Viral_family Species Name Aliases UniProtID_Ref UniProt_Name_Ref UniProt_IDs_Orthologs Binding_ligand Function Primary_secondary_vTR ChIP ChIP_seq Structure_PDB_ID Reporter_assay EMSA Other_assays Human_infection_evidence Notes Functional_annotation (none) Hepatitis delta virus S-HDAg HDAg, LHDAg, P24, Small delta antigen P0C6L3 SHDAG_HDVD3 A0A0P0KG82,A0A185QEB0,A0A185QEB2,A0A185QEV2,A0A185QEW3,A0A185QEX3,A0A190LCH6,A0A190LCI6,A0A190LCJ6,A0A190LCL2,A0A190LCM2,A0A190LCN4,A0A190LCP3,A0A221S7Z0,A0A221S7Z2,A0A221S7Z5,A0A221S872,A0A221S875,A4ZN24,A4ZN28,A4ZN30,A4ZN32,A4ZN33,A4ZN34,A4ZN37,A4ZN38,A4ZN41,A4ZN42,A4ZN43,A4ZN44,A4ZN52,A4ZN66,A4ZN69,A4ZN70,A4ZN71,A4ZN72,A4ZN77,A4ZN79,A4ZN80,A4ZN81,A4ZN85,A4ZN86,A4ZN91,A4ZN96,A4ZN97,A4ZN98,A4ZN99,A4ZNA0,A4ZNA3,A4ZNA5,A4ZNA6,A4ZNB1,A4ZNB3,A4ZNB8,A4ZNC1,A4ZNC4,A4ZNH4,A5A0U5,A5A0U6,A5A0U9,D7RA49,P06934,P25880,P25881,P25882,P25989,P29833,P29997,Q6DUC3,Q6QT49,Q71DP5,Q81835,Q9E925,Q9E926 ssRNA TR, Rep S N N N D(18653455) N D(30153423, RNA-binding protein pull-down assay), D(18653455) 24198831.0 Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity). Adenoviridae Human adenovirus A E1A Early E1A 29.5 kDa protein, Early E1A protein P03259 E1A_ADE12 A0A3G1HCH6,D0Z5R8,Q6JGG5,Q6JGG8 indirect/unknown TR P I(19129215, 21715488) N N D(7951410) D(7951410) D(7951410) Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore. This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Adenoviridae Human adenovirus A E2A DBP, DNA-binding protein, Early 2A protein, Early E2A DNA-binding protein P04498 DNB2_ADE12 A0A3G8WIW6,D0Z5T4,D3JIT2 dsDNA TR, Rep S N N N I(11581372) I(12502807, 8039495) N Fields Virology Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP. Adenoviridae Human adenovirus A E3 14.7 kDa protein, E3 14.7K, E3 14.7K homologue protein, E3B 14.7 KD protein D0Z5U4 D0Z5U4_ADE31 D3JIU2,Q65288 indirect/unknown TR, other S N N N I(16423054) I(16423054, 11991979) N Fields Virology Q65288 is inferred from Human adenovirus C protein P68976 mitigation of host defenses by virus Adenoviridae Human adenovirus A E4 E4 ORF6 protein, Early E4 34 kDa protein P36710 E434_ADE12 A0A3G8W3L7 indirect/unknown TR P N N N I(8633237, 1832724, 2137929) I(1832724, 2137929) N Fields Virology P36710 is inferred from Human adenovirus C protein P03238 Modulates viral and host transcriptional activity to promote viral genome replication. Stimulates viral E2a promoter activity by binding and inducing dimerization of host E2F. During viral infection E1A protein binds to cellular retinablastoma (RB) family members and disociates these repressors from a complex with E2F proteins. Free E2F is then bound to E4orf6/7 which leads to transactivation of viral E2 promoter, and cellular promoters such as E2F-1 promoter. Activation of cellular E2F targets promote cell cycle S phase and thereby possibly favorises viral DNA replication process. Adenoviridae Human adenovirus A IVa2 Packaging protein 1, Packaging protein IVa2 P12540 PKG1_ADE12 A0A3G8WBN6,D0Z5S2,D3JIS0 dsDNA TR, NAP S I(15681437) N N I(8627656, 15327897) I(22884292, 8627656, 15681437) I(15780869, DNA-binding protein pull-down assay) Fields Virology Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1. Adenoviridae Human adenovirus A L2 L2 protein pVII, L2 protein VII, Major core protein pVII, Pre-core protein VII, Pre-histone-like nucleoprotein, Protein VII, pVII, PVII D0Z5S8 D0Z5S8_ADE31 dsDNA TR, NAP S N N N N I(6828374, 27362237) I(15780869, DNA-binding protein pull-down assay) Fields Virology D0Z5S8 is inferred from Human adenovirus C protein P68950 Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus. Adenoviridae Human adenovirus B E1A Early E1A 28 kDa protein, Early E1A protein P03256 E1A_ADE07 A0A0A7DXW5,A0A0A7DY38,A0A1U9ALF8,A0A1U9ALG4,A0A219PC17,A0A386NAE6,A0A386NAK0,A0A386NCD8,A0A386NCU0,D2DM82,D6BP20,Q2KRU4,Q2KS74,Q2KS76,Q2KS77,Q2KSL5,Q2KSL6,Q4JEQ5,Q4JEQ6,Q5EY85,Q5EY86,Q5YKW5,Q5YKX2,Q6JGG9,Q6RK99,Q7T953,Q7T954,Q8JSK3,Q8JSK4,R4HLK4,R4HMJ7 indirect/unknown TR P I(19129215, 21715488) N N I(19129215, 10446138) I(10446138) N Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore. This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Adenoviridae Human adenovirus B E2A DBP, DNA-binding protein, Early 2A protein, Early E2A DNA-binding protein P04497 DNB2_ADE07 A0A219PC53,A0A219PC79,D0EF47,D2DMA0,Q2KRW8,Q2KS36,Q2KSI4,Q2Y0H2,Q5EY61,Q6RK85,Q6YL70,Q7T934,R4HLE7 dsDNA TR, Rep S N N N I(11581372) I(12502807, 8039495) N Fields Virology Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP. Adenoviridae Human adenovirus B E3 14 kDa protein, 14.7 kDa protein, 15.3 kDa protein, E3 14.7 kDa protein, E3B, Early E3 15.3 kDa protein, ORF 15.3 kDa P11315 E3145_ADE03 D2DMA9,P15135,Q2KSH2,Q2Y0F9,Q5EY47,Q67732,Q83121,Q91CJ8,Q9PX47,R4HML9 indirect/unknown TR, other S N N N I(16423054) I(16423054, 11991979) N Fields Virology D2DMA9 is inferred from Human adenovirus C protein P68976 Protects virus-infected cells from TNF-induced cytolysis. Adenoviridae Human adenovirus B E4 299 aa, 32 kDa protein, 33.2 kDa protein, 34 kDa protein, E4 33.2 kDa protein, E4 33 kDa protein, E4 ORF6 34.7 kDa protein, E4 ORF6/7, E4 ORF6 protein, E4 ORF (Fragment), ORF 6/7, Orf6/7 protein, ORF6/7 D0EF64 D0EF64_ADE07 A0A096XFF7,D2DMB1,I1V198,K7SXT6,Q2KRV1,Q2KS47,Q2KSJ0,Q2Y0F6,Q4JEL5,Q5EY43,Q7T924,R4HLG5 indirect/unknown TR P N N N I(8633237, 1832724, 2137929) I(1832724, 2137929) N Fields Virology D0EF64 is inferred from Human adenovirus C protein P03238 Modulates viral and host transcriptional activity to promote viral genome replication. Stimulates viral E2a promoter activity by binding and inducing dimerization of host E2F. During viral infection E1A protein binds to cellular retinablastoma (RB) family members and disociates these repressors from a complex with E2F proteins. Free E2F is then bound to E4orf6/7 which leads to transactivation of viral E2 promoter, and cellular promoters such as E2F-1 promoter. Activation of cellular E2F targets promote cell cycle S phase and thereby possibly favorises viral DNA replication process. Adenoviridae Human adenovirus B IVa2 E2B, Packaging protein 1, Packaging protein IVa2 P03273 PKG1_ADE07 A0A0A7DXV0,D2DM86,I1V164,Q2KRY3,Q2KS70,Q2KSL0,Q2Y0J0,Q5EY79,Q6RK95,Q7T948,R4HMK1 dsDNA TR, NAP S I(15681437) N N I(8627656, 15327897) I(22884292, 8627656, 15681437) I(15780869, DNA-binding protein pull-down assay) Fields Virology Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1. Adenoviridae Human adenovirus B L2 L2 protein pVII, L2 protein VII, Major core protein pVII, Pre-core protein VII, Pre-histone-like nucleoprotein, Protein VII, pVII, PVII D0EF42 D0EF42_ADE07 D2DM94,Q2KRX4,Q2KS41,Q2KSJ8,Q2Y0H8,Q5EY66,Q6RK90,Q7T940,R4HLK6 dsDNA TR, NAP S N N N N I(6828374, 27362237) I(3743550, cross-linking), I(15163739, Immunofluorescence) Fields Virology D0EF42 is inferred from Human adenovirus C protein P68950 Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus. Adenoviridae Human adenovirus C E1A Early E1A 32 kDa protein, Early E1A protein P03255 E1A_ADE05 A0A1U9ALK2,A0A3G1HBN7,E1U5L3,E1U5L4,E7DY80,P03254,P03254-2,P03255-2,Q2KS29,Q6JGH2,Q6JGH3,Q6VGV9,Q6VGW0,Q71BY7,Q71BY8,W8VTN3 indirect/unknown TR P D(19129215, 21715488) N 2KJE, 2R7G D(19129215, 10446138) D(10446138) N Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore. This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26405230). Adenoviridae Human adenovirus C E2A DBP, DNA-binding protein, Early 2A protein, Early E2A DNA-binding protein, Early E2A DNA-binding protein,,E2a_1 P03264 DNB2_ADE02 A0A0U5C455,A0A1U9ALL4,E1U5P2,E7DY93,P03265,Q2KS06,Q6VGU4,Q71BW6,W8VNG9 dsDNA TR, Rep S N N N D(11581372) D(12502807, 8039495) N Fields Virology Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its release from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP. Adenoviridae Human adenovirus C E3 E3-14.7k, Early 3 14.7 kDa protein P68976 E3145_ADE02 A0A0U5BYW0,A0A127WKD0,A0A3G8W4Y8 indirect/unknown TR, other S N N N D(16423054) D(16423054, 11991979) D(16423054) Fields Virology May prevent Nf-kappaB activation by immune signals like Tumor necrosis factor, presumably by inhibiting NFKB1 dimer DNA-binding. May act directly at the TNF receptor to inhibit signaling. Adenoviridae Human adenovirus C E4 E4-ORF6/7, Early 4 ORF6/7 control protein, Early E4 17 kDa protein P03238 E4RF5_ADE02 A0A0U4XAB1,A0A0U5BPW3,A0A0U5CNF1,A0A127WK23,A0A1U9ALN2,A0A3G8WH84,E1U5Q6 indirect/unknown TR P N N N D(8633237, 1832724, 2137929) D(1832724, 2137929) D(8035503) Fields Virology Modulates viral and host transcriptional activity to promote viral genome replication. Stimulates viral E2a promoter activity by binding and inducing dimerization of host E2F. During viral infection E1A protein binds to cellular retinablastoma (RB) family members and dissociates these repressors from a complex with E2F proteins. Free E2F is then bound to E4orf6/7 which leads to transactivation of viral E2 promoter, and cellular promoters such as E2F-1 promoter. Activation of cellular E2F targets promote cell cycle S phase and thereby possibly favorises viral DNA replication process. Adenoviridae Human adenovirus C IVa2 Packaging protein 1, Packaging protein IVa2, pIVa2 P03272 PKG1_ADE02 A0A0U5BYH2,A0A0U5BZK4,A0A127WJS4,A0A1U9ALL6,A0A3G8W3U4,A8D0L0,E1U5M2,E7DY84,Q6VGV5 dsDNA TR, NAP S D(15681437) N N D(8627656, 15327897) D(22884292, 8627656, 15681437) D(15780869, DNA-binding protein pull-down assay) Fields Virology Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1. Adenoviridae Human adenovirus C L2 L2 protein pVII, L2 protein VII, Major core protein pVII, ppVII, Pre-core protein VII, Pre-histone-like nucleoprotein, Protein VII, pro-VII, pVII, PVII P68950 NP_ADE02 A8D0L7,E1U5N6,P68951,Q71BX2 dsDNA TR, NAP S N N N N D(6828374, 27362237) D(3743550, cross-linking), D(15163739, Immunofluorescence) Fields Virology Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus. Adenoviridae Human adenovirus D E1A 21 kDa protein, 21.2 kDa protein, E1A 12S, E1A 12S protein, Early E1A 12s, Early E1A 12S, Early E1A protein Q9YLA0 Q9YLA0_ADE09 A0A1B1W8K3,A0A1P7YXD4,A0A1P7YXL4,A0A1P7YY79,A0A1Y1C2A5,B2VQE2,B9A5A6,B9A5E2,B9A5H8,E1CII9,F1DT55,K7ZRT6,M0QU00,Q9YLA1 indirect/unknown TR P I(19129215, 21715488) N N I(19129215, 10446138) I(10446138) N Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Adenoviridae Human adenovirus D E2A DBP, DNA binding protein, DNA-binding protein, Early 2A protein, Early E2A DNA-binding protein B2VQF8 B2VQF8_9ADEN A0A1B1W8H7,A0A1P7YXH3,A0A1P7YYU8,B9A5C2,E1CIK5,F1DT72,K7ZJX4,M0QU16,Q5TJ02 dsDNA TR, Rep S N N N I(11581372) I(12502807, 8039495) N Fields Virology B2VQF8 is inferred from Human adenovirus B protein P04497 Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP. Adenoviridae Human adenovirus D E3 14.7K protein, 14.7kDa protein, Early E3B 14.7 kDa protein Q9JFM0 Q9JFM0_ADE08 Q76C83,Q76EL2,Q7TBG6,Q9JFM3 indirect/unknown TR, other S N N N I(16423054) I(16423054, 11991979) N Fields Virology Q9JFM0 is inferred from Human adenovirus C protein P68976 mitigation of host defenses by virus Adenoviridae Human adenovirus D E4 31 kDa protein, 34 kDa, 34 kDa protein, 34.1 kDa protein, 34kDa protein, Early E4 34 kDa protein P89083 E434_ADE09 A0A1B1W7J1,B2VQH1,B9A5D5,B9A5H1,B9A5K7,E1CIL8,F1DT87,K7ZLM0,M0QU32 indirect/unknown TR P N N N I(8633237, 1832724, 2137929) I(1832724, 2137929) N Fields Virology F1DT87 is inferred from Human adenovirus C protein P03238 Modulates viral and host transcriptional activity to promote viral genome replication. Stimulates viral E2a promoter activity by binding and inducing dimerization of host E2F. During viral infection E1A protein binds to cellular retinablastoma (RB) family members and disociates these repressors from a complex with E2F proteins. Free E2F is then bound to E4orf6/7 which leads to transactivation of viral E2 promoter, and cellular promoters such as E2F-1 promoter. Activation of cellular E2F targets promote cell cycle S phase and thereby possibly favorises viral DNA replication process. Adenoviridae Human adenovirus D IVa2 Packaging protein 1, Packaging protein IVa2, pIVa2, PIVa2, PIVa2 protein F1DT60 F1DT60_ADE17 A0A1P8C866,A0A2Z5WHY4,B2VQE6,B9A5B0,B9A5E6,E1CIJ3,K7ZQ22,M0QU04,Q5TJ14 dsDNA TR, NAP S I(15681437) N N I(8627656, 15327897) I(22884292, 8627656, 15681437) I(15780869, DNA-binding protein pull-down assay) Fields Virology F1DT60 is inferred from Human adenovirus C protein P03272 Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1. Adenoviridae Human adenovirus D L2 L2 protein pVII, L2 protein VII, Major core protein pVII, Pre-core protein VII, Pre-histone-like nucleoprotein, Protein VII, pVII, PVII B9A5B6 B9A5B6_ADE08 B9A5F2,E1CIJ9,F1DT66,K7ZRT8,M0QU10 dsDNA TR, NAP S N N N N I(6828374, 27362237) I(3743550, cross-linking), I(15163739, Immunofluorescence) Fields Virology B9A5B6 is inferred from Human adenovirus C protein P68950 Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus. Adenoviridae Human adenovirus E E1A Early E1A 28 kDa protein, Early E1A protein P10407 E1A_ADE04 A0A1U9AL55,A0A1W2KFI9,Q2KSG8,Q2KSH0,Q2KSH1,Q4JEV1,Q5GFD1,Q5VHC6,Q5YKX0,Q64835,Q64836,T1SQR0,T1SRS7,T1STJ3 indirect/unknown TR P I(19129215, 21715488) N N I(19129215, 10446138) I(10446138) N Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore. This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Adenoviridae Human adenovirus E E2A DBP, DNA-binding protein, Early 2A protein, Early E2A DNA-binding protein P06500 DNB2_ADE04 A0A1W2KFE2,A0A1W2KFI6,Q2KSE6,Q5GFA6 dsDNA TR, Rep S N N N I(11581372) I(12502807, 8039495) N Fields Virology Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP. Adenoviridae Human adenovirus E E3 14.7 kDa protein, Control protein E3 14.7K, E3 14.7 kDa protein Q2KSD4 Q2KSD4_ADE04 Q8BEK9 indirect/unknown TR, other S N N N I(16423054) I(16423054, 11991979) N Fields Virology Q8BEK9 is inferred from Human adenovirus C protein P68976 mitigation of host defenses by virus Adenoviridae Human adenovirus E E4 15.9 kDa protein, E4 15.9 kDa protein Q5GF91 Q5GF91_ADE04 Q2KSD2 indirect/unknown TR P N N N I(8633237, 1832724, 2137929) I(1832724, 2137929) N Fields Virology Q5GF91 is inferred from Human adenovirus C protein P03238 Modulates viral and host transcriptional activity to promote viral genome replication. Stimulates viral E2a promoter activity by binding and inducing dimerization of host E2F. During viral infection E1A protein binds to cellular retinablastoma (RB) family members and disociates these repressors from a complex with E2F proteins. Free E2F is then bound to E4orf6/7 which leads to transactivation of viral E2 promoter, and cellular promoters such as E2F-1 promoter. Activation of cellular E2F targets promote cell cycle S phase and thereby possibly favorises viral DNA replication process. Adenoviridae Human adenovirus E IVa2 IVa2 protein, Maturation protein IVa2, Packaging protein 1, Packaging protein IVa2 Q5GFC2 Q5GFC2_ADE04 A0A1W2KF59,Q2KSG1 dsDNA TR, NAP S I(15681437) N N I(8627656, 15327897) I(22884292, 8627656, 15681437) I(15780869, DNA-binding protein pull-down assay) Fields Virology Q5GFC2 is inferred from Human adenovirus C protein P03272 Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1. Adenoviridae Human adenovirus E L2 L2 protein pVII, L2 protein VII, Major core protein pVII, Pre-core protein VII, Pre-histone-like nucleoprotein, Protein VII, pVII, PVII Q2KSF2 Q2KSF2_ADE04 dsDNA TR, NAP S N N N N I(6828374, 27362237) I(3743550, cross-linking), I(15163739, Immunofluorescence) Fields Virology Q2KSF2 is inferred from Human adenovirus C protein P68950 Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus. Adenoviridae Human adenovirus F E1A Early E1A 27 kDa protein, Early E1A protein P10541 E1A_ADE40 A0A142G3J1,A0A1S6ELR7,A0A3G4WBK4,A0A3G8WC02,B5SNR0,F4ZCJ7,P10542,Q64824,Q64881,W0RYQ2 indirect/unknown TR P I(19129215, 21715488) N N I(19129215, 