depending on E2RE's position with
regards to proximal promoter elements including the TATA-box.
Repression occurs by sterically hindering the assembly of the
transcription initiation complex. |
|
213 |
Papillomaviridae |
Human papillomavirus type 5 |
E6 |
Protein E6 |
P06930 |
VE6_HPV05 |
A0A221SN86,A0A221SN96,A9XCP0,A9XCP7,A9XCQ4,A9XCR8,F8RC52,F8RC53,F8RC54,P24836,P26556,Q4PZJ4,Q4PZJ5,Q4PZJ6,Q4PZJ7,Q4PZJ8,Q4PZJ9,Q4PZK0,Q6LBH6,Q76WJ7,Q80927,Q81962,Q81985,Q81986,R9QCH1 |
indirect/unknown |
TR, Other |
P |
I(15664194) |
N |
N |
I(31002735, 11275986, 22210627) |
I(11275986) |
N |
Fields Virology |
|
Plays a major role in the induction and maintenance of
cellular transformation. E6 associates with host UBE3A/E6-AP
ubiquitin-protein ligase and modulates its activity. Protects
host keratinocytes from apoptosis by mediating the
degradation of host BAK1. May also inhibit host immune
response. |
|
214 |
Papillomaviridae |
Human papillomavirus type 5 |
E7 |
Protein E7 |
P06932 |
VE7_HPV05 |
A0A075LXE0,A0A075LYA7,A0A075LYB3,A0A075LYW2,A0A0N7I701,A0A0P0E4Z9,A0A0P0EBY8,A0A0P0EGY4,A0A0P0EME8,A0A140FA98,A0A140FAA6,A0A159DZX5,A0A192YER2,A0A192YG58,C7DYE0,C7DYE2,C7DYE4,C7DYE6,C7DYE8,C7DYF0,C7DYF2,C7DYF4,C7DYF6,C7DYF8,C7DYG0,C7DYG2,C7DYG4,C7DYG6,C7DYG8,C7DYH0,C7DYH2,C7DYH4,C7DYH6,C7DYH8,C7DYI0,C7DYI2,C7DYI4,C7DYI6,C7DYI8,C7DYJ0,C7DYJ2,C7DYJ4,C7DYJ6,C7DYJ8,C7DYK0,C7DYK2,C7DYK4,C7DYK6,C7DYK8,C7DYL0,C7DYL2,D0EDB6,F1AST1,F1AST2,F8S525,F8S541,F8S581,N0DP29,N0DQQ9,P26559,P36831,Q76WJ6,Q81019,Q8B5X6,R9QBR6 |
indirect/unknown |
TR, Other |
P |
I(22099967) |
N |
N |
I(22210627, 7933087, 9426463, 11039910) |
N |
N |
Fields Virology |
|
Plays a role in viral genome replication by driving entry
of quiescent cells into the cell cycle. Stimulation of
progression from G1 to S phase allows the virus to
efficiently use the cellular DNA replicating machinery to
achieve viral genome replication. E7 protein has both
transforming and trans-activating activities. Induces the
disassembly of the E2F1 transcription factor from RB1, with
subsequent transcriptional activation of E2F1-regulated
S-phase genes. Interferes with host histone deacetylation
mediated by HDAC1 and HDAC2, leading to transcription
activation. Plays also a role in the inhibition of both
antiviral and antiproliferative functions of host interferon
alpha. Interaction with host TMEM173/STING impairs the
ability of TMEM173/STING to sense cytosolic DNA and promote
the production of type I interferon (IFN-alpha and
IFN-beta). |
|
215 |
Paramyxoviridae |
Hendra virus |
Phosphoprotein |
Protein P, P/V/C |
O55778 |
PHOSP_HENDH |
|
indirect/unknown |
TR, Rep |
S |
N |
N |
4HEO |
I(7491765) |
N |
N |
25281398.0 |
|
Essential component of the RNA polymerase transcription
and replication complex. Binds the viral ribonucleocapsid and
positions the L polymerase on the template (By
similarity). |
|
216 |
Paramyxoviridae |
Human parainfluenza virus 1 |
Phosphoprotein |
P, P/C, Protein P, P/V/C |
P32530 |
PHOSP_PI1HB |
A0A059QA57,A0A059QA62,A0A059QA70,A0A059QA80,A0A059QAA8,A0A0G2R217,A0A1B2CW80,A0A1B2CW98,J7FNR1,J7FNT1,J7FNV2,J7FNW9,J7FNZ0,J7FP15,J7FP39,J7FP63,J7FQG2,J7FQI5,J7FQK8,J7FQL3,J7FQM7,J7FQP8,J7FQS6,J7FQV6,J7FQY2,J7FQY6,J7FSL2,J7FSN8,J7FSR7,J7FSU6,J7FSX6,J7FT03,J7FT30,J7FT61,J7FV05,J7FV29,J7FV56,J7FV78,J7FVA3,J7FVD2,J7FVG2,J7FVJ3,J7FXC5,J7FXE6,J7FXJ1,J7FXL5,J7FXN8,P28054,P32531,P32532,Q8QT31,T1UCF4,T1UCG6,T1UCH5,T1UF53,T1UF64,T1UF81,T1UF92,T1UFA1,T1UFB1 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
I(7491765) |
N |
N |
12692097.0 |
|
This protein is probably a component of the active
polymerase. It may function in template binding. |
|
217 |
Paramyxoviridae |
Human parainfluenza virus 2 |
Phosphoprotein |
Protein P, P/V |
P23056 |
PHOSP_PI2HT |
P23055 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
I(7491765) |
N |
N |
12692097.0 |
|
Essential component of the RNA polymerase and the nascent
chain assembly complex. Also required during RNA
synthesis. |
|
218 |
Paramyxoviridae |
Human parainfluenza virus 3 |
Phosphoprotein |
P, Protein P, P/V/D |
P06162 |
PHOSP_PI3H4 |
A0A023PFB4,A0A023PFG3,A0A023PFL0,A0A023PFQ5,A0A023PFZ5,A0A023PG51,A0A023PG69,A0A023PGA3,A0A023PGB4,A0A023PGD8,A0A023PGK3,A0A023PGS2,A0A023PGV1,A0A023PGY1,A0A023PGZ3,A0A023PH10,A0A023PH42,A0A023PH43,A0A023PH67,A0A023PH76,A0A023PH96,A0A023PHA5,A0A023PHD4,A0A023PHE7,A0A023PHF9,A0A023PHI5,A0A023PHI8,A0A023PHJ3,A0A023PHL9,A0A023PHN2,A0A023PHQ2,A0A023PHR4,A0A023PHS5,A0A023PHT7,A0A023PHX6,A0A023PI22,A0A023PI55,A0A023PI62,A0A023PI93,A0A023PIC6,A0A023PIJ5,A0A059Q9Z8,A0A059QA10,A0A059QA21,A0A059QA33,A0A059QA45,A0A059QA55,A0A059QA84,A0A059QAB7,A0A059QAB8,A0A059QAE1,A0A059QAF7,A0A059QAG4,A0A059QAH6,A0A059QAI0,A0A059QAJ6,A0A059QAM4,A0A059QBW4,A0A059QBZ1,A0A059QC16,A0A059QC39,A0A059QC70,A0A059QC91,A0A059QDV8,A0A059QDY9,A0A059QE20,A0A059QE50,A0A059QE92,A0A059QEF4,A0A0G2R241,A0A1C9FM37,A0A1C9FM46,A0A1C9FM56,A0A1C9FM77,A0A1C9FM79,A0A1C9FM80,A0A1C9FM90,A9Z0P3,B1A5Q1,B3GQS8,B8XXB5,O89234,Q81076,Q84742,R4X5Y3,T1UCU1,T1UCW0,T1UCY2,T1UD00,T1UD33,T1UD36,T1UD58,T1UD73,T1UE22,T1UE62,T1UEB9,T1UEG1,T1UFF6,T1UFJ6,T1UFQ1,U5L3E2 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
I(7491765) |
N |
N |
12692097.0 |
|
Essential component of the RNA polymerase and the nascent
chain assembly complex. Also required during RNA
synthesis. |
|
219 |
Paramyxoviridae |
Human parainfluenza virus 4a |
Phosphoprotein |
Protein P, P/V |
P22044 |
PHOSP_PI4HA |
|
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
I(7491765) |
N |
N |
12692097.0 |
|
Essential component of the RNA polymerase and the nascent
chain assembly complex. Also required during RNA
synthesis. |
|
220 |
Paramyxoviridae |
Human parainfluenza virus 4b |
Phosphoprotein |
Protein P, P/V |
P21738 |
PHOSP_PI4HB |
A0A097F1I3,A0A1V0E0T4,A0A1V0E1P9,A0A1V0E1R5,A0A1W6DZN5,A0A1Z1XG58,H6WF05 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
I(7491765) |
N |
N |
12692097.0 |
|
Essential component of the RNA polymerase and the nascent
chain assembly complex. Also required during RNA
synthesis. |
|
221 |
Paramyxoviridae |
Measles virus |
Phosphoprotein |
C, P, Protein P, P/V |
P35974 |
PHOSP_MEASA |
A0A076FF09,A0A0A7DYR3,A0A0M3TG67,A0A0M3TG73,A0A0M3TG74,A0A0M3TG86,A0A0M3TG91,A0A0M3TGB0,A0A0M3TGC6,A0A0M4MCX4,A0A0M4MD66,A0A0M4MMI7,A0A0M4MQY5,A0A0M4N184,A0A0M4NEZ8,A0A0S1LL08,A0A0S1LL25,A0A140G963,A0A158UZJ4,A0A158V0F3,A0A158V2K3,A0A161UC10,A0A1C9U7M5,A0A1Z1ED88,A0A1Z1EDF0,A0A1Z1EDF8,A0A2R4LPH0,A0A2U7XVG9,A0A343LQ65,A0A3Q8BM42,A0A3Q8GW16,A0A3Q8GW50,A0A3Q8GW72,A0A3Q8GYD4,A0A3Q8GZ35,A0A3Q8H141,A0A3S5GNX2,A4URT3,A7XPM0,A7XPM1,A7XPM2,A7XPM3,A7XPM4,A7XPM5,A7XPM6,A7XPM7,A7XPM8,A7XPM9,A7XPN0,A7XPN1,A7XPN2,A7XPN3,A7XPN4,A7XPN5,A9YTL4,A9YTM2,B1AAA8,B1GX84,B1GX85,B1GX86,B1GX87,B1GX88,B1GX89,B1GX90,B1GX91,B1GX92,B1GX93,B1GX94,B1GX95,B1GX96,B1GX97,B1GX98,B1GX99,B1GXA0,B1GXA1,B2BML3,B2KPM4,B7TB11,B8PZQ7,B9A7E8,B9A7L7,C6L654,C8CAZ2,E2I6N2,E2I9Q7,E5RS81,E7DW48,E7DW50,E7DW52,E7DW54,E7DW62,E7DW64,E7DW68,E7DW70,E7DW72,E7DW76,E7DW78,E7DW80,E7DW84,E7DW86,E7DW92,E7DW94,E7DW96,E7DW98,E7DWA2,E7DWA8,E7DWB0,E7DWB2,E7DWB6,E7DWB8,E7DWC4,E7DWC6,E7DWC8,E7DWD0,E7DWD2,E7DWD4,E7DWD6,E7DWD8,E7DWF5,E7DWG1,E7DWG3,E7DWG5,E7DWG7,E7DWG9,E7DWH2,E7DWH4,E7DWH6,E7DWH8,E7DWI0,E7DWI4,E7DWI7,E7DWI9,E7DWJ1,E7DWJ3,E7DWJ7,E7DWJ9,E7DWK1,E7DWK3,E7DWK5,E7DWK7,E7DWL7,E7DWM1,E7DWM3,E7DWM5,E7DWM9,F1BCV1,F1BCV2,F1BCV3,F1BCV4,F1BCV5,F1BCV6,F1BCV7,F1BCV9,F1BCW3,F1BCW5,F1BCW6,F1BCW7,F1BCX0,F1BD28,F1BD31,F1BD34,F1BD35,F1BD37,F1BD45,F1BD46,F1BD53,F1BD54,F1BD55,F1BD57,F1BD59,F1BD61,F1BD62,F1BD64,F1BD65,F1BD67,F1BD69,F1BD71,F1BD77,F1BD78,F1BD79,F1BD80,F1BD84,F6I820,F6I821,F6I823,F6I825,F6I826,F6I828,F6I832,F6I833,F6I834,F8U897,G4XDT2,G5DD33,G5DD41,G5DD49,G5DD57,G5DD65,G5DD73,G5DD81,G5DD89,G5DD97,K9N4J4,K9N4K5,K9N5R1,P03422,P26033,P90485,Q00793,Q04159,Q2LJ39,Q2LJ47,Q2LJ55,Q2LJ63,Q76VZ7,Q77M20,Q77M25,Q77M31,Q77M42,Q783Q7,Q83320,Q83321,Q83623,Q8JQ52,Q8JT18,Q8JT21,Q9IC38,Q9IFK7,Q9WMB4,Q9YZZ2,Q9YZZ5,W8VRE9,X5D6I5,X5D6J1,X5D6J8,X5D6K5,X5D6L1,X5D6L7,X5D6M5,X5D6N2,X5D6Q1,X5D6Q9,X5D6R4,X5D6R7,X5D6S0,X5D6S4,X5D6S8,X5D6T1,X5D6T4,X5D6T9,X5DBD8,X5DBE2,X5DBE7,X5DBF3,X5DBF8,X5DBG3,X5DBG7,X5DBI4,X5DBJ2,X5DBJ6,X5DBJ9,X5DBK3,X5DBK6,X5DBL0,X5DBL3,X5DBL6,X5DBM0,X5DBM2,X5DBZ6,X5DD01,X5DD05,X5DD11,X5DD18,X5DD25,X5DD33,X5DD39,X5DD46,X5DD65,X5DD68,X5DD72,X5DD76,X5DD80,X5DD84,X5DD88,X5DD90,X5DD96,X5DDA1,X5DST0,X5DST5,X5DSU2,X5DSV0,X5DSV8,X5DSW3,X5DSW8,X5DSX2,X5DSZ1,X5DSZ4,X5DSZ8,X5DT03,X5DT07,X5DT10,X5DT14,X5DT19,X5DT23,X5DT28,X5DT32,X5DVE4,X5DVE9,X5DVF5,X5DVF9,X5DVG3,X5DVG9,X5DVH5,X5DVI1,X5DVK0,X5DVK9,X5DVL2,X5DVL5,X5DVL8,X5DVM1,X5DVM5,X5DVM9,X5DVN1,X5DVN3 |
indirect/unknown |
TR, Rep |
S |
N |
N |
4BHV, 4C5Q |
I(7491765) |
N |
D(31381607, 8578862) |
25483511.0 |
|
Essential component of the RNA polymerase and the nascent
chain assembly complex. Also required during RNA
synthesis. |
|
222 |
Paramyxoviridae |
Nipah virus |
Phosphoprotein |
Non-structural protein V, P, Protein W, P/V/C, P/V/W/C, V
protein, W protein |
Q4VCQ1 |
Q4VCQ1_NIPAV |
A0A1L7B8D0,A0A1L7B8D3,A0A3G1QY20,A0A3G1QY27,A0A3G1QY38,D2DEB8,E2II04,H6V847,H6V848,H6V860,H6V869,H6V870,H6V871,Q4VCP9,Q4VCQ0,Q997F2 |
indirect/unknown |
TR, Rep |
S |
N |
N |
4N5B |
I(7491765) |
N |
N |
30647521.0 |
|
RNA binding;RNA-directed 5'-3' RNA polymerase
activity;transcription, DNA-templated;viral genome
replication |
|
223 |
Parvoviridae |
Adeno-associated virus |
Rep52 |
Protein Rep52 |
Q89270 |
REP52_AAV2S |
|
indirect/unknown |
TR, NAP, Rep |
S |
N |
N |
N |
N |
D(16775308) |
D(12824181) |
21212830.0 |
|
Plays a critical role during packaging of viral DNA into
empty capsids, where they are thought to be part of the
packaging motor complex. The single stranded genomic DNA is
packaged in a 3' to 5' direction and requires the association
between viral DNA and Rep40. Regulates host PKA activity by
interacting with host PRKX as a mechanism to interfere with
helper virus propagation and to promote its own
replication. |
|
224 |
Parvoviridae |
Adeno-associated virus |
Rep68 |
Protein Rep68 |
P03132 |
REP68_AAV2S |
|
dsDNA |
TR, Rep |
S |
N |
N |
1S9H, 1U0J, 4ZO0, 4ZQ9, 5DCX |
D(1845899) |
D(16775308, 15596798) |
D(16775308, 15596798) |
21212830.0 |
|
Plays an essential role in the initiation of viral DNA
synthesis. Binds specifically to an inverted terminal repeat
element (ITR) on the 3' and 5' ends of the viral DNA, where
it cleaves a site specifically to generate a priming site for
initiation of the synthesis of a complementary strand. Plays
also a role as transcriptional regulator, DNA helicase and as
key factor in site-specific integration of the viral genome.
Inhibits the host cell cycle G1/S and G2/M transitions. These
arrests may provide essential cellular factors for viral DNA
replication. |
|
225 |
Parvoviridae |
Adeno-associated virus |
Rep78 |
Protein Rep78 |
Q89268 |
REP78_AAV2S |
A9RAH9,O56136,O56138,Q670Q9,Q670R1,Q670R3,Q670R5,Q670R7 |
dsDNA |
TR, Rep |
S |
D(15596798) |
N |
5BYG |
D(10531369, 1845899) |
D(10531369, 10666281, 16775308) |
N |
21212830.0 |
|
Plays an essential role in the initiation of viral DNA
synthesis. Binds specifically to an inverted terminal repeat
element (ITR) on the 3' and 5' ends of the viral DNA, where
it cleaves a site specifically to generate a priming site for
initiation of the synthesis of a complementary strand. Plays
also a role as transcriptional regulator, DNA helicase and as
key factors in site-specific integration of the viral genome.
Regulates host PKA activity by interacting with host PRKX as
a mechanism of interfering with helper virus propagation and
promoting its own replication. Inhibits the host cell cycle
G1/S, S and G2/M transitions. These arrests may provide
essential cellular factors for viral DNA replication. |
|
226 |
Parvoviridae |
Human parvovirus 4 |
NS1 |
Nonstructural protein, Nonstructural protein 1,
Nonstructural protein 1,, Non-structural protein, ORF1 |
F6KS47 |
F6KS47_9VIRU |
A0A0C4L654,A0A0C4L9E0,A7J3Q4,A7J3Q8,B0YZG4,B0YZG8,B0YZI4,D0FM80,D0FM90,D1M7U5,F6KS50,H9A241,H9A247,H9A250,H9A253,J9PN41,J9PNK6,J9PNL4,J9PPZ7 |
dsDNA |
TR, Rep |
S |
N |
N |
N |
I(8970971) |
I(27809499, 24418564) |
I(27809499, FA), I(11853402, Dnase I footprinting) |
22492853.0 |
F6KS47 is inferred from Adeno-associated virus protein
Q89270 |
ATP binding,DNA replication,viral genome replication |
|
227 |
Parvoviridae |
Human parvovirus B19 |
NS1 |
Initiator protein NS1, NCVP1, Non-capsid protein NS-1,
Non-structural protein 1, Non-structural protein NS1 |
Q9PZT1 |
NS1_PAVHV |
A0A076JV48,A0A076JZ43,A0A077B001,A0A097C0L5,A0A097C0M3,A0A097C0M7,A0A097C0N6,A0A0N9H666,A0A0N9H6S8,A0A0N9H8I9,A0A0N9H9D5,A0A0N9H9F8,A0A0S2Z242,A0A0S2Z256,A0A0S2Z2A0,A0A0S2Z2D7,A0A0S2Z2F9,A0A0S2Z2I2,A0A0S2Z2I4,A0A0S2Z2K1,A0A0S2Z2K5,A0A0S2Z2K8,A0A0S2Z2M3,A0A0S2Z2P9,A0A0S2Z2X0,A0A0S2Z356,A0A0X8XHP5,A0A223LL20,A0A3Q9D3C3,A0A3R5YZH1,A1A400,A1BML3,A1BML8,A3F778,B8YQ89,D2EBU8,D4AHY8,D6CHV0,E5L8C4,E5L8C6,I7BP20,J3SB70,J3SB73,J3SB76,J3SB79,J3SB82,J3SB85,J3SB88,J3SB91,J3SB94,J3SB97,J3SBA0,J3SBA3,J3SBA6,J3SET8,J3SEV0,J3SIA5,J3SIB2,J3SMR7,J3SMS1,J3SMS4,J3SMS7,J3SMT0,J3SMT3,J3SMT6,J3SMT9,J3SMU2,J3SMU5,J3SMU8,J3SMV1,J3SMV4,J3SN47,J3SN59,J3SN73,J3SN76,J3SN79,J3SN82,J3SN85,J3SN88,J3SN91,J3SN94,J3SN97,J3SNA0,J3SNA3,J7FCE3,J7FCE6,J7FCE9,J7FCF4,J7FCF7,J7FCQ7,J7FCR0,J7FCR7,J7FCS0,J7FD52,J7FD55,J7FD60,J7FD63,J7FDJ3,J7FDJ6,J7FDJ9,J7FDK2,J7FDZ9,J7FE02,J7FE05,J7FE08,J7FE11,Q206Z8,Q207A1,Q207A4,Q207A7,Q207B0,Q2I001,Q2I006,Q2MJ80,Q2MJ83,Q2MJ86,Q2PZ28,Q308H9,Q308I3,Q38IT5,Q38IU0,Q38IU5,Q38IV0,Q3KTM4,Q6DT44,Q6KBB7,Q6RCN2,Q6TV13,Q75U70,Q75U73,Q75U76,Q75U79,Q75U85,Q75U88,Q75U94,Q8JN58,Q913X2,Q9JGP9,Q9JGQ0,Q9JGS1,Q9PZT3,Q9PZT5,Q9PZT7,Q9PZT9,Q9PZU1,Q9WKM1,S5YS34,S5YS39,S5YS41,S5YS44,S5YSP7,S5YY54,S5YY89,S5YY94,S5YYA5,S5YYB0,S5YYB6,S5YYC7,S5YYD9,S5YYE2,S5YYF0,S5Z5M0,S5Z5U6,S5Z5V2,S5Z611,S5ZHB5,S5ZHF2,S5ZHP5,S5ZHQ1,S5ZHQ5,S5ZHQ9,S5ZXZ5,S5ZXZ7,S5ZY10,S5ZY14,S5ZY63,S5ZY70,S5ZY80,S5ZY87 |
dsDNA |
TR, Rep |
S |
N |
N |
N |
D(8970971) |
D(27809499, 24418564) |
D(27809499, FA), D(11853402, Dnase I footprinting) |
22492853.0 |
|
Multifunctional protein essential for viral DNA
replication, which cooperatively interacts with the viral DNA
origin of replication and transactivates several promoters
including the viral p6 promoter (PubMed:27809499,
PubMed:24418564, PubMed:11853402). Binds the origin of
replication and performs an endonucleolytic nick within a
conserved sequence in the viral genome, thereby initiating
the rolling circle replication (RCR) (PubMed:27809499).
Participates in the transcriptional regulation the viral p6
promoter that regulates all viral transcripts and the
cellular CDN1A or IL6 promoters (PubMed:8970971,
PubMed:11853402). Transactivates several host promoters some
of which induce the S cell cycle phase for the production of
host replicative proteins (PubMed:20890043, PubMed:15518826,
PubMed:24049177). Upregulates the expression of host E2F4 and
E2F5 and interacts with both these factors thereby inhibiting
the host cell cycle G2/M transition (PubMed:20890043). This
arrest promotes apoptosis for viral release (PubMed:20890043,
PubMed:9525624). |
|
228 |
Peribunyaviridae |
Bunyamwera virus |
N |
Non-structural protein NS-S, NS |
P16494 |
NSS_BUNYW |
A0A0A7KU45,A0A0A7KY99,A0A0G2T176,A0A0G2T1F8,A0A0G2T1M9,A0A0G2T1U8,A0A0U2GIU0,G4Y821,Q8V617 |
indirect/unknown |
TR, Other |
P |
N |
N |
N |
D(15150262) |
N |
N |
29707545.0 |
|
Inhibits host transcriptional machinery, by producing
modifications to the phosphorylation state of the C-terminal
domain (CTD) of RNA polymerase II. Inhibits phosphorylation
at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD
of RNA polymerase II, suggesting that the elongation step of
transcription and/or 3'-end processing is prevented.
Inhibition of host transcription machinery leads to shut off
of host cell protein synthesis and inhibition of the host
innate immune response. NSs also seems to be involved in the
nuclear relocalization of host PABP1. |
|
229 |
Peribunyaviridae |
Bunyavirus La Crosse |
N |
Non-structural protein NS-S, NSs |
P04874 |
NSS_BUNLC |
A5HC88,D3K4J5,D3K4J7,D3K4J9,D3K4K1,D3K4K3,D3K4K5,D3K4K7,D3K4K9,D3K4L1,D3K4L3,D3K4L5,D3K4L7,D3K4L9,D3K4M1,D3K4M3,D3K4M5,D3K4M7,D3K4M9,D3K4N1,D3K4N3,D3K4N5,D3K4N7,D3K4N9,D3K4P1,D3K4P3,D3K4P5,D3K4P7,D3K4P9,D3K4Q1,D3K4Q3,D3K4Q5,D3K4Q7,D3K4Q9,D3K4R1,D3K4R3,D3K4R5,D3K4R7,D3K4R9,D3K4S1,D3K4S3,D3K505,D3K507,D3K509,D3K511,D6NSL4,D6NSL8,F6JSE2,F6JSG2,F6JSH4,P09614,Q8JPQ9,Q917M9 |
indirect/unknown |
TR, Other |
P |
N |
N |
N |
I(15150262) |
N |
N |
26375904.0 |
|
Inhibits host transcriptional machinery, by producing
modifications to the phosphorylation state of the C-terminal
domain (CTD) of RNA polymerase II. Inhibits phosphorylation
at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD
of RNA polymerase II, suggesting that the elongation step of
transcription and/or 3'-end processing is prevented.
Inhibition of host transcription machinery leads to shut off
of host cell protein synthesis and inhibition of the host
innate immune response. NSs also seems to be involved in the
nuclear relocalization of host PABP1 (By similarity). |
|
230 |
Peribunyaviridae |
Bunyavirus snowshoe hare |
N |
Non-structural protein, Non-structural protein NS-S,
NSs |
P03514 |
NSS_BUNSH |
A9YU76 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(12133999) |
N |
N |
22798366.0 |
P03514 is inferred from Bunyavirus La Crosse protein
P16494 |
Inhibits host transcriptional machinery, by producing
modifications to the phosphorylation state of the C-terminal
domain (CTD) of RNA polymerase II. Inhibits phosphorylation
at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD
of RNA polymerase II, suggesting that the elongation step of
transcription and/or 3'-end processing is prevented.
Inhibition of host transcription machinery leads to shut off
of host cell protein synthesis and inhibition of the host
innate immune response. NSs also seems to be involved in the
nuclear relocalization of host PABP1 (By similarity). |
|
231 |
Peribunyaviridae |
Bwamba orthobunyavirus |
NSs |
Nonstructural protein NSs, NSs protein |
B3U4X9 |
B3U4X9_9VIRU |
|
indirect/unknown |
TR, Other |
P |
N |
N |
N |
I(15150262) |
N |
N |
25188437.0 |
B3U4X9 is inferred from Bunyavirus La Crosse protein
P16494 |
viral process |
|
232 |
Peribunyaviridae |
California encephalitis orthobunyavirus |
NSs |
Nonstructural protein NSs, NSs protein |
Q66003 |
Q66003_9VIRU |
A0A385KLS1,Q66002 |
indirect/unknown |
TR, Other |
P |
N |
N |
N |
I(22345363, 15331713) |
N |
N |
Fields Virology |
Q66003 is inferred from Bunyamwera virus protein
P16494 |
viral process |
|
233 |
Phenuiviridae |
Rift valley fever virus |
NSs |
Non-structural protein S |
P21698 |
NSS_RVFVZ |
A0A3S5XDL9,A7KBW6,A7KBW7,O72702,O73535,O73536,O73537,O73538,O73539,O73540,O73541,O73542,O73543,O73544,O73545,O73546,O73547,O73548,O73549,Q7T6F4,Q7T6F5,Q8JUF9 |
indirect/unknown |
TR, Other |
P |
N |
N |
2N0Y, 5OOO |
D(22345363, 15331713) |
N |
D(15331713) |
21188836.0 |
|
Plays a role in the escape of host innate immune response
by promoting the degradation of host EIF2AK2/PKR and
inhibiting host transcription. Cytoplasmic NSs interacts with
host FBXW11 to degrade PKR whereas nuclear pool binds to host
FBXO3 to target TFIIH subunit GTF2H1 for proteasomal
degradation (PubMed:19197350, PubMed:19211744,
PubMed:21543505, PubMed:23063407, PubMed:26837067). Forms
filaments in the nucleus that may sequester NSs binding
partners, causing cell cycle arrest (PubMed:28915104,
PubMed:10233964). |
|
234 |
Pneumoviridae |
Human metapneumovirus |
M2-1 |
Envelope-associated 22 kDa protein, M2, Matrix M2-1 |
Q6WB97 |
M21_HMPVC |
A0A2H4ZA70,C4B9I0,C5MRS8,F4YZY3,M9V764,M9V801,M9V8F9,M9V8I5,Q0GMS7,Q0GMT0,T1UEZ8,X4Y081,X4Y6I6,X4Y849,X4YLV7 |
ssRNA |
TR |
P |
N |
N |
4CS9 |
I(22675274) |
I(22675274) |
I(11024112) |
18820584.0 |
|
Acts as a transcriptional elongation factor to prevent
premature termination during transcription thus allowing
complete synthesis of viral mRNAs. Functions also as a
processivity and antitermination factor to permit transit of
the polymerase through intergenic regions to access promoter
distal genes. Plays a role in the association of the matrix
protein with the nucleocapsid, which initiates assembly and
budding (By similarity). |
|
235 |
Pneumoviridae |
Human metapneumovirus |
M2-2 |
M2, Matrix protein M2-2 |
Q6WB96 |
M22_HMPVC |
A0A1C9UMW8,A0A2H4ZA68,A0A2H4ZAG0,A0A2H4ZAL7,A0A2R4KPG0,B8X6L4,C4B9I1,G3KCK1,G3KCL0,M4QFJ4,M4QFL8,M4QJH5,M4QSN4,Q0GMS9,Q6QQH9,Q6WBA5,T1UCE1,X4XYU4,X4Y8N5,X4YM65 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
I(10500164) |
N |
I(10500164) |
18820584.0 |
|
Mediates the regulatory switch from transcription to RNA
replication. Acts late in infection by inhibiting viral
transcription and up-regulating RNA replication (By
similarity). Plays a major role in antagonizing the type I
IFN-mediated antiviral response. Interacts with host MAVS and
prevents the interaction with its upstream partner
DDX58/RIG-I in the signaling pathway leading to interferon
production. |
|
236 |
Pneumoviridae |
Human respiratory syncytial virus |
M2-1 |
Envelope-associated 22 kDa protein, M2, Matrix M2-1 |
O42050 |
M21_HRSVB |
A0A023R760,A0A023R9H2,A0A023RAB4,A0A023RB46,A0A059TDC1,A0A059TDD0,A0A059TDD2,A0A059TDK0,A0A059TDS3,A0A059TDT2,A0A059TE43,A0A059TE80,A0A059TE92,A0A059TEB2,A0A059TED8,A0A076FRX0,A0A076FS08,A0A0A7NQY1,A0A0A7NR76,A0A0A7NS85,A0A0A7NSD8,A0A0A7NTH8,A0A0A7NTR2,A0A0A7NWI0,A0A0A7NWV7,A0A0E3JJE6,A0A0E3LZC2,A0A0X8CVT2,A0A0X8CW62,A0A0X9WN34,A0A0X9WNF5,A0A0X9WYQ7,A0A109QCV3,A0A109QF38,A0A109QF47,A0A109QFG0,A0A109QFU4,A0A120HQL9,A0A140H350,A0A140H3H1,A0A140H3I2,A0A142MLF2,A0A142MLU4,A0A142MME4,A0A142MMF8,A0A142MML9,A0A142MMY8,A0A142MN24,A0A142MN83,A0A142MNE0,A0A142MP28,A0A142MP67,A0A142MQE4,A0A142MQL3,A0A142MS12,A0A142MTE5,A0A142MTN4,A0A1B2VRY5,A0A1B2VTF5,A0A1B2VTV8,A0A1B2VU04,A0A1B2VUC4,A0A1B2VUQ6,A0A1B2VUR2,A0A1B2VV16,A0A1C9V116,A0A1C9V131,A0A1C9V1G1,A0A1C9V236,A0A1C9V2L7,A0A1C9V2L9,A0A1S5SHT2,A0A344X9C8,A0A384ZDG5,A0A384ZEL0,A0A384ZHM7,A0A384ZI92,A0A3Q8TDD0,G8EJ00,P04545,S5ZI93,T1UDB8,V5N720,V5N732,V5N764,V5N7P0,V5N7T2,V5N863,V5N8G0,V5N8M0,V5N9G7,X4Y2X6,X4Y354,X4Y4A9,X4Y4R1,X4Y5B0,X4Y9B5,X4YAG2,X4YBX8,X4YC51,X4YCE8,X4YCG8,X4YCK1,X4YRJ3,X4YRV8,X4YSL7,X4YT50 |
ssRNA |
TR |
P |
N |
N |
N |
D(22675274) |
D(22675274) |
D(11024112) |
27486734.0 |
|
Acts as a transcriptional elongation factor to prevent
premature termination during transcription thus allowing
complete synthesis of RSV mRNAs. Functions also as a
processivity and antitermination factor to permit transit of
the polymerase through intergenic regions to access promoter
distal genes. Plays a role in the association of the matrix
protein with the nucleocapsid, which initiates assembly and
budding. Also, can activate NF-kappa-B through association
with host RELA (By similarity). |
|
237 |
Pneumoviridae |
Human respiratory syncytial virus |
M2-2 |
M2, Matrix M2-2, Matrix protein M2-2 |
O42047 |
M22_HRSVB |
A0A023R862,A0A023RAK9,A0A023RAR0,A0A023RAW2,A0A059TD79,A0A059TD88,A0A059TD97,A0A059TDB9,A0A059TDL1,A0A059TDM2,A0A059TDN5,A0A059TDU3,A0A059TDW5,A0A059TE08,A0A059TE10,A0A059TE20,A0A059TE62,A0A059TE76,A0A059TE86,A0A059TEF7,A0A088S989,A0A088SBH4,A0A088STR4,A0A0A7NQN2,A0A0A7NRD7,A0A0A7NRW9,A0A0A7NRZ5,A0A0A7NSC6,A0A0A7NSS3,A0A0A7NSZ2,A0A0A7NTQ4,A0A0A7NW37,A0A0A7NWD7,A0A0C5BY14,A0A0U2X6D1,A0A0X8CUQ7,A0A0X8CV01,A0A0X8CVY3,A0A0X8CWA4,A0A0X8CWK3,A0A0X8CWL7,A0A0X8CX84,A0A0X8D1Y1,A0A0X9WEC3,A0A0X9WNJ9,A0A0X9WQ87,A0A0X9XCQ9,A0A0X9XSH9,A0A0X9XZP0,A0A109QF63,A0A120HQH2,A0A140H3H2,A0A142MLB5,A0A142MLT2,A0A142MLW9,A0A142MLZ4,A0A142MMA1,A0A142MND2,A0A142MNS2,A0A142MP32,A0A142MPS0,A0A142MQ01,A0A142MQ24,A0A142MQB9,A0A142MQQ3,A0A142MRP9,A0A142MRQ8,A0A142MRT1,A0A142MSE7,A0A142MSN4,A0A142MTD2,A0A1B2VRZ4,A0A1B2VT71,A0A1B2VTT6,A0A1C9V163,A0A1C9V1B2,A0A1C9V1B7,A0A1C9V1C5,A0A1C9V1K6,A0A1C9V273,A0A1C9V2D1,A0A1C9V2L4,A0A1C9V3M2,A0A1C9V3M4,A0A1P8L302,A0A1P8L312,A0A1P8L326,A0A1P8L340,A0A1P8L345,A0A1P8L3C1,A0A1P8L3J1,A0A1P8L3L8,A0A1P8L3L9,A0A1P8L3N1,A0A1P8L3R6,A0A1V0G3V1,A0A1V0G3V3,A0A1V0G3Y9,A0A219V069,A0A219V0B8,A0A219V1R2,A0A220QKK0,A0A240ESV1,A0A240ET90,A0A240ETA0,A0A2H4HTW4,A0A2H4WKD5,A0A2H4WKH4,A0A2H4WKI3,A0A2H4WKJ7,A0A2H4WKK7,A0A2H4WKM6,A0A2H4WKU2,A0A2H4WKZ5,A0A2H4WL43,A0A2H4WL88,A0A2H4WL89,A0A2H4WL96,A0A2H4WLC5,A0A2H4WLJ5,A0A2H4WLK0,A0A2H4WLK1,A0A2H4WLK4,A0A2H4WLR1,A0A2H4WLS0,A0A2H4WLW4,A0A2H4WM08,A0A2H4WM68,A0A2H4WM69,A0A2I6PIW0,A0A2Z4Z400,A0A344X9C9,A0A348FUX5,A0A348FUZ7,A0A348FV41,A0A384ZD99,A0A384ZDA6,A0A384ZDE7,A0A384ZDJ1,A0A384ZDP1,A0A384ZDQ6,A0A384ZE42,A0A384ZEB4,A0A384ZFD6,A0A384ZFQ7,A0A384ZGM2,A0A384ZHC5,A0A384ZIB7,A0A384ZIM0,A0A385MKF8,A0A385MKK5,A0A385MKM5,A0A385MKY3,A0A385MKY9,A0A385ML21,A0A385ML27,A0A385MLE1,A0A385MLJ5,A0A385MLV9,A0A385MLZ9,A0A385MM88,A0A385MMM9,A0A385MMY7,A0A385MNA9,A0A385MNH8,A0A385MP38,A0A385MPR2,G8EID1,G8EIF3,G8EIN0,G8EIP1,G8EIT4,G8EJ11,I1V243,I6TQU9,I6TQX6,K4G1T0,K4G1U1,K4G1X4,K4G267,K4G278,K4G291,K4G2E0,K4G2F1,K4G2G2,K4G8U6,K4G974,P88812,R9TBJ8,R9TBV7,R9TC35,R9TCE7,R9TCH9,R9TCV3,R9TD10,R9TDD3,R9TFD3,R9TGG7,R9TGM0,S5YT63,T1UDA9,T1UFV4,V5N6W9,V5N770,V5N7H4,V5N7S2,V5N7T7,V5N7T8,V5N800,V5N9B2,V5N9Q5,V9VEA7,X4Y2T5,X4Y2X0,X4Y459,X4YC44,X4YF41,X4YQG7,X4YRX7,X4YS61,X4YSE2,X4YUD1 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
D(10500164) |
N |
D(10500164) |
27486734.0 |
|
Mediates the regulatory switch from transcription to RNA
replication. Acts late in infection by inhibiting viral
transcription and up-regulating RNA replication (By
similarity). |
|
238 |
Pneumoviridae |
Human respiratory syncytial virus |
NS1 |
1C, Non-structural protein 1, Non-structural protein
1C |
P0DOE9 |
NS1_HRSVA |
A0A023RAP1,A0A023RAP2,A0A059TDA4,A0A059TE30,A0A059TEA8,A0A059TEC6,A0A076FRG5,A0A076FRP0,A0A076FRZ6,A0A088S969,A0A088S9L5,A0A088S9Q0,A0A088SBF8,A0A0A7ESZ7,A0A0A7NQK8,A0A0A7NR06,A0A0A7NTB6,A0A0A7NW88,A0A0C5CHB8,A0A0E3JFY9,A0A0E3JJF0,A0A0N7AZB8,A0A0N7AZU8,A0A0N7AZW5,A0A0N7B004,A0A0X8CUX3,A0A0X8CV39,A0A0X8CV54,A0A0X8CVU3,A0A0X8D1H5,A0A0X9WFH4,A0A0X9WJP4,A0A0X9WNC3,A0A0X9YMG0,A0A109Q8Y4,A0A109QEZ3,A0A109QF81,A0A109QF99,A0A142MN86,A0A142MNL6,A0A142MR26,A0A142MR29,A0A142MS90,A0A142MSN6,A0A142MSP0,A0A142MTA9,A0A1B2VR66,A0A1B2VR76,A0A1B2VRC9,A0A1B2VRD0,A0A1B2VRG3,A0A1B2VRG9,A0A1B2VRK3,A0A1B2VRP7,A0A1B2VRQ7,A0A1B2VRV1,A0A1B2VRX1,A0A1B2VS19,A0A1B2VS39,A0A1B2VS48,A0A1B2VS52,A0A1B2VS65,A0A1B2VS80,A0A1B2VS84,A0A1B2VSA0,A0A1B2VSE3,A0A1B2VSH6,A0A1B2VSI1,A0A1B2VSM9,A0A1B2VST7,A0A1B2VSV0,A0A1B2VSV5,A0A1B2VSY0,A0A1B2VSY7,A0A1B2VT51,A0A1B2VT63,A0A1B2VT69,A0A1B2VT83,A0A1B2VT94,A0A1B2VT96,A0A1B2VTB8,A0A1B2VTC1,A0A1B2VTC4,A0A1B2VTD8,A0A1B2VTF8,A0A1B2VTG3,A0A1B2VTG4,A0A1B2VTK9,A0A1B2VTL3,A0A1B2VTM8,A0A1B2VTN0,A0A1B2VTN8,A0A1B2VTP7,A0A1B2VTQ3,A0A1B2VTS2,A0A1B2VTS4,A0A1B2VTT3,A0A1B2VTT4,A0A1B2VTV5,A0A1B2VTV9,A0A1B2VTW6,A0A1B2VU02,A0A1B2VU38,A0A1B2VU48,A0A1B2VU55,A0A1B2VU65,A0A1B2VU70,A0A1B2VU78,A0A1B2VU81,A0A1B2VU82,A0A1B2VU88,A0A1B2VU95,A0A1B2VUA4,A0A1B2VUE3,A0A1B2VUG6,A0A1B2VUJ1,A0A1B2VUJ9,A0A1B2VUK4,A0A1B2VUK6,A0A1B2VUL5,A0A1B2VUL7,A0A1B2VUM0,A0A1B2VUM4,A0A1B2VUN6,A0A1B2VUQ1,A0A1B2VUR4,A0A1B2VUS0,A0A1B2VUT2,A0A1B2VUW2,A0A1B2VUY0,A0A1B2VUZ1,A0A1B2VV04,A0A1B2VV13,A0A1B2VV32,A0A1B2VV64,A0A1C9V0V3,A0A1C9V0X8,A0A1C9V1C9,A0A1C9V1K2,A0A1C9V1N8,A0A1C9V3D2,A0A1C9V3K7,A0A1P8L3N0,A0A1P8L3T5,A0A219V0C0,A0A219V0N1,A0A219V114,A0A219V1P3,A0A220QKI1,A0A240ESZ3,A0A2H4WKM9,A0A2H4WKW4,A0A2H4WKZ0,A0A2H4WLA5,A0A2H4WLL9,A0A2H5BXT7,A0A348FUV5,A0A348FUY8,A0A384ZCX6,A0A384ZD04,A0A384ZD36,A0A384ZDB2,A0A384ZDB3,A0A384ZDI4,A0A384ZDK9,A0A384ZDY9,A0A384ZE34,A0A384ZE47,A0A384ZE63,A0A384ZE76,A0A384ZE81,A0A384ZER9,A0A384ZET1,A0A384ZEV2,A0A384ZEY9,A0A384ZF13,A0A384ZFF8,A0A384ZFM4,A0A384ZFU1,A0A384ZFW2,A0A384ZFX9,A0A384ZFY9,A0A384ZG16,A0A384ZG51,A0A384ZG82,A0A384ZGC2,A0A384ZGG9,A0A384ZGI6,A0A384ZGK2,A0A384ZGW1,A0A384ZGW2,A0A384ZH11,A0A384ZH71,A0A384ZHA1,A0A384ZHF7,A0A384ZHH1,A0A384ZHK6,A0A384ZHS5,A0A384ZHT3,A0A384ZHT8,A0A384ZI47,A0A384ZID6,A0A384ZJ47,D8L6X1,E0WLV8,E0WLW0,E0WLW8,E0WLX4,E0WLX8,E0WLZ0,E0WLZ2,E0WLZ6,E0WM00,E0WM08,E0WM12,E0WM16,E0WM18,E0WM26,E0WMQ1,G3C7U4,G8EIQ4,G8EIV8,I1V245,I6TFE5,K4G252,K4G274,K4G2M9,K4G8K1,K7QLZ3,K7QM45,K7QM88,K7QM91,K7QMA9,K7QMD7,K7QME5,K7QMZ2,K7QMZ6,O09716,O42083,P04544,P0DOE8,P24568,Q4KRX1,Q86306,R9TBY3,R9TCN8,R9TGK0,S5Z6Q7,V5N7F0,V5N7L4,V5N7V2,V5NA43,W8E1P4,X4Y4C8,X4YC42,X4YC71,X4YRG2,X4YSB5,X4YSJ2 |
indirect/unknown |
TR, Rep, Other |
S |
N |
D(unpublished) |
N |
D(28665409, 15827150, 30558248) |
N |
D(9445048) |
27486734.0 |
|
Plays a major role in antagonizing the type I
IFN-mediated antiviral response. Acts cooperatively with NS2
to repress activation and nuclear translocation of host
IFN-regulatory factor IRF-3. Interacts with host MAVS and
prevents the interaction with its upstream partner
DDX58/RIG-I in the signaling pathway leading to interferon
production. Mediates the proteasomal degradation of host
STAT2 with elongin-cullin E3 ligase. Suppresses premature
apoptosis by an NF-kappa-B-dependent, interferon-independent
mechanism and thus facilitates virus growth. Additionally,
NS1 may serve some inhibitory role in viral transcription and
RNA replication. |
|
239 |
Pneumoviridae |
Human respiratory syncytial virus |
NS2 |
1B, Non-structural protein 1B, Non-structural protein 2,
Non-structural protein 2,Non-structural protein 1B |
P04543 |
NS2_HRSVA |
A0A023R830,A0A023R8E9,A0A023R8N9,A0A023R9I4,A0A023RA27,A0A023RA93,A0A059TE26,A0A059TE72,A0A059TEA2,A0A059TEF4,A0A060AG29,A0A060AHX0,A0A075D1R7,A0A075D1S8,A0A088S9K5,A0A088S9P1,A0A088SBF0,A0A088STT8,A0A0A7EB38,A0A0A7NQS6,A0A0A7NRK6,A0A0A7NRZ4,A0A0A7NT36,A0A0A7NTS5,A0A0A7NVS6,A0A0A7NVZ7,A0A0B5HHW4,A0A0B5HI09,A0A0B5HKC4,A0A0B5HPI0,A0A0E3GJT7,A0A0E3JJF2,A0A0E3LZC5,A0A0K0WTK1,A0A0N7ATI3,A0A0N7AUF0,A0A0X8CV14,A0A0X8CVP7,A0A0X8CVW4,A0A0X8CW71,A0A0X8D1A1,A0A0X9Y758,A0A0X9YM76,A0A109QA27,A0A109QF01,A0A120HQ64,A0A142MLQ4,A0A142MM12,A0A142MMA4,A0A142MNY1,A0A142MP94,A0A142MPB2,A0A142MQH2,A0A142MR38,A0A142MRB4,A0A142MRN0,A0A142MS94,A0A142MTJ5,A0A1B2VSE2,A0A1B2VUP9,A0A1B2VUS2,A0A1B2VV91,A0A1C9V187,A0A1C9V2R9,A0A1C9V385,A0A1C9V3K1,A0A1C9V3N0,A0A1P8L309,A0A1P8L388,A0A1P8L3F9,A0A1P8L3L5,A0A1V0BZ80,A0A1V0E2A8,A0A1Y0AVJ4,A0A219V0E0,A0A219V0P6,A0A219V1E6,A0A240ESZ4,A0A240ET33,A0A249Y6G1,A0A2H4N9A4,A0A2H4WKV6,A0A2H4WL58,A0A2H4WLD3,A0A2H4WLG6,A0A2H4WLM7,A0A2H4WLM8,A0A2H4WLW6,A0A2Z4Z441,A0A348FV22,A0A384ZEI2,A0A384ZEK3,A0A384ZFR9,A0A384ZG84,A0A384ZG97,A0A384ZH23,A0A384ZH48,A0A384ZHN3,A0A384ZHU2,A0A384ZHU8,A0A384ZIH2,A0A385ML73,A0A385ML91,A0A385MLX3,A0A385MMB0,A0A385MMC9,A0A385MN52,A0A385MN71,A0A385MNF0,A0A385MNM0,A0A385MNX2,A0A385MNZ9,A0A385MPD5,A0A386BXW1,A0A3G3NDU9,A0A3G3NFT1,A0A3G3NG18,A0A3Q8TDK8,A0A3Q8TEI7,C3UPA8,D8L6X2,E0WLV9,E0WLW5,E0WLW9,E0WLX5,E0WLY9,E0WLZ3,E0WLZ5,E0WM19,E0WM23,E0WMQ2,G8EIX0,G8FR15,G8FR70,I6TQX1,I6UJV8,K4G1V7,K4G272,K4G2D4,K4G905,K7QMY7,K7QMZ9,K7QN21,O12405,O42038,P24569,Q6V2F3,Q76TL1,Q86305,R9TCM6,R9TD28,R9TDF4,R9TF62,R9TFF7,R9TG22,V5N745,V5N794,V5N7E8,V5N7K8,V5N7Q9,V5N7U5,V5N858,V5N9I0,V5NA34,W8E0C3,X4Y3J0,X4Y5K9,X4Y5Y6,X4Y9H0,X4YCW8,X4YF64,X4YQI8,X4YQW8,X4YS53,X4YUK4,X5FNU1,X5FP42,X5FP72,X5FQ06,X5FQ21,X5FQ89,X5FQN9,X5FQS3 |
indirect/unknown |
TR, Other |
S |
N |
N |
N |
D(19193793, 15827150) |
N |
D(19193793) |
27486734.0 |
|
Plays a major role in antagonizing the type I
IFN-mediated antiviral response. Acts cooperatively with NS1
to repress activation and nuclear translocation of host
IFN-regulatory factor IRF-3. Interacts with the host
cytoplasmic sensor of viral nucleic acids DDX58/RIG-I and
prevents the interaction with its downstream partner MAVS.