10446138) I(10446138) N Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore. This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation. The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Adenoviridae Human adenovirus F E2A DBP, DNA-binding protein, Early 2A protein, Early E2A DNA-binding protein P11806 DNB2_ADE40 A0A060ILQ0,A0A060ILW5,A0A142G3K6,A0A1S6ELQ0,A0A1S6ELU3,A0A1S6ELX1,A0A3G4WEW3,A0A3G8W3Y9,B5SNS7,E2IJY9,P11807,W0RYE2 dsDNA TR, Rep S N N N I(11581372) I(12502807, 8039495) N Fields Virology Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP. Adenoviridae Human adenovirus F E3 Control protein E3 14.7K, E3 14.0 kDa protein (Homologous to Ad2 E3 14.7 kDa protein), E3 14.0 kd protein, E3 14.7K, E3 14.7K protein Q98817 Q98817_ADE41 indirect/unknown TR, other S N N N I(16423054) I(16423054, 11991979) N Fields Virology Q98817 is inferred from Human adenovirus C protein P68976 mitigation of host defenses by virus Adenoviridae Human adenovirus F E4 E4 ORF6/7, ORF6/7 Q64857 Q64857_ADE40 A0A142G3L9,A0A3G8W5U1 indirect/unknown TR P N N N I(8633237, 1832724, 2137929) I(1832724, 2137929) N Fields Virology Q64857 is inferred from Human adenovirus C protein P03238 Modulates viral and host transcriptional activity to promote viral genome replication. Stimulates viral E2a promoter activity by binding and inducing dimerization of host E2F. During viral infection E1A protein binds to cellular retinablastoma (RB) family members and disociates these repressors from a complex with E2F proteins. Free E2F is then bound to E4orf6/7 which leads to transactivation of viral E2 promoter, and cellular promoters such as E2F-1 promoter. Activation of cellular E2F targets promote cell cycle S phase and thereby possibly favorises viral DNA replication process. Adenoviridae Human adenovirus F IVa2 Packaging protein 1, Packaging protein IVa2 P48752 PKG1_ADE40 A0A142G3J5,B5SNR4 dsDNA TR, NAP S I(15681437) N N I(8627656, 15327897) I(22884292, 8627656, 15681437) I(15780869, DNA-binding protein pull-down assay) Fields Virology P48752 is inferred from Human adenovirus C protein P03272 Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1. Adenoviridae Human adenovirus F L2 L2 protein pVII, L2 protein VII, Major core protein pVII, Pre-core protein VII, Pre-histone-like nucleoprotein, Protein VII, pVII, PVII Q89532 NP_ADE40 A0A142G3K1,A0A1S6ELN7,B5SNS1,E2IJY3 dsDNA TR, NAP S N N N N I(6828374, 27362237) I(3743550, cross-linking), I(15163739, Immunofluorescence) Fields Virology Q89532 is inferred from Human adenovirus C protein P68950 Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus. Arenaviridae Junin mammarenavirus N Nucleocapsid protein, Nucleoprotein, Protein N P14239 NCAP_JUNIN A0A0M4MQK9,C1K9K0,C1K9K4,C5MKK3,D1GI65,D2CFM2,D2CFM5,D2CFR6,D2CFR8,D2CFS0,D2CFS2,D2CFS4,D2CFS6,D2CFS8,D2CFT0,D2CFT2,O10431,O10432,O10433,Q2XP54,Q6IVU2,Q6UY72 ssRNA TR, NAP, Rep S N N 4K7E I(21085117, 21262835) N D(20007272), I(22084115, RNA complex structure) 30123198.0 Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction. Arenaviridae Lassa virus N Nucleocapsid protein, Nucleoprotein, Protein N P13699 NCAP_LASSJ Q6GWS1 ssRNA TR, NAP, Rep S N N 3MWP, 3MWT, 3MX2, 3MX5, 3Q7B, 3Q7C, 4FVU, 4G9Z, 4GV3, 4GV6, 4GV9 D(21085117, 21262835) N D(23553456), D(22084115, RNA complex structure) 29596412.0 Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction. Arenaviridae Lujo mammarenavirus N Nucleocapsid protein, Nucleoprotein C5ILC2 C5ILC2_9VIRU ssRNA TR, NAP, Rep S N N N I(21085117, 21262835) N I(22084115, RNA complex structure) 30123198.0 C5ILC2 is inferred from Lassa virus protein P13699 viral nucleocapsid Arenaviridae Lymphocytic choriomeningitis virus N Nucleocapsid protein, Nucleoprotein, Protein N P07400 NCAP_LYCVW A0A218M2F8,P09992 ssRNA TR, NAP, Rep S N N N D(12610166, 10729120) N D(10729120), I(22084115, RNA complex structure) 22889536.0 Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction. Arenaviridae Machupo virus N NP, Nucleocapsid protein, Nucleoprotein, Nucleoprotein (Fragment), Protein N P26578 NCAP_MACHU A0A1U8ZS29,A0A1U8ZS66,A0A1U8ZS72,A0A1U8ZS90,A0A1U8ZSD0,A0A1U8ZSR6,A9JR11,A9JR13,A9JR15,A9JR19,A9JR21,C7AZ57,C7AZ59,C7AZ61,C7AZ63,C7AZ65,G9J1N3,Q6IUF6,Q6IVT4,Q6PXP5,Q8AZ68 ssRNA TR, NAP, Rep S N N N I(21085117, 21262835) N D(20007272), I(22084115, RNA complex structure) 22607481.0 Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction. Arenaviridae Sabia mammarenavirus N Nucleocapsid protein, Nucleoprotein, Protein N Q90038 NCAP_SABVB H6V7J3 ssRNA TR, NAP, Rep S N N N I(21085117, 21262835) N D(20007272), I(22084115, RNA complex structure) 30123198.0 Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction. Arenaviridae Whitewater Arroyo mammarenavirus N NP, Nucleocapsid protein, Nucleoprotein, Protein N Q91PB2 NCAP_WWAVU Q8BDE2,V9LTH7,V9LTK9,V9LTM7 ssRNA TR, NAP, Rep S N N N I(21085117, 21262835) N I(22084115, RNA complex structure) 28736175.0 Q91PB2 is inferred from Lassa virus protein P13699 Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction. Bornaviridae Borna disease virus 1 P P protein, p23, p24, Phosphoprotein, P/X P0C799 PHOSP_BDVV A4D837,A5A7J0,O10393,O10402,O10404,O10405,O10406,Q1HVJ9,Q1L311,Q53WV0,Q53WV1,Q5GLA5,Q5GLB1,Q5GLC9,Q5XWT9,Q5XWU0,Q5XWU1,Q5XWU2,Q5XWU3,Q65456,Q65457,Q65458,Q76RA4,Q774E4,Q80G14,Q80G15,Q9DRF2,Q9DRF3,Q9E7S5,Q9E7S8,Q9IV61,Q9IV62,Q9IW59,Q9JGP3,Q9Q4W4,X2D1D2,X2D1D5 indirect/unknown TR, Rep S N N N D(15509569, 14581561) N D(14581561, 15509569) 14581561.0 Essential component of the RNA polymerase transcription and replication complex. Acts as a scaffold which brings L in close proximity to the N-RNA complex. Plays a role in the segregation of the viral genome in host daughter cells during mitosis by interacting with host HMGB1, a host chromatin-remodeling DNA architectural protein, thereby stabilizing RNP on chromosomes. Interacts with host TBK1 and thus interferes with activation of cellular antiviral state. Inhibits cellular histone acetyltransferase activities. Bornaviridae Borna disease virus 2 P Phosphoprotein, P protein Q9Q9U9 Q9Q9U9_9MONO indirect/unknown TR, Rep S N N N D(15509569, 14581561) N D(14581561, 15509569) 14581561.0 Viral nucleocapsid Coronaviridae Human coronavirus 229E (HCoV-229E) E E protein, Envelope small membrane protein, sM, sM protein P19741 VEMP_CVH22 A0A059SEL9,A0A384L4F1,J9VDX2,S5YAG7,S5YGS8 indirect/unknown TR, Other S N N N N N I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) 32006468.0 Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Coronaviridae Human coronavirus 229E (HCoV-229E) N NC, Nucleocapsid protein, Nucleoprotein, Protein N P15130 NCAP_CVH22 A0A059SGB0,A0A097ZMN8,A0A097ZMN9,A0A097ZMP1,A0A097ZMP2,A0A097ZMP3,A0A097ZMR3,A0A127ATI4,A0A127ATI5,A0A127ATI6,A0A127ATI8,A0A127ATJ0,A0A127ATJ4,A0A127ATJ5,A0A127ATJ6,A0A127ATJ8,A0A127ATM6,A0A127ATM8,A0A127ATP2,A0A127AU31,A0A127AU35,A0A127AUT5,A0A127AUU5,A0A127AWS1,A0A127AWT0,A0A193BL28,A0A1B3TN93,A0A1L7B914,A0A1L7B917,A0A1L7B932,A0A1L7B959,A0A1V0BZ85,A0A1V0E0Z0,A0A1W6DZN2,A0A1Z1R303,A0A223FUI1,A0A384QXL5,A0A384QXL7,A0A384QXY0,A0A384QZB4,A0A384R2K5,A0A384R2L0,A0A384RBS5,A0A384RBS7,A0A384RHP2,J9V7P0,J9V7P5,Q1HVM7,Q1HVM8,Q1HVM9,Q1HVN3,Q1HVN6,Q1HVN7,Q1HVN9,Q1HVP0,Q1HVP1,Q1HVP2,Q1HVP3,Q1HVP5,Q1HVP6,Q1HVP8,Q1HVP9,Q1HVQ0,S5YAG2,S5Z1H9,S5ZJ09,U3PTJ0,U3PUD7 ssRNA, dsDNA TR, Rep, NAP S I(16546436;18055455) N N D(15890900) I(16546436;15759315;25700263) I(14623261;29793506) 32006468.0 P15130 is inferred from Human SARS coronavirus protein P59595 Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronaviridae Human coronavirus HKU1 E E protein, Envelope small membrane protein, sM, sM protein Q5MQC8 VEMP_CVHN1 A0A224ANC8,Q0ZJ83,Q0ZJ91,Q0ZJB5,Q0ZJD1,Q0ZME5,Q14EA8,S5YA38,S5YTP7 indirect/unknown TR, Other S N N N N N I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) 32006468.0 Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Coronaviridae Human coronavirus HKU1 N NC, Nucleocapsid protein, Nucleoprotein, Protein N Q5MQC6 NCAP_CVHN1 A0A0C5PN53,A0A0C5PWK5,A0A0C5PXY9,A0A0C5Q0N4,A0A0C5Q9E2,A0A127ASV7,A0A127ASV8,A0A127ASW6,A0A127ASW7,A0A127ASY7,A0A127ASZ8,A0A127AT27,A0A127AT34,A0A127AT49,A0A127AT59,A0A127AT66,A0A127AT73,A0A127ATF0,A0A127ATF4,A0A127ATT6,A0A127ATU5,A0A127ATV4,A0A127AUB1,A0A127AUC1,A0A127AW89,A0A127AWE0,A0A1Y0EV09,A0A3Q9JNH6,E0YJ48,Q0PRK0,Q0ZJD7,Q0ZJE5,Q0ZJH7,Q0ZME3,Q14EA6,Q19U24,Q19U25,Q19U26,Q19U29,Q19U34,Q19U36,S5ZBQ7,U3NAH8 ssRNA, dsDNA TR, Rep, NAP S I(16546436;18055455) N N I(16546436;14623261;18055455;17108024;15890900) I(16546436;15759315;25700263) I(14623261;29793506) 32006468.0 Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronaviridae Human coronavirus NL63 (HCoV-NL63) E Envelope small membrane protein, NC, Nucleocapsid protein, Nucleoprotein, Protein N Q6Q1S0 VEMP_CVHNL Q5SBN7 indirect/unknown TR, Other S N N N N N I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) 32006468.0 Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Coronaviridae Human coronavirus NL63 (HCoV-NL63) N NC, Nucleocapsid protein, Nucleoprotein, Protein N Q6Q1R8 NCAP_CVHNL A0A127ATP0,A0A127ATQ0,A0A127ATQ1,A0A127ATQ4,A0A127ATQ7,A0A127ATQ8,A0A127ATR0,A0A127ATR3,A0A127ATR6,A0A127ATR7,A0A127ATS0,A0A127ATS3,A0A127ATS5,A0A127ATS6,A0A127ATS9,A0A127ATT3,A0A127ATT5,A0A127ATT9,A0A127ATU8,A0A127ATV6,A0A127ATV7,A0A127ATW2,A0A127ATW4,A0A127ATX3,A0A127ATX8,A0A127ATY1,A0A127ATY7,A0A127ATY8,A0A127AU18,A0A127AU23,A0A127AU27,A0A127AU68,A0A127AU79,A0A127AU90,A0A127AUA1,A0A127AV25,A0A127AV38,A0A127AV50,A0A127AV68,A0A127AX00,A0A127AX15,A0A127AX50,A0A127AX58,A0A1Y0EV18,A0A2L0WQF7,A0A2P1E938,A0A2P1E945,A0A2P1E948,A0A2P1E959,A0A2P1E971,A0A2U8JDM2,A0A384R2N5,A0A384RBU9,A0A384RBV1,A0T2T5,H9EJ20,H9EJ69,H9EJ76,H9EJA4,I7DJE7,Q06XQ0,Q06XQ1,Q06XQ2,Q06XQ3,Q06XQ4,Q06XQ5,Q06XQ6,Q06XQ7,Q06XQ8,Q06Y12,Q0GMF2,U3M6A0,U3M7G3 ssRNA, dsDNA TR, Rep, NAP S I(16546436;18055455) N 5EPW I(16546436;14623261;18055455;17108024;15890900) D(25700263) I(14623261;29793506) 32006468.0 Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronaviridae Human coronavirus OC43 (HCoV-OC43) E E protein, Envelope small membrane protein, sM, sM protein Q04854 VEMP_CVHOC A0A140E067,Q4VID3,Q4VIE2,U3M6J8,U3M6Q3,U3M6Z1,U3M6Z8,U3M703,U3M734 indirect/unknown TR, Other S N N N N N I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) 32006468.0 Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Coronaviridae Human coronavirus OC43 (HCoV-OC43) N NC, Nucleocapsid protein, Nucleoprotein, Protein N P33469 NCAP_CVHOC A0A0A0YP48,A0A0B4N5U7,A0A0B4N5V5,A0A0B4N684,A0A0B4N6G5,A0A0B4N6G8,A0A0B4N6W6,A0A0B4N7F3,A0A0B4N7G3,A0A0B4N7G5,A0A0B4Q800,A0A0B4Q8L7,A0A0B4UEK7,A0A0B4UFS5,A0A0C5PN59,A0A0C5PN66,A0A0C5PN72,A0A0C5PWL1,A0A0C5PWL5,A0A0C5PWM1,A0A0C5PWM6,A0A0C5PXZ8,A0A0C5PY00,A0A0C5PY04,A0A0C5Q0P0,A0A0C5Q0P6,A0A0C5Q0Q2,A0A0C5Q9E8,A0A0C5Q9F4,A0A0C5Q9G1,A0A0G2RC60,A0A0G2RC64,A0A0G2RC66,A0A0G2RC68,A0A0G2RC70,A0A0G2RC83,A0A0G2RC86,A0A0G2RC94,A0A0G2RCA8,A0A0G2RCB5,A0A0G2RCY1,A0A0G2RCZ3,A0A0K0KPA1,A0A0K0KPA2,A0A0K0KPB1,A0A0K0KPQ5,A0A0K0KQ87,A0A0K0KQA8,A0A0K0L8G1,A0A0K0L9S6,A0A127AT13,A0A127AT23,A0A127AT26,A0A127AT35,A0A127AT45,A0A127AT53,A0A127AT99,A0A127ATA3,A0A127ATA6,A0A127ATA7,A0A127ATA9,A0A127ATB4,A0A127ATB6,A0A127ATC1,A0A127ATJ2,A0A127ATK0,A0A127ATZ8,A0A127AU02,A0A127AUL9,A0A127AUM9,A0A127AWJ2,A0A127AWK6,A0A127AWL7,A0A140E069,A0A1C8Z4S7,A0A1L7H9A3,A0A1S5VG93,A0A1S5VGD1,A0A1S5VGI5,A0A1S5VGJ0,A0A1V0BZ77,A0A1W6DZM9,A0A1W6DZV4,A0A1W6DZW0,A0A1W6DZX0,A0A1Y0EV19,A0A2D1CLX3,A0A2D1QW28,A0A385H5N1,A0A385H5Q3,A0A385H5U7,A0A385H5X1,A0A385H5Z4,A0A385H6E5,A0A385H6Q1,A0A385H6V0,G5CJB5,G5CJC3,Q4VID1,Q4VIE0,Q696P4,Q6SA23,U3M6V0,U3M6V7,U3M7I5,U3M7J7,U3M7K1,U3M7Z4,U3M7Z6,U3M7Z8,U3M804,U3M816,U3M820,U3M822,U3M826,U3M828 ssRNA, dsDNA TR, Rep, NAP S I(16546436;18055455) N N I(16546436;14623261;18055455;17108024;15890900) I(16546436;15759315;25700263) I(14623261;29793506) 32006468.0 Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronaviridae Human SARS coronavirus 3b Accessory protein 3b, Non-structural protein 3b, ns3b, ORF3b,SARSCoVgp06, ORF4, Protein X2 P59633 NS3B_CVHSA A0A0U2PTX6,A0A3G5BIZ2,B8Q8Q5,B8Q8R6,B8Q8S8,B8Q8T9,B8Q8V0,B8Q8W1,C4P6Q9,D2DJW6,D2E1D4,D2E1E9,D2E223,D2E252,D2E267,D2E2F4,D2E2T6,D3KDM7,J9T0L3,Q19QW8,Q1EFN0,Q1EFP3,Q1T6X4,Q3S2C3,Q3ZTC3,Q3ZTD8,Q4JDQ2,Q4JDR5,Q5DIC3,Q692E2,Q6GYQ9,Q6JH36,Q6JH44,Q6R7Y4,Q6RCW3,Q6RCX4,Q6RCY5,Q6RCZ6,Q6RD07,Q6RD18,Q6RD29,Q6RD40,Q6RD51,Q6RD62,Q6S8D5,Q6T1E1,Q6TPE6,Q6VA76,Q6VA87,Q6VA98,Q6WGN1,U5WHZ3,U5WI10,U5WLA7 indirect/unknown TR, Rep, Other S D(22253733) N N D(22253733) N N 27344959.0 Induces host cell G0/G1 arrest and apoptosis. Coronaviridae Human SARS coronavirus E E protein, Envelope small membrane protein, sM, sM protei, sM protein P59637 VEMP_CVHSA A0A0K1Z002,A0A0K1Z029,A0A0U2PTJ4,A0A3G5BJ03,A2TGS2,B8Q8Q6,B8Q8R7,B8Q8S9,B8Q8U0,B8Q8V1,B8Q8W2,C4P6R0,D2DJW7,D2E1D5,D2E1F0,D2E224,D2E253,D2E268,D2E2J8,D2E2M8,D2E2S3,D2E2T7,D3KDM8,D3KDQ6,D5HJQ3,D5HJR4,D5HJS5,D5HJT6,D5HJW0,D5HJX1,D5HJY2,D5HJZ3,D5HK04,J9TE86,Q19QW7,Q1EFM9,Q1EFP2,Q1T6X3,Q3LZU0,Q3LZV1,Q3S2C2,Q3ZTC2,Q3ZTD7,Q4JDQ1,Q4JDR4,Q5DIC2,Q5Y298,Q692E1,Q6GYQ8,Q6JH35,Q6JH43,Q6QJ39,Q6R7Y3,Q6RCW2,Q6RCX3,Q6RCY4,Q6RCZ5,Q6RD06,Q6RD17,Q6RD28,Q6RD39,Q6RD50,Q6RD61,Q6S8D4,Q6SRI1,Q6SRI5,Q6SRI9,Q6SRJ3,Q6SRJ7,Q6SRK1,Q6SRK5,Q6SRK9,Q6SRL3,Q6SRL7,Q6SRM1,Q6SRM5,Q6SRM9,Q6SRN3,Q6SRN7,Q6SRP1,Q6SRP5,Q6SRP9,Q6T1D9,Q6TPE5,Q6VA75,Q6VA86,Q6VA97,Q6WGP2,U5WI28,U5WI54,U5WLL8 indirect/unknown TR, Other S N N N N N I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) 27344959.0 Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction. Coronaviridae Human SARS coronavirus N NC, Nucleocapsid protein, Nucleoprotein, Protein N P59595 NCAP_CVHSA A0A0K1YZZ7,A0A0K1Z0P8,A0A0U2NR12,A0A3G5BJ14,A2TGS3,B8Q8R0,B8Q8S2,B8Q8T3,B8Q8U4,B8Q8V5,B8Q8W6,C4P6R7,D2DJX3,D2E1E2,D2E1F7,D2E216,D2E230,D2E275,D2E2E7,D2E2N5,D3KDN4,D5HJQ9,D5HJS0,D5HJT1,D5HJU2,D5HJV5,D5HJW6,D5HJX7,D5HJY8,D5HJZ9,D5HK10,Q19QW0,Q1EFM2,Q1EFN5,Q1T6X0,Q3I5K0,Q3I5K3,Q3LZU2,Q3LZV6,Q3S2B5,Q3ZTB6,Q3ZTD1,Q4JDP5,Q4JDQ8,Q5DIB8,Q692D7,Q6GYQ2,Q6JH33,Q6JH41,Q6QHB3,Q6QHB4,Q6QHB5,Q6QJ37,Q6R7X9,Q6RCV8,Q6RCW9,Q6RCY0,Q6RCZ1,Q6RD02,Q6RD13,Q6RD35,Q6RD46,Q6RD57,Q6S8C7,Q6S8E1,Q6T1D2,Q6TPE0,Q6UPD4,Q6UUW1,Q6UZE8,Q6UZF2,Q6V583,Q6VA71,Q6VA82,Q6VA93,U5WIP0,U5WLA2,U5WLN3 ssRNA, dsDNA TR, Rep,NAP S D(16546436;18055455) N 2OFZ D(16546436;14623261;18055455;17108024) D(16546436;15759315) D(14623261, TransFactor analysis assay) 27344959.0 Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronaviridae Middle East respiratory syndrome-related coronavirus; Human coronavirus EMC E E protein, Envelope small membrane protein, M, sM protein R9UQN1 R9UQN1_9BETC A0A075E1D8,A0A0G3VM72,A0A0G3VM78,A0A0S3IVQ1,A0A0U2GLG8,A0A0U2GP61,A0A1D6Y7S6,K0BRH1,K9N5R3,M4SQZ1,R9WYQ9,T2BBC7,T2BBI3 indirect/unknown TR, Other S N N N N N I(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) 27344959.0 Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Coronaviridae Middle East respiratory syndrome-related coronavirus; Human coronavirus EMC N NC, Nucleocapsid protein, Nucleoprotein, Protein N K9N4V7 NCAP_CVEMC A0A023NFV4,A0A023VZL1,A0A023VZM0,A0A024E1L1,A0A068FIZ3,A0A068FM93,A0A068FR27,A0A0A0QHI8,A0A0A7E7L7,A0A0A7KVQ1,A0A0D3MU51,A0A0D3MU65,A0A0G2UKT0,A0A0G3KE78,A0A0R7E423,A0A0U2GLA1,A0A0U2GM98,A0A0U2GMX8,A0A0U2GPN9,A0A0U2GQM3,A0A0U2GQX0,A0A0U4BQZ8,A0A140AZ32,A0A141LLD8,K0BVN3,M1S193,M4SRY6,R9UM87,T2B9H8,T2B9R0,T2BBB8,T2BBK0,V9TXP8,W5ZZJ8,W5ZZL9,W5ZZM7,W5ZZP8,W5ZZV0,W6A8J1,W8NMH3 ssRNA, dsDNA TR, Rep, NAP S I(16546436;18055455) N N I(16546436;14623261;18055455;17108024;15890900) I(16546436;15759315;25700263) D(29793506, Filter binding assay ) 27344959.0 K9N4V7 is inferred from Human SARS coronavirus protein P59595 Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronaviridae Human SARS coronavirus 2 E E protein, Envelope small membrane protein, ORF4, sM protein, structural protein P0DTC4 VEMP_SARS2 indirect/unknown TR, Other S N N N N N D(https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3.full.pdf) 32072569.0 Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction. Coronaviridae Human SARS coronavirus 2 N NC, Nucleocapsid