Mediates the proteasomal degradation of host STAT2 with
Elongin-Cullin E3 ligase. Induces activation of NF-kappa-B.
Suppresses premature apoptosis by an NF-kappa-B-dependent,
interferon-independent mechanism and thus facilitates virus
growth. May also inhibit viral transcription and RNA
replication. |
|
240 |
Pneumoviridae |
Human respiratory syncytial virus |
Phosphoprotein |
P, Protein P |
P03421 |
PHOSP_HRSVA |
A0A023R796,A0A023R931,A0A023R9H0,A0A023R9X3,A0A023RAW9,A0A023RB54,A0A059TD78,A0A059TDA9,A0A059TDC0,A0A059TDF6,A0A059TDK1,A0A059TDN4,A0A059TDP5,A0A059TDU4,A0A059TDW6,A0A059TDX7,A0A059TEE1,A0A059TEG5,A0A0A7NRI4,A0A0A7NTQ9,A0A0B5H8J4,A0A0B5HBQ7,A0A0B5HBR0,A0A0B5HBW0,A0A0B5HP07,A0A0B5HPA9,A0A0B5HPC5,A0A0B5HPR7,A0A0K0WTK9,A0A0N7ATJ7,A0A0N7ATT1,A0A0N7ATY2,A0A0N7AUS2,A0A0N7AV14,A0A0N7AZ16,A0A0N7AZE2,A0A0N7AZH2,A0A0N7AZI8,A0A0N7B002,A0A0X8CUQ8,A0A0X8CUV1,A0A0X8CV22,A0A0X8CW06,A0A0X8CX11,A0A0X9WMU9,A0A0X9WYK0,A0A0X9XGP1,A0A0X9XZG1,A0A0X9YMD9,A0A120HQ68,A0A120HQ74,A0A120HQF5,A0A120HQJ1,A0A120HQQ2,A0A140H334,A0A140H3G6,A0A140H3I8,A0A142MLZ0,A0A142MML1,A0A142MMQ9,A0A142MNC8,A0A142MNP1,A0A142MNY4,A0A142MPT4,A0A142MQK9,A0A142MR33,A0A142MRC6,A0A142MT43,A0A142MTU1,A0A1B2VSC7,A0A1B2VSP3,A0A1B2VSX6,A0A1B2VTC9,A0A1B2VTP2,A0A1B2VU10,A0A1B2VUZ0,A0A1C9V167,A0A1C9V175,A0A1C9V195,A0A1C9V1K3,A0A1C9V1M4,A0A1C9V2B2,A0A1C9V2G9,A0A1C9V2R8,A0A1C9V340,A0A1C9V367,A0A1C9V3B2,A0A1C9V3K6,A0A1C9V3Q0,A0A1P8J9Y5,A0A1V0G3P6,A0A1V0G3R8,A0A1V0G425,A0A1W6LX83,A0A1Y0AUC6,A0A1Y0AUD1,A0A1Y0AUU0,A0A1Y0AUW1,A0A1Y0AV62,A0A1Y0AVH6,A0A219V0G5,A0A219V0Y7,A0A219V1D0,A0A219V1P9,A0A240ESU6,A0A240ET35,A0A249Y6F2,A0A249Y6G5,A0A2H4N9D3,A0A2H4WKC9,A0A2H4WKS8,A0A2H4WKT4,A0A2H4WL41,A0A2H4WL85,A0A2H4WLA8,A0A2H4WLL5,A0A2H4WLQ9,A0A2H4WLR2,A0A2H4WLX1,A0A2H5BXX0,A0A2U9NKX0,A0A2Z4Z422,A0A344X9A1,A0A344X9D4,A0A348FV24,A0A384ZCY9,A0A384ZFT9,A0A384ZGS7,A0A384ZGZ3,A0A384ZH06,A0A384ZHN0,A0A384ZHV3,A0A384ZI22,A0A384ZIF5,A0A384ZII8,A0A384ZIU7,A0A385MKH7,A0A385MKI8,A0A385MKL1,A0A385MKU3,A0A385ML22,A0A385ML33,A0A385MLR4,A0A385MLT1,A0A385MM07,A0A385MM18,A0A385MMB4,A0A385MMP1,A0A385MMT6,A0A385MN26,A0A385MN46,A0A385MNI7,A0A385MNN3,A0A385MNW5,A0A385MPH8,A0A385MPW8,A0A3G3NDI3,A0A3G3NE50,A0A3G3NEL4,A0A3G3NFT0,A0A3G3NGN2,A0A3G3NH86,A0A3G3NHD3,A0A3Q8TBM7,G3C7R7,G8EIC5,G8EIJ1,G8EIL3,G8EIM4,G8EIR7,G8EIT9,G8EIV0,G8EIW1,I1V237,I6TFI2,O09633,O09717,O42062,P12579,P14156,P24567,Q04161,Q4KRW8,Q8UYD5,Q8V218,Q8V219,Q8V221,R9TG31,V5N740,V5N775,V5N7N3,V5N7N6,V5N7S5,V5N8A3,W8E4V8,X4Y3M5,X4Y679,X4YAF6,X4YBX5,X4YCE3,X4YCJ5,X4YCP4,X4YCT2,X4YD07,X4YD13,X4YF46,X4YQU8,X4YS93,X4YSD4,X4YSL4 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
D(7491765) |
N |
N |
27486734.0 |
|
Acts as a cofactor that serves both to stabilize the
protein L and to place the polymerase complex on the N:RNA
template. |
|
241 |
Polyomaviridae |
BK polyomavirus |
Agnoprotein |
Agno |
P14998 |
AGNO_POVBA |
A0A0G4CPA0,A0A1Q1MRD3,A0A223ZI77,A0A2H4Z6N5,A1IHW3,A1IHY7,A1IHZ9,A1II17,A1II41,A1II47,A1II83,A7BGR0,A7BH00,A7BH12,B6EXG3,B6VQB6,B9X1T9,B9X1V1,B9X1V7,B9X1W3,Q0PCM8,Q0PCN9,Q0PDF1,Q0PDG9,Q1ESU1,Q1ESU7,Q2PRN3,Q2WG17,Q65614,Q6GWH9,Q6GWN3,Q6GWQ7,Q89856 |
dsDNA |
TR, DR, Rep |
S |
N |
N |
N |
I(11152520) |
I(22840425) |
I(6262654) |
27381292.0 |
|
Alters the structure of the nuclear envelope by
interacting with host CBX5 and disrupting CBX5 association
with LBR. Involved in the perinuclear-nuclear localization of
the capsid protein VP1 during virion assembly and maturation.
Plays an important role in the release of progeny virions
from infected cells and in viral propagation, probably by
acting as a viral ionic channel in the host plasma membrane.
Allows influx of extracellular calcium ions in the host cell.
May contribute to viral genome transcription and translation
of viral late proteins (By similarity). |
|
242 |
Polyomaviridae |
BK polyomavirus |
Large T antigen |
LT, LT-AG |
P03071 |
LT_POVBK |
A0A1Q1MQ55,A0A1V0QSU1,A0A1V0QSU6,A0A2H4Z6M7,A0A2H4Z6P1,A7BGN4,P14999,Q068W4,Q0PCN5,Q0PDA5,Q6GWH5,Q6GWI1,Q6GWI7,Q6GWJ9,Q6GWK5,Q6GWL1,Q6GWL7,Q6GWM3,Q6GWN5,Q6GWQ3,U5NGJ3 |
dsDNA |
TR, Rep |
S |
I(27462916; 15265983; 18642444) |
N |
N |
I(8709258) |
I(22840425) |
I(3003386, 168585, 6251241, 202398) |
27381292.0 |
|
Isoform large T antigen is a key early protein essential
for both driving viral replication and inducing cellular
transformation. Plays a role in viral genome replication by
driving entry of quiescent cells into the cell cycle and by
autoregulating the synthesis of viral early mRNA. Displays
highly oncogenic activities by corrupting the host cellular
checkpoint mechanisms that guard cell division and the
transcription, replication, and repair of DNA. Participates
in the modulation of cellular gene expression preceeding
viral DNA replication. This step involves binding to host key
cell cycle regulators retinoblastoma protein RB1/pRb and
TP53. Induces the disassembly of host E2F1 transcription
factors from RB1, thus promoting transcriptional activation
of E2F1-regulated S-phase genes. Inhibits host TP53 binding
to DNA, abrogating the ability of TP53 to stimulate gene
expression. Plays the role of a TFIID-associated factor (TAF)
in transcription initiation for all three RNA polymerases, by
stabilizing the TBP-TFIIA complex on promoters. Initiates
viral DNA replication and unwinding via interactions with the
viral origin of replication. Binds two adjacent sites in the
SV40 origin. The replication fork movement is facilitated by
Large T antigen helicase activity. Activates the
transcription of viral late mRNA, through host TBP and TFIIA
stabilization. Interferes with histone deacetylation mediated
by HDAC1, leading to activation of transcription (By
similarity). |
|
243 |
Polyomaviridae |
BK polyomavirus |
Small T antigen |
Small t antigen, ST, ST-AG |
P15000 |
ST_POVBA |
A0A023SFN7,A0A2H4Z6N1,A0A2H4Z6P9,B2ZRH5,B2ZRI3,B2ZRI5,B2ZRI7,B2ZRJ1,B2ZRK4,B2ZRK6,B2ZRL0,B2ZRL2,B2ZRL6,B2ZRL8,B2ZRM0,B2ZRM2,B2ZRM6,B2ZRM8,B2ZRN0,B2ZRN5,B2ZRN7,B2ZRN9,B2ZRP1,B2ZRP3,B2ZRP7,B2ZRQ3,Q6GWH4,Q6GWI6,Q6GWJ8,Q6GWL0,Q6GWL6,Q6GWN4,Q6GWQ2 |
indirect/unknown |
TR, Other |
S |
I(19282432) |
N |
N |
I(19282432) |
I(19282432) |
I(17158797) |
27381292.0 |
|
Promotes efficient viral genome replication by
accelerating both G1 and S phase progression of the cell
cycle. Inhibits host PP2A by binding to the A subunit,
thereby displacing lower affinity regulatory B subunit.
Inactivation of PP2A in turn results in the transactivation
of cyclin A and cyclin D1 promoters. Late during the
infection cycle, ST may induce dephosphorylation of host
MTOR, leading to the inhibition of cap-dependent translation.
May establish and maintain high levels of viral genomes
during persistent infection in cell culture. |
|
244 |
Polyomaviridae |
JC polyomavirus |
Agnoprotein |
Agno, Agno protein, Agnogene, Agnoprotein (Fragment),
Agnoprotein (LP1), Truncated agnoprotein |
P03086 |
AGNO_POVJC |
A0A173G677,A0A1E1FFS4,A0A1E1FFT6,A0A286R3X0,A0A286R3Z6,A0A286R3Z8,A0ZST9,C0SQA6,C0SQF4,C0SQH8,C0SQI4,J9XN85,K7QRQ6,K7QSR0,K7QW67,K7R6U0,O42075,O55863,O55870,O55873,O57296,P88896,P90499,Q4LFQ9,Q4LFW9,Q4W708,Q5YKE2,Q5YKE8,Q5YKP1,Q5YL44,Q679M8,Q679N4,Q679P0,Q69C52,Q6EH30,Q768G9,Q768H5,Q768I1,Q783F8,Q7T3Y5,Q7TDV5,Q82946,Q8AZ44,Q8B0K8,Q8BF42,Q8BF48,Q8BF50,Q8JJJ6,Q8JJJ8,Q8JUC0,Q8JUD7,Q8JWJ0,Q8JWJ1,Q8JWJ2,Q8JWJ6,Q8JWJ7,Q8JZI8,Q8JZJ0,Q8JZJ6,Q8JZJ7,Q8JZJ8,Q8JZJ9,Q8V6G0,Q8V6G2,Q8V6G5,Q8V6H5,Q910S4,Q910S7,Q91C18,Q91C19,Q91DE4,Q91DG4,Q91DH1,Q91DH5,Q91NM9,Q91NN5,Q91NN9,Q91NP8,Q91SI4,Q98Y35,Q993Y6,Q9DH65,Q9DPC8,Q9DUG2,Q9Q1G5,Q9Q1G6,W0LSY0,W6MEN0 |
dsDNA |
TR, DR, Rep |
S |
N |
N |
N |
D(11152520) |
D(22840425) |
I(6262654) |
27381292.0 |
|
Alters the structure of the nuclear envelope by
interacting with host CBX5 and disrupting CBX5 association
with LBR. Involved in the perinuclear-nuclear localization of
the capsid protein VP1 during virion assembly and maturation.
Plays an important role in the release of progeny virions
from infected cells and in viral propagation, probably by
acting as a viral ionic channel in the host plasma membrane.
Allows influx of extracellular calcium ions in the host cell.
May contribute to viral genome transcription and translation
of viral late proteins. |
|
245 |
Polyomaviridae |
JC polyomavirus |
Large T antigen |
LT, LT-AG |
P03072 |
LT_POVJC |
A0A0A0RHI4,A0A1E1FFU6,A0A286R3U4,A0A286R403,I0B5Z5,O55871,O55875,P88898,Q0MQN6,Q5YKC6,Q5YKD8,Q5YKL9,Q5YKN1,Q5YKN7,Q679N0,Q679N6,Q69C48,Q69F69,Q6EH26,Q7TDV3,Q7TDV4,Q8JJJ0,Q8JJK3,Q8JUB1,Q8JUB6,Q8JUB9,Q8JUC2,Q8JUC5,Q8JUC9,Q8JUD0,Q8JUD1,Q8JUD5,Q8JUD8,Q8JUE1,Q8JUE2,Q8JWI7,Q8JWJ3,Q8JWJ4,Q8JWJ5,Q8JZJ2,Q8JZK0,Q8V6F7,Q8V6F8,Q8V6G1,Q8V6G3,Q8V6G6,Q8V6G7,Q8V6H1,Q8V6H4,Q910D2,Q91C15,Q91C16,Q91DE5,Q91DE6,Q91DF4,Q91DF5,Q91DF8,Q91DG2,Q91DG3,Q91DH0,Q91DH2,Q91NL2,Q91NL5,Q91NL8,Q91NM2,Q91NM6,Q91NN1,Q91NP7,Q91NP9,Q993Y2,Q993Y4,Q993Y5,Q9DPC0,Q9DPC5,Q9DPC9,Q9DUG5,Q9WM07,Q9WM08,Q9WM10 |
dsDNA |
TR, Rep |
S |
I(27462916; 15265983; 18642444) |
N |
N |
I(8709258) |
D(22840425) |
I(3003386, 168585, 6251241, 202398) |
27381292.0 |
|
Isoform large T antigen is a key early protein essential
for both driving viral replication and inducing cellular
transformation. Plays a role in viral genome replication by
driving entry of quiescent cells into the cell cycle and by
autoregulating the synthesis of viral early mRNA. Displays
highly oncogenic activities by corrupting the host cellular
checkpoint mechanisms that guard cell division and the
transcription, replication, and repair of DNA. Participates
in the modulation of cellular gene expression preceeding
viral DNA replication. This step involves binding to host key
cell cycle regulators retinoblastoma protein RB1/pRb and
TP53. Induces the disassembly of host E2F1 transcription
factors from RB1, thus promoting transcriptional activation
of E2F1-regulated S-phase genes. Inhibits host TP53 binding
to DNA, abrogating the ability of TP53 to stimulate gene
expression. Plays the role of a TFIID-associated factor (TAF)
in transcription initiation for all three RNA polymerases, by
stabilizing the TBP-TFIIA complex on promoters. Initiates
viral DNA replication and unwinding via interactions with the
viral origin of replication. Binds two adjacent sites in the
SV40 origin. The replication fork movement is facilitated by
Large T antigen helicase activity. Activates the
transcription of viral late mRNA, through host TBP and TFIIA
stabilization. Interferes with histone deacetylation mediated
by HDAC1, leading to activation of transcription. |
|
246 |
Polyomaviridae |
JC polyomavirus |
Small T antigen |
Small t antigen, ST, ST-AG |
P03083 |
ST_POVJC |
A0A286R3T1,A0A385NI07,A0A385NI69,O55876,Q69F68,Q8JUB5,Q8JUC1,Q8JUC8,Q8JUD4,Q8V6H0,Q8V6H3,Q910Q3,Q91DE7,Q91DE9,Q91NL4,Q91NL7,Q91NM7,Q91NN0,Q91NP3,Q9DPB9,Q9DPC4 |
indirect/unknown |
TR, Other |
S |
D(19282432) |
N |
N |
D(19282432) |
D(19282432) |
I(17158797) |
27381292.0 |
|
Promotes efficient viral genome replication by
accelerating both G1 and S phase progression of the cell
cycle. Inhibits host PP2A by binding to the A subunit,
thereby displacing lower affinity regulatory B subunit.
Inactivation of PP2A in turn results in the transactivation
of cyclin A and cyclin D1 promoters. Late during the
infection cycle, ST may induce dephosphorylation of host
MTOR, leading to the inhibition of cap-dependent translation.
May establish and maintain high levels of viral genomes
during persistent infection in cell culture. |
|
247 |
Polyomaviridae |
KI polyomavirus |
Large T antigen |
|
A6YGN7 |
A6YGN7_9POLY |
A6YGP2,A6YGP7,B3FQQ5,P0DOI5,P0DOI6 |
dsDNA |
TR, Rep |
S |
I(27462916; 15265983; 18642444) |
N |
N |
I(8709258) |
I(22840425) |
I(3003386, 168585, 6251241, 202398) |
18976572.0 |
A6YGN7 is inferred from JC polyomavirus protein
P03083 |
ATP binding,DNA replication origin binding,hydrolase
activity,DNA replication |
|
248 |
Polyomaviridae |
KI polyomavirus |
Small T antigen |
Small t antigen, ST, ST-AG |
P0DOI9 |
ST_POVK6 |
P0DOJ0 |
indirect/unknown |
TR, Other |
S |
I(19282432) |
N |
N |
I(19282432) |
I(19282432) |
I(17158797) |
18976572.0 |
|
Promotes efficient viral genome replication by
accelerating both G1 and S phase progression of the cell
cycle. Inhibits host PP2A by binding to the A subunit,
thereby displacing lower affinity regulatory B subunit.
Inactivation of PP2A in turn results in the transactivation
of cyclin A and cyclin D1 promoters. Late during the
infection cycle, ST may induce dephosphorylation of host
MTOR, leading to the inhibition of cap-dependent translation.
May establish and maintain high levels of viral genomes
during persistent infection in cell culture. |
|
249 |
Polyomaviridae |
Merkel cell polyomavirus |
Large T antigen |
Large T antigen LT, Large T antigen protein, LT, T
antigen |
B6DVW7 |
B6DVW7_9POLY |
E2IPR7,E2IPR9,E2IPS1,E2IPS3,E2IPS4,E2IPS6,E2IPS7,E2IPS9,E2IPT0,E2IPT2,E2IPT4,K4P1F8,X2G9P4 |
dsDNA |
TR, Rep |
S |
D(28461484) |
N |
N |
D(28461484) |
D(25006834) |
I(3003386, 168585, 6251241, 202398) |
23217622.0 |
|
ATP binding,DNA replication origin binding,hydrolase
activity,DNA replication |
|
250 |
Polyomaviridae |
Merkel cell polyomavirus |
Small T antigen |
ST, STAg |
U6C6B2 |
U6C6B2_9POLY |
A0A2S1LV38,B0G0V7,B6DVX0,B6DVX6,B6DVY4,B8ZX49,B8ZX51,B8ZX57,C6KKZ9,C6KL03,C6KL05,C6KL07,D6QW80,D6QW84,D6QWD2,G8EHJ4,G8FT05,I0ISA5,T2HFI7,T2HFT7,T2HFZ4,U6C643,U6C665,U6C6W7,U6C7Y2,U6C841,U6C845,X2G6N5 |
indirect/unknown |
TR, Other |
S |
I(19282432) |
N |
N |
D(24067965; 24109239) |
I(19282432) |
I(17158797) |
23217622.0 |
|
Not annotated |
|
251 |
Polyomaviridae |
Simian virus 40 |
Large T antigen |
large, LT, LT-AG |
P03070 |
LT_SV40 |
A7XWJ9,A7XWL1,A7XWN5,Q0Z8T6,Q2I7F9,Q6QIR8,Q77PF5,Q8JMI9,Q98ZP7,Q9J7C9,Q9W8G8,Q9WND0 |
dsDNA |
TR, Rep |
S |
D(27462916; 15265983; 18642444) |
N |
1SVM |
D(15265983; 18642444) |
D(14990710; 10438844; 10954561) |
D(3003386, 168585, 6251241, 202398) |
9923853.0 |
|
Isoform large T antigen is a key early protein essential
for both driving viral replication and inducing cellular
transformation. Plays a role in viral genome replication by
driving entry of quiescent cells into the cell cycle and by
autoregulating the synthesis of viral early mRNA. Displays
highly oncogenic activities by corrupting the host cellular
checkpoint mechanisms that guard cell division and the
transcription, replication, and repair of DNA. Participates
in the modulation of cellular gene expression preceeding
viral DNA replication. This step involves binding to host key
cell cycle regulators retinoblastoma protein RB1/pRb and
TP53. Induces the disassembly of host E2F1 transcription
factors from RB1, thus promoting transcriptional activation
of E2F1-regulated S-phase genes. Inhibits host TP53 binding
to DNA, abrogating the ability of TP53 to stimulate gene
expression. Plays the role of a TFIID-associated factor (TAF)
in transcription initiation for all three RNA polymerases, by
stabilizing the TBP-TFIIA complex on promoters. Initiates
viral DNA replication and unwinding via interactions with the
viral origin of replication. Binds two adjacent sites in the
SV40 origin. The replication fork movement is facilitated by
Large T antigen helicase activity. Activates the
transcription of viral late mRNA, through host TBP and TFIIA
stabilization. Interferes with histone deacetylation mediated
by HDAC1, leading to activation of transcription. May
inactivate the growth-suppressing properties of the E3
ubiquitin ligase CUL7. |
|
252 |
Polyomaviridae |
Simian virus 40 |
Small T antigen |
small, Small t antigen, ST, ST-AG |
P03081 |
ST_SV40 |
Q2I7F8,Q77JR6 |
indirect/unknown |
TR, Other |
S |
N |
N |
2PF4 |
D(15684382; 8917510) |
D(8917510) |
D(17158797) |
9923853.0 |
|
Promotes efficient viral genome replication by
accelerating both G1 and S phase progression of the cell
cycle. Inhibits host PP2A by binding to the A subunit,
thereby displacing lower affinity regulatory B subunit.
Inactivation of PP2A in turn results in the transactivation
of cyclin A and cyclin D1 promoters. Late during the
infection cycle, ST may induce dephosphorylation of host
eIF4E-binding protein EIF4EBP1 leading to the inhibition of
cap-dependent translation. May establish and maintain high
levels of viral genomes during persistent infection in cell
culture. |
|
253 |
Polyomaviridae |
WU polyomavirus |
Large T antigen |
LT, LT-AG |
A5HBG1 |
LT_POVWU |
A0A023IX55,A0A0F6PCE1,A0A1Z1RFH7,A0A1Z1RFJ4,A0A1Z1RFK4,A0A1Z1RGY2,A0A2S0DAE5,A0A2S0DAF7,A0A2S0DAG6,A0A2U3T9J1,A0A2U3T9M9,A0A2U3T9Q0,A0A346TQD9,A0A346TQF4,A0A346TQH9,A9YUH2,B3FQR5,B3V7B6,B3V7C1,B3V7C6,C3VQ34,C3VQ36,C3VQ41,C3VQ46,D0F055,D0F075,D0F080,D3XCG4,D3XCH4,D3XCP9,D3XCR4,D3XCT4,D3XCV4,D3XCV9,D3XCY4,D3XD04,D3XD19 |
dsDNA |
TR, Rep |
S |
I(27462916; 15265983; 18642444) |
N |
N |
I(8709258) |
I(22840425) |
I(3003386, 168585, 6251241, 202398) |
21994565.0 |
A5HBG1 is inferred from JC polyomavirus protein
P03083 |
Isoform large T antigen is a key early protein essential
for both driving viral replication and inducing cellular
transformation. Plays a role in viral genome replication by
driving entry of quiescent cells into the cell cycle and by
autoregulating the synthesis of viral early mRNA. Displays
highly oncogenic activities by corrupting the host cellular
checkpoint mechanisms that guard cell division and the
transcription, replication, and repair of DNA. Participates
in the modulation of cellular gene expression preceeding
viral DNA replication. This step involves binding to host key
cell cycle regulators retinoblastoma protein RB1/pRb and
TP53. Induces the disassembly of host E2F1 transcription
factors from RB1, thus promoting transcriptional activation
of E2F1-regulated S-phase genes. Inhibits host TP53 binding
to DNA, abrogating the ability of TP53 to stimulate gene
expression. Plays the role of a TFIID-associated factor (TAF)
in transcription initiation for all three RNA polymerases, by
stabilizing the TBP-TFIIA complex on promoters. Initiates
viral DNA replication and unwinding via interactions with the
viral origin of replication. Binds two adjacent sites in the
SV40 origin. The replication fork movement is facilitated by
Large T antigen helicase activity. Activates the
transcription of viral late mRNA, through host TBP and TFIIA
stabilization. Interferes with histone deacetylation mediated
by HDAC1, leading to activation of transcription. |
|
254 |
Polyomaviridae |
WU polyomavirus |
Small T antigen |
Small t antigen, ST, ST-AG |
A5HBD7 |
ST_POVWU |
A0A023IWX3,A0A0F6PCF2,A0A2U3T9P7,A0A2U3T9T2,A0A346TQI0,A9YUH3,B3V7B7,B3V7C2,B3V7C7,B9VQY3,B9VQY4,C3VQ42,C3VQ47,D0F056,D0F066,D3XCF0,D3XCH0,D3XCL0,D3XCV5,D3XD10,E2FKL4,E2FKL5,E2FKL6,E2FKL7,E2FKL8,E2FKL9,E2FKM0 |
indirect/unknown |
TR, Other |
S |
I(19282432) |
N |
N |
I(19282432) |
I(19282432) |
I(17158797) |
21994565.0 |
|
Promotes efficient viral genome replication by
accelerating both G1 and S phase progression of the cell
cycle. Inhibits host PP2A by binding to the A subunit,
thereby displacing lower affinity regulatory B subunit.
Inactivation of PP2A in turn results in the transactivation
of cyclin A and cyclin D1 promoters. Late during the
infection cycle, ST may induce dephosphorylation of host
MTOR, leading to the inhibition of cap-dependent translation.
May establish and maintain high levels of viral genomes
during persistent infection in cell culture. |
|
255 |
Poxviridae |
Bovine papular stomatitis virus |
NPH-1 |
BVTX09c1_072, Transcription termination factor NPH-I |
Q6TVB6 |
Q6TVB6_9POXV |
A0A0E3XAG7 |
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
I(9472022) |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
22362531.0 |
Inferred from Vaccinia virus NPH-1. Involved in
transcription termination (27189950) |
ATP binding,nucleoside-triphosphatase
activity,transcription, DNA-templated |
|
256 |
Poxviridae |
Bovine papular stomatitis virus |
NPH-II |
BVTX09c1_036, ORF036 RNA helicase NPH-II, RNA helicase
NPH-II |
Q6TVF2 |
Q6TVF2_9POXV |
A0A0E3T6Y5 |
ssDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
I(8505308) |
I(20110368, 2839505, 4364422) |
22362531.0 |
|
helicase activity |
|
257 |
Poxviridae |
Bovine papular stomatitis virus |
ORF083 |
BVTX09c1_083, Early transcription factor VETFL, ORF083
early transcription factor VETFL |
Q6TVA5 |
Q6TVA5_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
22362531.0 |
|
positive regulation of transcription, DNA-templated |
|
258 |
Poxviridae |
Bovine papular stomatitis virus |
ORF084 |
BVTX09c1_084, BVTX09c15_084, BVTX09c5_084, Intermediate
transcription factor VITF-3, ORF084 intermediate
transcription factor VITF-3 |
Q6TVA4 |
Q6TVA4_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
22362531.0 |
|
Not annotated |
|
259 |
Poxviridae |
Bovine papular stomatitis virus |
Phosphoprotein |
BVTX09c1_032, DNA-binding phosphoprotein, ORF032
DNA-binding phosphoprotein, Putative DNA binding
phosphoprotein |
V5LTE9 |
V5LTE9_9POXV |
A0A0E3XBH8,Q6TVF6,V5LUD0 |
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
22362531.0 |
V5LTE9 is inferred from Orf virus protein Q6TVT8. Ligand
is based on prediction domains. |
single-stranded DNA binding |
|
260 |
Poxviridae |
Bovine papular stomatitis virus |
RAP94 |
BVTX09c15_060, ORF060 RNA polymerase-associated protein
RAP94, RNA polymerase-associated protein RAP94 |
Q6TVC8 |
Q6TVC8_9POXV |
A0A0E3XBV7 |
ssRNA |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
22362531.0 |
Q6TVC8 is inferred from Molluscum contagiosum virus
protein Q98252 |
DNA-binding transcription factor activity |
|
261 |
Poxviridae |
Bovine papular stomatitis virus |
VETFs |
BVTX09c15_069, ORF069 early transcription factor
VETFs |
Q6TVB9 |
Q6TVB9_9POXV |
A0A0E3XAS4 |
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
22362531.0 |
|
integral component of membrane |
|
262 |
Poxviridae |
Bovine papular stomatitis virus |
VITF-3 |
BVTX09c1_100, Intermediate transcription factor VITF-3,
ORF100 intermediate transcription factor VITF-3 |
Q6TV88 |
Q6TV88_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
22362531.0 |
|
Not annotated |
|
263 |
Poxviridae |
Bovine papular stomatitis virus |
VLTF-1 |
BVTX09c15_045, Late transcription factor VLTF-1, ORF045
late transcription factor VLTF-1 |
Q6TVE3 |
Q6TVE3_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
22362531.0 |
|
regulation of transcription, DNA-templated |
|
264 |
Poxviridae |
Bovine papular stomatitis virus |
VLTF-2 |
BVTX09c1_076, BVTX09c15_076, BVTX09c5_076, Late
transcription factor VLTF-2, ORF076 late transcription factor
VLTF-2 |
Q6TVB2 |
Q6TVB2_9POXV |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
22362531.0 |
|
zinc ion binding |
|
265 |
Poxviridae |
Bovine papular stomatitis virus |
VLTF-3 |
BVTX09c1_077, BVTX09c15_077, BVTX09c5_077, Late
transcription factor VLTF-3, ORF077 late transcription factor
VLTF-3 |
Q6TVB1 |
Q6TVB1_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
22362531.0 |
|
regulation of viral transcription |
|
266 |
Poxviridae |
Bovine papular stomatitis virus |
VLTF-4 |
BVTX09c15_061, ORF061 late transcription factor
VLTF-4 |
Q6TVC7 |
Q6TVC7_9POXV |
A0A0E3XAB9 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(8794318, Transcription Assay) |
22362531.0 |
|
viral envelope |
|
267 |
Poxviridae |
Bovine papular stomatitis virus |
VP8 |
DNA-binding virion core protein VP8, ORF050 DNA-binding
virion core protein VP8 |
Q6TVD8 |
Q6TVD8_9POXV |
A0A0E3XAB6 |
dsDNA, ssDNA, ssRNA, dsRNA |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
22362531.0 |
Q6TVD8 is inferred from Orf virus protein Q6TVS0 |
DNA binding,structural molecule activity,viral
capsid |
|
268 |
Poxviridae |
Cowpox virus |
ATPase |
CPXV128, CPXV128 protein, CPXV_GER91_3_120,
CPXV_UK2000_K2984_121, E11L, Nucleoside triphosphate
phosphohydrolase-I |
Q0NPW0 |
Q0NPW0_COWPX |
A0A1X9T706,A0A212PN19,A0A212PXC4,A0A212Q0S7,A0A212QBP3,A0A212QF28,A0A290GQC0,A0A2R8F699,A0A2R8F8J3,G0XSL1,G0XX58,G0XXS0,Q80DX1,Q8QMV1,U5TA95,U5TH94,U5TL23 |
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
N |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
Fields Virology |
Q0NPW0 is inferred from Bovine papular stomatitis virus
protein Q6TVB6. Involved in transcription termination
(27189950). |
ATP binding,nucleoside-triphosphatase
activity,transcription, DNA-templated |
|
269 |
Poxviridae |
Cowpox virus |
CPXV082 |
CPXV082 CDS, CPXV082 protein, CPXV_FIN2000_MAN_077,
CPXV_GER1990_2_077, CPXV_GER1998_2_077, L3L, SsDNA-binding
phosphoprotein |
Q8QMY7 |
Q8QMY7_COWPX |
A0A1B5FLL2,A0A1X9T8A7,A0A1X9T9H7,A0A212PNL9,A0A212PWW6,A0A212Q1T2,A0A212Q3S3,A0A212QAR0,A0A290G6V1,A0A2R8F5R8,A0A3Q9TCS7,G0XSG7,G0XTD2,G0XTZ5,G0XUL0,G0XV73,G0XVT9,G0XWF3,G0XX14,G0XXM6,Q0NQ03,Q76QK8,U5T9P9,U5TAE0,U5TB25 |
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
Fields Virology |
Q8QMY7 is inferred from Orf virus protein Q6TVT8 |
single-stranded DNA binding |
|
270 |
Poxviridae |
Cowpox virus |
CPXV156 |
CPXV156 protein, VITF3L |
Q8QMT0 |
Q8QMT0_COWPX |
A0A0K2YY52,A0A1X9T7M3,A0A212PR33,G0XUT1,G0XWM4 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
Fields Virology |
|
Not annotated |
|
271 |
Poxviridae |
Cowpox virus |
NPH-II |
CPXV_FRA2001_NANCY_082, DExH-NPH-II, L8R,
RNA-helicase |
G0XU00 |
G0XU00_COWPX |
A0A1S5WL07,G0XSH2,G0XTD7,G0XV78,G0XVU4,G0XWF8,G0XX19,G0XXN1,Q0NPZ8 |
ssDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
I(8505308) |
I(20110368, 2839505, 4364422) |
Fields Virology |
|
ATP binding,helicase activity,nucleic acid binding |
|
272 |
Poxviridae |
Cowpox virus |
RAP94 |
CPXV113, CPXV113 protein, CPXV_GER1990_2_107,
CPXV_GER91_3_106, CPXV_NOR1994_MAN_107, J4L protein, RNA
polymerase subunit RAP94 |
Q0NPX4 |
Q0NPX4_COWPX |
A0A1B5FLM3,A0A1S5WL33,A0A1V0FXA5,A0A1X9T7J1,A0A1X9TAC4,A0A1X9TB56,A0A212PQT9,A0A212PTE6,A0A212PU56,A0A212PWW4,A0A212Q3P6,A0A290G4Y9,A0A290G7N2,G0XSJ7,G0XTG2,G0XU25,G0XUP0,G0XVW9,G0XWI3,G0XXQ6,Q80DY0,Q8QMW3,U5TA80,U5TDQ9,U5TK54,U5TPC8 |
ssRNA |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
Fields Virology |
Q0NPX4 is inferred from Molluscum contagiosum virus
protein Q98252 |
DNA-binding transcription factor activity |
|
273 |
Poxviridae |
Cowpox virus |
VETFL |
82kDa large subunit of early gene transcription factor
VETF, A8L, A8L protein, CPX139, CPXV139, CPXV139 protein,
CPXV_GER91_3_130, CPXV_NOR1994_MAN_131, Early gene
transcription factor VETF 82 kDa large subunit, Early gene
transcription factor VETF 82kDa large subunit |
Q0NPV0 |
Q0NPV0_COWPX |
A0A1X9T7I9,A0A212PNT3,A0A212PPV0,A0A212Q0X2,A0A212Q246,A0A212Q430,A0A290GA76,A0A290GLX5,A0A2R8F5T9,A0A3Q9TBA2,G0XSM1,G0XU49,G0XUR4,G0XVC7,G0XVZ3,G0XWK7,G0XX68,Q80DW4,Q8QMU3,U5TA85,U5TD88,U5TG43,U5TGS1 |
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
Fields Virology |
Q0NPV0 is inferred from Bovine papular stomatitis virus
protein Q6TVA5 |
positive regulation of transcription, DNA-templated |
|
274 |
Poxviridae |
Cowpox virus |
VETFs |
70 kDa VETF transcription factor small subunit, 70kDa
small subunit of early transcription initiation factor VETF,
CPXV123, CPXV123 protein, CPXV_FIN2000_MAN_116, E6R, E6R
protein, Early gene transcription factor VETF 70 kDa small
subunit, Early gene transcription factor VETF 70kDa small
subunit |
Q76QJ5 |
Q76QJ5_COWPX |
A0A212PQ86,A0A212Q0R7,A0A212Q433,A0A2R8F8M7,G0XSK6,G0XU34,G0XVB2,G0XVX8,G0XWJ2,Q0NPW5,Q8QMV4,U5T9K9,U5TAT0,U5TC84 |
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
Fields Virology |
Q76QJ5 is inferred from Bovine papular stomatitis virus
protein Q6TVB9 |
ATP binding,DNA binding,hydrolase activity,integral
component of membrane |
|
275 |
Poxviridae |
Cowpox virus |
VITF-3 |
32 kDa small subunit of transcription factor VITF-3, A9R,
A9R protein, CPXV140 protein, Transcription factor VITF-3 32
kDa small subunit |
A0A0K2YTA9 |
A0A0K2YTA9_COWPX |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
Fields Virology |
|
Not annotated |
|
276 |
Poxviridae |
Cowpox virus |
VLTF-1 |
CPXV097 protein, H9R, Late gene transcription factor
VLTF-1 protein |
Q76QK3 |
Q76QK3_COWPX |
G0XUM4 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
Fields Virology |
Q76QK3 is inferred from Orf virus protein Q6TVS5 |
regulation of transcription, DNA-templated,integral
component of membrane |
|
277 |
Poxviridae |
Cowpox virus |
VLTF-2 |
A1L protein, CPXV132, CPXV132 protein, Late gene
transcription factor VLTF-2 protein |
Q0NPV7 |
Q0NPV7_COWPX |
G0XTH9,G0XVY6,G0XWK0,Q80DW9 |
dsDNA |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
Fields Virology |
Q0NPV7 is inferred from Molluscum contagiosum virus
protein Q98270 |
zinc ion binding |
|
278 |
Poxviridae |
Cowpox virus |
VLTF-3 |
A2L protein, CPXV133, CPXV133 protein, Late gene
transcription factor VLTF-3 protein |
Q76QJ1 |
Q76QJ1_COWPX |
Q8QMU8 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
Fields Virology |
Q76QJ1 is inferred from Molluscum contagiosum virus
protein Q98271 |
regulation of viral transcription |
|
279 |
Poxviridae |
Cowpox virus |
VLTF-4 |
CPXV114, CPXV114 protein, CPXV_GER91_3_107, J5R, J5R
protein, Morphogenesis-related substrate of B1R kinase,
Substrate of B1R kinase, VLTF-4 viral late transcription
factor |
Q0NPX3 |
Q0NPX3_COWPX |
A0A1B5FLM5,A0A1S5WL30,A0A1X9T7T5,A0A1X9T8H8,A0A212PNP9,A0A212PQU1,A0A212Q403,A0A212QEI9,A0A212RA96,G0XSJ8,G0XTG3,G0XU26,G0XUP1,G0XVA4,G0XVX0,G0XWI4,G0XX45,G0XXQ7,Q80DX9,Q8QMW2,U5TDR6,U5TJX5,U5TK75 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(8794318, Transcription Assay) |
Fields Virology |
Q0NPX3 is inferred from Vaccinia virus protein
Q76RC5 |
viral envelope |
|
280 |
Poxviridae |
Cowpox virus |
VP8 |
Core protein vp8, CPXV102, CPXV102 protein,
CPXV_GER1980_EP4_096 |
G0XUM9 |
G0XUM9_COWPX |
G0XVV8,G0XX33,Q8QMX2 |
dsDNA, ssDNA, ssRNA, dsRNA |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
Fields Virology |
G0XUM9 is inferred from Orf virus protein Q6TVS0 |
structural molecule activity,viral capsid |
|
281 |
Poxviridae |
Molluscum contagiosum virus |
MC046L |
MC046 |
Q98214 |
Q98214_MCV1 |
A0A3Q9NMU6 |
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
24558417.0 |
Q98214 is inferred from Orf virus protein Q6TVT8 |
single-stranded DNA binding |
|
282 |
Poxviridae |
Molluscum contagiosum virus |
MC067R |
|
Q98235 |
Q98235_MCV1 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
24558417.0 |
Q98235 is inferred from Orf virus protein Q6TVS5 |
regulation of transcription, DNA-templated |
|
283 |
Poxviridae |
Molluscum contagiosum virus |
MC073R |
CX4 protein |
Q98241 |
Q98241_MCV1 |
|
indirect/unknown |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
24558417.0 |
Q98241 is inferred from Orf virus protein Q6TVS0 |
structural molecule activity,viral capsid |
|
284 |
Poxviridae |
Molluscum contagiosum virus |
MC085L |
MC085 |
Q98252 |
Q98252_MCV1 |
A0A3Q9NM16 |
ssRNA |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
24558417.0 |
Has a RAP94 domain |
DNA-binding transcription factor activity |
|
285 |
Poxviridae |
Molluscum contagiosum virus |
MC103L |
MC103 |
Q98270 |
Q98270_MCV1 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
24558417.0 |
Has a VLTF2 domain |
zinc ion binding |
|
286 |
Poxviridae |
Molluscum contagiosum virus |
MC104L |
MC104 |
Q98271 |
Q98271_MCV1 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
24558417.0 |
Has a VLTF3 domain |
regulation of viral transcription |
|
287 |
Poxviridae |
Molluscum contagiosum virus |
MC111R |
MC111 |
Q98278 |
Q98278_MCV1 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
24558417.0 |
Q98278 is inferred from Cowpox virus protein
A0A0K2YTA9 |
Not annotated |
|
288 |
Poxviridae |
Molluscum contagiosum virus |
MC128R |
MC128 |
Q98295 |
Q98295_MCV1 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
24558417.0 |
Q98295 is inferred from Bovine papular stomatitis virus
protein Q6TV88 |
Not annotated |
|
289 |
Poxviridae |
Molluscum contagiosum virus |
NPH-1 |
NPH1, Nucleoside triphosphatase I, Nucleoside
triphosphate phosphohydrolase I |
Q98267 |
NTP1_MCV1 |
|
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
I(9472022) |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
24558417.0 |
Q98267 is inferred from Bovine papular stomatitis virus
protein Q6TVB6. Involved in transcription termination
(27189950). |
DNA-dependent ATPase required for providing the needed
energy to achieve the termination of early transcripts. Acts
in concert with the RAP94 subunit of the virion RNA
polymerase and the capping enzyme/VTF to catalyze release of
UUUUUNU-containing nascent RNA from the elongation complex.