protein, Nucleoprotein, Protein N P0DTC9 NCAP_SARS2 ssRNA, dsDNA TR, Rep, NAP S I(16546436;18055455) N N I(16546436;14623261;18055455;17108024;15890900) I(16546436;15759315;25700263) I(14623261;29793506) 32072569.0 YP_009724397.2_11 is inferred from Human SARS coronavirus protein P59595 Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Filoviridae Bundibugyo ebolavirus NP Nucleocapsid protein, Nucleoprotein B8XCM7 B8XCM7_9MONO R4QJ68 ssRNA NAP, TR, Rep S N N 5VKD I(31952352; 9971816) I(28566377) I(28593988) 21987745.0 RNA binding,viral RNA genome packaging,helical viral capsid,host cell cytoplasm,viral nucleocapsid Filoviridae Bundibugyo ebolavirus VP30 Minor nucleoprotein, Minor nucleoprotein VP30 B8XCN3 B8XCN3_9MONO R4QUH9 ssRNA TR, NAP, Rep S N N N I(27279615, 23493393, 27755595) I(27279615) I(12163572) 21987745.0 R4QUH9 is inferred from Zaire ebolavirus protein Q05323 Metal ion binding,viral nucleocapsid Filoviridae Bundibugyo ebolavirus VP35 Polymerase cofactor VP35, Polymerase complex protein B8XCM8 B8XCM8_9MONO R4QGV8 dsRNA TR, NAP, Rep S N N N I(9971816, 11027311, 12829834, 19557165) I(27642076) I(19557165) 21987745.0 R4QGV8 is inferred from Zaire ebolavirus protein Q05127 Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Filoviridae Ebola virus NP Nucleocapsid protein, Nucleoprotein A0A2Z2FMG9 A0A2Z2FMG9_9MONO A0A0E3H7K1,A0A0E3KX27,A0A141BR54,A0A1C4HD05,A0A2Z2FIR4,A0A2Z2FJ72,A0A2Z2FJB7,A0A2Z2FJH7,A0A2Z2FNR0,A0A2Z2FWI4 ssRNA NAP, TR, Rep S N N N D(31952352; 9971816) I(28566377) D(28593988) Fields Virology RNA binding,viral RNA genome packaging,helical viral capsid,host cell cytoplasm,viral nucleocapsid Filoviridae Ebola virus VP30 Minor nucleoprotein VP30 A0A0E3KX28 A0A0E3KX28_9MONO A0A2Z2FME8 ssRNA TR, NAP, Rep S N N N D(27279615, 23493393, 27755595) D(27279615; 27315567) D(12163572, 27279615) Fields Virology metal ion binding,viral nucleocapsid Filoviridae Ebola virus VP35 Polymerase cofactor VP35 A0A1C4HDK9 A0A1C4HDK9_9MONO A0A0E3N983 dsRNA TR, NAP, Rep S N N N D(9971816, 11027311, 12829834, 19557165) D(27642076) D(19557165) Fields Virology Plays an essential role +U68:U85in viral RNA synthesis and also a role in suppressing innate immune signaling. Filoviridae Lake Victoria marburgvirus NP NC, Nucleocapsid protein, Nucleoprotein, Protein N P27588 NCAP_MABVM A9Q1G5,A9Q1H2,C0IT76,C0IT83,G9HWE2,P35263,Q1PD53,Q1PD74,Q1PDA9,Q1PDB6,Q1PDD0,Q6UY69 ssRNA NAP, TR, Rep S N N 6APP I(31952352; 9971816) I(28566377) I(28593988) 31131088.0 Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). Filoviridae Lake Victoria marburgvirus VP30 Minor nucleoprotein VP30, Transcription activator VP30 P35258 VP30_MABVM P41326,Q1PD49,Q1PD56,Q1PDA5,Q1PDB2,Q1PDB9,Q1PDC6,Q6UY65 ssRNA TR, NAP, Rep S N N 5T3W I(27279615, 23493393, 27755595) I(27279615) I(12163572) 31131088.0 Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity). Filoviridae Lake Victoria marburgvirus VP35 Marburg VP35, mVP35, Polymerase cofactor VP35 P35259 VP35_MABVM Q03039,Q1PD52,Q1PDA8,Q1PDB5,Q1PDC9,Q6UY68 dsRNA TR, NAP, Rep S N N 4GH9, 4GHA, 5TOH, 5TOI I(9971816, 11027311, 12829834, 19557165) I(27642076) I(19557165) 31131088.0 Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Filoviridae Marburg marburgvirus NP Nucleocapsid protein, Nucleoprotein C7B276 C7B276_9MONO A0A077D355,A0A0U2M3H8,A0A385L0K9,C7B248,C7B269,C7B283,E0X0Z7,E0X111,K4MQ25,K4MQC5,K4MQF4,K4MQY0,K4MR07,K4MR89,K4MRA8,K4MSQ7,K4MSZ0,K4MT16,K4N3C7,K4N3K2,K4N3V7 ssRNA NAP, TR, Rep S N N N D(9971816;9765419) D(28566377) I(28593988) 31146800.0 RNA binding,viral RNA genome packaging,helical viral capsid,host cell cytoplasm,viral nucleocapsid Filoviridae Marburg marburgvirus VP30 Minor nucleoprotein VP30, Viral protein 30, VP30 minor nucleoprotein C7B280 C7B280_9MONO A0A077CZD4,A0A1U8ZSA8,A0A385L0L3,C7B252,C7B273,E0X101,K4MQ93,K4MQB7,K4MQE5,K4MR00,K4MSM3,K4MSU4,K4MSY4,K4MSZ1,K4MT90,K4N3J5,K4N3M2 ssRNA TR, NAP, Rep S N N N D(9765419) I(27279615) I(12163572) 31146800.0 metal ion binding,viral nucleocapsid Filoviridae Marburg marburgvirus VP35 Polymerase cofactor VP35 C7B270 C7B270_9MONO A0A077CY87,A0A0B4WUN1,A0A0B4WW37,A0A0E3NAG7,A0A1L6C7S2,A0A2H4CAK4,C7B277,E0X0Z8,O36427 dsRNA TR, NAP, Rep S N N N D(9765419) I(27642076) I(19557165) 31146800.0 Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Filoviridae Reston ebolavirus NP Nucleocapsid protein, Nucleoprotein, Protein N, Reston NP, rNP Q8JPY1 NCAP_EBORR A0A1I9VT52,A0A1Y0K5B8,A0A1Y0K5E1,A0A1Y0K5E6,A0A343J1N2,A0A343J1P1,C6G8D3,C6G8E1,C6G8E9,L7RI74,Q91DE1 ssRNA NAP, TR, Rep S N N 5W2B I(31952352; 9971816) I(28566377) I(28593988) 28542463, 24699737 Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response. VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm. Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid. Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription. Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1. Filoviridae Reston ebolavirus VP30 Minor nucleoprotein VP30, Transcription activation factor VP30, Transcription activator VP30, Truncated transcription activation factor VP30 Q8JPX6 VP30_EBORR A0A1I9VT58,A0A1Y0K5D8,A0A343J1N8,C6G8D8,C6G8E6,C6G8F4,L7RFD4,L7RI71,Q91DD6 ssRNA TR, NAP, Rep S N N N I(27279615, 23493393, 27755595) I(27279615) I(12163572) 28542463, 24699737 Q8JPX6 is inferred from Zaire ebolavirus protein Q05323 Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity). Filoviridae Reston ebolavirus VP35 Polymerase cofactor VP35, Polymerase complex protein VP35 Q8JPY0 VP35_EBORR A0A1I9VT53,A0A343J1P2,C6G8D4,C6G8E2,C6G8F0,L7RF08,L7RFC8,Q91DE0 dsRNA TR, NAP, Rep S N N N I(9971816, 11027311, 12829834, 19557165) I(27642076) I(19557165) 28542463, 24699737 Q8JPY0 is inferred from Zaire ebolavirus protein Q05127 Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity). Filoviridae Sudan ebolavirus NP Nucleocapsid protein, Nucleoprotein, Protein N Q5XX08 NCAP_EBOSU A0A0E3N979,A0A0N9QTI0,A0A1L7B8B1,A0A2U8KL52,A0A2U8KLA7,B0LPL4,C4PK55,I7FUR1,M4J9H3,Q9QP77,R4QTJ0 ssRNA NAP, TR, Rep S N N 6OAF I(31952352; 9971816) I(28566377) I(28593988) 28545034.0 Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response. VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm. Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid. Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription. Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1. Filoviridae Sudan ebolavirus VP30 Minor nucleoprotein, Minor nucleoprotein VP30, Transcription activator VP30, Viral protein 30 Q5XX03 VP30_EBOSU A0A0E3NAE6,B0LPL9,I7FWC9,M4J9H6,R4P2H0,R4QUF0 ssRNA TR, NAP, Rep S N N N I(27279615, 23493393, 27755595) I(27279615) I(12163572) 28545034.0 Q5XX03 is inferred from Zaire ebolavirus protein Q05323 Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity). Filoviridae Sudan ebolavirus VP35 Polymerase cofactor VP35, Viral protein 35 Q5XX07 VP35_EBOSU A0A0E3N5D2,A0A0N9Q7A6,B0LPL5,C4PK56,I7FLL9,R4NUK7,R4QGR7 dsRNA TR, NAP, Rep S N N N I(9971816, 11027311, 12829834, 19557165) I(27642076) I(19557165) 28545034.0 Q5XX07 is inferred from Zaire ebolavirus protein Q05127 Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity). Filoviridae Zaire ebolavirus NP Ebola NP, eNP, Nucleocapsid protein, Nucleoprotein, Protein N P18272 NCAP_EBOZM A0A068J945,A0A068J9B9,A0A075W933,A0A075WG99,A0A096YGX0,A0A0A7PCE0,A0A0D4D8I2,A0A0D5W848,A0A0D5W865,A0A0D5W876,A0A0D5W897,A0A0D5W8E5,A0A0D5W8K5,A0A0D5W8N2,A0A0D5W8N9,A0A0D5W8U8,A0A0D5W957,A0A0D5W989,A0A0D5W9A2,A0A0D5W9C4,A0A0E3GLU4,A0A0E3TL09,A0A0E3TL91,A0A0E3TLB3,A0A0E3TLI7,A0A0E3TLJ4,A0A0E3TLM0,A0A0E3TLN8,A0A0E3TLR4,A0A0E3TLU1,A0A0E3TLU2,A0A0E3TLW5,A0A0E3TLZ1,A0A0E3TM18,A0A0E3TM19,A0A0E3TMF2,A0A0E3TMH8,A0A0E3TMK2,A0A0E3TMK6,A0A0E3TMN6,A0A0E3TMR4,A0A0E3TMS8,A0A0E3TMW3,A0A0E3TMX8,A0A0E3TMZ7,A0A0E3TN27,A0A0E3TN97,A0A0E3TNH7,A0A0E3TNK0,A0A0E3TNX9,A0A0E3X8E1,A0A0E3XJA0,A0A0E3XJB4,A0A0E3XJS6,A0A0E3XJW0,A0A0E3XJY7,A0A0E3XJZ8,A0A0E3XK34,A0A0E3XK48,A0A0E3XK58,A0A0E3XKU6,A0A0E3XKW4,A0A0E3XL13,A0A0E3XL94,A0A0E3XLF1,A0A0E3XLG4,A0A0E3XLG8,A0A0E3XLL9,A0A0E3XLQ1,A0A0E3XLR5,A0A0E3XLX7,A0A0E3XM43,A0A0F6PCY0,A0A0F6PD20,A0A0F6PDL5,A0A0F6PDL7,A0A0F6PE43,A0A0F6PE50,A0A0F6PEB1,A0A0F6PFN6,A0A0F6PG50,A0A0F6PGB6,A0A0F6PGL9,A0A0F6PGT9,A0A0F6PHL7,A0A0F7DDS0,A0A0F7DDT8,A0A0F7DDX4,A0A0F7IMS2,A0A0F7IMW8,A0A0F7ING0,A0A0F7IQ00,A0A0F7IQT2,A0A0F7IRF1,A0A0G2Y8P8,A0A0G2Y8U2,A0A0G2Y8W8,A0A0G2YAC4,A0A0G2YAP4,A0A0G2YAR8,A0A0G2YAT2,A0A0G2YB39,A0A0G2YCG7,A0A0G2YD31,A0A0G2YDZ4,A0A0G2YEH7,A0A0G2YGJ1,A0A0G2YGK1,A0A0G2YHE2,A0A0G2YHH9,A0A0G2YIW8,A0A0H3VU44,A0A0H3VUH4,A0A0H3VV97,A0A0H3VVT3,A0A0H3VXA2,A0A0H3VYJ4,A0A0H3VYM0,A0A0H3VYM9,A0A0K1NXJ4,A0A0K1NXX0,A0A0K1NY14,A0A0K1NYC4,A0A0K1NYD3,A0A0K1NYE8,A0A0K1NYH3,A0A0K1NYT7,A0A0K1NZA3,A0A0M4RGV8,A0A0N9BE19,A0A0N9QXB6,A0A0N9QXW1,A0A0S0GAE9,A0A0S0GAT9,A0A0S0GBJ7,A0A0S0H198,A0A0S0H215,A0A0S0H2Q7,A0A0S0H2R5,A0A0S0H2S9,A0A0S0H383,A0A0S0H385,A0A0S0H3C5,A0A0S0H3D3,A0A0S0H430,A0A0S0H572,A0A0S0HC67,A0A0S0HDV6,A0A0S2RN13,A0A0U3MRZ4,A0A0U3V214,A0A0U3V2G4,A0A0U3V4C0,A0A0U3V6V7,A0A0U3VB98,A0A0U3VJA1,A0A0U4CUH6,A0A0U4D4X6,A0A0U4DB33,A0A0U4DBA8,A0A0U4DCH1,A0A0U4DD37,A0A0U4DGL1,A0A0U4DGS4,A0A0U4E4B3,A0A0U4E4X5,A0A0U4EBG4,A0A0U4EBR7,A0A0U4EBZ4,A0A0U4EES8,A0A0U4EGH6,A0A0U4EGX9,A0A0U4ENR9,A0A0U4EP82,A0A0U4EPI4,A0A0U4EPQ5,A0A0U4EQU8,A0A0U4ESJ8,A0A0U4ET89,A0A0U4ETP8,A0A0U4EW56,A0A0U4EWH3,A0A0U4EXV0,A0A0U4EYY3,A0A0U4F6D6,A0A141LL89,A0A165Q9F3,A0A172QC61,A0A172QC79,A0A172QC87,A0A1L2BID6,A0A1L2BIG9,A0A1L2BIR4,A0A1L2BIY4,A0A1L2BJ48,A0A1L2BJD9,A0A1L2BJG4,A0A1L7B882,A0A1L7B8E4,A0A1X9IXM9,A0A288QU69,A0A2I4PDK8,A0A2I4PDT9,A0A2I4PE21,A0A2I4PED3,A0A2I4Q526,A0A2I4Q545,A0A2I4SAN4,A0A2I4SAT9,A0A2I4SAU6,A0A2U8KL40,A0A2U9QPQ7,A0A345BF59,A0A345BF77,A0A345BFD1,A0A3G1S963,A0A3G1TWY2,A0A3G2LM13,A0A3G2LM48,A0A3G2LM81,A0A3G2XD84,A0A3G2XE25,A0A3G2XE33,A0A3G2XEF7,A0A3G2XEP4,A0A3G2XG98,A0A3G2XH51,A0A3Q8HGW6,A0A3Q8HHE4,A0A3Q8HHH5,A0A3Q8HHT0,A0A3Q8HI48,A0A3Q8HIF8,A0A3Q8HII1,A0A3Q8HIZ0,A0A3Q8HJA9,A0A3Q8HK17,A0A3Q8HQL2,A8TSK5,A8TSL1,A8TSL7,A8TSM3,A8TSM9,A8TSN5,A8TSP1,A8TSP9,A8TSQ5,A8TSR2,A8TSR7,A8TSS3,A9QPL6,G8DB37,I0DHA6,L7QHT6,L7QHU5,L7QI42,L7QI51,L7QIA8,O72142,Q913A5,Q9QCE9,X5GXS8,X5HMY5 ssRNA NAP, TR, Rep S N N 4ZTA D(31516086) I(28566377) D(20421407) 20957152.0 Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response (PubMed:26119732, PubMed:25865894, PubMed:30333622, PubMed:16719918). VP35 binds to and stabilizes monomeric NP, keeping it soluble (PubMed:26119732, PubMed:25865894). Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released (PubMed:29144446). The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm (PubMed:22247782). Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid (PubMed:30333622). Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription (PubMed:29290611, PubMed:27755595). Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1 (PubMed:28794491, PubMed:30301857). Filoviridae Zaire ebolavirus VP30 Ebola VP30, eVP30, Hexameric zinc-finger protein VP30, Minor nucleoprotein VP30, Transcription activator VP30 Q05323 VP30_EBOZM A0A0A7P6S7,A0A0D4D8P9,A0A0D5W867,A0A0D5W881,A0A0D5W8K4,A0A0D5W8L5,A0A0D5W8P3,A0A0D5W8Q0,A0A0D5W8S4,A0A0D5W9G0,A0A0E3TKV3,A0A0E3TLF2,A0A0E3TLT1,A0A0E3TNA7,A0A0E3XJ86,A0A0E3XKF2,A0A0E3XL58,A0A0F6PD42,A0A0F6PD98,A0A0F6PDF6,A0A0F6PE67,A0A0F6PGB0,A0A0F7IMJ5,A0A0F7IML9,A0A0F7IMR4,A0A0G2YEA1,A0A0G2YEX8,A0A0G2YGG0,A0A0K1NXF0,A0A0K1NY74,A0A0K1NY97,A0A0K1NYB8,A0A0K1NYX1,A0A0K1NZ17,A0A0N9BE47,A0A0S0G9Y9,A0A0S0H3V9,A0A0S0H5G2,A0A0S0H693,A0A0S0HCI9,A0A0S0HCX3,A0A0U3MQS2,A0A0U3MRQ2,A0A0U3V2Q4,A0A0U3V2T6,A0A0U3V4I1,A0A0U3V9C5,A0A0U3VJZ0,A0A0U4CS06,A0A0U4D596,A0A0U4D5B5,A0A0U4E233,A0A0U4E3T0,A0A0U4E6R5,A0A0U4EJT4,A0A0U4ENB6,A0A0U4F7Q3,A0A144INH8,A0A165Q6Y8,A0A165Q9K2,A0A1L2BIG8,A0A1X9ITK5,A0A1X9IWG5,A0A2I4PDJ3,A0A2I4PEA3,A0A2I4Q549,A0A2I4Q575,A0A3G2LMC4,A0A3Q8HH29,A0A3Q8HQ01,L7QHS4,L7QI14,L7QI23 ssRNA TR, NAP, Rep S N N 5DVW, 5T3T D(18829754, 27279615, 9971816) D(27279615) D(20421407) 20957152.0 Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. In turn, clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists also stop-start transcription at gene junctions to promote transcription of downstream genes. Filoviridae Zaire ebolavirus VP35 Ebola VP35, eVP35, Polymerase cofactor VP35 Q05127 VP35_EBOZM A0A096YGW9,A0A0A0UG55,A0A0A7P6T2,A0A0D4D9D7,A0A0D5W860,A0A0D5W888,A0A0D5W8A6,A0A0D5W8D3,A0A0D5W8F8,A0A0D5W8I0,A0A0D5W8K1,A0A0D5W8L0,A0A0D5W8L3,A0A0D5W8P1,A0A0D5W8P9,A0A0D5W8S0,A0A0D5W8Y3,A0A0D5W907,A0A0D5W910,A0A0D5W932,A0A0D5W967,A0A0D5W9C3,A0A0D5W9F6,A0A0E3JNL8,A0A0E3TL62,A0A0E3TLJ9,A0A0E3TLL9,A0A0E3TN58,A0A0E3TND3,A0A0E3TP51,A0A0E3XJ79,A0A0E3XL17,A0A0E3XLC2,A0A0F6PCZ9,A0A0F6PD95,A0A0F6PDS1,A0A0F6PDT0,A0A0F6PE53,A0A0F6PEA2,A0A0F6PEB0,A0A0F6PEX9,A0A0F6PG67,A0A0F6PGM5,A0A0F6PGU9,A0A0F6PH54,A0A0F7IM75,A0A0F7IMK4,A0A0G2YA07,A0A0G2YB97,A0A0G2YCE4,A0A0G2YCW0,A0A0G2YD36,A0A0G2YFC9,A0A0G2YGH5,A0A0G2YGK9,A0A0G2YGN0,A0A0G2YH23,A0A0G2YI78,A0A0G2YIT8,A0A0K1NXW9,A0A0K1NY24,A0A0K1NY41,A0A0K1NY91,A0A0K1NY92,A0A0K1NYD4,A0A0K1NYD6,A0A0K1NYW6,A0A0K1NZ58,A0A0K1NZE7,A0A0N7E4U0,A0A0N7E4U2,A0A0S0GA68,A0A0S0GBT2,A0A0S0GCF5,A0A0S0H1F0,A0A0S0H2X8,A0A0S0H3D9,A0A0S0H3X8,A0A0S0H3Y5,A0A0S0H453,A0A0S0H4A9,A0A0S0H4M9,A0A0S0H4P4,A0A0S0H6B4,A0A0S0HAT4,A0A0S0HBA9,A0A0S0HCX5,A0A0S0HDX3,A0A0S0HEE4,A0A0S0HEH4,A0A0U3MI82,A0A0U3MLC1,A0A0U4D7K3,A0A0U4DBV4,A0A0U4E017,A0A0U4E4W0,A0A0U4EJL2,A0A0U4EJR8,A0A0U4EPG5,A0A0U4FDH1,A0A141LKX3,A0A165Q6T7,A0A165Q7K3,A0A172QC54,A0A172QC60,A0A1L2BI43,A0A1L2BIB3,A0A1L2BIE6,A0A1L7B886,A0A1L7B8N5,A0A2I4PDK5,A0A2I4PEH1,A0A2I4PEM7,A0A2I4SAM2,A0A2I4SAS7,A0A2I4SAT1,A0A2U9QPQ6,A0A345K436,A0A3G2LLZ4,A0A3G2LM16,A0A3G2XDA3,A0A3G2XDB5,A0A3G2XDD1,A0A3G2XDD3,A0A3G2XDY9,A0A3G2XGG3,A9QPL7,I0DHA7,L7QI13,L7QI22,L7QI35,V9TIA7 dsRNA TR, NAP, Rep S N N 3FKE, 3L25, 3L26, 3L27, 3L28, 3L29, 4IBB, 4IBC, 4IBD, 4IBE, 4IBF, 4IBG, 4IBI, 4IBJ, 4IBK, 4IJE, 4IJF, 4YPI, 4ZTA, 4ZTG, 4ZTI, 6GBO, 6GBP D(9971816, 11027311, 12829834, 19557165) I(27642076) D(20421407) 20957152.0 Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Prevents establishment of cellular antiviral state, thereby suppressing host DC maturation (PubMed:26962215). Acts by inhibiting host DDX58/RIG-I activation both by shielding dsRNA from detection and by preventing PRKRA binding to DDX58 (PubMed:23870315). Blocks virus-induced phosphorylation and activation of interferon regulatory factor 3/IRF3, a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition of host IKBKE and TBK1, producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the host interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (PubMed:17065211). Flaviviridae Hepatitis C virus Genome polyprotein Cleaved into the following 11 chains-Core protein p21 P27958 POLG_HCVH