NPH-I must bind ssDNA in order to exhibit ATPase activity (By
similarity). |
|
290 |
Poxviridae |
Molluscum contagiosum virus |
NPH-II |
NPH2, NTPase II, Nucleoside triphosphatase II, RNA
helicase NPH-II |
Q98218 |
NPH2_MCV1 |
|
ssDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
I(8505308) |
I(20110368, 2839505, 4364422) |
24558417.0 |
|
NTP-dependent helicase that catalyzes unidirectional
unwinding of 3'tailed duplex RNAs and plays an important role
during transcription of early mRNAs, presumably by preventing
R-loop formation behind the elongating RNA polymerase. Might
also play a role in the export of newly synthesized mRNA
chains out of the core into the cytoplasm. Required for
replication and propagation of viral particles (By
similarity). |
|
291 |
Poxviridae |
Molluscum contagiosum virus |
VETFL |
Early transcription factor 82 kDa subunit, ETF large
subunit, MC110L |
Q98277 |
ETF2_MCV1 |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
24558417.0 |
|
Acts with RNA polymerase to initiate transcription from
early gene promoters. Is recruited by the RPO-associated
protein of 94 kDa (RAP94) to form the early transcription
complex, which also contains the core RNA polymerase. ETF
heterodimer binds to early gene promoters (By
similarity). |
|
292 |
Poxviridae |
Molluscum contagiosum virus |
VETFs |
ATP-dependent helicase VETFS, Early transcription factor
70 kDa subunit, Early transcription factor 70 kDa subunit ,
ETF small subunit, MC095R |
Q98262 |
ETF1_MCV1 |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
24558417.0 |
|
Acts with RNA polymerase to initiate transcription from
early gene promoters. Is recruited by the RPO-associated
protein of 94 kDa (RAP94) to form the early transcription
complex, which also contains the core RNA polymerase. ETF
heterodimer binds to early gene promoters (By
similarity). |
|
293 |
Poxviridae |
Monkeypox virus |
A9R |
32 kDa small subunit of transcription factor VITF-3,
32kDa small subunit of transcription factor VITF-3 used for
intermediate gene expression, Transcription factor VITF-3 32
kDa small subunit, VITF-3 34kDa subunit |
Q3I8P5 |
Q3I8P5_MONPV |
F1DJH2,Q3I7J8,Q5IXQ6,Q8V4W7,V9NQ18 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
29927927.0 |
|
|
|
294 |
Poxviridae |
Monkeypox virus |
E11L |
ATPase, Bifunctional ATPase/nucleoside triphosphate
phosphohydrolase-I, NPH1 |
Q3I8Q6 |
Q3I8Q6_MONPV |
A0A0F6N8U0,Q5IXR7 |
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
N |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
29927927.0 |
Q3I8Q6 is inferred from Bovine papular stomatitis virus
protein Q6TVB6. Involved in transcription termination
(27189950). |
ATP binding,nucleoside-triphosphatase
activity,transcription, DNA-templated |
|
295 |
Poxviridae |
Monkeypox virus |
I3L |
DNA-binding phosphoprotein, SsDNA-binding
phosphoprotein |
Q8V516 |
Q8V516_MONPV |
F1DJB7,Q3I8V0,Q5IXW1 |
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
29927927.0 |
Q8V516 is inferred from Orf virus protein Q6TVT8 |
single-stranded DNA binding |
|
296 |
Poxviridae |
Monkeypox virus |
I8R |
Bifunctional DNA-RNA-helicase-DExH-NPH-II, DExH-NPH-II,
RNA helicase NPH-II, RNA-helicase |
Q3I8U5 |
Q3I8U5_MONPV |
Q8V511 |
dsDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
I(8505308) |
I(20110368) |
29927927.0 |
|
helicase activity |
|
297 |
Poxviridae |
Monkeypox virus |
RAP94 |
H4L, MPXV-COP-088, MPXV_USA2003_039_099 |
Q3I8S0 |
Q3I8S0_MONPV |
Q3I7M3,Q5IXT1,Q8V4Z1 |
ssRNA |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
29927927.0 |
Q3I8S0 is inferred from Molluscum contagiosum virus
protein Q98252 |
DNA-binding transcription factor activity |
|
298 |
Poxviridae |
Monkeypox virus |
VETFL |
82 kDa large subunit of early gene transcription factor
VETF, A8L, Early gene transcription factor VETF 82 kDa large
subunit, VETF-L (Early transcription factor large) |
Q3I8P6 |
Q3I8P6_MONPV |
Q5IXQ7,Q8V4W8 |
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
29927927.0 |
Q3I8P6 is inferred from Bovine papular stomatitis virus
protein Q6TVA5 |
positive regulation of transcription, DNA-templated |
|
299 |
Poxviridae |
Monkeypox virus |
VETFs |
70 kDa small subunit of early gene transcription factor
VETF, E6R, Morphogenesis, MPXV-COP-097, MPXV-SL-097,
MPXV-WRAIR097, VETF2, VETF-s (Early transcription factor
small) |
Q5IXS2 |
Q5IXS2_MONPV |
F1DIW0,Q3I8R1 |
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
29927927.0 |
Q5IXS2 is inferred from Bovine papular stomatitis virus
protein Q6TVB9 |
ATP binding,DNA binding,hydrolase activity,integral
component of membrane |
|
300 |
Poxviridae |
Monkeypox virus |
VITF3L |
A24R, Intermediate transcription factor 3 large subunit,
VITF-3 45 kDa subunit |
Q8V4V4 |
VTF3L_MONPV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
29927927.0 |
|
Acts with RNA polymerase to initiate transcription from
intermediate gene promoters. |
|
301 |
Poxviridae |
Monkeypox virus |
VLTF-1 |
G9R, Late gene transcription VLTF-1, Late transcription
factor VLTF-1, MPXV-COP-072, MPXV-SL-072, MPXV-WRAIR072 |
Q5IXU7 |
Q5IXU7_MONPV |
F1DJD1,Q77HN3 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
29927927.0 |
Q5IXU7 is inferred from Orf virus protein Q6TVS5 |
regulation of transcription, DNA-templated,integral
component of membrane |
|
302 |
Poxviridae |
Monkeypox virus |
VLTF-2 |
A1L, Late gene transcription factor VLTF-2, Late
transcription factor VLTF-2, MPXV-COP-105, MPXV-SL-105,
MPXV-WRAIR105, Viral late gene transcription factor 2 |
Q5IXR4 |
Q5IXR4_MONPV |
Q77HM9 |
dsDNA |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
29927927.0 |
Q5IXR4 is inferred from Molluscum contagiosum virus
protein Q98270 |
zinc ion binding |
|
303 |
Poxviridae |
Monkeypox virus |
VLTF-3 |
A2L, Late gene transcription factor VLTF-3, Late
transcription factor VLTF-3, MPXV-COP-106, MPXV-SL-106,
MPXV-WRAIR106, Viral late gene transcription factor 3 |
Q5IXR3 |
Q5IXR3_MONPV |
Q3I8Q2,Q8V4X4 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
29927927.0 |
Q5IXR3 is inferred from Molluscum contagiosum virus
protein Q98271 |
regulation of viral transcription |
|
304 |
Poxviridae |
Monkeypox virus |
VLTF-4 |
H5R, Late gene transcription factor VLTF-4, Late
transcription factor VLTF-4, MPXV-COP-089, MPXV-SL-089,
MPXV-WRAIR089 |
Q5IXT0 |
Q5IXT0_MONPV |
F1DIV2,F1DJE8,Q3I8R9 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(8794318, Transcription Assay) |
29927927.0 |
Q5IXT0 is inferred from Vaccinia virus protein
Q76RC5 |
viral envelope |
|
305 |
Poxviridae |
Monkeypox virus |
VP8 |
Core protein vp8, DNA-binding virion core protein, L4R,
M4R, MPXV-COP-077, MPXV-SL-077, MPXV-WRAIR077 |
Q5IXU2 |
Q5IXU2_MONPV |
Q8V4Z9 |
dsDNA, ssDNA, ssRNA, dsRNA |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
29927927.0 |
Q5IXU2 is inferred from Orf virus protein Q6TVS0 |
DNA binding,structural molecule activity,viral
capsid |
|
306 |
Poxviridae |
Orf virus |
NPH-1 |
ORF072 transcription termination factor NPH-I, ORFV072,
PP62, Transcription termination factor NPH-I |
Q6TVP8 |
Q6TVP8_ORFSA |
A0A0R8HW06,A0A0R8IAB0,F1AX80,Q2F8A3,W5U9E8 |
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
I(9472022) |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
25807056.0 |
Q6TVP8 is inferred from Bovine papular stomatitis virus
protein Q6TVB6. Involved in transcription termination
(27189950). |
ATP binding,nucleoside-triphosphatase
activity,transcription, DNA-templated |
|
307 |
Poxviridae |
Orf virus |
ORF038 |
G2R-like protein, Late transcription elongation factor,
ORF038 late transcription elongation factor, ORFV038,
PP176 |
Q6TVT1 |
Q6TVT1_ORFSA |
A0A0R8IE54,F1AX11,Q2F8D6,Q80B06,W5U438 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
N |
25807056.0 |
Q6TVT1 is inferred from Bovine papular stomatitis virus
protein Q6TVE9 |
translation elongation factor activity |
|
308 |
Poxviridae |
Orf virus |
ORF100 |
ORF100 intermediate transcription factor VITF-3 |
Q6TVM0 |
Q6TVM0_ORFSA |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
25807056.0 |
|
Not annotated |
|
309 |
Poxviridae |
Orf virus |
ORFV036 |
RNA helicase NPH-II |
A0A0R8I9X5 |
A0A0R8I9X5_ORFV |
A0A0F6N1X0,A0A0R8I802,Q6TVT4,Q6TW64 |
dsDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
I(8505308) |
I(20110368) |
25807056.0 |
|
helicase activity |
|
310 |
Poxviridae |
Orf virus |
Phosphoprotein |
ORF032, ORF032 DNA-binding phosphoprotein |
Q6TVT8 |
Q6TVT8_ORFSA |
Q6TW68 |
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
25807056.0 |
Ligand is based on predicted domains |
single-stranded DNA binding |
|
311 |
Poxviridae |
Orf virus |
RAP94 |
F2L, ORF060 RNA polymerase-associated protein RAP94,
ORFV060, PP81, PP82, RNA polymerase-associated protein RAP94,
RNA-polymerase associated protein RAP94 |
Q6TVR0 |
Q6TVR0_ORFSA |
A0A0R8HSC6,A0A0R8HVU7,A0A0R8HW49,A0A0R8I9E8,F1AX49,F1AX50,Q86619,W5U3P9 |
ssRNA |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
25807056.0 |
Q6TVR0 is inferred from Molluscum contagiosum virus
protein Q98252 |
DNA-binding transcription factor activity |
|
312 |
Poxviridae |
Orf virus |
VETFL |
Early transcription factor, Early transcription factor
VETFL, ORF083 early transcription factor VETFL, ORFV083,
PP53 |
Q6TVN7 |
Q6TVN7_ORFSA |
A0A0R8HJ22,A0A0R8I2G6,F1AXA1,Q2F892,Q6TW17,W5U3D9 |
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
25807056.0 |
Q6TVN7 is inferred from Bovine papular stomatitis virus
protein Q6TVA5 |
positive regulation of transcription, DNA-templated |
|
313 |
Poxviridae |
Orf virus |
VETFs |
Early transcription factor, Early transcription factor
VETFs, ORF069 early transcription factor VETFs, ORFV069,
PP213 |
Q6TVQ1 |
Q6TVQ1_ORFSA |
A0A0F6N1P6,A0A0R8HK40,A0A0R8HYN4,F1AX73,Q2F8A6,Q6TW31,W5U458 |
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
25807056.0 |
Q6TVQ1 is inferred from Bovine papular stomatitis virus
protein Q6TVB9 |
integral component of membrane |
|
314 |
Poxviridae |
Orf virus |
VITF-3 |
ORF084, ORF084 intermediate transcription factor VITF-3,
ORFV084 |
Q6TVN6 |
Q6TVN6_ORFSA |
A0A0F6N1Q9,A0A0R8IA15 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
25807056.0 |
|
Not annotated |
|
315 |
Poxviridae |
Orf virus |
VLTF-1 |
ORF045, ORF045 late transcription factor VLTF-1 |
Q6TVS5 |
Q6TVS5_ORFSA |
A0A0F6N1V9 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
25807056.0 |
|
regulation of transcription, DNA-templated |
|
316 |
Poxviridae |
Orf virus |
VLTF-2 |
ORF076, ORF076 late transcription factor VLTF-2 |
Q6TVP4 |
Q6TVP4_ORFSA |
Q6TW24 |
dsDNA |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
25807056.0 |
|
zinc ion binding |
|
317 |
Poxviridae |
Orf virus |
VLTF-3 |
Late transcription factor VLTF3, Late transcription
factor VLTF-3, ORF077 late transcription factor VLTF-3,
ORFV077, PP57 |
Q6TVP3 |
Q6TVP3_ORFSA |
A0A0R8I8Z6,F1AX92,Q6TW23 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
25807056.0 |
Q6TVP3 is inferred from Molluscum contagiosum virus
protein Q98271 |
regulation of viral transcription |
|
318 |
Poxviridae |
Orf virus |
VLTF-4 |
ORF061, ORF061 late transcription factor VLTF-4 |
Q6TVQ9 |
Q6TVQ9_ORFSA |
Q6TW39,W5U383 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(8794318, Transcription Assay) |
25807056.0 |
|
viral envelope |
|
319 |
Poxviridae |
Orf virus |
VP8 |
ORF050, ORF050 DNA-binding virion core protein VP8,
ORF050/VP8 |
Q6TVS0 |
Q6TVS0_ORFSA |
A0A0R8HUZ3,A0A0R8I369,A0A0R8I3R6,Q6TW50,W5U3P1 |
dsDNA, ssDNA, ssRNA, dsRNA |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
25807056.0 |
|
DNA binding,structural molecule activity,viral
capsid |
|
320 |
Poxviridae |
Pseudocowpox virus |
Early transcription factor |
|
D3IZN1 |
D3IZN1_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
25674608.0 |
|
positive regulation of transcription, DNA-templated |
|
321 |
Poxviridae |
Pseudocowpox virus |
Intermediate transcription factor |
|
D3IZN2 |
D3IZN2_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
25674608.0 |
|
Not annotated |
|
322 |
Poxviridae |
Pseudocowpox virus |
Late transcription elongation factor |
|
D3IZI6 |
D3IZI6_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
N |
25674608.0 |
|
translation elongation factor activity |
|
323 |
Poxviridae |
Pseudocowpox virus |
NPH-1 |
|
D3IZL9 |
D3IZL9_9POXV |
|
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
I(9472022) |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
25674608.0 |
D3IZL9 is inferred from Bovine papular stomatitis virus
protein Q6TVB6. Involved in transcription termination
(27189950). |
ATP binding,nucleoside-triphosphatase
activity,transcription, DNA-templated |
|
324 |
Poxviridae |
Pseudocowpox virus |
NPH-II |
RNA helicase NPH-II |
D3IZI3 |
D3IZI3_9POXV |
D3IZ52 |
ssDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
I(8505308) |
I(20110368, 2839505, 4364422) |
25674608.0 |
|
helicase activity |
|
325 |
Poxviridae |
Pseudocowpox virus |
Phosphoprotein |
DNA-binding phosphoprotein, Putative DNA binding
phosphoprotein |
D3IZH9 |
D3IZH9_9POXV |
V5LTE8,V5LUD5,V5LVH9 |
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
25674608.0 |
D3IZH9 is inferred from Orf virus protein Q6TVT8. Ligand
is based on predicted domains. |
single-stranded DNA binding |
|
326 |
Poxviridae |
Pseudocowpox virus |
RAP94 |
RNA-polymerase associated RAP94 |
D3IZK7 |
D3IZK7_9POXV |
|
ssRNA |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
25674608.0 |
D3IZK7 is inferred from Molluscum contagiosum virus
protein Q98252 |
DNA-binding transcription factor activity |
|
327 |
Poxviridae |
Pseudocowpox virus |
VETFs |
Early transcription factor |
D3IZL6 |
D3IZL6_9POXV |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
25674608.0 |
|
integral component of membrane |
|
328 |
Poxviridae |
Pseudocowpox virus |
Virion core protein |
|
D3IZJ7 |
D3IZJ7_9POXV |
|
dsDNA, ssDNA, ssRNA, dsRNA |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
25674608.0 |
D3IZJ7 is inferred from Orf virus protein Q6TVS0 |
structural molecule activity,viral capsid |
|
329 |
Poxviridae |
Pseudocowpox virus |
VITF-3 |
Intermediate transcription factor VITF3 |
D3IZP8 |
D3IZP8_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
25674608.0 |
|
Not annotated |
|
330 |
Poxviridae |
Pseudocowpox virus |
VLTF-1 |
Late transcription factor |
D3IZJ2 |
D3IZJ2_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
25674608.0 |
|
regulation of transcription, DNA-templated |
|
331 |
Poxviridae |
Pseudocowpox virus |
VLTF-2 |
Late transcription factor VLTF2 |
D3IZM4 |
D3IZM4_9POXV |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
25674608.0 |
|
zinc ion binding |
|
332 |
Poxviridae |
Pseudocowpox virus |
VLTF-3 |
Late transcription factor VLTF3 |
D3IZ94 |
D3IZ94_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
25674608.0 |
|
regulation of viral transcription |
|
333 |
Poxviridae |
Pseudocowpox virus |
VLTF-4 |
Late transcription factor VLTF4 |
D3IZK8 |
D3IZK8_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(8794318, Transcription Assay) |
25674608.0 |
|
viral envelope |
|
334 |
Poxviridae |
Tanapox virus |
45L |
SsDNA-binding phosphoprotein |
A7XCG4 |
A7XCG4_9POXV |
|
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
25255815.0 |
A7XCG4 is inferred from Orf virus protein Q6TVT8 |
single-stranded DNA binding |
|
335 |
Poxviridae |
Tanapox virus |
49R |
Helicase |
A7XCG8 |
A7XCG8_9POXV |
|
dsDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
I(8505308) |
I(20110368) |
25255815.0 |
|
ATP binding,helicase activity,nucleic acid binding |
|
336 |
Poxviridae |
Tanapox virus |
99R |
Intermediate transcription factor VITF-3, VITF-3 |
A7XCM8 |
A7XCM8_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
25255815.0 |
|
Not annotated |
|
337 |
Poxviridae |
Tanapox virus |
NPH-1 |
88L, Transcription termination factor NPH-1 |
A7XCL5 |
A7XCL5_9POXV |
|
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
I(9472022) |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
25255815.0 |
A7XCL5 is inferred from Bovine papular stomatitis virus
protein Q6TVB6. Involved in transcription termination
(27189950). |
ATP binding,nucleoside-triphosphatase
activity,transcription, DNA-templated |
|
338 |
Poxviridae |
Tanapox virus |
RAP94 |
75L, RNA polymerase-associated RAP94 |
A7XCK0 |
A7XCK0_9POXV |
|
ssRNA |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
25255815.0 |
|
DNA-binding transcription factor activity |
|
339 |
Poxviridae |
Tanapox virus |
VETF1 |
98L, Early transcription factor VETF1 |
A7XCM7 |
A7XCM7_9POXV |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
25255815.0 |
|
positive regulation of transcription, DNA-templated |
|
340 |
Poxviridae |
Tanapox virus |
VETFs |
84R, Early transcription factor VETFs |
A7XCL0 |
A7XCL0_9POXV |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
25255815.0 |
|
ATP binding,DNA binding,hydrolase activity,integral
component of membrane |
|
341 |
Poxviridae |
Tanapox virus |
VITF-3 |
115R, Intermediate transcription factor VITF-3 |
A7XCP7 |
A7XCP7_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
25255815.0 |
|
|
|
342 |
Poxviridae |
Tanapox virus |
VLTF-1 |
58R, Late transcription factor VLTF-1 |
A7XCH9 |
A7XCH9_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
25255815.0 |
A7XCH9 is inferred from Orf virus protein Q6TVS5 |
regulation of transcription, DNA-templated |
|
343 |
Poxviridae |
Tanapox virus |
VLTF-2 |
91L, Late transcription factor VLTF-2 |
A7XCL8 |
A7XCL8_9POXV |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
25255815.0 |
|
zinc ion binding |
|
344 |
Poxviridae |
Tanapox virus |
VLTF-3 |
92L, Late transcription factor VLTF-3 |
A7XCM0 |
A7XCM0_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
25255815.0 |
|
regulation of viral transcription |
|
345 |
Poxviridae |
Tanapox virus |
VLTF-4 |
76R, Late transcription factor VLTF-4 |
A7XCK1 |
A7XCK1_9POXV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(8794318, Transcription Assay) |
25255815.0 |
|
viral envelope |
|
346 |
Poxviridae |
Tanapox virus |
VP8 |
63R, Core protein VP8 |
A7XCI6 |
A7XCI6_9POXV |
|
dsDNA, ssDNA, ssRNA, dsRNA |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
25255815.0 |
A7XCI6 is inferred from Orf virus protein Q6TVS0 |
structural molecule activity,viral capsid |
|
347 |
Poxviridae |
Vaccinia virus |
NPH1 |
44.1rMVA_104, ATPase, CVA122, D11L, Early gene
termination factor/Nucleoside triphosphatase I, Factor X,
GL151, Nucleoside triphosphatase I, Nucleoside triphosphate
phosphohydrolase-I, Putative uncharacterized protein,
VACV112, VACV_BRZ_SERRO2_114, VACV-DUKE-124,
VACV_IOC_B388_142, W86/88-1-112 |
Q1PIT3 |
Q1PIT3_9POXV |
A0A0A7A5M3,A0A0M4S9W7,A0A2I2MC53,A0A2I6J1B6,A4GDH1,A9J1V1,B9U1K8,L7QJK3,O57214,P05807,P20637,Q1PIT3,V5QZL6 |
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
D(8230476) |
N |
D(7829483) |
Fields Virology |
|
ATP binding,nucleoside-triphosphatase
activity,transcription, DNA-templated |
|
348 |
Poxviridae |
Vaccinia virus |
I3L |
30k DNA binding phosphoprotein, DNA-binding
phosphoprotein, GL094, MVA064L, Protein I3, SsDNA-binding
phosphoprotein, TI3L, VAC_DPP12_083, VAC_TKT3_062,
VACV_BRZ_SERRO2_070, VACV_IOC_B141_098, VACWR072,
W86/88-1-068 |
P12923 |
I3_VACCW |
A0A0A1CQQ4,A0A0A7A5D0,A0A0M4SA87,A0A0R5TUB6,A0A2I2MDT9,B9U1F0,H2DU26,O93118,P20499,Q1PIX7,Q49QJ4,Q9JFC7,V5R1E3 |
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
D(9525612) |
N |
Fields Virology |
|
Plays an essential role in viral DNA replication. Binds
to ssDNA with high affinity and localizes to cytoplasmic
factories where nascent viral genomes accumulate. May disrupt
loops, hairpins and other secondary structures present on
ssDNA to reduce and eliminate pausing of viral DNA polymerase
at specific sites during elongation. |
|
349 |
Poxviridae |
Vaccinia virus |
NPH-II |
I8R, NPH2, NTPase II, Nucleoside triphosphatase II, RNA
helicase I8, RNA helicase NPH-II |
P12927 |
NPH2_VACCW |
|
ssDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
D(8505308; 7609038) |
D(20110368, 2839505, 4364422) |
Fields Virology |
|
NTP-dependent helicase that catalyzes unidirectional
unwinding of 3'tailed duplex RNAs and plays an important role
during transcription of early mRNAs, presumably by preventing
R-loop formation behind the elongating RNA polymerase. Might
also play a role in the export of newly synthesized mRNA
chains out of the core into the cytoplasm. Required for
replication and propagation of viral particles. |
|
350 |
Poxviridae |
Vaccinia virus |
RAP94 |
H4L, Protein H4, RNA polymerase-associated
transcription-specificity factor RAP94, RPO-associated
protein of 94 kDa, VACWR102 |
P68438 |
RAP94_VACCW |
A0A0A1CQS7,A0A0A1CRL1,A0A0A1CUE4,A0A0A7A5E7,A0A0M5M2K1,A0A2I2MDW5,A0A2I6TDW8,A9J1S4,B9U1I7,M9WEP8,M9WGZ2,P68439,Q1PIU7 |
ssRNA |
TR |
P |
N |
N |
N |
D(1565650) |
N |
D(11279216, 18455214, 8125977) |
Fields Virology |
|
DNA-directed RNA polymerase-associated factor required
for the transcription of viral early genes as well as for
transcription termination. Within minutes after virus entry,
recruits the core RNA polymerase, the early transcription
factor (ETF) and other enzymes needed for transcription
initiation, elongation, and termination thereby allowing
synthesis of early mRNAs which are extruded through pores in
the core particle. Recruits the multifunctional J3 protein,
with poly(A) polymerase-stimulatory, cap
nucleoside-2'-O-methyltransferase, and transcription
elongation activities. Interacts with NPH-I, a DNA-dependent
ATPase required for the termination of early transcripts.
Acts as a transcription termination factor by binding,
together with the capping enzyme/VTF, to the termination
motif 5'-UUUUUNU-3' in the nascent mRNA. Involved as well in
the packaging of RNA polymerase and other components needed
for early transcription in assembling virus particles. |
|
351 |
Poxviridae |
Vaccinia virus |
VETFL |
CVA132, Early transcription factor (VETF) large
subunit |
A9J0Q5 |
A9J0Q5_VACCA |
|
dsDNA |
TR |
P |
N |
N |
N |
D(8376362) |
D(1869571, 8376362) |
D(1869571, 8428951, 2839505) |
Fields Virology |
|
positive regulation of transcription, DNA-templated |
|
352 |
Poxviridae |
Vaccinia virus |
VETFs |
ATP-dependent helicase VETFS, CVA117, D6R, Early
transcription factor 70 kDa subunit, ETF small subunit,
Vaccinia virus early transcription factor small subunit,
VACWR111, VETF D6 subunit, VETF small subunit, VETFS |
P04308 |
ETF1_VACCW |
A0A160NBD6,A0A2I6J267,A9J1U1,P20634,Q9JFA3 |
dsDNA |
TR |
P |
N |
N |
N |
D(8376362) |
D(7784215, 1869571, 8350421, 8376362) |
D(1869571, 8428951, 2839505) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
early gene promoters. Is recruited by the RPO-associated
protein of 94 kDa (RAP94) to form the early transcription
complex, which also contains the core RNA polymerase. ETF
heterodimer binds to early gene promoters. |
|
353 |
Poxviridae |
Vaccinia virus |
VITF3L |
A23R, A8R, Intermediate transcription factor 3 large
subunit, VITF-3 45 kDa subunit |
P20998 |
VITF3_VACCC |
Q76RB3,Q77TH8,Q80HV2 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
intermediate gene promoters. |
|
354 |
Poxviridae |
Vaccinia virus |
VITF3S |
A8R, Intermediate transcription factor 3 small subunit,
VITF-3 32 kDa subunit, VITF-3 small subunit |
P20986 |
VTF3S_VACCC |
P68719,P68720 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
intermediate gene promoters. |
|
355 |
Poxviridae |
Vaccinia virus |
VLTF-1 |
Late transcription factor 1, Trans-activator protein GK1,
VLTF1 |
P68613 |
VLTF1_VACCW |
A0A2I2MC25,A0A2I6J169,A9J1P3,B9U1G8,P68612,Q1M1N3 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
D(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
Fields Virology |
|
Associates with RNA polymerase to initiate transcription
from late gene promoters. |
|
356 |
Poxviridae |
Vaccinia virus |
VLTF-2 |
A1L, Trans-activator protein A1, VACWR119, Viral late
gene transcription factor 2, VLTF2, VLTF-X |
P07610 |
VLTF2_VACCW |
A0A2I2MC49,A0A2I6J298,A9J0N9,B9U1L7,M9XDS9,P20982,Q1PIT0 |
dsDNA |
TR |
P |
N |
N |
N |
D(8371339) |
D(9445047) |
D(8371339) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
late gene promoters. |
|
357 |
Poxviridae |
Vaccinia virus |
VLTF-3 |
A2L, CVA126,GL161, Trans-activator protein A2,
VACV_BRZ_SERRO2_118, VACV_IOC_B141_146,A2L, VACWR120, Viral
late gene transcription factor 3, VLTF3 |
P68319 |
VLTF3_VACCW |
A0A0A7A6B8,A0A0M5M2K3,A0A2I2MC78,A0A2I6J289,A9J0P1,B9U1L8,Q76ZR2 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
late gene promoters. |
|
358 |
Poxviridae |
Vaccinia virus |
VLTF-4 |
H5R,GL131,VAC_DPP13_114,VACV_BRZ_SERRO2_101, late
transcription factor, Late gene transcription factor VLTF-4,
MVA095R |
Q76RC5 |
Q76RC5_9POXV |
A0A2I2MC42,A0A2I6J256,B9U1I8,H2DV26,M9WGD8,Q1PIU6 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
D(8794318, Transcription Assay) |
Fields Virology |
|
viral envelope |
|
359 |
Poxviridae |
Vaccinia virus |
VP8 |
25 kDa major core protein, Core protein VP8, DNA-binding
virion core protein VP8, F5 polypeptide, L4 core protein,
L4R, P25K, VACWR091 |
P03295 |
VP8_VACCW |
A0A0A7A5K7,A0A2I6J178,A0A2I6J232,A0ERU0,B9U1H3,L7QJ25,P20981,Q1M1M8,Q49PP2,Q76RD0,Q77TK7 |
dsDNA, ssDNA, ssRNA, dsRNA |
NAP, TR |
S |
N |
N |
N |
N |
D(9321647) |
D(3201752, 9321647) |
Fields Virology |
|
Major core structural protein. |
|
360 |
Poxviridae |
Variola virus |
I3L |
K3L, L3L, L3L protein, Protein I3, SsDNA-binding
phosphoprotein, VARV_BRZ66_39_061, VARV_JAP46_yam_061,
VARV_SAF65_102_061, VARV_SOM77_1252_061,
VARV_SUM70_228_061 |
P0DOP3 |
I3_VAR67 |
A0A1U8QRX5,P33000,Q0N589,Q0N8Q3,Q0NAF4,Q0NCR4,Q0NG81,Q0NLZ6 |
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
Fields Virology |
P33000 is inferred from Orf virus protein Q6TVT8 |
Single-stranded DNA (ssDNA)-binding phosphoprotein which
stimulates the enzymatic activity of vaccinia ribonucleotide
reductase. In the absence of magnesium and at low I3
concentration, I3 forms beaded nucleosome-like structures on
ssDNA. In the presence of magnesium and at high I3
concentration, I3 and DNA aggregate into large branched
filamentous structures. Might be essential for viral parental
DNA replication. |
|
361 |
Poxviridae |
Variola virus |
NPH-1 |
ATPase, ATPase nucleoside triphosphate
phosphohydrolase-I, D11L, N1L, NPH1, nucleoside triphosphate
phosphohydrolase-I, Nucleoside triphosphatase I, Nucleoside
triphosphate phosphohydrolase I, VARV_BEN68_59_105,
VARV_BRZ66_39_105, VARV_JAP46_yam_105, VARV_SAF65_102_105,
VARV_UNK52_but_105, VARV-VD21-UVic-107 |
P0DOQ3 |
NTP1_VAR67 |
P0DOQ3,P33066,Q0N545,Q0N5Q2,Q0NBG5,Q0NCM0,Q0NG37,Q0NLV2 |
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
I(9472022) |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
Fields Virology |
P33066 is inferred from Bovine papular stomatitis virus
protein Q6TVB6. Involved in transcription termination
(27189950). |
DNA-dependent ATPase required for providing the needed
energy to achieve the termination of early transcripts. Acts
in concert with the RAP94 subunit of the virion RNA
polymerase and the capping enzyme/VTF to catalyze release of
UUUUUNU-containing nascent RNA from the elongation complex.
NPH-I must bind ssDNA in order to exhibit ATPase activity (By
similarity). |
|
362 |
Poxviridae |
Variola virus |
NPH-II |
I8R, NPH2, NTPase II, Nucleoside triphosphatase II,
Nucleoside triphosphate phosphohydrolase II, RNA helicase I8,
RNA helicase NPH-II |
P0DSU5 |
NPH2_VAR67 |
A0A1L6K3L4,P33051,Q0N584,Q0N5U1,Q0N848,Q0NAE9,Q0NCQ9,Q0NDB5,Q0NG76,Q0NLZ1 |
ssDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
I(8505308) |
I(20110368, 2839505, 4364422) |
Fields Virology |
|
NTP-dependent helicase that catalyzes unidirectional
unwinding of 3'tailed duplex RNAs and plays an important role
during transcription of early mRNAs, presumably by preventing
R-loop formation behind the elongating RNA polymerase. Might
also play a role in the export of newly synthesized mRNA
chains out of the core into the cytoplasm. Required for
replication and propagation of viral particles (By
similarity). |
|
363 |
Poxviridae |
Variola virus |
RAP94 |
H4L, Protein H4, RNA polymerase-associated
transcription-specificity factor RAP94, RPO-associated
protein of 94 kDa |
P0DSR3 |
RAP94_VAR67 |
A0A1U8QUB4,P33067,Q0N559,Q0N823,Q0NCN4,Q0NEZ8,Q0NG51,Q0NLW6,Q0NWC1,Q89218 |
ssRNA |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
Fields Virology |
|
DNA-directed RNA polymerase-associated factor required
for the transcription of viral early genes as well as for
transcription termination. Within minutes after virus entry,
recruits the core RNA polymerase, the early transcription
factor (ETF) and other enzymes needed for transcription
initiation, elongation, and termination thereby allowing
synthesis of early mRNAs which are extruded through pores in
the core particle. Recruits the multifunctional J3 protein,
with poly(A) polymerase-stimulatory, cap
nucleoside-2'-O-methyltransferase, and transcription
elongation activities. Interacts with NPH-I, a DNA-dependent
ATPase required for the termination of early transcripts.
Acts as a transcription termination factor by binding,
together with the capping enzyme/VTF, to the termination
motif 5'-UUUUUNU-3' in the nascent mRNA. Involved as well in
the packaging of RNA polymerase and other components needed
for early transcription in assembling virus particles (By
similarity). |
|
364 |
Poxviridae |
Variola virus |
VETFL |
A7L, Early transcription factor 82 kDa subunit, ETF large
subunit, VETF A7 subunit |
P0DOU7 |
ETF2_VAR67 |
P33806,Q0N535,Q0N5P2,Q0N697,Q0NCL0,Q0NG27,Q0NLU2 |
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
early gene promoters. Is recruited by the RPO-associated
protein of 94 kDa (RAP94) to form the early transcription
complex, which also contains the core RNA polymerase. ETF
heterodimer binds to early gene promoters (By
similarity). |
|
365 |
Poxviridae |
Variola virus |
VETFs |
ATP-dependent helicase VETFS, D6R, Early transcription
factor 70 kDa subunit, ETF small subunit, VETF D6 subunit,
VETFS |
P0DON9 |
ETF1_VAR67 |
A0A1L6K3P8,P33056,Q0N550,Q0N5Q7,Q0N814,Q0NCM5,Q0NG42,Q0NLV7,Q0NS90 |
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
early gene promoters. Is recruited by the RPO-associated
protein of 94 kDa (RAP94) to form the early transcription
complex, which also contains the core RNA polymerase. ETF
heterodimer binds to early gene promoters (By
similarity). |
|
366 |
Poxviridae |
Variola virus |
VITF3L |
A23R, A24R, Intermediate transcription factor 3 large
subunit, VITF-3 45 kDa subunit |
P0DSR9 |
VITF3_VAR67 |
P33846,Q0N518,Q0NCJ3,Q0NG10,Q0NLS5 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
intermediate gene promoters. |
|
367 |
Poxviridae |
Variola virus |
VITF3S |
A8R, Intermediate transcription factor 3 small subunit,
VITF-3 32 kDa subunit, VITF-3 small subunit |
P0DSP9 |
VTF3S_VAR67 |
A0A1U8QNQ5,P33834,Q0N534,Q0NCK9,Q0ND65,Q0NG26,Q0NLU1,Q89179 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
intermediate gene promoters. |
|
368 |
Poxviridae |
Variola virus |
VLTF-1 |
G8R, H8R, I9R, Late transcription factor 1,
Trans-activator protein GK1, VARV_BRZ66_39_075,
VARV_JAP46_yam_075, VLTF1 |
P32990 |
VLTF1_VAR67 |
A0A1U8QUS9,Q0N575,Q0NG67,Q0NLY2,Q85380 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
Fields Virology |
|
Associates with RNA polymerase to initiate transcription
from late gene promoters. |
|
369 |
Poxviridae |
Variola virus |
VLTF-2 |
A1L, Trans-activator protein A1, Viral late gene
transcription factor 2, VLTF2 |
P0DSV3 |
VLTF2_VAR67 |
A0A1L6K3Q8,A0A1U8QHI5,P33814,Q0N542,Q0NCL7,Q0NG34,Q0NJJ8,Q0NLU9 |
dsDNA |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
late gene promoters. |
|
370 |
Poxviridae |
Variola virus |
VLTF-3 |
A2L, Trans-activator protein A2, Viral late gene
transcription factor 3, VLTF3 |
P0DOT5 |
VLTF3_VAR67 |
A0A1U8QTT4,P68320,Q0N541,Q0NCL6,Q0NG33,Q0NLU8 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
Fields Virology |
|
Acts with RNA polymerase to initiate transcription from
late gene promoters. |
|
371 |
Poxviridae |
Variola virus |
VLTF-4 |
H5R, H5R protein, I5R, J5R, Late transcription elongation
factor H5, VLTF-4 viral late transcription factor |
P33062 |
H5_VAR67 |
A0A1L6K3P0,A0A1U8QWZ4,Q0N558,Q0N5R5,Q0N6C0,Q0N6X0,Q0N8M2,Q0NBH8,Q0NCN3,Q0ND89,Q0NG50,Q0NGQ2,Q0NLW5,Q0NU07,Q85386,Q89219 |
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(8794318, Transcription Assay) |
Fields Virology |
P33062 is inferred from Vaccinia virus protein
Q76RC5 |
Involved in the co-transcriptional or
post-transcriptional endoribonucleolytic cleavage that
generates sequence-homogeneous 3' ends during late
transcription. Involved in postreplicative transcription
elongation on intermediate and late genes (Probable). Also
involved in DNA replication and in multiple steps of virion
morphogenesis. Required both for inclusion of virosoplasm
into crescents as well as for maturation of immature virions
(IV) into mature virions (MV) (By similarity). |
|
372 |
Poxviridae |
Variola virus |
VP8 |
25 kDa major core protein, Core protein vp8, Core protein
VP8, L4 core protein, L4R, N4R, P25K |
P0DSW9 |
VP8_VAR67 |
A0A1U8QWC9,P33039,Q0N570,Q0NCP5,Q0NEF6,Q0NG62,Q0NLX7,Q89214 |
dsDNA, ssDNA, ssRNA, dsRNA |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
Fields Virology |
P33039 is inferred from Orf virus protein Q6TVS0 |
Major core structural protein. |
|
373 |
Poxviridae |
Yaba monkey tumor virus |
115R |
|
Q6TUQ4 |
Q6TUQ4_YMTV5 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
14645589.0 |
Q6TUQ4 is inferred from Bovine papular stomatitis virus
protein Q6TV88 |
Not annotated |
|
374 |
Poxviridae |
Yaba monkey tumor virus |
45L |
|
Q6TUW8 |
Q6TUW8_YMTV5 |
|
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
14645589.0 |
Q6TUW8 is inferred from Orf virus protein Q6TVT8 |
single-stranded DNA binding |
|
375 |
Poxviridae |
Yaba monkey tumor virus |
49R |
RNA helicase NPH-II |
Q6TUW4 |
Q6TUW4_YMTV5 |
|
dsDNA, ssRNA |
TR, TNA, Rep |
S |
N |
N |
N |
N |
I(8505308) |
I(20110368) |
14645589.0 |
|
nucleoside-triphosphatase activity |
|
376 |
Poxviridae |
Yaba monkey tumor virus |
58R |
|
Q6TUV5 |
Q6TUV5_YMTV5 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
14645589.0 |
Q6TUV5 is inferred from Orf virus protein Q6TVS5 |
regulation of transcription, DNA-templated |
|
377 |
Poxviridae |
Yaba monkey tumor virus |
63R |
|
Q6TUV0 |
Q6TUV0_YMTV5 |
|
indirect/unknown |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
14645589.0 |
Q6TUV0 is inferred from Orf virus protein Q6TVS0 |
structural molecule activity,viral capsid |
|
378 |
Poxviridae |
Yaba monkey tumor virus |
75L |
|
Q6TUU0 |
Q6TUU0_YMTV5 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
14645589.0 |
Q6TUU0 is inferred from Molluscum contagiosum virus
protein Q98252 |
DNA-binding transcription factor activity |
|
379 |
Poxviridae |
Yaba monkey tumor virus |
76R |
|
Q6TUT9 |
Q6TUT9_YMTV5 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(8794318, Transcription Assay) |
14645589.0 |
Q6TUT9 is inferred from Vaccinia virus protein
Q76RC5 |
viral envelope |
|
380 |
Poxviridae |
Yaba monkey tumor virus |
91L |
|
Q6TUS7 |
Q6TUS7_YMTV5 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
14645589.0 |
Q6TUS7 is inferred from Molluscum contagiosum virus
protein Q98270 |
zinc ion binding |
|
381 |
Poxviridae |
Yaba monkey tumor virus |
92L |
|
Q6TUS6 |
Q6TUS6_YMTV5 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
14645589.0 |
Q6TUS6 is inferred from Molluscum contagiosum virus
protein Q98271 |
regulation of viral transcription |
|
382 |
Poxviridae |
Yaba monkey tumor virus |
99R |
|
Q6TUS0 |
Q6TUS0_YMTV5 |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
14645589.0 |
Q6TUS0 is inferred from Cowpox virus protein
A0A0K2YTA9 |
Not annotated |
|
383 |
Poxviridae |
Yaba monkey tumor virus |
NPH-1 |
88L, B5L, NPH I, Nucleoside triphosphatase I, Nucleoside
triphosphate phosphohydrolase I |
Q9QB93 |
NTP1_YMTV5 |
|
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
I(9472022) |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
14645589.0 |
Q9QB93 is inferred from Bovine papular stomatitis virus
protein Q6TVB6. Involved in transcription termination
(27189950). |
DNA-dependent ATPase required for providing the needed
energy to achieve the termination of early transcripts. Acts
in concert with the RAP94 subunit of the virion RNA
polymerase and the capping enzyme/VTF to catalyze release of
UUUUUNU-containing nascent RNA from the elongation complex.
NPH-I must bind ssDNA in order to exhibit ATPase activity (By
similarity). |
|
384 |
Poxviridae |
Yaba monkey tumor virus |
VETFL |
98L, B14L, Early transcription factor 82 kDa subunit, ETF
large subunit |
Q9QB84 |
ETF2_YMTV5 |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
14645589.0 |
Q9QB84 is inferred from Bovine papular stomatitis virus
protein Q6TVA5 |
Acts with RNA polymerase to initiate transcription from
early gene promoters. Is recruited by the RPO-associated
protein of 94 kDa (RAP94) to form the early transcription
complex, which also contains the core RNA polymerase. ETF
heterodimer binds to early gene promoters (By
similarity). |
|
385 |
Poxviridae |
Yaba monkey tumor virus |
VETFs |
84R, ATP-dependent helicase VETFS, B1R, Early
transcription factor 70 kDa subunit, VETF small subunit,
VETFS |
Q9QB97 |
ETF1_YMTV5 |
|
dsDNA |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
14645589.0 |
|
Acts with RNA polymerase to initiate transcription from
early gene promoters. A DNA-dependent ATPase activity is
associated with VETF. |
|
386 |
Poxviridae |
Yaba-like disease virus |
115R |
115R protein |
Q9DHJ8 |
Q9DHJ8_YLDV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
11581398.0 |
Q9DHJ8 is inferred from Bovine papular stomatitis virus
protein Q6TV88 |
Not annotated |
|
387 |
Poxviridae |
Yaba-like disease virus |
45L |
45L protein |
Q9DHR7 |
Q9DHR7_YLDV |
|
ssDNA |
TR, Rep |
S |
N |
N |
N |
N |
I(9525612) |
N |
11581398.0 |
Q9DHR7 is inferred from Orf virus protein Q6TVT8 |
single-stranded DNA binding |
|
388 |
Poxviridae |
Yaba-like disease virus |
58R |
58R protein |
Q9DHQ5 |
Q9DHQ5_YLDV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(15471883, Transcription Assay), I(2041091,
Transcription Assay), I(2476568, Transcription Assay) |
11581398.0 |
Q9DHQ5 is inferred from Orf virus protein Q6TVS5 |
regulation of transcription, DNA-templated |
|
389 |
Poxviridae |
Yaba-like disease virus |
63R |
63R protein |
Q9DHQ0 |
Q9DHQ0_YLDV |
|
indirect/unknown |
NAP, TR |
S |
N |
N |
N |
N |
I(9321647) |
I(3201752, 9321647) |
11581398.0 |
Q9DHQ0 is inferred from Orf virus protein Q6TVS0 |
structural molecule activity,viral capsid |
|
390 |
Poxviridae |
Yaba-like disease virus |
75L |
75L protein |
Q9DHN8 |
Q9DHN8_YLDV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(1565650) |
N |
I(11279216, 18455214, 8125977) |
11581398.0 |
Q9DHN8 is inferred from Molluscum contagiosum virus
protein Q98252 |
DNA-binding transcription factor activity |
|
391 |
Poxviridae |
Yaba-like disease virus |
76R |
76R protein |
Q9DHN7 |
Q9DHN7_YLDV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(8794318, Transcription Assay) |
11581398.0 |
Q9DHN7 is inferred from Tanapox virus protein Q76RC5 |
viral envelope |
|
392 |
Poxviridae |
Yaba-like disease virus |
84R |
84R protein |
Q9DHM9 |
Q9DHM9_YLDV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8376362) |
I(7784215, 1869571, 8350421, 8376362) |
I(1869571, 8428951) |
11581398.0 |
Q9DHM9 is inferred from Bovine papular stomatitis virus
protein Q6TVB9 |
ATP binding,DNA binding,hydrolase activity,integral
component of membrane |
|
393 |
Poxviridae |
Yaba-like disease virus |
88L |
88L protein |
Q9DHM5 |
Q9DHM5_YLDV |
|
dsDNA, ssDNA |
TR |
P |
N |
N |
N |
I(8230476) |
N |
I(11279216, Transcription Termination Assay), I(27189950,
Transcription Termination Assay), I(7829483) |
11581398.0 |
Q9DHM5 is inferred from Bovine papular stomatitis virus
protein Q6TVB6 |
ATP binding,nucleoside-triphosphatase
activity,transcription, DNA-templated |
|
394 |
Poxviridae |
Yaba-like disease virus |
91L |
91L protein |
Q9DHM2 |
Q9DHM2_YLDV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371339) |