A0A1X9Q776,A0A1X9Q782,A0A1X9Q784,A0A1X9Q787,A0A1X9Q788,A0A1X9Q790,A0A1X9Q798,A0A1X9Q7A4,A0A1X9Q7A5,A0A1X9Q7A7,A0A1X9Q7A8,A0A1X9Q7B3,A0A1X9Q7B5,A0A1X9Q7B6,A0A1X9Q7F9,A0A1X9Q7G7,A0A1X9Q7G8,A0A1X9Q7H0,A0A1X9Q7H1,A0A1X9Q7H2,A0A1X9Q7H4,A0A1X9Q7H6,A0A1X9Q7I0,A0A1X9Q7I2,A0A1X9Q7I6,A0A1X9Q7I8,A0A1X9Q7M9,A0A1X9Q7N5,A0A1X9Q7P0,A0A1X9Q7P4,A0A1X9Q7P8,A0A1X9Q7T5,A0A1X9Q809,A0A1X9Q843,A0A1X9Q844,A0A1X9Q845,A0A1X9Q860,A0A1X9Q868,A6N8C5,A8DEQ3,A8DER9,A8DES5,A8DF52,A8DF65,A8DF80,A8DF92,A8DFA3,A8DFB2,A8DFB8,A8DFC4,A8DFD0,A8DFD6,A8DFE3,A8DFF0,A8DFF3,A8DFF5,A8DFG4,A8DFP3,A8DFQ2,A8DFR2,A8DFS1,A8DFT0,A8DFT8,A8DFU5,A8DFV3,A8DFW2,A8DFW9,A8DFX7,A8DFY4,A8DFY6,A8DFZ1,A8DG21,A8DG30,A8DG50,A8DG59,A8DG69,A8DG81,A8DG88,A8DG98,A8DGA7,A8DGB7,A8DGC9,A8DGD8,A8DGF9,A8DGH0,A8DGI0,A8DGN1,A8DGP0,A8DGP9,A8DGQ7,A8DGR6,A8DGS6,A8DGV7,A8DGW5,A8DGX1,A8DGX9,A8DH64,A8DH72,A8DH77,A8DH84,A8DH90,A8DH96,A8DHA2,A8DHB9,A8DHE5,A8DHE9,A8DHF6,A8DHH1,A8DHV8,A8DHW9,A8QIN1,A8QIN2,A8QIN3,A8QIN4,A8QIN5,A8QIN7,A8QIN8,A8QIP8,A8WE32,A8WE34,A8WE36,A8WEV8,A8WFA4,A8WFA6,A9LLG7,A9LLH0,A9LLH2,B1PPI0,B1PPI5,B1PPI7,B1PPI9,B1PPJ1,B1PPJ3,B1PPJ6,B1PPJ8,B1PPK0,B1PPK2,B1PPK6,B1PPL0,B1PPL2,B1PPL5,B1PPL7,B1PPL9,B1PPM3,B1PPM5,B1PPM9,B1PPN4,B1PPN6,B1PPN8,B1PPP0,B1PPP2,B1PPP4,B1PPP6,B1PPP8,B1PPQ0,B1PPQ2,B1PPQ4,B1PPQ8,B1PPR2,B1PPR5,B1PPS1,B1PPS4,B1PPT0,B2CNA8,B2CNB0,B2CNB4,B2CNB6,B2CNB8,B2D1G7,B2D1G9,B2LXT0,B2ZGC3,B2ZGC5,B2ZTK5,B2ZTK7,B2ZTK9,B3TKD8,B3TKE0,B3TKE4,B3TKE6,B3TKE8,B3TKF0,B3TKF2,B3TKF4,B3TKF8,B3TKG0,B3TKG2,B3TKG4,B3TKG6,B3TKG8,B3TKH2,B3TKH4,B3TKH6,B3TKI6,B3TKI8,B3TKJ4,B3TKJ5,B3TKJ7,B3TKJ9,B3TKK3,B3TKK5,B3TKK7,B3TKK9,B3TKL1,B3TKL3,B3TKL5,B3TKL7,B3TKM0,B3TKM2,B3TKM4,B3TKM6,B3TKM8,B3TKN0,B3TKN2,B3TKN4,B3TKN6,B3TKN8,B3TKP0,B3TKP2,B3TKP3,B3TKP5,B3TKP7,B3TKP9,B3TKQ1,B3TKQ3,B3TKQ5,B3TKQ7,B3TKQ9,B3TKR1,B3TKR7,B3TKR9,B3TKS1,B3TKS5,B3TKS7,B3TKS8,B3TKT0,B3TKT2,B3TKT6,B3TKT8,B3TKU0,B3TKU2,B3TKU4,B3TKU6,B3TKU8,B3TKV0,B3TKV2,B3TKV4,B3TKV6,B3TKV8,B3TKW0,B3TKW2,B3TKW4,B3TKW6,B3TKW8,B3TKX0,B3TKX2,B3TKX4,B3TKX6,B3TKX8,B3TKY0,B3TKY2,B3TKY4,B3TKY6,B3TKY8,B3TKZ0,B3TKZ2,B3TKZ4,B3TKZ6,B3TKZ8,B3TL00,B3TL02,B3TL05,B3TL07,B3TL10,B3TL12,B3TL14,B3TL16,B3TL18,B3TL20,B3TL22,B3TL27,B3TL29,B3TL31,B3TL33,B3TL36,B3TL43,B3TL49,B3TL51,B3TL53,B3TL56,B3TL69,B3TL71,B3TL79,B3TL81,B3TL83,B3TL85,B3TL93,B3TL95,B5M916,B5M920,B5M922,B5M925,B5M928,B5M930,B5M932,B5TBA9,B5TBB2,B5TBB4,B5U654,B5U658,B5U6M7,B5U6M9,B5U6N1,B6VGD0,B6VGD2,B6VGD7,B6VJ19,C4MR37,C4MR38,C4MR39,C4MR40,C4MR41,C4MR42,C4MR43,C4MR44,C4MR45,C4MR46,C4MR47,C4MR49,C4MR50,C4MR51,C4MR52,C4MR53,C4MR54,C4MR55,C4MR56,C4MR57,C4MR58,C4MR59,C4MR60,C4MR61,C4MR62,C4MR63,C4MR64,C4MR65,C4MR66,C4MR67,C4MR68,C4MR69,C4MR70,C4MR71,C4MR72,C4MR73,C4MR74,C4MR75,C4MR76,C4MR77,C4MR78,C4MR79,C4MR80,C4MR81,C4MR82,C4MR83,C4MR84,C4MR85,C4MR86,C4MR87,C4MR88,C4MR89,C4MR90,C4MR91,C4MR92,C4MR93,C4MR94,C4MR95,C4MR97,C4MR99,C4MRA0,C4MRA1,C4MRA2,C4MRA3,C4MRA4,C4MRA5,C4MRA6,C4MRA7,C4MRA8,C4MRA9,C4MRB0,C4MRB1,C4MRB2,C4MRB3,C4MRB4,C7G539,D2CVL5,H6TCE5,H6TCE7,H6TCE8,H6TCE9,H6TCF0,H6TCF1,Q03463,Q9ELS8,S4UXY5,S4UXY7,S4UXY9,S4UXZ3,S4UXZ6,S4UXZ8,S4UXZ9,S4UY00,S4UY01,S4UY02,S4UY03,S4UY04,S4UY05,S4UY06,S4UY08,S4UY10,S4UY14,S4UY17,S4UY19,S4UYB5,S4UYB9,S4UYC1,S4UYC2,S4UYC4,S4UYC6,S4UYC7,S4UYC8,S4UYD0,S4UYD2,S4UYD4,S4UYD5,S4UYD7,S4UYE1,S4UYE2,S4UYE4,S4UYE5,S4UYE9,S4UYF0,S4UYF1,S4UYQ2,S4UYQ7,S4UYQ9,S4UYR2,S4UYR5,S4UYR9,S4UYS2,S4UYS4,S4UYS6,S4UYS8,S4UYT0,S4UYT1,S4UYT2,S4UYT4,S4UYT5,S4UYT6,S4UYT8,S4UZ41,S4UZ44,S4UZ47,S4UZ50,S4UZ54,S4UZ58,S4UZ60,S4UZ61,S4UZ62,S4UZ63,S4UZ64,S4UZ67,S4UZ68,S4UZ69,S4UZ71,S4UZ73,S4UZ76,S4UZ78,S4UZ79,S4UZG4,S4UZG5,S4UZG6,S4UZG7,S4UZG9,S4UZH0,S4UZH2,S4UZH3,S4UZH5,S4UZH6,S4UZH7,S4UZH9,S4UZI0,S4UZI1,S4UZI2,S4UZI3,S4UZI4,S4UZI5,S4UZI6 dsRNA TR, NAP, Other S N N 1A1R, 1A1V, 1CWX, 1HEI, 1JR6, 1N1L D(10544138) D(10924497) D(10544138) Fields Virology Core protein p21: Packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation (PubMed:23799612). Interacts with, and activates STAT3 leading to cellular transformation. Represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation (PubMed:11086025). Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Induces up-regulation of FAS promoter activity, and thereby contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (PubMed:14602201). Envelope glycoprotein E1: Forms a heterodimer with envelope glycoprotein E2 that mediates virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to host LDLR, CD81 and SCARB1/SR-BI receptors (PubMed:12615904). However, additional liver specific cofactors may be required for entry. The fusion function is carried by E1 (PubMed:14990718, PubMed:15371595, PubMed:16894197, PubMed:16533059). Envelope glycoprotein E2: Forms a heterodimer with envelope glycoprotein E1 that mediates virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to host LDLR, CD81 and SCARB1/SR-BI receptors (PubMed:12615904), but additional liver specific cofactors may be required for entry. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection. Viroporin p7: Plays an essential role in the virus replication cycle by acting as a viroporin. Creates a pore in the host reticulum endoplasmic and as a consequence releases Ca2+ in the cytoplasm of infected cell. Targets also host mitochondria and induces mitochondrial depolarization (PubMed:29039530). In turn, high levels of cyctoplasmic calcium may trigger membrane trafficking and transport of viral ER-associated proteins to viroplasms, sites of viral genome replication. In addition of its role as a viroporin, acts as a lipid raft adhesion factor (PubMed:27320856). Protease NS2-3: Cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation. Serine protease NS3: Displays three enzymatic activities: a serine protease with a chymotrypsin-like fold, a NTPase and a RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B (PubMed:8189513). NS3/NS4A complex also prevents phosphorylation of host IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS (PubMed:16301520). Non-structural protein 4A: Peptide cofactor which forms a non-covalent complex with the N-terminal of NS3 serine protease. Non-structural protein 4B: Induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex. NS4B polymerization or in protein-protein interactions activity may contribute to its function in membranous web formation (PubMed:23868571). Plays also a role in the inhibition of host innate response by inhibiting host TLR3-mediated interferon signaling. Mechanistically, promotes host TRIF protein degradation in a caspase8-dependent manner (PubMed:29782532). Non-structural protein 5A: Component of the replication complex involved in RNA-binding. Its interaction with host VAPB may target the viral replication complex to vesicles. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. The hyperphosphorylated form of NS5A is an inhibitor of viral replication. RNA-directed RNA polymerase: Plays an essential role in the virus replication. Hepadnaviridae Hepatitis B virus HBx Peptide X, Protein X, Px, X P0C686 X_HBVC1 A0A060A215,A0A060A625,A0A060A691,A0A060A6W8,A0A060AAM5,A0A060AB18,A0A060AB60,A0A060CJH4,A0A060CNF3,A0A060CP25,A0A067YSC9,A0A067YSG3,A0A067YST1,A0A067YSX0,A0A067YSZ4,A0A067YTH8,A0A067YTM9,A0A067YTS0,A0A067YU08,A0A067YU73,A0A067YUA7,A0A067YUE2,A0A067YUG9,A0A067YUJ1,A0A067YUP6,A0A067YUR5,A0A067YUT6,A0A067YUT9,A0A067YUW7,A0A067YV23,A0A067YV25,A0A067YV34,A0A067YV61,A0A067YVH3,A0A067YVP5,A0A067YVT2,A0A067YVV0,A0A067YVW2,A0A067YVX6,A0A067YWL3,A0A067YWN2,A0A067YWQ7,A0A067YWT4,A0A067YWU4,A0A067YWV9,A0A067YWX6,A0A067YWZ6,A0A067YX24,A0A067YXB4,A0A067YXH9,A0A067YXU2,A0A067YY49,A0A067YYA1,A0A075D8X9,A0A075D922,A0A075D983,A0A075D9Y3,A0A075DA09,A0A075DA55,A0A075DA67,A0A075DA80,A0A075DAP3,A0A075DAT4,A0A075DAW9,A0A075DAZ2,A0A075DB43,A0A075DBT5,A0A075DBU1,A0A075T6J6,A0A077EQB3,A0A0A0V835,A0A0A0V8W4,A0A0G2QWQ5,A0A0G2QWY8,A0A0G3EXJ8,A0A0G3EYX8,A0A0G3EZ59,A0A0G3EZQ6,A0A0G3F0M2,A0A0G3F1C1,A0A0G3F1E9,A0A0G3F1V7,A0A0G3F256,A0A0G3F2A3,A0A0G3F2V3,A0A0G3F2W2,A0A0G3F311,A0A0G3F376,A0A0G3F3N8,A0A0G3F4D1,A0A0G3F4Y2,A0A0G3F549,A0A0G3F559,A0A0G3F5R7,A0A0G3F666,A0A0G3F6R7,A0A0K0K6H8,A0A0K0K6I8,A0A0K0K6J9,A0A0K0K6M2,A0A0K0K6M5,A0A0K0K6N2,A0A0K0K6R4,A0A0K0WRU8,A0A0K0WZ59,A0A0S1RTH5,A0A0U3LF26,A0A1B1LVD7,A0A1B3SNS0,A0A1W5XAX3,A0A249JRC5,A0A286QXF4,A0A290G3R8,A0A290G413,A0A2H4NKA4,A0A2H4NKH4,A0A2H4NL94,A0A2H4NLA4,A0A2H4NLA6,A0A2H4NLF6,A0A2H4NLF8,A0A2H4NLH4,A0A2H4NLL5,A0A2H4NLM7,A0A2H4NLP1,A0A2H4NM06,A0A2H4NM11,A0A2H4NM90,A0A2H4NMB6,A0A2H4NMD0,A0A2H4NMS1,A0A2H4NN58,A0A2H4NNA6,A0A2H4NNB2,A0A2H4NNE7,A0A2H4NNG5,A0A2H4NNI4,A0A2Z6DS46,A0A346RSZ9,A0A346RT27,A0A346RT31,A0A346RT35,A0A346RT39,A0A346RT99,A0A3Q9HHF8,A0A3S5ICN4,A0FDK1,A5GZG6,A5GZH1,A5GZI2,A5GZJ0,A5GZK1,A5GZK9,A5GZL6,A5GZN2,A5GZN6,A5HKP8,A5HKQ4,A5LG64,A5LG76,A5LG84,A5LG92,A5LGB6,A6MG24,A6MG36,A7M682,A7M686,A8J461,A8J478,A8J5I3,A8R7F4,B0FCC1,B0FD21,B0FD41,B0FD94,B1B5L8,B1Q2W8,B2CY06,B2CY33,B2CZW0,B2LWA4,B2LWD7,B3V3R9,B4YT99,B5A2H5,B5ASU1,B5ASW3,B5B482,B5B494,B5B4B1,B5B4C4,B5B4G1,B5B4H9,B5B4J0,B5B4J7,B5B4P8,B5BPH9,B5BPK7,B5BPN1,B5BPR3,B5BPS1,B5BPT6,B5BPU0,B5BPU4,B5BPV6,B5BPW5,B5BPX6,B5BPY8,B5M520,B5M573,B5M576,B5M582,B5M5A9,B5M5B2,B5M5J9,B5M5K2,B5M5K6,B5M5L7,B5M5P4,B5M5V6,B5M5V9,B5M5X4,B5TXI5,B5TXK2,B5TXL1,B5TY06,B5TY09,B6EUP5,B7TTN0,B7TU29,B7TU66,B7TUB0,B7TUB9,B7TUE5,B7TUW8,B9VK29,B9VK45,B9VKC0,B9VKD1,B9VKG2,B9VKK5,B9VKP0,B9VKQ5,B9VKY1,B9VL15,B9VL31,B9VL35,C0SVX4,C0SVX6,C1K177,C1K1B6,C1K1C8,C1K1G7,C1K1K6,C1K1N4,C1K1Z2,C1K1Z8,C1K220,C5WK20,C5WK24,C5WK28,C7G2Z1,D0E579,D0E590,D0E5A5,D0E5B5,D0E5D1,D0E5F5,D0E5G7,D0E5I4,D0E5K5,D0E5P0,D0E5Q1,D0E5W6,D0E5X0,D0E643,D0E677,D0E684,D0E696,D0E6A4,D0E6A8,D0ESR9,D0UDN6,D0UDP1,D0UDQ6,D0UDR1,D0UDT1,D0UDT6,D0UDX9,D0UDY9,D0UE09,D0UE46,D0UE60,D0UE84,D0UE93,D0UE97,D0UEA9,D0VXG7,D2CGU5,D2JMN8,D2JMT5,D3Y5S0,D6QVP4,D8VB84,D9U5A9,D9U5H4,E5RD27,E5RD43,E5RD55,F5C7K1,F5C7K8,F5C7Q7,G1EIE8,G1EIF2,G1EIF4,G1EIF8,G1EIG3,G3XGU2,G3XGU6,G3XLB5,G4XMC5,G4XMG5,G9HVE4,G9HZX0,G9HZX1,G9HZX2,G9HZX4,G9HZX5,G9HZY5,G9HZY7,G9HZZ2,G9HZZ9,G9I018,G9I019,G9I021,G9M9Q7,H1ACW6,H1ACY2,H1AE16,H1AE19,H1AE20,H1AE26,H1AE33,H1AE34,H1AE40,H1AE44,H1AE49,H1AE50,H1AE52,H1AE53,H1AE59,H1AE61,H1AE66,H1AE68,H1AE74,H1AE78,H1AE79,H2ERA7,H3K3E8,H3K3L8,I0DH59,I0DH70,I0DH71,I0DH81,I0DH84,I0DH85,I0DH87,I0DH90,I3RTG2,I6XQK3,I6YLZ5,I6YM12,J7IFV6,J7INA2,K0F4R2,K0F4Y6,K0FBC6,K0FBH3,K0FCI9,K0FGT3,K4N0Z4,K4N2P0,K4N2U9,K7QG64,K7QGH7,K7QGZ9,K7QH35,L0HAK4,L0HBS8,O42033,O42065,O91520,O91550,P12936,Q04288,Q06AN6,Q0PVA4,Q1XHE0,Q2EIE9,Q2V2L4,Q3V642,Q4FD63,Q4FD75,Q4FDH3,Q58W10,Q5DW04,Q5KR13,Q5KR29,Q5KR37,Q5KR41,Q5R2M1,Q5R2N7,Q5SDK3,Q5SDK7,Q5SDL4,Q69027,Q7TDA7,Q7TDA8,Q7TDA9,Q805R6,Q80GZ0,Q80IS2,Q80JB9,Q80JC0,Q80JC1,Q80JC2,Q80JC8,Q80MQ6,Q80MR2,Q81109,Q81133,Q8BCI3,Q8JVC7,Q8JXA9,Q8QY54,Q8V1I7,Q8V1J3,Q8V1M6,Q910W8,Q91IN9,Q91IP3,Q91R65,Q91S91,Q99HU6,Q99HV1,Q9DH55,Q9DKR3,Q9DKR4,Q9DKS7,Q9E935,Q9PX27,Q9PX52,Q9QMJ9,Q9QMK2,Q9QN50,Q9WMC0,Q9YZR0,Q9YZR1,Q9YZR6,Q9YZS5,Q9YZT6,Q9YZU4,Q9YZU7,Q9YZU9,Q9YZV1,S4WC30,S4WD77,S4WEV9,S4WIB4,S4WIH4,T1YVH2,V5LDL0,V9P3T8,V9P494,W8E0P8,X4YQZ5,X4YR22,X4YRB2,X4YSM4,X4YXY3,X4YY13,X4YY84,X4YYT9,X4YZ76,X4YZQ5,X4YZY0,X4Z047,X4Z061,X4Z170,X4Z1A9,X4ZCP4,X4ZCY8,X4ZE40,X4ZEJ8,X4ZEL4,X4ZEN0,X4ZES8,X4ZFE0,X4ZFX8 dsDNA TR, Other P D(27302019) D(28212627, 29933745) N D(11604508, 28102638) D(11604508) D(1602534) Fields Virology Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. Herpesviridae Cercopithecine alphaherpesvirus 2 RL2 Immediate early protein ICP0 Q5Y0P4 Q5Y0P4_9ALPH dsDNA TR, Other S N N N I(18539148, 15494213, 2552142, 2820720, 20686034) I(15494213) I(6098466; 25497088) 12603998.0 ICP0 homolog Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100. Prevents antiviral response to viral DNA induced by IFI16 by degrading it. Additionally, inhibits host IRF3 nuclear signaling to prevent interferon production by the infected cells. Interestingly, the E3 ubiquitin ligase activity associated with the RING finger domain does not seem to be directly required to inhibit the activation of IRF3 but instead plays a critical role in modulating the cellular localization of ICP0. Upon reactivation of latent genome, suppresses the silencing of viral DNA by dissociating either HDAC1 or HDAC2 from the HDAC-RCOR1-REST-KDM1A complex localized at the ND10 structures and causes their dispersal. Two cellular histone ubiquitin ligases RNF8 and RNF168 are also targeted by ICP0 for degradation, leading to a loss of ubiquitinated forms of H2A, a relief of transcriptional repression, and the activation of latent viral genomes. Enhances the localization of host CCND3 to ND10 bodies that serve as precursors of replication compartments to enable efficient viral replication. Like many RING-finger E3 ubiquitin ligases, ICP0 can induce its own ubiquitination, an activity that promotes its instability due to its targeting to the 26S proteasome for degradation. ICP0 restricts this process by recruiting the cellular ubiquitin-specific protease USP7 that cleaves the anchored ubiquitin chains from ICP0, thereby promoting its stabilization. Herpesviridae Cercopithecine alphaherpesvirus 2 RS1 ICP4, Immediate early protein ICP4 Q5Y0M9 Q5Y0M9_9ALPH dsDNA TR P I(26984403) I(28611249) N I(26984403) I(22496239, 26984403) I(28505309) 12603998.0 host cell nucleus;positive regulation of transcription, DNA-templated Herpesviridae Cercopithecine alphaherpesvirus 2 UL29 DBP, Major DNA-binding protein, Single-strand DNA-binding protein Q5Y0S3 Q5Y0S3_9ALPH dsDNA, ssDNA TR, Rep, DR S N N N I(20585571) I(26676794, 30598436) I(2987527) 12603998.0 Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA. Herpesviridae Cercopithecine alphaherpesvirus 2 UL48 Major tegument protein VP16, Tegument protein, Transactivating tegument protein VP16 Q5Y0Q4 Q5Y0Q4_9ALPH dsDNA TR P I(19321615) N N I(2538647) I(11416146, 2538647) I(11416146) 12603998.0 DNA binding;regulation of transcription, DNA-templated Herpesviridae Cercopithecine alphaherpesvirus 2 UL54 Immediate early protein ICP27 Q5Y0P7 Q5Y0P7_9ALPH dsDNA, ssDNA, ssRNA, dsRNA TR, TNA P N N N I(25712217) I(19783816) I(19783816, Yeast three-hybrid analysis, NMR) 12603998.0 ICP27 homolog regulation of transcription, DNA-templated Herpesviridae Cercopithecine alphaherpesvirus 2 US1 Immediate early protein ICP22, Regulatory protein ICP22 Q5Y0P2 Q5Y0P2_9ALPH indirect/unknown TR P I(25233083, 23029222) N N I(25712217, 30863402) N I(25712217) 12603998.0 Functions as a general transcriptional regulator of cellular and viral mRNAs mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response. Herpesviridae Cercopithecine herpesvirus 1 RL2 Immediate early protein ICP0, Ubiquitin E3 ligase ICP0 A0A059WI18 A0A059WI18_CHV1 0A059WDD4 dsDNA TR, Other S N N N I(18539148, 15494213, 2552142, 2820720, 20686034) I(15494213) I(6098466; 25497088) 12603998.0 ICP0 homolog Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100. Prevents antiviral response to viral DNA induced by IFI16 by degrading it. Additionally, inhibits host IRF3 nuclear signaling to prevent interferon production by the infected cells. Interestingly, the E3 ubiquitin ligase activity associated with the RING finger domain does not seem to be directly required to inhibit the activation of IRF3 but instead plays a critical role in modulating the cellular localization of ICP0. Upon reactivation of latent genome, suppresses the silencing of viral DNA by dissociating either HDAC1 or HDAC2 from the HDAC-RCOR1-REST-KDM1A complex localized at the ND10 structures and causes their dispersal. Two cellular histone ubiquitin ligases RNF8 and RNF168 are also targeted by ICP0 for degradation, leading to a loss of ubiquitinated forms of H2A, a relief of transcriptional repression, and the activation of latent viral genomes. Enhances the localization of host CCND3 to ND10 bodies that serve as precursors of replication compartments to enable efficient viral replication. Like many RING-finger E3 ubiquitin ligases, ICP0 can induce its own ubiquitination, an activity that promotes its instability due to its targeting to the 26S proteasome for degradation. ICP0 restricts this process by recruiting the cellular ubiquitin-specific protease USP7 that cleaves the anchored ubiquitin chains from ICP0, thereby promoting its stabilization. Herpesviridae Cercopithecine herpesvirus 1 RS1 ICP4, Immediate early protein ICP4 Q7T401 Q7T401_CHV1 A0A059WI86,A0A1X9WFW5,A0A1X9WG45,A0A1X9WG88,A0A1X9WG94,A0A1X9WHE3,A0A1X9WI28,A0A1X9WIB5,A0A1X9WIH6,A0A1X9WIL9,A0A1X9WIS4 dsDNA TR P I(26984403) I(28611249) N I(26984403) I(22496239, 26984403) I(28505309) 12603998.0 positive regulation of transcription, DNA-templated,host cell nucleus Herpesviridae Cercopithecine herpesvirus 1 UL29 DBP, Major DNA-binding protein, Single-strand DNA-binding protein Q805Z9 Q805Z9_CHV1 A0A1X9WF78,A0A1X9WFT8,A0A1X9WFU2,A0A1X9WG66,A0A1X9WHS8,A0A1X9WIW2 dsDNA, ssDNA TR, Rep, DR S N N N I(20585571) I(26676794, 30598436) I(2987527) 12603998.0 Q805Z9 is inferred from Cercopithecine alphaherpesvirus 2 protein Q5Y0S3 Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA. Herpesviridae Cercopithecine herpesvirus 1 UL48 Major tegument protein VP16, Tegument protein, Transactivating tegument protein VP16 Q805Y1 Q805Y1_CHV1 A0A059WDC4,A0A1X9WFH9,A0A1X9WGD5,A0A1X9WHR9,A0A1X9WI32,A0A1X9WIY8 dsDNA TR P I(19321615) N N I(2538647) I(11416146, 2538647) I(11416146) 12603998.0 DNA binding;regulation of transcription, DNA-templated Herpesviridae Cercopithecine herpesvirus 1 UL54 Immediate early protein, Immediate early protein ICP27, Multifunctional expression regulator Q805X4 Q805X4_CHV1 A0A059WP42,A0A1X9WF94,A0A1X9WFD7,A0A1X9WGK1,A0A1X9WHQ3,A0A1X9WI66,A0A1X9WIB1 dsDNA, ssDNA, ssRNA, dsRNA TR, TNA P N N N I(25712217) I(19783816) I(19783816, Yeast three-hybrid analysis, NMR) 12603998.0 ICP27 homolog regulation of transcription, DNA-templated Herpesviridae Cercopithecine herpesvirus 1 US1 Immediate early protein ICP22, Regulatory protein ICP22 Q7T5C5 Q7T5C5_CHV1 A0A059WP48,A0A1X9WFA0,A0A1X9WFD9,A0A1X9WFQ7,A0A1X9WHH9,A0A1X9WHY3,A0A1X9WIJ4,A0A1X9WIR3 indirect/unknown TR P I(25233083, 23029222) N N I(25712217, 30863402) N I(25712217) 12603998.0 Functions as a general transcriptional regulator of cellular and viral mRNAs mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response. Herpesviridae Human herpesvirus 1; Herpes simplex virus 1 ICP0 Alpha-0 protein, E3 ubiquitin-protein ligase ICP0, IE110, Immediate-early protein IE110, RING-type E3 ubiquitin transferase ICP0, Trans-acting transcriptional protein ICP0, Trans-acting transcriptional protein ICP0 , VMW110 P08393 ICP0_HHV11 A0A0F6TMA8,A0A0F7CWV0,A0A0F7CX66,A0A0F7CXM5,A0A0F7CXT2,A0A0F7CXW1,A0A0F7CY33,A0A0F7CY77,A0A0F7CYD5,A0A0F7GQZ5,A0A0F7GR62,A0A0F7GRM9,A0A0F7GS15,A0A0F7GSK5,A0A0F7GSQ3,A0A0F7GT05,A0A0F7GTF5,A0A0F7GTH7,A0A0F7GTR3,A0A0F7GU10,A0A0F7GU88,A0A0F7GV83,A0A0F7GVF0,A0A0F7GW03,A0A0F7GW86,A0A0F7GX28,A0A0F7GXE2,A0A0F7MZW1,A0A0S1TJG0,A0A0S1TJU7,A0A0S1TL48,A0A0S2I6L3,A0A181ZG35,A0A181ZG46,A0A193GSD7,A0A193GSS8,A0A193GT95,A0A193GTE7,A0A193GTH4,A0A193GTN4,A0A193GTW0,A0A193GTW3,A0A193GU35,A0A193GUI9,A0A193GUJ6,A0A193GUP1,A0A193GUR4,A0A193GUX0,A0A193GV30,A0A193GVR5,A0A193GW67,A0A193GW73,A0A193GWM3,A0A193GWV3,A0A193GXB0,A0A1C3J693,A0A1C3J6C6,A0A1C3J6E2,A0A1C3J6E4,A0A1C3J6N4,A0A1C3J716,A0A1C3J749,A0A1C3J7K9,A0A1C3J7Q4,A0A1C3J7X0,A0A1C3J7Z9,A0A1C3K9E0,A0A1D9CK31,A0A1V0E4Z7,A0A290Y1F5,A0A2U9A3L9,A0A2U9AAR9,A0A2U9ABP7,A0A2U9ABT1,A0A2Z4GZE1,A0A2Z4H0U7,A0A2Z4H1E3,A0A2Z4H1P0,A0A2Z4H1Y3,A0A2Z4H2C8,A0A2Z4H2N9,A0A2Z4H2V1,A0A2Z4H2V5,A0A2Z4H3G6,A0A2Z4H3U3,A0A2Z4H4P0,A0A2Z4H4X5,A0A2Z4H5E2,A0A2Z4H5P4,A0A2Z4H5W9,A0A2Z4H614,A0A2Z4H6U6,A0A2Z4H6Y6,A0A2Z4H8C0,A0A2Z4H9C0,A0A2Z4HAC0,A0A2Z4HAK7,A0A2Z4HAT8,A0A2Z4HAY7,A0A2Z4HBW8,A0A2Z4HBY4,A0A2Z4HCB2,A0A2Z4HCC6,A0A2Z4HE50,A0A2Z4HEE5,A0A2Z4HEQ7,A0A2Z4HFF6,A0A3G1LC33,B9VQC7,D3YPC2,D3YPF7,F8RCI7,F8RCS6,F8RDF7,F8RDN3,F8RE37,F8REB3,F8REI9,F8REZ2,F8RF66,F8RFE3,F8RFX1,F8RG89,G8H5J4,G8H854,G8H8C3,G8H8P9,G8H8X1,G8H8Y7,G8H957,G8HBH2,H9E965,I3TC55,I3TC56,J7GUK9,J7H0H8,Q09I79,U5TMT3 dsDNA TR, Other S N N 5C56 D(18539148, 15494213, 2552142, 2820720, 20686034) D(15494213) D(6098466; 25497088) Fields Virology Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100. Prevents antiviral response to viral DNA induced by IFI16 by degrading it. Additionally, inhibits host IRF3 nuclear signaling to prevent interferon production by the infected cells. Interestingly, the E3 ubiquitin ligase activity associated with the RING finger domain does not seem to be directly required to inhibit the activation of IRF3 but instead plays a critical role in modulating the cellular localization of ICP0. Upon reactivation of latent genome, suppresses the silencing of viral DNA by dissociating either HDAC1 or HDAC2 from the HDAC-RCOR1-REST-KDM1A complex localized at the ND10 structures and causes their dispersal. Two cellular histone ubiquitin ligases RNF8 and RNF168 are also targeted by ICP0 for degradation, leading to a loss of ubiquitinated forms of H2A, a relief of transcriptional repression, and the activation of latent viral genomes. Enhances the localization of host CCND3 to ND10 bodies that serve as precursors of replication compartments to enable efficient viral replication. Like many RING-finger E3 ubiquitin ligases, ICP0 can induce its own ubiquitination, an activity that promotes its instability due to its targeting to the 26S proteasome for degradation. ICP0 restricts this process by recruiting the cellular ubiquitin-specific protease USP7 that cleaves the anchored ubiquitin chains from ICP0, thereby promoting its stabilization. Herpesviridae Human herpesvirus 1; Herpes simplex virus 1 RS1 Alpha-4 protein, ICP4, IE175, Infected cell protein 4, Major viral transcription factor ICP4, Major viral transcription factor ICP4 RS1, RS1.2, Transcriptional activator IE175, Transcriptional regulator ICP4 P08392 ICP4_HHV11 A0A0B5E5S4,A0A0B5EBZ6,A0A0F6TMP9,A0A0F7CX08,A0A0F7CXB0,A0A0F7CXL0,A0A0F7CY62,A0A0F7GR69,A0A0F7GS44,A0A0F7GVD0,A0A0F7GVQ1,A0A0F7GWJ5,A0A0S1TJ69,A0A0S1TJB1,A0A0X8E9W1,A0A193GSU1,A0A193GT76,A0A193GTA0,A0A193GTY9,A0A193GUC1,A0A193GV99,A0A193GVK4,A0A193GW58,A0A193GWU4,A0A193GX28,A0A193GXR6,A0A1C3J777,A0A1C3J7A4,A0A1C3J7I7,A0A1C3J7R6,A0A1C3J7T6,A0A1C3J7V9,A0A1C3J807,A0A1C3J815,A0A1C3K9I9,A0A1D9CK53,A0A1V0E590,A0A290Y188,A0A290Y1F8,A0A2U9ABK0,A0A2Z4GZD9,A0A2Z4GZG8,A0A2Z4GZN3,A0A2Z4H0A9,A0A2Z4H0B3,A0A2Z4H1V7,A0A2Z4H250,A0A2Z4H2C3,A0A2Z4H2W5,A0A2Z4H2Y6,A0A2Z4H2Z8,A0A2Z4H4F0,A0A2Z4H4K9,A0A2Z4H4P5,A0A2Z4H559,A0A2Z4H5Q1,A0A2Z4H6S2,A0A2Z4H6V6,A0A2Z4H7F9,A0A2Z4H7P9,A0A2Z4H7U3,A0A2Z4H986,A0A2Z4HAX0,A0A2Z4HB37,A0A2Z4HB72,A0A2Z4HBC0,A0A2Z4HBK8,A0A2Z4HBR2,A0A2Z4HCI3,A0A2Z4HCS0,A0A2Z4HCS6,A0A2Z4HDY8,A0A2Z4HEG2,A0A2Z4HEH1,A0A2Z4HEZ5,A0A2Z4HFA5,A0A2Z4HFJ4,A0A2Z4LE53,A0A2Z4LFE8,B9VQC5,D3YPC4,D3YPL8,F8RCC6,F8RCI9,F8RCS9,F8RD83,F8RDF9,F8RDN6,F8RDW3,F8RE39,F8REJ2,F8RER9,F8REZ4,F8RF68,F8RFE5,F8RFL6,F8RG91,F8RGG8,G8H8J2,G8H943,G8HBH4,H9E981,I1UYM4,I3TCD6,J7GV28,Q09I77,U5TQG7 dsDNA TR P D(26984403) D(28611249) 5MHJ D(26984403; 21998580; 18539148) D(22496239, 26984403; 21998580) D(28505309) Fields Virology Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription. Binds with high affinity to the sequence 5'-ATCGTC-3'. Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation. Negatively regulates its own transcription. This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription. Herpesviridae Human herpesvirus 1; Herpes simplex virus 1 UL29 DBP, ICP8, Major DNA-binding protein P04296 DNBI_HHV11 A0A0B5E506,A0A0B5EAK3,A0A0B5ED26,A0A0S1TES2,A0A0S1TIP6,A0A181ZGK5,A0A181ZGT1,A0A181ZHM5,A0A290Y1C7,A0A2U9A559,A0A2U9A5G9,A0A2U9A5R4,A0A2U9A614,A0A2U9A670,A0A2U9A6Q7,A0A2U9A7J1,A0A2U9A994,A0A2U9A9S5,A0A2U9ABP2,A0A2Z2D682,A0A2Z4H192,A0A2Z4H1V4,A0A2Z4H2S6,A0A2Z4H493,A0A2Z4H5K9,A0A2Z4H6I9,A0A2Z4H705,A0A2Z4H7A8,A0A2Z4H7J3,A0A2Z4H8N3,A0A2Z4H9Z2,A0A2Z4HBR6,A0A2Z4HBU1,A0A2Z4HD21,A0A2Z4HED3,A0A2Z4HEQ2,G8H881,G8H8M0,G8H8U2,I3TC88,P17469,P17470,Q2MGU6,Q2MGU7,Q2MGV1 dsDNA, ssDNA TR, Rep, DR S N N 1URJ I(20585571) D(26676794, 30598436) D(2987527) Fields Virology Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA. Herpesviridae Human herpesvirus 1; Herpes simplex virus 1 UL48 Alpha trans-inducing protein, Alpha-TIF, ICP25, Tegument protein VP16, Vmw65, VP16 P06492 VP16_HHV11 A0A0B5EBV9,A0A0F7GRN8,A0A0X8EA31,A0A109R0Q6,A0A110AV46,A0A110AX28,A0A140GKG8,A0A181ZFV5,A0A181ZGY2,A0A181ZHC6,A0A193GUI5,A0A1C3J6Y6,A0A1C3J7F2,A0A1C3J7F6,A0A1D9CK22,A0A1V0E561,A0A2U9A5R5,A0A2U9A645,A0A2U9A6S4,A0A2U9A847,A0A2U9A8N0,A0A2U9ABI7,A0A2U9AC12,A0A2Z2D2L3,A0A2Z4H418,A0A2Z4H451,A0A2Z4H850,A0A2Z4HC21,A0A2Z4HC83,A0A2Z4HEG6,D3YPB2,D3YPK6,F8RCZ3,F8RDE7,F8REY2,F8RF56,F8RG79,G8H933,G8HBG2,I3TCA8,J7GUJ5,U5TMS3 dsDNA TR P D(19321615) N 16VP, 2PHE, 2PHG D(2538647) D(11416146, 2538647) D(11416146) Fields Virology Binds to DNA with host TFs Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection. Herpesviridae Human herpesvirus 1; Herpes simplex virus 1 UL54 ICP27, Immediate-early protein IE63, Infected cell protein 27, mRNA export factor, VMW63 P10238 ICP27_HHV11 A0A076N1M8,A0A089WX37,A0A181ZFZ5,A0A181ZG53,A0A290Y181,A0A2U9A4C7,A0A2U9A6X5,A0A2U9A8Q3,A0A2U9A975,A0A2U9ABC8,A0A2Z4H1C0,A0A2Z4H2L7,A0A2Z4H3W4,A0A2Z4H4C4,A0A2Z4H541,A0A2Z4H661,A0A2Z4H7A3,A0A2Z4H805,A0A2Z4H871,A0A2Z4H937,A0A2Z4HBG5,A0A2Z4HCG4,A0A2Z4HEX6,A0A2Z4HF86,A0A2Z4HF92,A0A2Z4LF63,G8H8A5,G8H8P6,G8H8W8,G8H940,P36295 dsDNA, ssDNA, ssRNA, dsRNA TR, TNA P N N 2KT5, 4YXP, 5BQK D(18539148) D(19783816; 1853914) D(19783816, Yeast three-hybrid analysis, NMR) Fields Virology Multifunctional regulator of the expression of viral genes that contributes to the shutoff of host protein synthesis and mediates nuclear export of viral intronless mRNAs. Early in infection, this immediate early (EI) protein mediates the inhibition of cellular splicing. This results in the accumulation of unprocessed 3'end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off early after virus infection. Later in the infection, it helps recruit cellular RNA polymerase II to viral replication sites and promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP. ICP27 binds to NUP62 which may provide facilitated viral mRNA export and may indirectly compete with some host cell transport receptors for binding and inhibit cellular nucleocytoplasmic transport pathways (PubMed:22334672). Also stimulates translation of viral transcripts. Repression of host gene expression blocks the cell cycle at the G1 phase and prevents apoptosis. Seems to silence the 3' splice site of the promyelocytic leukemia (PML) intron 7a, thereby switching PML isoforms from PML-II to PML-V. This could be linked to the accelerated mRNA export induced by ICP27 which might not provide sufficient time for PML pre-mRNA to be spliced in the nucleus. Herpesviridae Human herpesvirus 1; Herpes simplex virus 1 US1 ICP22, Immediate-early protein IE68, Infected cell protein 22, Transcriptional regulator ICP22 P04485 ICP22_HHV11 A0A089YQP5,A0A0B5E4A8,A0A0S1TKF2,A0A181ZFQ8,A0A181ZFX4,A0A181ZG17,A0A181ZH58,A0A181ZHB1,A0A181ZHL3,A0A290Y190,A0A2U9A3V9,A0A2U9A473,A0A2U9A612,A0A2U9A653,A0A2U9A738,A0A2U9A8A8,A0A2U9A8H3,A0A2U9A988,A0A2Z4GZP5,A0A2Z4GZY6,A0A2Z4H1M5,A0A2Z4H668,A0A2Z4H8Q8,A0A2Z4H9C8,A0A2Z4HAC1,A0A2Z4HBP6,A0A2Z4HBT9,A0A2Z4HCT0,A0A2Z4HCU3,A0A2Z4HCZ9,A0A2Z4HDW9,A0A2Z4HE75,A0A2Z4HF25,Q09I76 indirect/unknown TR P D(25233083, 23029222) N N D(19535441) N I(25712217) Fields Virology Functions as a general transcriptional regulator of cellular and viral mRNAs mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response. Herpesviridae Human herpesvirus 2; Herpes simplex virus 2 RL2 E3 ubiquitin-protein ligase ICP0, RING-type E3 ubiquitin transferaseICP0, VMW118 protein P28284 ICP0_HHV2H A0A290D0A4,A0A290DJM1,A0A290DPU6,A0A290DQ85,A0A290DQC7,A0A290Y3R4,A0A290Y3T1,A0A290Y453,A0A290Y4M0,A0A290Y4T0,A0A2U9DUX7,A0A2X0RYZ6,D6PUZ2,D6PUZ3,D6PUZ4,D6PUZ5,D6PUZ6,D6PUZ7,G9I221,G9I280,P89473,W0NW81 dsDNA TR, Other S N N N D(25712217) I(15494213) I(20106921, 11333917 Fields Virology Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100. Prevents antiviral response to viral DNA induced by IFI16 by degrading it. Additionally, inhibits host IRF3 nuclear signaling to prevent interferon production by the infected cells. Herpesviridae Human herpesvirus 2; Herpes simplex virus 2 RS1 Alpha-4 protein, ICP4, IE175, Infected cell protein 4, Major viral transcription factor ICP4 homolog, Transcriptional activator IE175 P90493 ICP4_HHV2H A0A290DJV7,A0A290DQ87,A0A290DQD8,A0A290Y3U5,A0A290Y4N5,A0A290Y4U9,A0A2H4PJL5,A0A2U9DVR1,A0A2U9DWA7,A0A2X0TFV2,G9I282 dsDNA TR P I(26984403) I(28611249) N D(25712217, 25673716) I(22496239, 26984403) I(28505309) Fields Virology Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription. Binds with high affinity to the sequence 5'-ATCGTC-3'. Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation. Negatively regulates its own transcription. This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription. Herpesviridae Human herpesvirus 2; Herpes simplex virus 2 UL29 DBP, DNA binding protein ICP8, ICP8, Major DNA-binding protein, Single-stranded DNA-binding protein P36384 DNBI_HHV2 A0A0E3U2R9,A0A0E3Y6D1,A0A0Y0R3K0,A0A0Y0RPP0,A0A0Y0RQH2,A0A109R1L2,A0A1D8M9D0,A0A1U9ZCS9,A0A1U9ZD80,A0A1U9ZDS2,A0A1U9ZDY0,A0A1U9ZFU3,A0A1U9ZGK2,A0A1U9ZGZ7,A0A1U9ZHX5,A0A1U9ZJ89,A0A1U9ZJG3,A0A1U9ZK04,A0A1U9ZKU7,A0A1U9ZLW5,A0A1U9ZM30,A0A218KLT5,A0A218KLU4,A0A290D402,A0A290D687,A0A290Y3N1,A0A290Y3X5,A0A290Y4D4,A0A290Y4L1,A0A290Y4Y4,A0A2U9DUT8,A0A2U9DVR8,G9I251,I6U4X4,P89452,Q69101,W0NSF6 dsDNA, ssDNA TR, Rep, DR S N N N I(20585571) I(26676794, 30598436) I(2987527) Fields Virology Q69101 is inferred from Cercopithecine alphaherpesvirus 2 protein Q5Y0S3 Single-stranded DNA-binding protein required for DNA replication. Herpesviridae Human herpesvirus 2; Herpes simplex virus 2 UL48 Transactivating tegument protein VP16, VP16, VP16 protein Q69113 Q69113_HHV2 A0A0Y0QTX6,A0A0Y0RIG1,A0A0Y0RUC4,A0A109R1E4,A0A120I2I5,A0A1U9ZDH2,A0A1U9ZE81,A0A1U9ZEL1,A0A1U9ZFX0,A0A1U9ZJL0,A0A1U9ZK94,A0A1U9ZKX9,A0A1U9ZLF9,G9I270,I6TLV8 dsDNA TR P I(19321615) N N I(2538647) I(11416146, 2538647) I(11416146) Fields Virology DNA binding,regulation of transcription, DNA-templated Herpesviridae Human herpesvirus 2; Herpes simplex virus 2 UL54 ICP27, Immediate-early protein IE63, Infected cell protein 27, mRNA export factor, VMW63 P28276 ICP27_HHV2H A0A1D8M9A7,A0A290D5Z7,A0A290DPS4,A0A290Y4K6,A0A2U9DVV4 dsDNA, ssDNA, ssRNA, dsRNA TR+J84, TNA P N N N D(25712217) I(19783816) I(19783816, Yeast three-hybrid analysis, NMR) Fields Virology ICP27 homolog Multifunctional regulator of the expression of viral genes that contributes to the shutoff of host protein synthesis and mediates nuclear export of viral intronless mRNAs. Early in infection, this immediate early (EI) protein mediates the inhibition of cellular splicing. This results in the accumulation of unprocessed 3'end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off early after virus infection. Later in the infection, it helps recruit cellular RNA polymerase II to viral replication sites and promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP. ICP27 binds to NUP62 which may provide facilitated viral mRNA export and may compete with some host cell transport receptors for binding and inhibit cellular nucleocytoplasmic transport pathways. Also stimulates translation of viral transcripts. Repression of host gene expression blocks the cell cycle at the G1 phase and prevents apoptosis (By similarity). Seems to silence the 3' splice site of the promyelocytic leukemia (PML) intron 7a, thereby switching PML isoforms from PML-II to PML-V. This could be linked to the accelerated mRNA export induced by ICP27 which might not provide sufficient time for PML pre-mRNA to be spliced in the nucleus. Herpesviridae Human herpesvirus 2; Herpes simplex virus 2 US1 P89474 ICP22_HHV2H A0A0E3U2V3,A0A0Y0R3N1,A0A0Y0RAR6,A0A0Y0RPR1,A0A0Y0RQK2,A0A0Y0RQR5,A0A109R0Y3,A0A110B8A0,A0A1U9ZDA4,A0A1U9ZDI2,A0A1U9ZDV1,A0A1U9ZEP9,A0A1U9ZF54,A0A1U9ZFY2,A0A1U9ZGL3,A0A1U9ZH77,A0A1U9ZH85,A0A1U9ZII6,A0A1U9ZJK5,A0A1U9ZJQ9,A0A1U9ZK70,A0A1U9ZLG9,A0A1U9ZLK1,A0A1U9ZLR4,A0A1U9ZM71,A0A1U9ZMI5,A0A290DCW2,A0A290Y3Z3,A0A290Y411,A0A290Y505,A0A2U9DVE6,A0A2U9DVM7,A0A2U9DX76,A0A2X0SBG7,G9I283 indirect/unknown TR P D(25712217) N N D(25712217, 30863402) N D(25712217) Fields Virology Functions as a general transcriptional regulator of cellular and viral mRNAs mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response. Herpesviridae Human herpesvirus 3; Varicella-zoster virus IE61 Immediate-early protein 61,E3 ubiquitin-protein ligase IE61, Modulator of cell state and gene expression, ORF61, ORF62-2, Ring-finger protein, Transactivator, Transcription regulator, Ubiquitin E3 ligase ICP0 Q6QCJ5 Q6QCJ5_HHV3 A0A0F7CWE3,A0A1B1JGJ2,G9IWI5,I7EJ31,Q0Q9A7,Q0Q9Q3,U5NTS2 dsDNA (20225013,table1) TR P N N N D(19457996, 22090112) N N Fields Virology ICP0 homolog ligase activity,metal ion binding Herpesviridae Human herpesvirus 3; Varicella-zoster virus IE62 ICP4, Immediate-early protein 62, Major viral transcription factor ICP4 homolog, ORF62, ORF71 P09310 ICP4_VZVD A0A076N2G9,A0A0F7CV41,A0A0F7CVI7,A0A0F7CW41,A0A0F7GJ31,A0A0F7GL21,A0A0F7GMV1,A0A1B1JEY7,A0A1B1JFB3,A0A1B1JFK7,A0A1B1JG10,A0A1B1JG79,A0A1B1JGD9,A0A1B1JGP6,A0A1B1JGU1,A0A1B1JGX5,A0A3G2KR87,G0ZLH3,I2CNT9,I7EJ42,Q6X674,Q80AB9,Q80AC0,Q80AC2,Q80AC4,Q8AZM1,Q993S8,Q99BU9,Q99BW7,Q9DK02,Q9DWX9,U5NPD5,U5NQ74,U5NQE5,U5NQJ5,U5NR65,U5NRF1,U5NS27,U5NSM0,U5NSM7,U5NTS8,U5NUT7,W5RSN1 dsDNA TR P I(26984403) I(28611249) N D(20631144, 15936796, 2556848, 21937644, 8230477, 19457996) D(21937644) I(28505309) Fields