I(9445047) |
I(8371339) |
11581398.0 |
Q9DHM2 is inferred from Molluscum contagiosum virus
protein Q98270 |
zinc ion binding |
|
395 |
Poxviridae |
Yaba-like disease virus |
92L |
92L protein |
Q9DHM1 |
Q9DHM1_YLDV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8371340) |
N |
I(8676468, Transcription Assay), I(8523544, Transcription
Assay) |
11581398.0 |
Q9DHM1 is inferred from Molluscum contagiosum virus
protein Q98271 |
regulation of viral transcription |
|
396 |
Poxviridae |
Yaba-like disease virus |
98L |
98L protein |
Q9DHL5 |
Q9DHL5_YLDV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
I(8376362) |
I(1869571, 8376362) |
I(1869571, 8428951) |
11581398.0 |
Q9DHL5 is inferred from Bovine papular stomatitis virus
protein Q6TVA5 |
positive regulation of transcription, DNA-templated |
|
397 |
Poxviridae |
Yaba-like disease virus |
99R |
99R protein |
Q9DHL4 |
Q9DHL4_YLDV |
|
indirect/unknown |
TR |
P |
N |
N |
N |
N |
N |
I(10077573, Transcription Assay), I(15471883,
Transcription Assay) |
11581398.0 |
Q9DHL4 is inferred from Cowpox virus protein
A0A0K2YTA9 |
Not annotated |
|
398 |
Retroviridae |
Human immunodeficiency virus 1 |
Tat |
Protein tat, tat, Transactivating regulatory protein |
P04608 |
TAT_HV1H2 |
A0A060KS15,A0A060KV49,A0A060KVI4,A0A076FNR3,A0A076V3Q8,A0A076V8N1,A0A076V943,A0A076V970,A0A089QCW2,A0A0K1RFJ0,A0A0K1RFL6,A0A0K1RFL8,A0A0S2CBE9,A0A0S2CBF6,A0A140GML0,A0A142J5A6,A0A142J5B5,A0A159C854,A0A159C9T1,A0A159C9V0,A0A159C9Z8,A0A159CAC9,A0A159CAP8,A0A161CFV2,A0A161CGQ6,A0A161CP30,A0A161CUQ5,A0A161CUV9,A0A161CV08,A0A161CVH7,A0A161CVX6,A0A161CW94,A0A161D3W4,A0A191CA08,A0A191CAI2,A0A191CAY4,A0A191CB60,A0A1L4AMD3,A0A1L5K0P5,A0A1L5K158,A0A1L5K1D0,A0A1L7DT27,A0A1L7DT44,A0A1L7DT47,A0A1L7DT66,A0A1L7DT91,A0A1L7DT95,A0A1L7DTB6,A0A1L7DTC9,A0A1L7DTF4,A0A1L7DTH0,A0A1L7E051,A0A1L7E086,A0A1L7E087,A0A1L7E088,A0A1L7E0C8,A0A1L7E0F9,A0A1L7E0G4,A0A1L7E0H2,A0A1L7E0J8,A0A1L7E0K6,A0A1L7E0K8,A0A1V0CPR5,A0A221SER0,A0A286LFT1,A0A2H4UM10,A0A2I6U5U1,A0A2I6U5W9,A0A2I6UA56,A0A2I6UAA8,A0A2I6UAP1,A0A2I6UAW6,A0A2I6UAX8,A0A2I6UB20,A0A2I6UB53,A0A2I6UB85,A0A2I6UBB9,A0A2I6UDU7,A0A2I6UE90,A0A2I6UEL9,A0A2I6UEW4,A0A2I6UEY9,A0A2L1KVE2,A0A2L1KVH1,A0A2L1KW66,A0A2L1KWQ3,A0A2L1KWR8,A0A2L1KX14,A0A2L1KXI4,A0A2L1KXX2,A0A2L1KXY1,A0A2L1KY88,A0A2P1IPK3,A0A2S1D2B0,A0A2S1J4U4,A0A346ARF5,A0A3G5NTJ6,A0A3G5NUD8,A0A3G5NVJ6,A0A3G5NWJ1,A0A3G5NXC4,A0A3G5NXJ3,A0A3G5NYA6,A0A3G5NYE3,A0A3G5NZ85,A0A3G5NZA5,A0A3G5NZA6,A0A3G5NZL3,A0A3G5NZN1,A0A3G5P091,A0A3G5P0G4,A0A3G5P116,A0A3G5P120,A0A3G5P1B7,A0A3G5P1C4,A0A3G5P1G0,A0A3G5P1I8,A0A3G5P1Y8,A0A3G5P1Z4,A0A3G5P267,A0A3G5P2F3,A0A3G5P2I3,A0A3G5P2J5,A0A3G5P2R2,A0A3G5P2Z0,A0A3G5P389,A0A3G5P3H0,A0A3G5P3Q1,A0A3G5P4H0,A0A3G8G526,A0ZVI9,A1DQV4,A1DQW3,A1DQW5,A1DQW7,A1DQW8,A1DQW9,A1DQX7,A1DQY0,A1DQY3,A1DQY5,A1DQY9,A1XFJ7,A1YAW1,A1YAX9,A3F992,A3F9A1,A3QVS4,A6MI20,A6MI21,A6MI22,A7YJW9,A8VGQ3,A8VGY9,A8VH75,A8VH95,A8VHA7,A8VHB4,A9U9H5,A9U9M0,A9U9M9,A9U9N8,A9U9S0,A9XCI1,B4YNJ3,B4YNL1,B4YNM3,B5AEQ4,B5AEU9,B7SWF0,B7TCC4,C4N7C1,C4N7J1,C5HA95,C5HAJ4,C5HAS7,C5HB94,C5HMU5,C5HN12,C5HNI8,C5HNW1,C5HNW7,C5HP06,C5HP90,C5HPB9,C5HR51,C5HS75,C7G256,C9E906,C9E908,C9E921,C9E988,D2CPM3,D2CPN7,D2CPN9,D2CPP0,D2CPR0,D2CPR1,D2CPS1,D2CPS6,D2CPS8,D2CPS9,D2CPU3,D2CPU4,D2K3B0,D3GG08,D3XND1,D3XND2,D3XND4,D4PC16,D4PC24,D4PE12,D5KEK7,D5KIN8,D5KIP6,D5KIS0,D5KIS8,D5KIY2,D5KIZ8,D5KJ06,D5KJ38,D5L1M9,D6NSX1,D6NVS0,D6NVS1,D6NVU0,D6NVU1,D6NVV2,D6NVW0,D6NVY1,D6NVY3,D6NVY7,D6NVY9,D6NVZ5,D6NW12,D6NW21,D6NW28,D6NW43,D6NW48,D6NW73,D6NW81,D6NW87,D6NW91,D6NW95,D6NW99,D6NWA0,D6NWA9,D6NWB6,D6NWC9,D6NWD4,D6NWE4,D6NWG1,D6NWH7,D6NWI8,D6NWI9,D6NWL1,D6NWM1,D6NWN0,D6NWN1,D6NWP0,D6NWP6,D6NWQ6,D6NWQ7,D6NWQ9,D6NWR0,D6NWR9,D6NWS1,D6NWV7,D6NWW8,D6NWY1,D6NWY7,D6NWZ8,D6NX04,D6NX09,D6NX22,D6NX24,D6NX29,D6NX32,D6NX42,D6NX46,D6NX50,D6NX58,D6NX59,D6NX60,D6NX61,D6NX65,D6NX72,D6NX88,D6R020,D6R056,E0A9Z8,E0AA13,E0AA18,E2CX23,E2CX68,F1B2A1,F1B2D3,F1B2G8,F1B2J4,F2YX68,F2YXK1,F2YXW5,F2YXX3,F5BD94,F5CFB7,G1FQH9,G9IQ96,H6CVW9,H6CW09,H6CW27,H6CWA4,H6CWD8,H6CX54,H6CX96,H6CXE0,H6CXE9,H6CXL2,I6N0A1,I6N0B0,I6N0B8,I6N0C6,I6N0D5,I6N0H9,I6QQN9,I6QTV7,I6R588,I6R5M0,I6R5Z2,I6R6E2,I6RBY5,I6RC25,I6RCG3,I6RG27,I6RGA6,I6RGK4,I6ZAD6,J3QYE6,J3QYF5,J3R262,J3R280,J3R298,J3R2A7,J3R8L1,J3R8M0,J3R8N0,J3R8N9,J3R8P8,J3RA22,J3RA49,J3RA58,J3RA67,J3RA77,J3RAX7,J3RB02,J3RB14,J3RB36,K4MKX3,K4MUI9,K4MYG3,M1KBE1,M1KBR3,M1LDW1,M4N2F6,M4N4H9,M4N943,M4N949,M4N966,M4NNN7,M4NRQ0,M4NRV8,M4PFA9,M4PHN2,M4PJ36,M4PJC5,M4PQG5,O42085,O92297,O92885,O92899,O93022,O93199,P90265,Q00EI6,Q0QL80,Q0QL89,Q1HGD2,Q1HGE1,Q1M0L8,Q1M0M7,Q1PAB4,Q1PAC0,Q2NMF7,Q2NMG6,Q2NMH5,Q2NMI4,Q2NMJ3,Q2NMM8,Q2NMP6,Q2NMS3,Q2NMT2,Q2NMU1,Q2NMV9,Q2NMW8,Q2NMX7,Q2NN30,Q2NN39,Q2NN65,Q2NN73,Q30BW0,Q30BX6,Q3SA27,Q462M7,Q462N6,Q4QXE2,Q4QXF9,Q507D6,Q507F1,Q52S52,Q52S62,Q5C9W8,Q5PYM7,Q5PYN4,Q5PYP0,Q5PYP7,Q5U882,Q5U8J9,Q672T0,Q672T8,Q673V9,Q6E6V7,Q6EFM4,Q6EG43,Q6EG88,Q6H1S1,Q6Q463,Q6RJ70,Q6RJ77,Q6RJ84,Q6RJ91,Q6RJ98,Q6RJA5,Q6RJC6,Q6RJD3,Q6RJE0,Q6RJE7,Q6RJG8,Q6RJH5,Q6Y0S7,Q6Y0T6,Q6Y0U6,Q6Y0V1,Q6Y0V2,Q74087,Q74810,Q76PP9,Q76W89,Q77688,Q7ZJC3,Q8AQT3,Q8AQV1,Q8AQW0,Q900A7,Q99BV6,Q99BV7,Q99BV8,Q99BV9,Q99BW0,Q99BW1,Q9DH20,Q9DHA9,Q9DQ29,Q9W9E3,Q9WJV2,Q9WJV9,Q9WJW7,Q9YP37,R9WY72,T2CGB4,T2CGG2,T2CHT3,T2CI19,U5YPQ4,U5YT43,U6BG48,W0FUJ1 |
dsDNA, ssRNA |
TR, Rep |
P |
D(26488441) |
D(22073215, 26488441, 26468528) |
3MI9, 3MIA, 4OR5, 5V61, 6CYT, 6MCE, 6MCF |
D(11909874) |
D(15994812, 10428378, 14981150) |
D(10428378) |
Fields Virology |
|
Nuclear transcriptional activator of viral gene
expression, that is essential for viral transcription from
the LTR promoter and replication. Acts as a sequence-specific
molecular adapter, directing components of the cellular
transcription machinery to the viral RNA to promote
processive transcription elongation by the RNA polymerase II
(RNA pol II) complex, thereby increasing the level of
full-length transcripts. In the absence of Tat, the RNA Pol
II generates short or non-processive transcripts that
terminate at approximately 60 bp from the initiation site.
Tat associates with the CCNT1/cyclin-T1 component of the
P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain
elongation. This binding increases Tat's affinity for a
hairpin structure at the 5'-end of all nascent viral mRNAs
referred to as the transactivation responsive RNA element
(TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively
to TAR RNA. The CDK9 component of P-TEFb and other
Tat-activated kinases hyperphosphorylate the C-terminus of
RNA Pol II that becomes stabilized and much more processive.
Other factors such as HTATSF1/Tat-SF1, SUPT5H/SPT5, and
HTATIP2 are also important for Tat's function. Besides its
effect on RNA Pol II processivity, Tat induces chromatin
remodeling of proviral genes by recruiting the histone
acetyltransferases (HATs) CREBBP, EP300 and PCAF to the
chromatin. This also contributes to the increase in proviral
transcription rate, especially when the provirus integrates
in transcriptionally silent region of the host genome. To
ensure maximal activation of the LTR, Tat mediates nuclear
translocation of NF-kappa-B by interacting with host RELA.
Through its interaction with host TBP, Tat may also modulate
transcription initiation. Tat can reactivate a latently
infected cell by penetrating in it and transactivating its
LTR promoter. In the cytoplasm, Tat is thought to act as a
translational activator of HIV-1 mRNAs. |
|
399 |
Retroviridae |
Human immunodeficiency virus 1 |
Vpr |
Protein Vpr, R ORF protein, Viral protein R |
P05928 |
VPR_HV1BR |
A0A1L5K181,A0A1L7E075,A0A1L7E0E4,A0A1P8DFL4,A0A1P8DFQ6,A0A1S6Q1Y8,A0A1S7G5I7,A0A1V0CPS3,A0A1V0CQ70,A0A2I6U569,A0A2I6U5R3,A0A2I6U656,A0A2I6U705,A0A2I6U757,A0A2I6U762,A0A2I6U778,A0A2I6U7M6,A0A2I6U992,A0A2I6U9P4,A0A2I6UB19,A0A2I6UB27,A0A2I6UB41,A0A2I6UBA3,A0A2I6UE01,A0A2I6UEX6,A0A2L1KWL5,A0A2L1KWR7,A0A2L1KXB7,A0A2L1KXV9,A0A2L1KXY0,A0A2S1D2C4,A0A2S1J4Z9,A0A2Z2U098,A0A2Z2U294,A0A346ARF4,A0A346BLV9,A0A346BLY6,A0A3G5NS07,A0A3G5NSG1,A0A3G5P0U6,A0A3G5P2U2,A0A3G5P404,A0A3G8G4Y4,A0A3G8G516,A5YMI3,A5YMJ1,A5YML7,A5YML9,A5YMM6,A5YMN9,A5YMP1,B2CK75,B2CK78,B2CK80,O73404,O73405,O73406,O73411,O73412,O73418,O73425,O89601,O89603,O89604,O89605,O89606,O89608,O89609,O89610,O89611,O89612,O89613,O89614,O89615,O89616,O89617,O89618,O89619,O89620,O89622,O89624,O89626,O89627,O89629,O89630,O89631,O89632,O89633,O89634,O89636,O89639,O89641,O89644,O89645,O89647,O89648,O89649,O89650,O89651,O89652,O89655,O89656,O89659,O89660,O89661,O89662,O89663,O89664,O89665,O89667,O89671,O89672,O89674,O89676,O89680,O89684,O89687,O89697,Q3HP77,Q3HP85,Q3HP91,Q3HP95,Q3HPA1,Q3HPA5,Q3HPB5,Q3HPC4,Q3HPD4,Q3HPD5,Q3HPE1,Q3HPF2,Q3HPF6,Q3HPH8,Q3HPI1,Q3HPI8,Q3HPJ3,Q3HPK0,Q3HPL6,Q3HPL8,Q3HPM2,Q3HPM3,Q3HPM5,Q3HPP4,Q3HPP8,Q3HPR2,Q3HPS8,Q3HPU2,Q3HPU3,Q3HPU6,Q3HPU9,Q3HPW0,Q3HPW8,Q3HPX2,Q3HPX6,Q3HPX8,Q3HPZ0,Q3HPZ1,Q3HPZ4,Q3HPZ9,Q3HQ04,Q3HQ07,Q3HQ14,Q3HQ25,Q3HQ39,Q3HQ40,Q3HQ48,Q3HQ80,Q3HQ83,Q3HQ84,Q3HQA3,Q3HQA9,Q3HQB6,Q3HQC8,Q3HQC9,Q3HQD4,Q3HQD9,Q3HQE0,Q3HQE1,Q3HQH7,Q3HQI1,Q3HQI4,Q3HQI5,Q3HQI7,Q3HQJ1,Q3HQK4,Q3HQM8,Q3HQP6,Q3HQP7,Q3HQQ4,Q3HQR1,Q3HQR7,Q3HQR8,Q3HQS1,Q3HQS4,Q9E285,Q9E287,Q9E289,Q9E290,Q9E291,Q9E292,Q9E293,Q9E294,Q9E296,Q9E297 |
indirect/unknown |
TR, TNA, Rep |
S |
N |
N |
N |
D(9560267) |
D(29042644) |
D(9560267, 29042644) |
Fields Virology |
|
During virus entry, plays a role in the transport of the
viral pre-integration (PIC) complex to the host nucleus. This
function is crucial for viral infection of non-dividing
macrophages. May act directly at the nuclear pore complex, by
binding nucleoporins phenylalanine-glycine (FG)-repeat
regions. |
|
400 |
Retroviridae |
Human immunodeficiency virus 2 |
Tat |
Protein tat, Protein Tat, Transactivating regulatory
protein |
P18098 |
TAT_HV2BE |
A0A0S3B0B1,A0A0U3VB96,A0A1L4CV17,A0A1L4CV23,A0A1L4CV30,A0A1L4CV41,A0A1L4CV44,A0A1L4CV58,A0A1L4CV62,A0A2D3HWP3,A0A2D3HWQ0,A0A2D3HWQ7,A0A2D3HWR8,A0A2D3HWS9,A0A2D3HWU1,A0A2D3HWU9,A0A2D3HWW0,A0A2D3HWW8,A0A2D3HWX9,A0A2D3HWY4,A0A2D3HWZ3,A0A2D3HX04,A0A385PLN6,A0A385PLS1,A0A385PSL7,A0A385PSQ4,B0YP97,B5TK20,B9VR79,C7G2W8,D7UPK3,D7UPL2,D7UPM1,L8AZ71,L8B2C8,L8B2J7,L8B2M8,L8B321,P88145,Q2PQT0,Q6R780,Q6R789,Q76625,Q7SNM0,Q8UTV3,Q9IBL5,Q9YTT6 |
dsDNA, ssRNA |
TR, Rep |
P |
I(26488441) |
I(22073215, 26488441) |
N |
I(11909874) |
I(15994812, 10428378, 14981150) |
I(10428378) |
Fields Virology |
|
Nuclear transcriptional activator of viral gene
expression, that is essential for viral transcription from
the LTR promoter and replication. Acts as a sequence-specific
molecular adapter, directing components of the cellular
transcription machinery to the viral RNA to promote
processive transcription elongation by the RNA polymerase II
(RNA pol II) complex, thereby increasing the level of
full-length transcripts. In the absence of Tat, the RNA Pol
II generates short or non-processive transcripts that
terminate at approximately 60 bp from the initiation site.
Tat associates with the CCNT1/cyclin-T1 component of the
P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain
elongation. This binding increases Tat's affinity for a
hairpin structure at the 5'-end of all nascent viral mRNAs
referred to as the transactivation responsive RNA element
(TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively
to TAR RNA. The CDK9 component of P-TEFb and other
Tat-activated kinases hyperphosphorylate the C-terminus of
RNA Pol II that becomes stabilized and much more processive
(By similarity). |
|
401 |
Retroviridae |
Human immunodeficiency virus 2 |
Vpr |
Protein Vpr, R ORF protein, Viral protein R |
P18100 |
VPR_HV2BE |
A0A1L4CV18,A0A1L4CV25,A0A1L4CV28,A0A1L4CV35,A0A1L4CV43,A0A2D3HWN8,A0A2D3HWQ2,A0A2D3HWQ9,A0A2D3HWS0,A0A2D3HWT1,A0A2D3HWU2,A0A2D3HWV2,A0A2D3HWW2,A0A2D3HWX3,A0A2D3HWY8,A0A2D3HWZ9,A0A2D3HX07,A0A2D3HX19,A0A385PLN9,A0A385PM41,A0A385PMN5,A0A385PP22,Q9Q1T3 |
indirect/unknown |
TR, TNA, Rep |
S |
N |
N |
N |
I(9560267) |
I(29042644) |
I(9560267, 29042644) |
Fields Virology |
|
Stimulates gene expression driven by the HIV-2 LTR.
Prevents infected cells from undergoing mitosis and
proliferating, by inducing arrest or delay in the G2 phase of
the cell cycle. Cell cycle arrest creates a favorable
environment for maximizing viral expression and production
(By similarity). |
|
402 |
Retroviridae |
Human spumaretrovirus |
Bel-1 |
Protein Bel-1, Tas, Transactivator of spumavirus,
Transcriptional transactivator |
P14353 |
BEL1_FOAMV |
Q9IHQ8,Q9IHR0,Q9QEJ6 |
dsDNA |
TR, Rep |
P |
N |
N |
N |
I(8356798, 8648727, 9621006) |
I(8648727, 9420252, 9621006) |
I(8648727, Footprinting), I(9420252, Footprinting) |
Fields Virology |
|
Transcriptional transactivator that activates the viral
internal promoter (IP), thereby enhancing its own expression.
This transactivation is repressed by nuclear factor I. Also
transactivates the long terminal repeat (LTR) promoter,
thereby inducing structural gene expression, initiating the
late phase of infection. It is therefore a key regulator of
viral gene expression. It directly binds to and activates DNA
target sites of viral promoters and those of distinct
cellular genes. Required for viral replication. |
|
403 |
Retroviridae |
Human T-cell leukemia virus 1; Human T-lymphotropic virus
1 |
HBZ |
HTLV-1 basic zipper factor |
P0C746 |
HBZ_HTL1A |
P0C747 |
indirect/unknown |
TR |
P |
D(17151132) |
D(30057145) |
N |
D(19064727, 12438606, 12937177, 17151132) |
D(17151132) |
N |
Fields Virology |
|
Contributes to the regulation of viral RNA transcription
by interacting with host proteins involved in transcriptional
activation such as ATF4, or CREB1, and by inhibiting their
activity. Additionally, HBZ suppresses host NF-kappa-B-driven
transcription mediated by host RELA as well as transcription
of some classical NF-kappa-B target genes, including IL8,
IL2RA, IRF4, VCAM1, and VEGFA. |
|
404 |
Retroviridae |
Human T-cell leukemia virus 1; Human T-lymphotropic virus
1 |
Tax |
Protein PX, Protein Tax-1, Protein X-LOR, tax,
Trans-activating transcriptional regulatory protein of
HTLV-1 |
P14079 |
TAX_HTL1C |
P03409,P0C222 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(15367606, 11861831) |
D(11861831) |
N |
Fields Virology |
|
Transcriptional activator that activates both the viral
long terminal repeat (LTR) and cellular promoters via
activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds
to three 21 bp repeat elements located within the LTRs,
referred to as Tax-responsive elements (TRE). Binding to TRE
requires the interaction with CREB1 and CREBBP. Also induces
chromatin remodeling of proviral LTR-mediated gene expression
by recruiting the histone acetyl transferases CREBBP and
EP300 to the chromatin, which results in histone acetylation.
Via its interaction with IKK regulatory subunit IKBKG, Tax-1
persistently stimulates I-kappa-B kinase (IKK), resulting in
constitutive activation of the transcription factor
NF-kappa-B. Induction of the nuclear expression of members of
the NFkB family of transcription factors, which leads to
up-regulated expression of many gene promoters containing
NFkB motifs. These genes include those encoding IL2, IL15,
IL2RA and IL15RA, leading to autocrine IL2/IL2RA and
IL15/IL15RA loops. The resulting T-cell proliferation leads
to malignant transformation and to the development of adult
T-cell leukemia (ATL). IL13, known to be linked to
leukemogenesis, is also up-regulated by Tax-1. Interaction
with PDZ domain-containing proteins induce IL2-independent
growth, which may be a factor in multi-step leukemogenesis.
Inhibits the action of at least three cellular tumor
suppressors p53/TP53, RB1 and DLG1, and suppresses their
abilities to dictate apoptosis in primary cells. Required for
viral replication (By similarity). |
|
405 |
Retroviridae |
Human T-cell leukemia virus 2 |
Tax |
Protein Tax-2, Trans-activating transcriptional
regulatory protein of HTLV-2 |
P03410 |
TAX_HTLV2 |
A0A0U2S9I1 |
indirect/unknown |
TR |
P |
N |
N |
N |
D(15367606, 11861831) |
D(11861831) |
N |
Fields Virology |
Tax does not directly bind DNA, but associates through
its N-terminus with the CREB protein (16155604). |
Transcriptional activator that activates both the viral
long terminal repeat (LTR) and cellular promoters via
activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds
to three 21 bp repeat elements located within the LTRs,
referred to as Tax-responsive elements (TRE). Binding to TRE
requires the interaction with CREB1 and CREBBP. Induces
T-cell transformation, although much less efficiently than
HTLV-1. Required for viral replication (By similarity). |
|
406 |
Retroviridae |
Human T-cell leukemia virus 3 |
Tax |
Protein Tax-3, Trans-activating transcriptional
regulatory protein of HTLV-3 |
Q0R5R1 |
TAX_HTL32 |
Q4U0X7 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(15367606, 11861831) |
I(11861831) |
N |
Fields Virology |
|
Transcriptional activator that activates both the viral
long terminal repeat (LTR) and cellular promoters via
activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds
to two 21 bp repeat elements located within the LTRs,
referred to as Tax-responsive element (TRE). Binding to TRE
requires the interaction with CREB1 and CREBBP. Activation of
NF-kappa-B leads to up-regulation of the expression of gene
promoters containing NFkB motifs like IL8 or BCL2L1. Inhibits
the action of p53/TP53 and MYCB. All these functions could
lead to the possible occurrence of lymphoproliferative
disorders. Required for viral replication (By
similarity). |
|
407 |
Retroviridae |
Human T-cell leukemia virus 3 |
Uncharacterized protein |
|
Q6LDW4 |
Q6LDW4_HTLV3 |
|
ssRNA |
TR, Rep |
P |
I(26488441) |
I(22073215, 26488441) |
N |
I(11909874) |
I(15994812, 10428378, 14981150) |
I(10428378) |
Fields Virology |
Q6LDW4 is inferred from Human immunodeficiency virus 1
protein P04608 |
RNA-binding transcription regulator activity,positive
regulation of viral transcription,host cell nucleus |
|
408 |
Retroviridae |
Human T-lymphotropic virus 4 |
Tax |
Tax protein |
A0A193H3A4 |
A0A193H3A4_9DELA |
B8LHM2,Q50E57 |
indirect/unknown |
TR |
P |
N |
N |
N |
I(15367606, 11861831) |
I(11861831) |
N |
Fields Virology |
|
2 iron, 2 sulfur cluster binding,oxidoreductase
activity,positive regulation of transcription,
DNA-templated |
|
409 |
Retroviridae |
Simian foamy virus |
Bel-1 |
bel1, Protein Bel-1, Taf, Tas, Transactivator of
spumavirus, Transcriptional transactivator |
Q87042 |
BEL1_SFVCP |
A0A1E1EMK5,A0A2H4PMA7,A0A2Z5HTX8,H6V7J1,K7YKU4,K7YKV0,K7YKV5,Q7SIS4,R9RVK5 |
dsDNA |
TR, Rep |
P |
N |
N |
N |
D(8356798, 8648727, 9621006) |
D(8648727, 9420252, 9621006) |
I(8648727, Footprinting), I(9420252, Footprinting) |
26446599.0 |
|
Transcriptional transactivator that activates the viral
internal promoter (IP), thereby enhancing its own expression.
This transactivation is repressed by nuclear factor I. Also
transactivates the long terminal repeat (LTR) promoter,
thereby inducing structural gene expression, initiating the
late phase of infection. It is therefore a key regulator of
viral gene expression. It directly binds to and activates DNA
target sites of viral promoters and those of distinct
cellular genes. Required for viral replication (By
similarity). |
|
410 |
Rhabdoviridae |
Australian bat lyssavirus |
P |
Phosphoprotein, Protein M1, Protein P |
Q9QSP3 |
PHOSP_ABLVB |
A0A088NJK8,A0A0S2VHH1,Q91RE3,Q91RE4,Q91RE5,Q91RE6,Q91RE7,Q9YZ23 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
I(26647356; 22740405; 27384657; 16973555) |
N |
I(19369340), I(8676480, in vitro Transcription Assay),
I(1309893, in vitro Transcription Assay) |
24556791.0 |
RNA polymerase cofactor |
Non catalytic polymerase cofactor and regulatory protein
that plays a role in viral transcription and replication.
Stabilizes the RNA polymerase L to the N-RNA template and
binds the soluble protein N, preventing it from encapsidating
non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta
signaling by binding and retaining phosphorylated STAT1 in
the cytoplasm or by inhibiting the DNA binding of STAT1 in
the nucleus (By similarity). |
|
411 |
Rhabdoviridae |
Duvenhage lyssavirus |
N |
NP, Nucleocapsid protein, Nucleoprotein, Protein N |
Q66453 |
NCAP_DUVV |
A0A0F6MWF3,B2XXZ9,D2CRL8,D2CRM5,I3W9E2 |
ssRNA |
TR, Rep |
S |
N |
N |
N |
I(11799201; 27384657; 31434934) |
I(15557246) |
I(26957093; 9603315) |
17326954.0 |
|
Encapsidates the genome, protecting it from nucleases. If
expressed without protein P it binds non-specifically RNA and
therefore can bind it's own mRNA. Interaction with protein P
abolishes any non-specific RNA binding, and prevents
phosphorylation. The soluble N-P complex encapsidates
specifically the genomic RNA, with protein N protecting the
genome like a pearl necklace. The encapsidated genomic RNA is
termed the nucleocapsid (NC) and serves as template for viral
transcription and replication. Protein N binds protein P in
the NC through a different interaction, and can be
phosphorylated. Subsequent viral replication is dependent on
intracellular concentration of newly synthesized protein N.
During replication, encapsidation by protein N is coupled to
RNA synthesis and all replicative products are resistant to
nucleases (By similarity). |
|
412 |
Rhabdoviridae |
Duvenhage lyssavirus |
P |
Isoform P2 of Phosphoprotein, Isoform P4 of
Phosphoprotein, Phosphoprotein, Phosphoprotein
Phosphoprotein, Protein M1, Protein P |
B2XY05 |
B2XY05_DUVV |
B2XY00,D2CRL7,I3W9E3 |
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
D(26647356) |
N |
I(1848304, in vitro Transcription Assay), I(8676480, in
vitro Transcription Assay), I(1309893, in vitro Transcription
Assay) |
17326954.0 |
RNA polymerase cofactor |
Non catalytic polymerase cofactor and regulatory protein
that plays a role in viral transcription and replication.
Stabilizes the RNA polymerase L to the N-RNA template and
binds the soluble protein N, preventing it from encapsidating
non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta
signaling by binding and retaining phosphorylated STAT1 in
the cytoplasm or by inhibiting the DNA binding of STAT1 in
the nucleus. |
|
413 |
Rhabdoviridae |
European bat lyssavirus 1 |
P |
Phosphoprotein, Protein M1, Protein P |
A4UHP9 |
PHOSP_EBLV1 |
|
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
I(26647356; 22740405; 27384657; 16973555) |
N |
I(1848304, in vitro Transcription Assay), I(8676480, in
vitro Transcription Assay), I(1309893, in vitro Transcription
Assay) |
29684025.0 |
RNA polymerase cofactor |
Non catalytic polymerase cofactor and regulatory protein
that plays a role in viral transcription and replication.
Stabilizes the RNA polymerase L to the N-RNA template and
binds the soluble protein N, preventing it from encapsidating
non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta
signaling by binding and retaining phosphorylated STAT1 in
the cytoplasm or by inhibiting the DNA binding of STAT1 in
the nucleus (By similarity). |
|
414 |
Rhabdoviridae |
European bat lyssavirus 2 |
P |
Isoform P2 of Phosphoprotein, Isoform P3 of
Phosphoprotein, Isoform P5 of Phosphoprotein, Phosphoprotein,
Phosphoprotein Phosphoprotein, Protein M1, Protein P |
A4UHQ4 |
PHOSP_EBLV2 |
|
indirect/unknown |
TR, Rep |
S |
N |
N |
N |
I(26647356; 22740405; 27384657; 16973555) |
N |
I(1848304, in vitro Transcription Assay), I(8676480, in
vitro Transcription Assay), I(1309893, in vitro Transcription
Assay) |
29684025.0 |
RNA polymerase cofactor |
Non catalytic polymerase cofactor and regulatory protein
that plays a role in viral transcription and replication.
Stabilizes the RNA polymerase L to the N-RNA template and
binds the soluble protein N, preventing it from encapsidating
non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta
signaling by binding and retaining phosphorylated STAT1 in
the cytoplasm or by inhibiting the DNA binding of STAT1 in
the nucleus (By similarity). |
|
415 |
Rhabdoviridae |
Mokola lyssavirus |
N |
NP, Nucleocapsid protein, Nucleoprotein, Protein N |
P0C570 |
NCAP_MOKV |
B2XXY9,B2XXZ4,D6Q0P5,D6Q0P9,E4W5W4,E4W5W5,Q5VKP7,Q83544,Q86593,S5DHS6,S5DHT9 |
ssRNA |
TR, Rep |
S |
N |
N |
N |
D(11799201) |
I(15557246) |
I(26957093; 9603315) |
28143485.0 |
|
Encapsidates the genome in a ratio of one protein N per
nine ribonucleotides, protecting it from nucleases. If
expressed without protein P it binds non-specifically RNA and
therefore can bind it's own mRNA. Interaction with protein P
abolishes any non-specific RNA binding, and prevents
phosphorylation. The soluble N-P complex encapsidates
specifically the genomic RNA, with protein N protecting the
genome like a pearl necklace. The encapsidated genomic RNA is
termed the nucleocapsid (NC) and serves as template for viral
transcription and replication. Protein N binds protein P in
the NC through a different interaction, and can be
phosphorylated. Subsequent viral replication is dependent on
intracellular concentration of newly synthesized protein N.
During replication, encapsidation by protein N is coupled to
RNA synthesis and all replicative products are resistant to
nucleases (By similarity). |
|
416 |
Rhabdoviridae |
Mokola lyssavirus |
P |
Phosphoprotein, Protein M1, Protein P |
P0C569 |
PHOSP_MOKV |
A0A1L2C1Z1,A0A1L2C1Z5,A0A1L2C227,B2XXZ0,B2XXZ5,O56775,O56777,Q86594,Q910M0,Q91RE0,Q91RE1,Q91RE2,R9Q7B8,R9Q7N9,R9Q7P1,S4S267,S4S2C0,S4S2C5,S5DMU3,S5DMV1,S5DMV6,S5DMW2,U5L226 |
indirect/unknown |
TR, Rep |
S |
N |
N |
2WZL |
D(26647356; 22740405) |
N |
I(1848304, in vitro Transcription Assay), I(8676480, in
vitro Transcription Assay), I(1309893, in vitro Transcription
Assay) |
28143485.0 |
RNA polymerase cofactor |
Non catalytic polymerase cofactor and regulatory protein
that plays a role in viral transcription and replication.
Stabilizes the RNA polymerase L to the N-RNA template and
binds the soluble protein N, preventing it from encapsidating
non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta
signaling by binding and retaining phosphorylated STAT1 in
the cytoplasm or by inhibiting the DNA binding of STAT1 in
the nucleus (By similarity). |
|
417 |
Rhabdoviridae |
Rabies virus |
N |
NP, Nucleoprotein, Protein N |
P06025 |
NCAP_RABVP |
A0A024A0B8,A0A024A0W3,A0A024A1B4,A0A059TB69,A0A059TB70,A0A059TB87,A0A059TB89,A0A059TB90,A0A059TB93,A0A059TB94,A0A059TB96,A0A059TB98,A0A059TBC0,A0A059TBC2,A0A059TBC4,A0A059TBE0,A0A059TBE1,A0A059TBE2,A0A059V8W4,A0A060N356,A0A088AXQ2,A0A089N960,A0A097P8D2,A0A097P8G3,A0A0M6VAI4,A0A0N9HLM0,A0A0R5SAT5,A0A0R5SAT8,A0A0R5SAU1,A0A0R5SAU5,A0A0R5SAU7,A0A0R5SAV4,A0A0R5SAW1,A0A0R5SAX0,A0A0R5SAX7,A0A0R7EZ21,A0A0R7EZ32,A0A0R7EZ33,A0A0R7EZ56,A0A0R7EZ74,A0A0R7EZ77,A0A0R7EZ92,A0A0R7EZB5,A0A0R7EZB6,A0A0R7EZB8,A0A0U3SBI6,A0A0U3SBL4,A0A0U3SSS1,A0A0U4BAC4,A0A0U4BIP6,A0A0U4C038,A0A0U4C066,A0A0Y0FT50,A0A109QK65,A0A125QVS9,A0A142D6R1,A0A165DA56,A0A1B0THU0,A0A1B0THU8,A0A1B4WGP6,A0A1B4WGQ5,A0A1D8BP49,A0A1D8BP50,A0A1D8BP64,A0A1D8BP68,A0A1D8BP72,A0A1D8BP73,A0A1D8BP76,A0A1D8BP83,A0A1D8BP84,A0A1D8BP85,A0A1D8BP88,A0A1D8BP93,A0A1D8BP94,A0A1D8BPA1,A0A1D8BPA2,A0A1D8BPA6,A0A1D8BPB2,A0A1D8BPB6,A0A1D8BPC0,A0A1D8BPC5,A0A1D8BPD5,A0A1D8BPD8,A0A1D8BPD9,A0A1D8BPF6,A0A1D8BPG1,A0A1D8BPG5,A0A1D8BPG8,A0A1D8BPH6,A0A1D8BPI8,A0A1D8BPJ9,A0A1D8BPK9,A0A1D8BPL0,A0A1D8BPL3,A0A1D8BPL5,A0A1D8BPL6,A0A1D8BPL7,A0A1D8BPM3,A0A1D8BPN1,A0A1D8BPN2,A0A1D8BPP9,A0A1D8BPQ0,A0A1D8BPQ7,A0A1D8BPR3,A0A1D8BPR5,A0A1D8BPR7,A0A1D8BPS1,A0A1D8BPS6,A0A1D8BPT2,A0A1D8BPT6,A0A1D8BPT9,A0A1D8BPU4,A0A1D8BPU8,A0A1D8BPV0,A0A1D8BPV2,A0A1D8BPV4,A0A1D8BPV5,A0A1D8BPV7,A0A1D8BPW0,A0A1D8BPW3,A0A1D8BPX9,A0A1D8BPY2,A0A1D8BPZ0,A0A1D8BPZ5,A0A1I9WAC1,A0A1I9WAC6,A0A1I9WAD0,A0A1I9WAD2,A0A1I9WAD3,A0A1I9WAD6,A0A1J0RF46,A0A1J0RFS2,A0A1J0RGL4,A0A1J0RGM5,A0A1J0RH62,A0A1J0RH71,A0A1J0RHB0,A0A1J0RHR8,A0A1J0RHS7,A3F5M0,A3F5Q5,A3F5T0,A4D874,A4D875,A4D881,A4D883,A4D884,A4D885,A4D888,A4D889,A4D891,A4D8A5,A4D8A6,A4D8B1,A4D8B7,A4D8C0,A4D8C1,A4D8C4,A4D8C5,A4D8C7,A4D8C8,A4D8C9,A4D8D0,A4D8D4,A4D8D6,A4D8D8,A4D8E4,A4D8E5,A4D8F5,A4D8F7,A4D8G6,A4D8G9,A4D8H0,A4D8H1,A6MF76,A7LFL9,A8CEB8,A8VR20,A9QXE5,A9Y0H9,A9Y0I5,A9Y0I6,A9Y0J1,A9Y0J3,A9Y0J4,A9Y0J5,A9Y0J6,A9Y0K5,B0EYQ3,B0FPH5,B3GQF0,B3GQF1,B3GQF2,B3GQF4,B3GQF5,B3GQF6,B3GQF7,B3GQF8,B3GQG0,B3GQG1,B3GQG2,B3GQG3,B3GQG6,B3GQG7,B3GQG8,B3GQG9,B3GQH0,B3GQH5,B3GQH7,B3GQH8,B3GQI1,B3GQI2,B3GQI3,B3GQI5,B3GQI6,B3GQI7,B3GQI8,B3GQJ0,B3GQJ1,B3GQJ2,B3GQJ3,B3GQJ4,B3GQJ6,B3GQJ7,B3GQJ8,B3GQK0,B5AAR7,B5AXD4,B5KMJ7,B5KML5,B5KMN5,B9VS70,C0IQG0,C0IQG2,C0IQG7,C0IQG9,C0IQH0,C0IQH2,C0IQH3,C0IQH4,C0IQH6,C0IQH8,C0IQI0,C0IQI1,C0IQI2,C0IQI3,C0IQI4,C0IQI5,C0IQI7,C0IQI8,C0IQJ0,C0IQJ1,C0IQJ2,C0ITH9,C0ITI1,C0ITI2,C0ITI3,C0ITI4,C0ITI8,C0ITI9,C0J5B6,C0J5B7,C0J5B9,C0J5C2,C0J5P8,C0J5Q5,C0J5S4,C0J5V0,C0J5V3,C0J5V4,C0J5V9,C0J5X2,C0J5Y3,C0J5Y5,C0JJL4,C0JJL5,C0JJL8,C0JJM0,C0JJM1,C0JJM2,C0JJM3,C0JJM5,C0JJM7,C0JJM8,C0JJN1,C0JJN2,C0JJN4,C0JJN7,C0JJN8,C0JJN9,C0JJP1,C0JJP2,C0JJP6,C0JJP7,C0JJP9,C0JJQ1,C0JJQ3,C0JJQ4,C0JJQ6,C3VID6,C4MH53,C6ZD73,C6ZD88,C7ADP4,C9WLX2,C9WLX4,C9WLX6,D2D2A8,D2D2B3,D2D2B7,D3JZP8,D4P3X7,D6Q090,D6Q0A4,D6Q0Q6,D6Q0Q8,E0X4L5,E0X4M3,E0Y5E6,E0Y5F4,E0Y5I1,E0Y5I7,E0Y5M2,E0Y5M5,E0Y5M7,E0Y5M8,E0Y5N0,E0Y5N3,E0Y5N8,E5E232,E5E233,E5E234,E5E236,E5E237,E5E238,E5E239,E5E241,E5E243,E5E245,E5E246,E5E249,E5E250,E5E252,E5E254,E5E255,E5E256,E5E257,E5E260,E5E263,E5E264,E5E265,E5E267,E5E268,E5E269,E5E271,E5E272,E5E273,E5E274,E5E275,E5E276,E5E278,E5E280,E5E281,E5E282,E5E283,E5E284,E5E285,E5E287,E5E288,E5E289,E5E290,E5E291,E5E292,E5E293,E5E294,E5E295,E5E297,E5E298,E5E299,E5E2A1,E5E2A2,E5E2A3,E5E2A4,E5E2A6,E5E2A7,E5E2A8,E5E2A9,E5E2B0,E5E2B8,E5E2C0,E5E2C2,E5E2C6,E5E2C7,E5E2C8,E5E2D0,E5E2D3,E5E2D6,E5E2D9,E5E2E2,E5E2E3,E5E2E4,E5E2E6,E5E2E7,E5E2E9,E5E2F5,E5E2F6,E5E2F8,E5E2F9,E5E2G3,E5E2G4,E5E2G5,E5E2G6,E5E2H0,E5E2H1,E5E2H2,E5E2H3,E5E2H5,E5E2H6,E5E2H7,E5E2H8,E5E2H9,E5E2I0,E5E2I2,E5E2I4,E5E2I7,E5E2I8,E5E2I9,E5E2J0,E5E2J1,E5E2J2,E5E2J3,E5E2J4,E5E2J5,E5E2J6,E5E2J7,E5E2K0,E5E2K1,E5E2K2,E5E2K5,E5E2K6,E5E2K7,E5E2K9,E5E2L0,E5E2L1,E5E2L5,E5E2L6,E5E2L7,E5E2L8,E5E2L9,E5E2M0,E5E2M1,E5E2M2,E5E2M3,E5E2M4,E5E2M7,E5E2N1,E5E2N2,E5E2N3,E5E2N4,E5E2N6,E5E2N7,E5E2N8,E5E2N9,E5E2P0,E5E2P1,E5E2P2,E5E2P3,E5E2P4,E5E2P5,E5E2P6,E5E2P7,E5E2P8,E5E2Q0,E5E2Q1,E5E2Q3,E5E2Q4,E5E2Q6,E5E2Q7,E5E2Q8,E5E2Q9,E5E2R3,E5E2R5,E5E2R6,E5E2R7,E5E2R8,E5E2R9,E5E2S0,E5E2S1,E5E2S2,E5E2S3,E5E2S5,E5E2S6,E5E2T1,E5E2T2,E5E2T3,E5E2T5,E5E2T6,E5E2T7,E5E2U1,E5E2U3,E5E2U5,E5E2U6,E5E2U8,E5E2V0,E5E2V1,E5E2V2,E5E2V6,E5E2V8,E5E2V9,E5E2W1,E5E2W5,E5E2W6,E5E2W7,F8UZL2,F8UZL5,F8UZL9,F8UZM4,F8UZM5,F8UZM6,F8UZN5,F8UZP5,G8XR30,G8XR34,H9N3Z9,H9N400,H9N402,H9N404,H9N409,H9N411,H9N412,H9N413,H9N415,H9N416,H9N418,H9N421,H9N424,H9N425,H9N426,H9N428,H9N430,H9N431,H9N432,H9N433,I4CJZ0,I6WDF0,I6WDF7,I6WDI9,I6WDM1,I6WDM7,I6WDN8,I6WDS9,I6WDT4,I6WE51,I6WEI5,I6YLU0,I7F434,J9S3H1,K9LIJ7,K9MRV2,K9MRV9,K9MRW2,K9MS20,K9MT90,K9MTA4,K9MTB5,K9MTB9,K9NVT2,M1GND6,M1H0W2,M1PLG0,M4JCU8,M4JCV1,M4JCV3,M4JCV4,M4JCW5,M4JCW7,M4JCW9,M4JCX1,M4JCX3,M4JCX6,M4JCX8,M4JCZ3,M4JCZ6,M4JD07,M4JD09,M4JD15,M4JD23,M4JD25,M4JD33,M4JD35,M4JD37,M4JD40,M4JD43,M4JD44,M4JD46,M4JD50,M4JD53,M4JD64,M4JD66,M4JD79,M4JD80,M4JDI0,M4JDI4,M4JDI6,M4JDI8,M4JDJ0,M4JDJ3,M4JDJ5,M4JDK1,M4JDK3,M4JDK6,M4JDK8,M4JDL0,M4JDL4,M4JDL9,M4JDM0,M4JDM4,M4JDM5,M4JDM6,M4JE89,M4JE95,M4JE96,M4JEA4,M4JEA6,M4JEA9,M4JEB1,M4JEB7,M4JEC1,M4JEC4,M4JEC6,M4JED8,M4JEE1,M4JEF1,M4JEF2,M4JEF6,M4JEF9,M4JEG5,M4JF52,M4JF54,M4JF56,M4JF62,M4JF65,M4JF68,M4JF72,M4JF75,M4JF78,M4JF81,M4JFB3,M4JFC5,P15197,P16285,Q0PE64,Q0PE66,Q0PE68,Q0PE72,Q0PE74,Q0PNB8,Q0Q0C4,Q0Q0D4,Q0Q0D7,Q0QDH5,Q19NZ2,Q4F904,Q52YR0,Q52YR4,Q52YR8,Q52YS3,Q52YS5,Q52YS6,Q52YT7,Q52YV1,Q52YV4,Q52YW3,Q52YW5,Q52YW9,Q52YX4,Q52YX9,Q5L4F8,Q66T65,Q69DB2,Q86410,Q86411,Q86426,Q86430,Q86431,Q86438,Q86453,Q8B6J9,Q8JXF6,Q8UYC3,Q8V0H0,Q8V0H3,Q8V0H5,Q8V415,Q8V416,Q8V417,Q8V419,Q8V420,Q8V424,Q8V426,Q8V427,Q8V428,Q91SM2,Q91SM3,Q91SM4,Q91SM5,Q91SM7,Q91SN1,Q91SN3,Q91SU2,Q91SU7,Q91SU9,Q91SV0,Q91SV1,Q91SV4,Q91SV7,Q91SW1,Q91SW5,Q91SW7,Q91SW9,Q91SX2,Q9WJY7,Q9WLM8,S5FP98,S5FQI9,S6BCW3,T2DL99,U5KJ83,U5S5Z2,U5S8N2,W6JI73 |
ssRNA |
TR, Rep |
S |
N |
N |
N |
D(27384657; 31434934) |
D(15557246) |
D(26957093; 9603315) |
23602163.0 |
|
Encapsidates the genome in a ratio of one protein N per
nine ribonucleotides, protecting it from nucleases. If
expressed without protein P it binds non-specifically RNA and
therefore can bind it's own mRNA. Interaction with protein P
abolishes any non-specific RNA binding, and prevents
phosphorylation. The soluble N-P complex encapsidates
specifically the genomic RNA, with protein N protecting the
genome like a pearl necklace. The encapsidated genomic RNA is
termed the nucleocapsid (NC) and serves as template for viral
transcription and replication. Protein N binds protein P in
the NC through a different interaction, and can be
phosphorylated. Subsequent viral replication is dependent on
intracellular concentration of newly synthesized protein N.
During replication, encapsidation by protein N is coupled to
RNA synthesis and all replicative products are resistant to
nucleases (By similarity). |
|
418 |
Rhabdoviridae |
Rabies virus |
P |
Phosphoprotein, Protein M1, Protein P |
P06747 |
PHOSP_RABVP |
A3F5R6,P15198,P16286,P22363,P69479,P69480,Q0GBX8,Q0GBY3,Q8B6J8,Q9IPJ8 |
indirect/unknown |
TR, Rep |
S |
N |
N |
3OA1 |
D(27384657; 26647356) |
N |
D(26957093) |
23602163.0 |
RNA polymerase cofactor |
Non catalytic polymerase cofactor and regulatory protein
that plays a role in viral transcription and replication.
Stabilizes the RNA polymerase L to the N-RNA template and
binds the soluble protein N, preventing it from encapsidating
non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta
signaling by binding and retaining phosphorylated STAT1 in
the cytoplasm or by inhibiting the DNA binding of STAT1 in
the nucleus. Might be involved, through interaction with host
dynein, in intracellular microtubule-dependent virus
transport of incoming virus from the synapse toward the cell
body (By similarity). |
|
419 |
Rhabdoviridae |
Vesicular stomatitis Indiana virus |
P |
P Protein, Phosphoprotein, Protein M1 |
P03520 |
PHOSP_VSIVA |
A0A140DCD4,A0A140DCD9,A0A3G1VCW6,P04879,P04880,Q89487,Q8B0H3,Q8B0H8,Q8B0I3,Q9IG72,Q9IG73,Q9IG74,Q9IG75,Q9IG76,Q9IG77,Q9IG78,Q9IG79,Q9IG80,Q9IG81,Q9IG82,W5U2W7 |
indirect/unknown |
TR, Rep |
S |
N |
N |
2K47 |
D(16973555) |
N |
D(3032453, in vitro Transcription Assay), D(1848304, in
vitro Transcription Assay), D(8676480, in vitro Transcription
Assay), D(1309893, in vitro Transcription Assay) |
2845825.0 |
RNA polymerase cofactor |
Essential component of the RNA polymerase transcription
and replication complex. Binds the viral ribonucleocapsid and
positions the L polymerase on the template. May act as a
chaperone for newly synthesized free N protein, so-called
N(0). Plays a role in virion assembly. |