Virology Transcriptional transactivator. May interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. Negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis. Herpesviridae Human herpesvirus 3; Varicella-zoster virus IE63 Immediate-early protein 63, ORF63, ORF70, Transcriptional regulator ICP22 homolog, Transcriptional regulator IE63 P09255 ICP22_VZVD A0A1B1JGF9,A0A1B1JGW2,A0A2Z5BRN6,A0A2Z5BRP5,A0A2Z5BRQ4,A0A2Z5BRQ9,A0A2Z5BRS1,A0A2Z5BRT2,A0A2Z5BSR7,A0A2Z5BSS5,A0A2Z5BTS0,A0A2Z5BTS7,A0A2Z5BUH2,A0A2Z5BUI1,A0A2Z5BUI9,A0A2Z5BUK8,A0A2Z5BUL5,A0A2Z5BV47,A0A2Z5BV56,A0A2Z5BV63,A0A2Z5BWY5,A0A2Z5BWY7,A0A2Z5BX41,A0A2Z5BX44,G3LF46,Q77NN7 indirect/unknown TR P N N N D(15843171, 11912195, 1316489, 15936796, 15936796, 21937644, 19457996) N D(15843171) Fields Virology Immediate early (EI) protein that functions as a transcriptional regulator of cellular and viral mRNAs mainly by interacting with several general transcription factors thereby disorganizing the preinitiation complex at certain promoters. May additionally help to regulate levels of histones in virus-infected cells by interacting with host ASF1. By inhibiting host transcriptional program, IE63 plays a major role in the ability of VZV to overcome the innate immune response to the virus. Herpesviridae Human herpesvirus 3; Varicella-zoster virus ORF10 Alpha trans-inducing protein, Alpha-TIF, ORF10 protein, ORF-10, Tegument protein 10, Tegument protein VP16 homolog, VP16 P09265 VP16_VZVD A0A0F7CW89,A0A1B1JG98,Q2PJ54,Q4JQW5,Q6QCP5 indirect/unknown TR P I(19321615) N N D(15522876, 8386275) I(11416146, 2538647) I(11416146) Fields Virology Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection (By similarity). Herpesviridae Human herpesvirus 3; Varicella-zoster virus ORF29 DBP, Major DNA-binding protein P09246 DNBI_VZVD A0A0F7CVJ5,A0A0F7CWJ5,A0A0F7GIL1,A0A0F7GKY5,I7D9F2,Q4JQU6,U5NU18,U5NU72 ssDNA TR, Rep, DR S N N N I(20585571) D(21937644) I(2987527) Fields Virology Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA. Herpesviridae Human herpesvirus 3; Varicella-zoster virus ORF4 Gene expression post-transcriptional regulator, ICP27, Multifunctional expression regulator, Post-transcriptional regulator, Post-transcriptional regulator of gene expression, Transactivator, UL54 Q6QCQ2 Q6QCQ2_HHV3 A0A075X2D8,A0A0F7CVL9,A0A0F7CWE6,A0A1B1JFU7,U5NPR6 dsDNA, ssDNA, ssRNA, dsRNA TR, TNA P N N N D(8389935, 9261438, 17634217, 2556848, 19457996) I(19783816) I(19783816, Yeast three-hybrid analysis, NMR) Fields Virology ICP27 homolog regulation of transcription, DNA-templated Herpesviridae Human herpesvirus 4; Epstein-Barr virus BALF2 DBP, Major DNA-binding protein, Major DNA-binding protein,DBP P03227 DNBI_EBVB9 A0A0C7TMQ4,A0A0C7TUF9,A0A0C7U097,A0A0S2YRG9,A0A0U3K2Q9,A0A0U3TGP5,A0A0U3TMI4,A0A0U3U8D7,A0A120GXZ4,A0A191T7N2,A0A1W7HH80,A0A1W7HHM5,A0A2D1LY71,A0A2D1LYV2,A0A2D1LZI4,A0A2D1M0K1,A0A2D1M0T4,A0A2S1MKR8,A0A2S1MLV4,A0A2S1MNV2,A0A2S1MPZ1,A0A2S1MQH8,A0A2S1MSX2,A0A2S1MUL4,A0A2S1MUV4,A0A2S1MV65,A0A2S1MWF2,A0A2S1MWR1,A0A2S1MX72,A0A2S1MX94,A0A2S1MY55,A0A2S1MYS1,A0A2S1N124,A0A2S1N1E3,A0A2S1N1K4,A0A2S1N246,A0A2S1N3C7,A0A2S1N3Z9,A0A2S1N521,A0A385J8J4,A0A385J8S6,A0A385J9A1,A0A385J9M3,A0A385J9X3,A0A385JAK5,A0A385JAS1,A0A385JAX3,K9UTM4,Q1HVB8,Q3KSN9,R4R989,V5KTZ5 ssDNA TR, Rep, DR S N N N N N D(9434720, 8806519) Fields Virology Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA. Herpesviridae Human herpesvirus 4; Epstein-Barr virus BcRF1 TBP-like protein BcRF1 P25215 UL87_EBVB9 A0A0C7T247,A0A0X8WTD9,K9URF1 dsDNA TR P N N N D(22457524, 25165108) D(22457524) N Fields Virology vPIC homologs DNA-binding protein that is required for viral late gene expression. Herpesviridae Human herpesvirus 4; Epstein-Barr virus BDLF3.5 BDLF3, BDLF3 protein, BDLF3.5 protein I1YP44 I1YP44_EBVG indirect/unknown TR P N N N D(25165108) N D(25165108) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 4; Epstein-Barr virus BDLF4 Uncharacterized protein BDLF4 P0CK56 UL92_EBVB9 G3CKS0,P0CK57 indirect/unknown TR P N N N D(25165108) N D(25165108) Fields Virology vPIC homologs host cell nucleus;DNA binding;DNA-binding transcription factor activity;protein dimerization activity;sequence-specific DNA binding;modulation by virus of host G0/G1 transition checkpoint;positive regulation of transcription, DNA-templated;regulation of transcription, DNA-templated;release from viral latency;suppression by virus of host IRF7 activity Herpesviridae Human herpesvirus 4; Epstein-Barr virus BFRF2 Uncharacterized protein BFRF2 P14347 BFRF2_EBVB9 A0A0B6VKS2 indirect/unknown TR P N N N D(25165108) N D(25165108) Fields Virology vPIC homologs viral process,viral tegument Herpesviridae Human herpesvirus 4; Epstein-Barr virus BGLF3 Protein BGLF3 P03220 UL95_EBVB9 A0A0B6VJ43,A0A0B6VMR4,A0A0C7NU37,A0A0C7SZ89,A0A0C7T510,A0A0C7T6N5,A0A0C7T892,A0A0C7T8Y5,A0A0C7TBC9,A0A1P7TZK4,A0A2D1LY20,A0A2S1MNR9,A0A2S1MR69,A0A2S1MRS3,A0A2S1MRX8,A0A2S1MUP2,A0A2S1MYJ5,A0A2S1N2D8,A0A2S1N2L3,A0A2S1N4W5,A0A385J8Q1,A0A385JAF2,A0A385JAM3,A0A3R5TNR6,A0A3R5U7A5,A0A3R5VQ48,A0A3R5WKF6,A0A3R5WKP5,A0A3R5XW44,A0A3R5YGK7,G3CKR7,K9USY2,Q3KSR4,V5KTY2 indirect/unknown TR P N N N D(25165108) N D(25165108) Fields Virology vPIC homologs viral tegument;viral process Herpesviridae Human herpesvirus 4; Epstein-Barr virus BMRF1 DNA polymerase processivity factor BMRF1, EA-D, Early antigen protein D, Polymerase accessory subunit P03191 EAD_EBVB9 K9UR48,P0C6Z0 dsDNA TR, Rep S N N N D(31462557) D(31462557) D(19801550, Nitrocellulose Filter Binding Assay) Fields Virology Plays an essential role in the viral lytic DNA replication by acting as the polymerase accessory subunit. Stimulates the viral DNA polymerase activity and appears to function with it as a holoenzyme. Increases the processivity of the viral polymerase, probably by acting as a sliding clamp that prevents dissociation of the polymerase from the active template. In addition, BMRF1 transcriptionally activates the early BHLF1 promoter. Herpesviridae Human herpesvirus 4; Epstein-Barr virus BVLF1 Protein BVLF1 Q2MG95 Q2MG95_EBVB9 I1YP55 indirect/unknown TR P N N N D(25165108) N D(25165108) Fields Virology vPIC homologs host cell nucleus;viral tegument;DNA binding;bidirectional double-stranded viral DNA replication Herpesviridae Human herpesvirus 4; Epstein-Barr virus EBNA1 BKRF1, EBNA-1, EBV nuclear antigen 1, Epstein-Barr nuclear antigen 1 P03211 EBNA1_EBVB9 A0A0U3AZS7,A0A2D1LZQ0,Q1HVF7 dsDNA TR, Rep P D(20929547) D(20929547, 26468528,29142137) 1B3T, 1VHI, 1YY6, 2FYY, 2FZ3, 3MV7, 3MV8, 3MV9, 4PRA, 4PRE, 4PRI, 4PRP, 5WMF, 5WUM, 5WUN, 6NPI, 6NPM, 6NPP, 6PW2 D(10799567) D(20929547, 10799567) Fields Virology Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival. Herpesviridae Human herpesvirus 4; Epstein-Barr virus EBNA2 BYRF1, EBNA-2, EBV nuclear antigen 2, Epstein-Barr nuclear antigen 2 P12978 EBNA2_EBVB9 A0A075FCH9,A0A075FCI7,A0A075FDA7,A0A075FDG8,A0A075FFC3,A0A075FFL0,A0A075FFX2,A0A075FGL9,A0A0A8IKS3,A0A0B6VHM4,A0A0C7NTX7,A0A0C7SZP2,A0A0C7T066,A0A0C7T1F2,A0A0C7T2F0,A0A0C7T426,A0A0C7T5P8,A0A0C7T5T4,A0A0C7T687,A0A0C7TCF1,A0A0C7TCX1,A0A0C7TEL7,A0A0C7TI73,A0A0C7TIT1,A0A0C7TKT1,A0A0C7TL19,A0A0C7TLJ0,A0A0C7TMR9,A0A0C7TN88,A0A0C7TNR8,A0A0C7TSE2,A0A0C7TUG9,A0A0C7TV69,A0A0C7TX39,A0A0C7TYV8,A0A0C7TZP5,A0A0C7U0A2,A0A0C7U0N0,A0A0E4D790,A0A0E4HQQ5,A0A0F6QKC9,A0A0S2YQC3,A0A0S2YR23,A0A0U2VT93,A0A0U3J1F9,A0A0U3J5M7,A0A0U3K2E3,A0A0U3SB38,A0A0U3SCD4,A0A0U3TM83,A0A0U3TY67,A0A0U3UKE0,A0A0X8W0J3,A0A0X8W0W5,A0A0X8XBT9,A0A0X8Z1K9,A0A125T0U7,A0A125T130,A0A191T6S4,A0A191T710,A0A191T790,A0A191T7H0,A0A1W5LUS2,A0A2D1LXX3,A0A2D1LY86,A0A2D1LYD8,A0A2D1LYN4,A0A2D1LYW2,A0A2D1LZ30,A0A2D1LZB0,A0A2D1M071,A0A2D1M0L5,A0A3R5TN76,A0A3R5TNW6,A0A3R5TRP0,A0A3R5TTM1,A0A3R5TU90,A0A3R5TUU2,A0A3R5TV00,A0A3R5TVV4,A0A3R5U305,A0A3R5U329,A0A3R5U471,A0A3R5U4S0,A0A3R5U5P5,A0A3R5U808,A0A3R5UAV2,A0A3R5UBI8,A0A3R5UCF3,A0A3R5UCS0,A0A3R5UD40,A0A3R5UDT7,A0A3R5UGT2,A0A3R5VW62,A0A3R5VZT8,A0A3R5W0Z1,A0A3R5W616,A0A3R5W7U3,A0A3R5W866,A0A3R5WD22,A0A3R5WKC0,A0A3R5WQ14,A0A3R5WQP7,A0A3R5WU22,A0A3R5WUM5,A0A3R5WWB4,A0A3R5WWE7,A0A3R5WWI4,A0A3R5WX09,A0A3R5WXB8,A0A3R5WY79,A0A3R5WYI2,A0A3R5WYN4,A0A3R5WZW6,A0A3R5X0F9,A0A3R5X0S5,A0A3R5X1P2,A0A3R5X4D5,A0A3R5X6P1,A0A3R5X741,A0A3R5X8A5,A0A3R5X9K2,A0A3R5XD17,A0A3R5XDF6,A0A3R5XDK0,A0A3R5XFA1,A0A3R5XIC4,A0A3R5XMU8,A0A3R5XR67,A0A3R5YDU1,A0A3R5YEE6,A0A3R5ZGU7,A0A3R5ZZ51,A0A3R6A0M6,A0A3R6A337,A0A3R6A9X6,I1YNZ9,K9UR36,K9URA4,Q3KSV2,R4QYS0,U5YU33 indirect/unknown TR P D(26845565, 24068937) D(21746931, 24068937, 26883634) 2MKR, 2N2J, 5HDA D(26845565) D(21710493, 9445037) N Fields Virology Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells. Herpesviridae Human herpesvirus 4; Epstein-Barr virus EBNA3A BLRF3-BERF1, EBNA3, EBNA-3, EBNA-3A, EBV nuclear antigen 3, EBV nuclear antigen 3A, Epstein-Barr nuclear antigen 3, Epstein-Barr nuclear antigen 3A P12977 EBNA3_EBVB9 A0A075FCV9,A0A075FCW4,A0A075FFK6,A0A075FGE2,A0A0A8IN05,A0A0B6VPX8,A0A0C7P0X9,A0A0C7SX58,A0A0C7SZG8,A0A0C7T019,A0A0C7T0J9,A0A0C7T1N7,A0A0C7T3A9,A0A0C7T3S7,A0A0C7T5I8,A0A0C7T6Q6,A0A0C7T6Z1,A0A0C7T8F1,A0A0C7T9C3,A0A0C7T9D1,A0A0C7TAY3,A0A0C7TBQ7,A0A0C7TD44,A0A0C7TFN4,A0A0C7TIG9,A0A0C7TKB3,A0A0C7TLT1,A0A0C7TLW3,A0A0C7TN30,A0A0C7TNK3,A0A0C7TPP7,A0A0C7TPQ7,A0A0C7TPS6,A0A0C7TQD5,A0A0C7TR83,A0A0C7TRR5,A0A0C7TSA1,A0A0C7TSL0,A0A0C7TSM3,A0A0C7TTD0,A0A0C7TU38,A0A0C7TUC1,A0A0C7TVT3,A0A0C7TVZ9,A0A0C7TWE5,A0A0C7TWV3,A0A0C7TYQ1,A0A0C7TZ60,A0A0C7TZJ3,A0A0C7U0I2,A0A0C7U378,A0A0F6QK09,A0A191T7B4,A0A191T7J2,A0A1W5LUA3,A0A1W5LUF8,A0A2D1LXZ8,A0A2D1LYG7,A0A2D1LYX5,A0A2D1LZ53,A0A2D1M0F9,A0A2S1MLI0,A0A3R5TLU3,A0A3R5TQC1,A0A3R5TU26,A0A3R5TUK3,A0A3R5TUX6,A0A3R5TX13,A0A3R5TXM2,A0A3R5TY93,A0A3R5TZE0,A0A3R5U0J0,A0A3R5U3V1,A0A3R5U4Q0,A0A3R5U5C4,A0A3R5U5V3,A0A3R5U6R9,A0A3R5U851,A0A3R5UBX8,A0A3R5UBZ5,A0A3R5UFL7,A0A3R5W1K4,A0A3R5W2D1,A0A3R5WDB0,A0A3R5WHZ1,A0A3R5WJQ0,A0A3R5WME6,A0A3R5WT39,A0A3R5WTU4,A0A3R5WXL4,A0A3R5WYV7,A0A3R5X5D7,A0A3R5XA97,A0A3R5XE13,A0A3R5XG85,A0A3R5XHM9,A0A3R5ZJQ4,A0A3R5ZMQ3,A0A3R6A954,A0A3R6ADF3,I1YP19,K9USU8,K9UT27,Q3KST2,Q69138,V5KUF0 indirect/unknown TR P D(26719268) D(26719268, 27903901, 24068937) 1M05, 1XR8, 5WMO D(12372828, 9499037, 8709211) D(8709211) D(12372828, 9499037) Fields Virology Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop. Herpesviridae Human herpesvirus 4; Epstein-Barr virus EBNA3B BERF2A-BERF2B, EBNA-3B, EBNA4, EBNA-4, EBV nuclear antigen 3B, EBV nuclear antigen 4, Epstein-Barr nuclear antigen 3B, Epstein-Barr nuclear antigen 4 P03203 EBNA4_EBVB9 A0A075FCS4,A0A075FDV6,A0A075FFW1,A0A075FGX8,A0A0B6VHN8,A0A0C7T689,A0A0F6QJ13,A0A0S2YQI6,A0A0S2YQL8,A0A0S2YQZ5,A0A0S2YR40,A0A0S2YRH7,A0A0S2YRK7,A0A0U3SNH2,A0A0U3SPQ3,A0A0U3TMR1,A0A0U3TXD3,A0A0U3U0Q9,A0A0U3UK97,A0A0X8WSM4,A0A0X8XBD6,A0A0X9A8U7,A0A0X9A9Q5,A0A109NQL8,A0A125T0X2,A0A125T156,A0A191T6V0,A0A191T735,A0A191T7J5,A0A2D1LY00,A0A2D1LYF8,A0A2D1LYQ0,A0A2D1LYY5,A0A2D1LZ71,A0A2D1LZD7,A0A2D1LZV8,A0A2D1M014,A0A2D1M0F4,A0A3R5TNF9,A0A3R5TP59,A0A3R5TPG0,A0A3R5TPS0,A0A3R5TQG9,A0A3R5TSJ0,A0A3R5TTM5,A0A3R5TUK0,A0A3R5TXL1,A0A3R5TZH9,A0A3R5TZN1,A0A3R5U7Y1,A0A3R5U9C9,A0A3R5UB62,A0A3R5UBE0,A0A3R5UBT5,A0A3R5UD37,A0A3R5UEB9,A0A3R5UF10,A0A3R5UFR7,A0A3R5VSI4,A0A3R5VTK1,A0A3R5W2X0,A0A3R5W7M9,A0A3R5WB92,A0A3R5WCP8,A0A3R5WLR6,A0A3R5WLT6,A0A3R5WPT2,A0A3R5WUM4,A0A3R5WUT6,A0A3R5WVA4,A0A3R5X152,A0A3R5X4L7,A0A3R5X4W3,A0A3R5X809,A0A3R5XAT0,A0A3R5XR04,A0A3R5XX02,A0A3R5XZ10,A0A3R5Y0F1,A0A3R5Y4K2,A0A3R5Y5B4,A0A3R5Y901,A0A3R5YB68,A0A3R5ZUB9,A0A3R5ZWY8,A0A3R5ZXN2,A0A3R6A7Y7,A0A3R6ACM8,G3CKQ8,I1YP20,K9URU7,K9US25,Q1HVG4,Q3KST1,Q69139,R4R679,U5YU54,V5KU13 indirect/unknown TR P D(26719268) D(26719268, 24068937, 27903901) N D(7975264) N N Fields Virology May be involved in transcriptional regulation of both viral and cellular genes by interacting with the host DNA-binding protein RBPJ. Herpesviridae Human herpesvirus 4; Epstein-Barr virus EBNA3C BERF3-BERF4, EBNA-3C, EBNA-4B, EBNA6, EBNA-6, EBV nuclear antigen 3C, EBV nuclear antigen 4B, EBV nuclear antigen 6, Epstein-Barr nuclear antigen 3C, Epstein-Barr nuclear antigen 4B, Epstein-Barr nuclear antigen 6 P03204 EBNA6_EBVB9 A0A0A8IMR0,A0A0B6VJ05,A0A0F6QLY8,A0A0S2YQE3,A0A0S2YQM8,A0A0S2YQU4,A0A0S2YR37,A0A0S2YRI8,A0A0U2IVT5,A0A0U3K2A9,A0A0U3SSI4,A0A0U3THE3,A0A0U3TY20,A0A0X8W0H0,A0A0X8W0R4,A0A0X8Z1G7,A0A109NNY9,A0A120GXX6,A0A120GY11,A0A125T0X3,A0A125T157,A0A191T6V5,A0A191T734,A0A191T7I9,A0A1W5LUG5,A0A1W5LUK3,A0A1W5LUQ5,A0A2D1LXZ6,A0A2D1LY82,A0A2D1LYF3,A0A2D1LYP4,A0A2D1LYY0,A0A2D1LZ65,A0A2D1LZD8,A0A2D1LZP5,A0A2D1LZW5,A0A2D1M0I0,Q3KST0,Q69140 indirect/unknown TR P D(24068937, 22357270, 26719268) D(24068937, 22357270, 26719268, 24344258, 27903901) 1CG9, 2BSR, 3DX6, 3DX7, 3DX8, 3DXA D(7745710, 11739688, 10799590) D(10799590, 8709211) D(11739688) Fields Virology Plays an essential role for the activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA6 probably contributes to a negative autoregulatory control loop. Alternatively, EBNA6 also regulates the transcription of the EBV oncogene LMP1 in a cell cycle-dependent manner. Modulates the activity of several host proteins involved in cell cycle regulation including host cyclin A, MYC, RB, p21 and p27 mainly through binding to the host SCF(SKP2) complex. Inhibits the promoter of host H2AX and targets H2AX to proteasomal degradation in order to promote latency and cell proliferation. Herpesviridae Human herpesvirus 4; Epstein-Barr virus EBNA-LP EBNA5, EBNA-5, EBNALP, EBNA-LP protein, EBV nuclear antigen 5, EBV nuclear antigen leader protein, Epstein-Barr 62-kDa polypeptide RNA from clone IB4WY-1, Epstein-Barr nuclear antigen 5, Epstein-Barr nuclear antigen leader protein, Epstein-Barr virus Ir1/U2 region protein T1 (Fragment), Latency protein, Leader protein Q8AZK7 EBNA5_EBVB9 A0A0A7DK99,A0A0S2YQH1,A0A0S2YQX5,A0A0S2YRB1,A0A0S2YRQ2,A0A0X8YIJ7,A0A125T0U6,A0A2D1LYW5,K9US68,K9USE8,P0C732,Q1HVI8,Q69125,Q69136,Q69147 indirect/unknown TR P N D(29467311, 24167291) 5X8N D(29467311) N D(29467311) Fields Virology Plays an important role in the establishment of B-cell immortalization by acting as an EBNA2 coactivator. This transcriptional activation preferentially enhances the expression of the major viral protein LMP1. The interaction between EBNA-LP and host SP100 correlates with coactivation of EBNA2 and the relocalization of SP100 from PML nuclear bodies into nucleoplasm. Herpesviridae Human herpesvirus 4; Epstein-Barr virus Rta BRLF1, Immediate-early protein Rta, Replication and transcription activator, RTA P03209 RTA_EBVB9 A0A075FGE7,A0A0A8IL74,A0A0B6VHK7,A0A0B6VMK6,A0A0B6VP67,A0A0B6VPY0,A0A0C7SX63,A0A0C7SZH5,A0A0C7T024,A0A0C7T3T2,A0A0C7T5J1,A0A0C7T650,A0A0C7TFN7,A0A0C7TI29,A0A0C7TI76,A0A0C7TMI1,A0A0C7TN35,A0A0C7TNL3,A0A0C7TR86,A0A0C7TRS0,A0A0C7TS97,A0A0C7TZJ8,A0A0C7U0I6,A0A0U3J154,A0A0U3TX69,A0A1W7HHU5,A0A2D1LYE8,A0A2D1M0G7,A0A2D1M0N6,A0A2S1MKD6,A0A2S1MQS6,A0A2S1MR54,A0A2S1MRJ6,A0A2S1MSH1,A0A2S1MTZ3,A0A2S1MUD3,A0A2S1MUN1,A0A2S1MUU8,A0A2S1MUY5,A0A2S1MVQ3,A0A2S1MVZ5,A0A2S1MXG7,A0A2S1MZE3,A0A2S1MZL7,A0A2S1N122,A0A2S1N1H8,A0A2S1N1T8,A0A2S1N2Q2,A0A2S1N3I5,A0A2S1N441,A0A2S1N4M4,A0A385J7S9,G3CKR1,K9UT49,Q1HVG0,Q3KSS7,V5KU06 dsDNA TR P D(17301127, 22379087) D(22379087) N D(17301127, 22379087) D(17301127, 22379087) N Fields Virology Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Upregulates human DCR3/TNFRSF6B by directly binding to its receptor. Herpesviridae Human herpesvirus 4; Epstein-Barr virus Zta BZLF1, EB1, Trans-activator protein BZLF1, Z, Zebra, ZEBRA, ZTA P03206 BZLF1_EBVB9 A0A060A1H7,A0A060A1R5,A0A060A624,A0A060A629,A0A0B6VMG6,A0A0C7T7Z0,A0A0C7TGZ2,A0A0C7TIV5,A0A0C7TJ79,A0A0C7TJC8,A0A0C7TLE1,A0A0C7TNH9,A0A0C7TP04,A0A0C7TST0,A0A0C7TUL0,A0A0U3K1L7,A0A0U3SKG1,A0A1W5LUA9,A0A2D1LYB2,A0A2D1M030,A0A2D1M0N0,A0A3R5TL42,A0A3R5TWW0,A0A3R5U420,A0A3R5VRE2,A0A3R5W4V8,A0A3R5WXE1,A0A3R5X5L7,A0A3R5X6C8,A0A3R5XWF5,G3CKR0,K9URC5,Q1HVG1,Q3KSS8,Q69115,Q69123,V5KU67 dsDNA TR P D(23015699) D(23015699, 25779048, 29142137) 1ZSD, 2AK4, 2AXF, 2AXG, 2C9L, 2C9N, 2NX5, 3KWW, 3KXF, 3SPV, 3VFN, 3VFO, 3VFP, 3VFR, 5SZX D(2157874) D(2157874, 2159531) D(2157874, 2159531) Fields Virology ICP0 homolog Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1). Herpesviridae Human herpesvirus 5; Human cytomegalovirus IE1 55 kDa immediate-early protein 1, UL123 P03169 VIE1_HCMVT A0A0A7CGH8,A0A0A7CH45,A0A0G2T6P9,A0A0G2T717,A0A0G2T934,A0A0G2T9V0,A0A0G2TB17,A0A0G2TCU8,A0A0G2TFI8,A0A0G2TFM5,A0A0G2TIG1,A0A0G2TJG7,A0A0G2TKF7,A0A0G2TMB8,A0A0G2TQM8,A0A0G2TR65,A0A0G2TT45,A0A0G2TTN7,A0A0G2TTY5,A0A0G2TUY9,A0A0G2TVN3,A0A0G2TVV8,A0A0G2TWD2,A0A0G2TZN5,A0A0G2U0L5,A0A0G2U0P4,A0A0G2U107,A0A0G2U5F3,A0A0G2U6D3,A0A0G2U775,A0A0G2U789,A0A0G2U9Y0,A0A0G2UA46,A0A0G2UB54,A0A0G2UB64,A0A0G2UBY0,A0A0G2UCW7,A0A0G2UF68,A0A0G2UFS7,A0A0G2UGT4,A0A0R5E2Q2,A0A0R5E3W7,A0A0R5E6M7,A0A0R5E7P5,A0A0R5E9Q8,A0A0R5E9Z2,A0A0R5EB18,A0A0R5EGD5,A0A126N8Q0,A0A126N954,A0A126N9K7,A0A126NAR7,A0A126NBL2,A0A126NC20,A0A126NCL1,A0A126NCY3,A0A126NDE2,A0A126NIT2,A0A140D1E4,A0A140IIR2,A0A140IJ80,A0A159B136,A0A159B2R2,A0A159B4L6,A0A159B5S3,A0A161C1V5,A0A191SCH8,A0A1L3IX30,A0A1L3IYI0,A0A2H4GFT1,A0A2H4GJ43,A0A2H4GK92,A0A2H4GLV7,A0A2H4GNL9,A0A2I2MMP9,B8YED9,C5MKW0,C8BLJ1,C8CFF3,C8CFW8,D2K3S2,D2K507,D2W9F5,D2W9H9,D2W9M7,D2W9Q1,D2W9S5,D2W9X3,D2W9Z7,E7DVQ4,P13202,Q6RXC2,Q6SWJ1,Q6SWL8,Q6SWP6,Q6SWS4,Q6SWV2,Q6SX10,Q6SX39,R4S3N7,V9LM41,V9LMP3,V9LP50,V9LPA5,V9LPS2,V9LRP7,V9LS79,V9PU14,V9PU19,V9PV04,X4YAG1 dsDNA TR P D(27733551) N 4QRU, 5E5A D(19776115, 27733551) N N Fields Virology ICP0 homolog Plays an important role in transactivating viral early genes as well as activating its own promoter. Targets and disrupts host PML/nuclear domain 10 (ND10). Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones. In addition, functions in counteracting the host innate antiviral response. Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2. Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters. Herpesviridae Human herpesvirus 5; Human cytomegalovirus IE2 Protein UL122, UL122, Viral transcription factor IE2 P19893 VIE2_HCMVA A0A0A0PU13,A0A0A7CFM1,A0A0A7CHB3,A0A0G2T7B8,A0A0G2T8I7,A0A0G2T9H8,A0A0G2T9P9,A0A0G2TAW2,A0A0G2TC19,A0A0G2TD78,A0A0G2TE28,A0A0G2TGN0,A0A0G2TI14,A0A0G2TIF9,A0A0G2TJ39,A0A0G2TLE4,A0A0G2TN04,A0A0G2TN92,A0A0G2TNS1,A0A0G2TPC1,A0A0G2TR93,A0A0G2TTK4,A0A0G2TVE6,A0A0G2TXS8,A0A0G2TYR3,A0A0G2TZ60,A0A0G2U2J8,A0A0G2U314,A0A0G2U3E1,A0A0G2U3Y8,A0A0G2U7G8,A0A0G2U7T0,A0A0G2UAC5,A0A0G2UC28,A0A0G2UCV3,A0A0G2UD10,A0A0G2UDJ2,A0A0G2UEQ5,A0A0G2UID8,A0A0G2UJ44,A0A0R5E660,A0A0R5E733,A0A0R5EB52,A0A0R5ECK4,A0A0R5ECZ5,A0A0R5EHA7,A0A126N9K6,A0A126NDW2,A0A126NF63,A0A126NGT3,A0A140D1E3,A0A140IIR1,A0A159AZC8,A0A159B0U1,A0A162DRE1,A0A191SBK7,A0A1L3IX19,A0A2H4GFS6,A0A2H4GHA4,A0A2H4GHN8,A0A2H4GL85,A0A2H4GP31,A0A2H4GQK7,B8YED8,C5MKV9,C8BLJ0,C8CFF2,D2IG93,D2K4M9,D2K506,D2K5K9,D2W9M6,D2W9S4,D2W9X2,D2W9Z6,D5LXA9,E7DVQ3,F5HE22,Q6RXC5,Q6SW29,Q6SWJ2,Q6SWL9,Q6SWP7,Q6SWS5,Q6SWV3,Q6SWY2,Q6SX11,Q6SX40,R4SHW1,V9LNF7,V9LQ15,V9LRJ7,V9LSG0,V9PUG0,V9PUQ9 dsDNA TR P D(27733551, 15479808) N N D(9875333, 27733551, 15479808, 28161581) D(10225210, 9875333) Fields Virology Stimulates viral early and late gene expression and thus play a crucial role in the regulation of productive infection. In addition, activates quiescent cells to reenter the cell cycle and upregulates several E2F-responsive genes, which are responsible for pushing the cell into S phase. In S-phase, inhibits cellular DNA synthesis and blocks further cell cycle progression. Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL29 Protein UL29/UL28 C0H677 UL298_HCMVA A0A0A7CFZ0,A0A0A7CGC5,A0A0G2T6M0,A0A0G2T800,A0A0G2TD10,A0A0G2TJD6,A0A0G2TLM9,A0A0G2TPJ7,A0A0G2TQE9,A0A0G2TSX7,A0A0G2TZ11,A0A0G2U0G4,A0A0G2U0K1,A0A0G2U0V6,A0A0G2U2S6,A0A0G2U5N3,A0A0G2U760,A0A0G2UFK8,A0A0G2UGK9,A0A0G2UHH1,A0A0R5E240,A0A0R5E2Z4,A0A0R5E4G4,A0A0R5E6C3,A0A0R5EA67,A0A0R5EC46,A0A0R5EDP6,A0A0U2Q734,A0A126N9C9,A0A126NDN5,A0A126NFE8,A0A140III8,A0A159B0Q9,A0A159B4J9,A0A162DUP8,A0A2H4GFP4,A0A2H4GH35,A0A2H4GI26,A0A2H4GJW2,A0A2H4GKT9,A0A2H4GPE8,A8T794,B8YE64,B9VXJ9,D2K5D5,D3YRW8,D5LX41,E7DVH9,F5HIG2,P16764,Q6SWA3,Q6XNK8,S5FXY3,V9LME7,V9LN39,V9LQ33,V9LS16,V9LSI1,V9PSW3,V9PUS9,V9PV83 dsDNA, ssDNA TR, Rep, DR S N N N D(20585571) I(26676794, 30598436) I(2987527) Fields Virology Contributes to activation of immediate-early gene expression. Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL34 Transcriptional regulator UL34 P16812 UL34_HCMVA A0A0A7CFS9,A0A0A7CFU8,A0A0A7CFZ2,A0A0A7CGD1,A0A0G2T6M2,A0A0G2T6X8,A0A0G2T8U9,A0A0G2T9R9,A0A0G2T9V2,A0A0G2TAW7,A0A0G2TBG1,A0A0G2TD15,A0A0G2TJE0,A0A0G2TK87,A0A0G2TKN5,A0A0G2TKP7,A0A0G2TM42,A0A0G2TTS1,A0A0G2TV84,A0A0G2TW58,A0A0G2TZ16,A0A0G2TZG7,A0A0G2U0E2,A0A0G2U0H0,A0A0G2U700,A0A0G2U9Y1,A0A0G2UAW6,A0A0G2UCD9,A0A0G2UCR1,A0A0G2UD52,A0A0G2UDU7,A0A0G2UGL3,A0A0G2UHH5,A0A0R5E3K5,A0A0R5E3P5,A0A0R5E443,A0A0R5E5U6,A0A0R5E6Z8,A0A0R5E8J6,A0A0R5E9J3,A0A126N8Y5,A0A126N9E3,A0A140D0Q8,A0A159AZ79,A0A159B019,A0A159B132,A0A191SBA6,A0A1I9XCP6,A0A1I9XDE2,A0A1L3IXT5,A0A2H4GDQ8,A0A2H4GG19,A0A2H4GKH8,A0A2H4GLN9,A0A2H4GNF1,A0A2I2MMI6,A0A3G6XL13,A8T7A1,B8YE70,C8BKY8,C8BLC1,C8CF83,C8CFP8,C8CPD5,D2K5A2,D3YRX3,D5LX46,E7DVI4,F5HC16,Q6VNV0,R4S5N4,V9LMF4,V9LMN6,V9LN29,V9PTQ8,V9PUT4,X4YA79 dsDNA TR P N D(29626748) N D(11390608) D(11390608) N Fields Virology Acts as a transcriptional repressor of the US3 gene expression through a specific DNA sequence named the transcriptional repressive element (tre). Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL49 Protein HFLF5, Uncharacterized protein UL49, Uncharacterized protein UL49,Protein HFLF5 P16786 UL49_HCMVA A0A0A0PIG0,A0A0A7CFW2,A0A0G2T6Y6,A0A0G2T7U5,A0A0G2TAX3,A0A0G2TD27,A0A0G2TFD1,A0A0G2TKA2,A0A0G2TPR1,A0A0G2TR21,A0A0G2TUT5,A0A0G2TW75,A0A0G2TXM7,A0A0G2TZY1,A0A0G2U0G0,A0A0G2U0V5,A0A0G2U4N6,A0A0G2U5C7,A0A0G2U5Q4,A0A0G2U679,A0A0G2U779,A0A0G2UAY1,A0A0G2UCF0,A0A0G2UD66,A0A0G2UFM8,A0A0G2UFN4,A0A0G2UG25,A0A0R5EA71,A0A0R5EC84,A0A0U2JPK2,A0A126NBX2,A0A126NCU9,A0A126ND93,A0A140D0S3,A0A159B0S4,A0A159B4B2,A0A162DZ71,A0A1L3IYU1,A0A2H4GDS4,A0A2H4GFN2,A0A2H4GIN6,A8T7C6,B8YE85,B9VXL8,C5MKQ5,C8BKK6,C8BLD6,C8CFR3,C8CPF0,D2K5F5,D3YRY8,D5LX61,E7DVJ9,F5HEF7,Q6RXG9,Q6SW82,R4S5P9,V9HX93,V9LMH3,V9LNW1,V9LQW8,V9LSI8,V9PSX2,V9PTS4 indirect/unknown TR P N N N D(25165108) N N Fields Virology vPIC homologs viral process,viral tegument Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL57 DBP, Major DNA-binding protein P17147 DNBI_HCMVA A0A0R5EAX5,A0A1L3IXF9,A0A1L3IXW0,A0A1L3IYC5,A0A2H4GDT7,A0A2H4GET4,A0A2H4GKC4,A0A2H4GP02,A0A2S0DCR9,A0A3G6XKQ2,A8T7D7,A9YU24,A9YU25,A9YU26,A9YU27,A9YU31,Q6RXG4,Q80MY8,V9LM77 dsDNA, ssDNA TR, Rep, DR S N N N N N D(9426445) Fields Virology Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein (PubMed:8230421). May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA. Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL69 mRNA export factor ICP27 homolog Q6SW73 ICP27_HCMVM A0A3G6XL32 dsDNA, ssDNA, ssRNA, dsRNA TR, TNA P N N N D(8189530, 16478985) N N Fields Virology ICP27 homolog Immediate early (EI) protein that plays many roles during productive infection including regulation of host cell cycle progression, regulation of viral gene expression or nuclear export of intronless viral RNAs. Acts as a transcriptional transactivator via interaction with the cellular transcription elongation factor SUPT6H and as a nuclear RNA export factor via interaction with UAP56, a component of the cellular mRNA export machinery (By similarity). Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL79 Protein UL79 P16752 UL79_HCMVA A0A0A0PKK4,A0A0A7CF34,A0A0A7CGG1,A0A0G2T6N3,A0A0G2T910,A0A0G2T9T2,A0A0G2TAY7,A0A0G2TBJ1,A0A0G2U0K7,A0A0G2U5D9,A0A0G2UB12,A0A0G2UG47,A0A0R5E690,A0A0R5E943,A0A126NDS7,A0A126NEP6,A0A159B014,A0A159B138,A0A1I9XCS0,A0A1L3IWY8,A0A2H4GK38,A0A2H4GN24,A0A2H4GNQ9,A0A2H4GPI2,A0A2I2MML7,A0A3G6XL37,A8T7F6,B8YEA4,B9VXN7,C5MKS5,C8BLF6,C8CFB8,C8CFT3,D2K5H5,D3YS03,D5LX75,F5HFM1,Q6SW63,V9LM10,V9LQ09,V9LQM3,V9LS53,V9PTX7,V9PTY8,V9PUX0 indirect/unknown TR P N N N N N D(21367901) Fields Virology vPIC homologs Plays a role in the expression of late transcripts bridging viral DNA replication and late gene expression during infection. Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL82 71 kDa upper matrix phosphoprotein, Phosphoprotein UL82, pp71, ppUL82, Protein pp71, Tegument protein UL82 P06726 PP71_HCMVA A0A0A7CGS9,A0A0G2TA12,A0A0G2TE35,A0A0G2TFG8,A0A0G2TLV2,A0A0G2TVB4,A0A0G2U825,A0A0G2U8I2,A0A0G2U9L4,A0A0G2UA33,A0A0G2UAJ0,A0A0G2UKQ3,A0A0R5E8M4,A0A140D1B2,A0A140D1S9,A0A159B0K5,A0A1L3IYE9,A0A2H4GFA1,A0A2H4GJN7,A0A2H4GK52,A0A2I2MM68,A0A3G6XKT7,A8T7G0,B8YEA7,B9VXP0,C8BKM9,C8BL26,C8CFC1,C8CPH3,D3YS06,R4SH92,V9LLY2,V9LNL7,V9LQC3,V9PTH3,V9PTY5,V9PUF9 indirect/unknown TR P N N N D(28132838, 1318413) N D(12610120) Fields Virology Stimulates viral immediate-early (IE) transcription. Plays a role in the inhibition of the host innate repsonse by targeting STING and thus the cGAS-STING pathway (PubMed:28132838). Counteracts also the DAXX-mediated repression of viral transcription. Displaces a DAXX-binding protein, ATRX, from nuclear domain 10 sites (ND10) shortly after infection. Increases the basal level of SUMOylated DAXX in infected cells. May also play a role in the progression of the host cell cycle through the G1 phase. Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL84 Initiator protein, Protein UL84, UL84 protein P29839 UL84_HCMVT A0A076JUV4,A0A0A0PKK9,A0A0A7CGG2,A0A0A7CH25,A0A0G2T6N5,A0A0G2T701,A0A0G2T913,A0A0G2TA27,A0A0G2TAZ0,A0A0G2TBJ3,A0A0G2TCR6,A0A0G2TD50,A0A0G2TG34,A0A0G2TH07,A0A0G2TI36,A0A0G2TJB4,A0A0G2TJD7,A0A0G2TJH9,A0A0G2TJI0,A0A0G2TN73,A0A0G2TQJ7,A0A0G2TR45,A0A0G2TRN3,A0A0G2TS06,A0A0G2TXQ2,A0A0G2TZ57,A0A0G2U0L2,A0A0G2U0P1,A0A0G2U105,A0A0G2U3Z0,A0A0G2U6A5,A0A0G2U960,A0A0G2UA21,A0A0G2UBV3,A0A0G2UCH0,A0A0G2UCU0,A0A0G2UD93,A0A0G2UFP7,A0A0G2UFQ2,A0A0G2UG52,A0A0G2UGQ0,A0A0R5E867,A0A0R5E9Q2,A0A0R5EA57,A0A0R5EAZ3,A0A0R5ECN0,A0A0R5EDV8,A0A126N924,A0A126NBJ0,A0A126NBZ0,A0A126NIL7,A0A140D0U8,A0A140D1B4,A0A159B2N6,A0A159B4L0,A0A161BXL4,A0A1I9XC23,A0A1L3IXH8,A0A2H4GEC9,A0A2H4GJ14,A0A2H4GJ70,A0A2H4GKM2,A0A2H4GQ12,A0A2H4GQI0,A8T7G3,A9YU44,A9YU45,A9YU46,A9YU47,A9YU48,A9YU49,A9YU51,B8YEA9,B9VXP2,C5MKT0,C8BLG1,C8CFC3,C8CPH5,D2K4K0,D2K4X7,D2K5I0,D3YS08,D5LX80,E7DVM4,P16727,Q6RXF3,R4S3J6,V9LM14,V9LMH2,V9LML4,V9LP17,V9LP67,V9LPN9,V9LRM2,V9LRU9,V9LS58,V9PTZ2,V9PUX5 ssRNA Rep, TNA, TR S N N N D(9261435) N D(20573826) Fields Virology Plays an essential role in viral DNA replication. May participate in the DNA replication initiation by interacting with the origin of lytic replication, oriLyt and subsequently recruiting other viral/cellular factors. Additionally, interacts with and shuttles IRS1 viral mRNA from the host nucleus to the cytoplasm (By similarity). Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL87 Protein UL87 P16730 UL87_HCMVA A0A0A7CGT1,A0A0A7CH46,A0A0G2T6S1,A0A0G2T7C6,A0A0G2T8L6,A0A0G2TA16,A0A0G2TA67,A0A0G2TAE2,A0A0G2TBC7,A0A0G2TCR3,A0A0G2TDF1,A0A0G2TE40,A0A0G2TE80,A0A0G2TFH3,A0A0G2TIF5,A0A0G2TJT9,A0A0G2TN44,A0A0G2TNU9,A0A0G2TQ45,A0A0G2TQ79,A0A0G2TY67,A0A0G2TZN0,A0A0G2U036,A0A0G2U4U8,A0A0G2U8A3,A0A0G2U9J7,A0A0G2UAJ6,A0A0G2UB23,A0A0G2UC04,A0A0G2UDG5,A0A0G2UKQ8,A0A0R5E2I0,A0A0R5E8Z4,A0A0R5ECI5,A0A0R5EFR1,A0A126N941,A0A126NAB8,A0A126NAM9,A0A126NBX7,A0A126NDT6,A0A140D1T4,A0A159B023,A0A159B0T6,A0A159B283,A0A159B4A0,A0A159B5D5,A0A191SC79,A0A1I9XC25,A0A1I9XEZ1,A0A1L3IXY1,A0A1L3IYY9,A0A2H4GMD9,A0A2H4GPJ5,A0A2H4GRL2,B8YEB2,B9VXP5,C8BKN4,C8BLG4,C8CFC6,C8CFU1,D2K4K3,D3YS11,D5LX83,F5HIL1,Q6SW55,S5ZY95,V9LLY7,V9LMW9,V9PUG3,V9PV44 dsDNA TR P N N N D(25165108) I(24403583) D(21507978) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL91 Protein UL91 P16797 UL91_HCMVA A0A076JQV0,A0A0G2TFZ4,A0A0G2TTF4,A0A0G2TVC5,A0A0G2TYZ8,A0A0G2U7V6,A0A0G2UEE4,A0A0R5E5N9,A0A0R5E608,A0A159B1K2,A0A2H4GKW5,A8T7H4,B8YEB5,B9VXP8,C8CFU4,D2K4K6,D2K5V2,D5LX86,E7DVN0,F5HFJ8,S6A6A7,V9LML0,V9LSJ5,V9PUH7 indirect/unknown TR P N N N D(25165108) N D(23720731) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL92 Protein UL92 P16798 UL92_HCMVA A0A076JW34,A0A0A7CFH5,A0A0G2TF71,A0A0G2U868,A0A1L3IXZ5,A0A2H4GQI1,B9VXP9,C8CFU5,D3YS15,E7DVN1,F5HAS7,Q6RXE7,S5ZAG0,V9LLV3 indirect/unknown TR P N N N D(25165108) N D(24131715) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 5; Human cytomegalovirus UL95 Protein UL95 P16801 UL95_HCMVA A0A0A0PKL9,A0A0A7CG46,A0A0G2T6N9,A0A0G2T707,A0A0G2T826,A0A0G2T9T8,A0A0G2TAZ9,A0A0G2TBK3,A0A0G2TCS8,A0A0G2TFG7,A0A0G2TG53,A0A0G2TI46,A0A0G2TJE7,A0A0G2TJI8,A0A0G2TKT4,A0A0G2TLT4,A0A0G2TLT6,A0A0G2TM98,A0A0G2TMC3,A0A0G2TQK8,A0A0G2TR53,A0A0G2TUX1,A0A0G2TVC3,A0A0G2TVL3,A0A0G2TVT4,A0A0G2TXR1,A0A0G2TZ69,A0A0G2U0Y6,A0A0G2U2Y6,A0A0G2U3Z5,A0A0G2U4S4,A0A0G2U5T9,A0A0G2U6B4,A0A0G2UA30,A0A0G2UFQ6,A0A0G2UH47,A0A0G2UHL8,A0A0R5E486,A0A0R5E5G7,A0A0R5E5I6,A0A0R5E8J7,A0A0R5E8V4,A0A0R5EC08,A0A126NAD0,A0A126NC00,A0A126NE98,A0A140D1C4,A0A140D1U1,A0A140IIP2,A0A159AZJ9,A0A159AZP6,A0A159B123,A0A159B4K0,A0A162DTW9,A0A1L3IX11,A0A2H4GG66,A0A2H4GJ23,A0A2H4GKN2,A0A2H4GM46,A0A2H4GQ22,A0A2H4GQI7,B8YEB9,C8BLH1,C8CFD3,C8CPI5,D2K4L0,D2K4Y7,D2K5V6,D5LX90,F5HB20,R4S3K7,S5ZGL2,V9LM21,V9LMI2,V9LP79,V9LPP8,V9LQN8,V9LRV9,V9PSZ3,V9PU01,V9PUY4,V9PVC5,X4YAD5 indirect/unknown TR P N N N D(25165108) N D(21507978) Fields Virology vPIC homologs Participates in the expression of late viral mRNAs. Expressed before viral DNA replication, UL95 assembles at the viral pre-replication complexes (pre-RCs) containing the early viral protein UL44. Herpesviridae Human herpesvirus 6A DR7L DR7R, Uncharacterized protein DR7 Q89743 DR7_HHV6U indirect/unknown TR P N N N D(8178493) N D(8178493) Fields Virology Involved in transactivation (Probable). Displays transforming activity. Herpesviridae Human herpesvirus 6A IE2 Immediate-early protein 2, U90/U86 Q8BB47 IE2_HHV6G dsDNA TR P N N N D(17005699, 12068008, 16884756) N D(16884756) Fields Virology Transcriptional transactivator. Herpesviridae Human herpesvirus 6A U33 Protein U33, UL49, XILF3 P52441 UL49_HHV6U A0A140AK60,M9TG08 indirect/unknown TR P N N N I(25165108) N N Fields Virology vPIC homologs viral process,viral tegument Herpesviridae Human herpesvirus 6A U41 DBP, Major DNA-binding protein P52338 DNBI_HHV6U dsDNA, ssDNA TR, Rep, DR S N N N I(20585571) I(26676794, 30598436) D(30469324) Fields Virology U41 is an ortholog of HSV-1 ICP8 (30469324) Single-stranded DNA-binding protein required for DNA replication. Herpesviridae Human herpesvirus 6A U42 ICP27, mRNA export factor ICP27 homolog, UL69 P52354 ICP27_HHV6U A0A0A7RNQ1 dsDNA, ssDNA, ssRNA, dsRNA TR, TNA P N N N I(8189530, 16478985) N N Fields Virology ICP27 homolog Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs. Herpesviridae Human herpesvirus 6A U52 Protein U52, UL79, XKLF1 P52469 UL79_HHV6U M9TG20 indirect/unknown TR P N N N N N I(21367901) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6A U58 5R, Protein U58, UL87 P24437 UL87_HHV6U A0A140AK87,M9TM32 indirect/unknown TR P N N N I(25165108) I(24403583) I(21507978) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6A U62 8R, Protein U62, Protein UL91, UL91 P24439 UL91_HHV6U A0A140AK90 indirect/unknown TR P N N N I(25165108) N I(23720731) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6A U63 9R, Protein U63, UL92 P24440 UL92_HHV6U M9TNG7 indirect/unknown TR P N N N I(25165108) N I(24131715) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6A U67 13R, Protein U67, UL95 P24444 UL95_HHV6U M9TIH4 indirect/unknown TR P N N N I(25165108) N I(21507978) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6A IE1 Immediate-early protein 1, pRF2/pRF3/pRF4, RF4, U90/U89 Q69567 IE1_HHV6U indirect/unknown TR P N N N D(17376932) D(17376932) N Fields Virology host cell cytoplasm;host cell nucleus;viral tegument;metal ion binding;regulation of transcription, DNA-templated Herpesviridae Human herpesvirus 6B DR7R DR7, Transactivator, Transforming transactivat Q9W9H8 Q9W9H8_HHV6H indirect/unknown TR P N N N D(8178493) N D(8178493) Fields Virology Transforming transactivator Herpesviridae Human herpesvirus 6B IE2 Immediate-early protein 2, U86, U90/U86 Q9QJ16 IE2_HHV6Z A0A219XVN1,A0A219XW25,A0A219XWE5,A0A219XWM9,A0A219XWU0,A0A219XXA5,A0A219XXU4,A0A219XY21,A0A219XYM7,A0A219XYW1,A0A219XZ48,A0A219Y0C1,A0A219Y0K1 dsDNA TR P N N N I(17005699, 12068008, 16884756) N N Fields Virology Transcriptional transactivator. Herpesviridae Human herpesvirus 6B U33 Capsid Protein, Protein U33, UL49 Q9QJ36 UL49_HHV6Z A0A219Y0F6,A0A2L2QCE9,Q9WT31 indirect/unknown TR P N N N I(25165108) N N Fields Virology vPIC homologs viral process,host cell membrane,integral component of membrane,viral tegument Herpesviridae Human herpesvirus 6B U41 DBP, Major DNA binding protein, Major DNA-binding protein, Single-stranded DNA-binding protein, U41 protein Q785N4 Q785N4_HHV6H A0A219XV25,P52538 dsDNA, ssDNA TR, Rep, DR S N N N I(20585571) I(26676794, 30598436) I(30469324) Fields Virology U41 is an ortholog of HSV-1 ICP8 (30469324) Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA. Herpesviridae Human herpesvirus 6B U42 ICP27, KA3L, mRNA export factor ICP27 homolog P52539 ICP27_HHV6Z dsDNA, ssDNA, ssRNA, dsRNA TR, TNA P N N N I(8189530, 16478985) N N Fields Virology ICP27 homolog Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs. Herpesviridae Human herpesvirus 6B U52 KA13L, Protein U52, U52 Protein, UL79 P52548 UL79_HHV6Z Q9WT21 indirect/unknown TR P N N N N N I(21367901) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6B U58 Protein U58, UL87 Q9QJ25 UL87_HHV6Z A0A219XWH2,A0A219XWU2,A0A219XXB8,A0A219Y0Y3,A0A2L2Q8X7,A0A2P1E573,A0A2P1E5H2,Q9WT15 indirect/unknown TR P N N N I(25165108) I(24403583) I(21507978) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6B U62 Protein U62, UL91 Q9QJ22 UL91_HHV6Z A0A219XV46,A0A2L2Q8Y5,A0A2L2QCH6,A0A2L2QEC4,Q9WT11 indirect/unknown TR P N N N I(25165108) N I(23720731) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6B U63 Protein U63, UL92 Q9QJ21 UL92_HHV6Z A0A219Y0A0,A0A2L2Q8Z1,A0A2L2QE97,Q9WT10 indirect/unknown TR P N N N I(25165108) N I(24131715) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6B U67 Protein U67, UL95 Q9WT06 UL95_HHV6Z A0A219Y007,A0A2L2Q907,A0A2P1E660 indirect/unknown TR P N N N I(25165108) N I(21507978) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 6B IE1 IE1 Protein, Immediate-early protein 1, U90 Q6XA69 Q6XA69_HHV6H A0A291ID66,A0A291ID67,A0A291ID73,A0A291ID74,A0A291ID75,A0A291ID93,A0A291IDA0,A0A291IDC1,Q6XA64,Q6XA65,Q6XA66,Q6XA67,Q6XA68,Q6XA70,Q6XA72,Q6XA73,Q77PU6,Q9QJ15 indirect/unknown TR P N N N D(17376932) D(17376932) N Fields Virology host cell nucleus;DNA binding;regulation of transcription, DNA-templated;viral process Herpesviridae Human herpesvirus 7 DR7' DR7, DR7 protein, DR7' protein Q89478 Q89478_HHV7J indirect/unknown TR P N N N I(8178493) N N Fields Virology host cell cytoplasm;host cell nucleus;viral tegument;metal ion binding;regulation of transcription, DNA-templated Herpesviridae Human herpesvirus 7 U33 Protein U33, UL49 P52442 UL49_HHV7J Q77Y75 indirect/unknown TR P N N N I(25165108) N N Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 7 U41 DBP, Major DNA-binding protein O56282 O56282_9BETA dsDNA, ssDNA TR, Rep, DR S N N N I(20585571) I(26676794, 30598436) I(30469324) Fields Virology O56282 is inferred from Human herpesvirus 5; Human cytomegalovirus protein P17147 Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA. Herpesviridae Human herpesvirus 7 U42 ICP27, mRNA export factor ICP27 homolog P52355 ICP27_HHV7J O56283 dsDNA, ssDNA, ssRNA, dsRNA TR, TNA P N N N I(8189530, 16478985) N N Fields Virology ICP27 homolog Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs. Herpesviridae Human herpesvirus 7 U52 Protein U52, UL79 P52470 UL79_HHV7J O56286,T2C8Y1 indirect/unknown TR P N N N N N I(21367901) Fields Virology vPIC homologs regulation of transcription, DNA-templated Herpesviridae Human herpesvirus 7 U58 Protein U58, UL87 P52363 UL87_HHV7J T2C969 indirect/unknown TR P N N N I(25165108) I(24403583) I(21507978) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 7 U62 Protein U62, UL91 P52365 UL91_HHV7J Q77Y59 indirect/unknown TR P N N N I(25165108) N I(23720731) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 7 U63 Protein U63, UL92 P52471 UL92_HHV7J Q77Y58 indirect/unknown TR P N N N I(25165108) N I(24131715) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 7 U67 Protein U67, UL95 P52472 UL95_HHV7J Q77Y57 indirect/unknown TR P N N N I(25165108) N I(21507978) Fields Virology vPIC homologs Not annotated Herpesviridae Human herpesvirus 7 U86 U86 protein Q69513 Q69513_HHV7J O56300 indirect/unknown TR P N N N I(17005699, 12068008, 16884756) N N Fields Virology regulation of transcription, DNA-templated Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus K8 E3 SUMO-protein ligase K-bZIP, E3 SUMO-protein transferase K-bZIP, KIE-1, RAP Q2HR82 KBZIP_HHV8P A0A0N9RNL1,A0A0N9RP86,A0A0N9RPS7,A0A0N9S314,A0A0N9S4U8,A0A0N9SDG5,A0A0N9SDK7,A0A0N9SDQ8,A0A0N9SFS2,A0A0N9SFT9,A0A193PN17,A0A2Z5TGL2,A0A2Z5TGX0,A0A2Z5TK66,D0UZR3,E5LBX3,K0FC23,O92597,P88939,Q77UV1,Q9WRJ7 dsDNA TR P D(12885907, 30998737) D(30998737) N D(12885907, 30998737) D(12885907, 30998737) N Fields Virology Plays a role in viral gene regulation and seems to be essential for KSHV reactivation. Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host TP53 AND RB1. Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus LANA ORF73 E5LC01 E5LC01_HHV8 A0A0N9S387,A0A0N9S3L8,A0A0N9SCV1,A0A0N9SCV5,A0A0N9SEW3,A0A0N9SF30,A0A0N9SF93,A0A0N9SNQ9,A0A193PND8,A0A2Z5THC2,A0A2Z5TRA4,D0UZU1,Q91LX9 dsDNA TR P D(30682185, 24696474, 22419807) D(24696474, 22419807, 25033463) 4UZC, 4UZB D(30682185) D(25947153, 22419807, 12015325) D(25947153, 12015325) Fields Virology DNA binding,nucleosome binding,host cell nucleus Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus ORF18 Protein UL79 homolog, UL79 Q2HRB4 UL79_HHV8P A0A0N9RN23,A0A0N9S3E8,A0A0N9SD38,A0A0N9SGT1,D0UZN0,J9QSB8 indirect/unknown TR P N N N D(30305361;26468530) N N Fields Virology  A specialized complex of viral transcriptional activators (vTAs) coordinate to direct expression of virus-encoded late genes. The vTAs in Kaposi’s sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24, ORF30, ORF31, ORF34, and ORF66.  Plays a role in the expression of late transcripts bridging viral DNA replication and late gene expression during infection. Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus ORF24 Gene 24 protein, ORF24 Protein, Protein ORF24 F5HFD2 ORF24_HHV8P Q98140 dsDNA TR P N N N D(30305361;26468530) Y(25544563) N Fields Virology  A specialized complex of viral transcriptional activators (vTAs) coordinate to direct expression of virus-encoded late genes. The vTAs in Kaposi’s sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24, ORF30, ORF31, ORF34, and ORF66.  Not annotated Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus ORF30 Protein ORF30 F5HES7 ORF30_HHV8P A0A0N7GET6,A0A2Z5U063 indirect/unknown TR P N N N D(30305361;26468530) N N Fields Virology  A specialized complex of viral transcriptional activators (vTAs) coordinate to direct expression of virus-encoded late genes. The vTAs in Kaposi’s sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24, ORF30, ORF31, ORF34, and ORF66.  Regulates the expression of late genes Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus ORF31 Gene 31 protein, ORF 31, Protein ORF31, UL92 Q2HRA1 UL92_HHV8P E5LBV4,Q98135 indirect/unknown TR P N N N D(30305361;26468530) N N Fields Virology  A specialized complex of viral transcriptional activators (vTAs) coordinate to direct expression of virus-encoded late genes. The vTAs in Kaposi’s sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24, ORF30, ORF31, ORF34, and ORF66.  May play a role in viral replication. Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus ORF34 Protein UL95 homolog, UL95 Q2HR98 UL95_HHV8P indirect/unknown TR P D(31095645) D(31095645) N D(30305361;26468530; 31095645) N N Fields Virology  A specialized complex of viral transcriptional activators (vTAs) coordinate to direct expression of virus-encoded late genes. The vTAs in Kaposi’s sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24, ORF30, ORF31, ORF34, and ORF66.  Participates in the expression of late viral mRNAs. Expressed before viral DNA replication, protein ORF34 assembles at the viral pre-replication complexes (pre-RCs) (By similarity). Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus ORF49 ORF49 Protein, Protein ORF49 Q2HR83 ORF49_HHV8P A0A0N9SE29,A0A0N9SF04,E5LBX2 indirect/unknown TR P N N N D(16501115) N D(16501115) Fields Virology Plays a role in the activation the host JNK/p38 pathways necessary for KSHV reactivation from latency and for viral replication. Induces transcriptional activation through host JUN of several ORF50-responsive promoters. Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus ORF52 ORF52 Protein F5HBL8 F5HBL8_HHV8 A0A0N7GEV0,A0A0N9RMV2 indirect/unknown TR, Other S N N N N N D(26320998) Fields Virology host cell cytoplasm;viral tegument;DNA binding;suppression by virus of host innate immune response Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus ORF6 Core gene UL29 family protein, DBP, Major DNA-binding protein, ORF 6 K0FHU3 K0FHU3_HHV8 A0A0N9RNY3,A0A0N9RUK2,A0A0N9RV39,A0A0N9S3V6,A0A0N9SC72,A0A0N9SDM5,A0A0N9SFW6,A0A0N9SHS5,A0A2Z5TGV3,O40913 ssDNA TR, Rep, DR S N N N N D(24850743) D(24850743, Fluorescence polarization analysis) Fields Virology single-stranded DNA binding,DNA replication,host cell nucleus Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus ORF66 ORF 66, Protein ORF66, UL49 F5HG20 UL49_HHV8P O40943 indirect/unknown TR P N N N D(30305361;26468530) N N Fields Virology  A specialized complex of viral transcriptional activators (vTAs) coordinate to direct expression of virus-encoded late genes. The vTAs in Kaposi’s sarcoma-associated herpesvirus (KSHV) are ORF18, ORF24, ORF30, ORF31, ORF34, and ORF66.  viral process,viral tegument Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus Rta ORF50, Putative transcription activator ORF50 F5HCV3 ORF50_HHV8P A0A0N7GF04,A0A0N9RUU4,A0A0N9RVD9,A0A0N9RX80,A0A0N9S418,A0A0N9SDX6,A0A0N9SE53,A0A0N9SEG4,A0A193PN21,A0A2Z5TKP1,E5LBX1,K0FCG0,O92608 dsDNA TR P D(19233445) D(19233445, 29302027, 30541837) N D(12154127, 11435569, 19233445) D(12154127, 11435569, 19233445) N Fields Virology Transcription activation. Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus vIRF-1 K9, Latent viral interferon regulatory factor, Lytic viral interferon regulatory factor, ORF K9, vIRF, VIRF-1, VIRF-1 protein Q77Q82 Q77Q82_HHV8 A0A0N9RX90,A0A0N9SEG2,A0A0N9SGV7,P88946 dsDNA TR P N N 4HLX, 4YSI D(9365244, 11027294, 10438822) D(10438822, 17855527) D(23435230) Fields Virology DNA-binding transcription factor activity,transcription regulatory region DNA binding Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus vIRF-2 K11, ORF K11, Viral IRF2-like protein, VIRF2 Q2HR71 VIRF2_HHV8P A0A193PN34,A0A2Z5TUW0,F5H9G3,O40941,P88948 dsDNA TR P D(26537687) D(26537687) 4P55 D(26537687) D(26537687) N Fields Virology Plays a role in the inhibition of host immune response. Acts by interacting with host EIF2AK2/PKR and inhibiting its activation. In turn, EIF2AK2/PKR substrates including EIF2S1 or histone H2A are not phosphorylated. Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus vIRF-3 B-cell specific latent nuclear protein, Interferon regulatory factor 3, K10.5, ORF K10.5, Viral IRF3-like protein, VIRF-3 protein, VIRF-3 Viral IRF3-like protein Q9DUN1 Q9DUN1_HHV8 D0UZS3,K0FCD9,O40940,Q99AM3 indirect/unknown TR P D(17728244, 19129183) N N D(22453922, 17728244, 19129183, 10933732, 17522209) D(17522209) N Fields Virology DNA-binding transcription factor activity,transcription regulatory region DNA binding Herpesviridae Human herpesvirus 8; Kaposi sarcoma-associated herpesvirus vIRF-4 K10, Viral IRF4-like protein Q2HR73 VIRF4_HHV8P A0A193PN61,F5H9D8,O40939,P88947 dsDNA TR P D(24335298) N 2XXN D(28342865, 20861242) N N Fields Virology Plays a role in host cell apoptosis modulation by promoting TP53/p53 ubiquitination and subsequent degradation and thus downregulating TP53/p53-mediated apoptosis. Herpesviridae Pseudorabies virus DBP ICP8, Major DNA-binding protein, UL29 P11870 DNBI_SUHVF dsDNA, ssDNA TR, Rep, DR S N N N I(20585571) I(26676794, 30598436) I(2987527) Fields Virology Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA. Herpesviridae Pseudorabies virus EP0 E3 ubiquitin-protein ligase ICP0, Early protein 0, Early Protein EP0, ICP0, RING-type E3 ubiquitin transferase ICP0, RL2 P29129 ICP0_SUHVF A0A0B4ZUF5,A0A0S2MM93,A0A142I9X0,A0A172XDT2,A0A1B2G2G1,B0FL91,B8Y463,G3G917,G3G997,I1WX43,Q5PPD2,Q9DYB6,T2FKB8 dsDNA TR, Other S N N N D(10426211, 9850990, 7595399) I(15494213) D(10426211) Fields Virology Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100. Herpesviridae Pseudorabies virus IE180 ICP4, IE, Immediate-early protein IE180, RS1 G3G929 G3G929_9ALPH A0A097I4Q1,A0A0B4ZXC3,A0A0B4ZXD4,A0A0D5C710,A0A0H4M3P1,A0A0S2MM72,A0A0X7ZX98,A0A140FAV4,A0A140FB14,A0A141B6X8,A0A172XDL4,A0A172XDM4,A0A1B2G2G2,B6UV86,G3G8V9,G3G918,P33479,Q5PP75,Q8JL63 dsDNA TR P N N N D(12881636, 9850990) D(12881636) D(2539489) Fields Virology positive regulation of transcription, DNA-templated,host cell nucleus Herpesviridae Pseudorabies virus RSP40 Transcriptional regulator ICP22 homolog, Transcriptional regulator ICP22 homolog， Immediate-early protein RSP40 P24827 ICP22_SUHVK indirect/unknown TR P I(25233083, 23029222) N N I(19535441) N N Fields Virology host cell nucleus;DNA binding;DNA-templated viral transcription;positive regulation of transcription, DNA-templated Herpesviridae Pseudorabies virus UL48 UL48 tegument protein Q8QXN6 Q8QXN6_SUHVK G3G8W8,Q5PP87,Q80KJ3 dsDNA TR P I(19321615) N N I(2538647) I(11416146, 2538647) I(11416146) Fields Virology host cell cytoplasm;host cell nucleus;metal ion binding;RNA binding;regulation of transcription, DNA-templated;viral process Herpesviridae Pseudorabies virus UL54 Early regulation protein UL54, ICP27, mRNA export factor ICP27 homolog, Protein UL54 Q85232 ICP27_SUHVK A0A0D5C668,Q6K1M1,Q9DL70,T2FL56 dsDNA, ssDNA, ssRNA, dsRNA TR, TNA P N N N I(25712217) I(19783816) I(19783816, Yeast three-hybrid analysis, NMR) Fields Virology ICP27 homolog Multifunctional regulator of the expression of viral genes that mediates nuclear export of viral intronless mRNAs. This immediate early (EI) protein promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP (By similarity). Orthomyxoviridae Influenza A NS1 Nonstructural Protein 1, Non-structural protein 1, NS, NS1A P03496 NS1_I34A1 A0A075ETP1,A0A075ETS1,A0A075ETV2,A0A075EU06,A0A075EU11,A0A075EU57,A0A075EUA6,A0A075EUD3,A0A075EUU4,A0A075EV20,A0A075EV61,A0A075EVF3,A0A075EWN4,A0A075EWW8,A0A075EXF8,A0A075EXX0,A0A089H8R8,A0A0A7E4T1,A0A0A7E4W7,A0A0A7E4X0,A0A0A7E4Z7,A0A0A7E560,A0A0A7E699,A0A0A7E6A8,A0A0A7E6E6,A0A0C6DX30,A0A0D3RZY3,A0A0M3YVZ6,A0A1C9ZU70,A0A1D8EMU4,A0A1D8EMY9,A0A1L5LBA5,A0A1U9W4W5,A0A2I6B733,A0A2R4QPM2,A0A343VTP4,A0A343VTQ9,A0A343VTR4,A0A343VTR9,A0A385P538,A0A3G1GLA5,A0M7Z1,A0M802,A0M813,A0M824,A0M835,A0M846,A0M857,A0M868,A0RSE2,A0RSL9,A0RSN0,A0RSP1,A1BL03,A1BL14,A2CGG4,A2CGH5,A2CGI6,A3DRG9,A3DRJ1,A3DRK2,A3DRL3,A3DRM4,A3DSA5,A3DSB6,A3DSC7,A3DSD8,A4D6R9,A4D6T0,A4D6U1,A4D6V2,A4D6W3,A4D6X4,A4D6Y5,A4D6Z6,A4D707,A4GBF7,A4GBG8,A4GBH9,A4GBJ0,A4GBQ6,A4GBX2,A4GBY3,A4GC16,A4GC93,A4GCA4,A4GCJ2,A4GCK3,A4GCM5,A4GCN6,A4GCP7,A4JZ56,A4JZ89,A4JZA0,A4K0Z4,A4K116,A4K127,A4K149,A4K171,A4U6U7,A4U6V8,A4U6Y0,A4U6Z1,A4U768,A4U779,A4U790,A4U7A1,A4U7B2,A4Z3W0,A4Z3X1,A4Z404,A4ZNQ3,A4ZNR3,A5GX47,A5GX69,A5GXC3,A5GXD4,A6M5K9,A6N9H7,A6ZIX6,A6ZIY5,A9C4V7,A9C995,B0KVE4,B2VMN7,B2VMP8,B2VMS0,B3EUU5,B3EUW7,B3EUX8,B3EUY9,B3EV00,B3EV11,B3RDQ2,B4UPB2,B4UPD4,B4UPI5,B4UQV5,B4UR32,B4UR43,B4UR54,B4UR65,B4UR76,B4URE2,B6A6G5,B6A6Q3,B6A6S5,B6A6T6,B6A6V8,B6A723,B6A767,B6A778,B6A7B1,B7NZ26,B8K0Q2,B8K0R3,C0RSJ6,C3PQG2,C3PQH3,C4LP16,C7RWF6,C7RWK0,C7RWL1,C7RWM2,C7S1W6,C7S1X7,C7S1Y8,C7S221,C7S243,C7S254,C7S276,C7S287,C7S298,C8XP22,C8XP33,C9S2A3,C9S2C9,C9S2D8,C9S2E7,C9S2F7,C9S2G6,C9S2H4,C9S2J1,C9S2K0,D3J182,D5F1T6,D5F1U6,D5F1V6,D6R8P6,D8KQS4,E1AFU6,E4UFQ5,E4UFQ7,E5FF42,E6XTN1,E6XTN8,E6XTP9,E6XTR0,E6XTS0,E6XTT1,E6XTU2,E6XTV2,E6XTW3,E6XTX3,E6XTY4,E6XUC0,E6XUD1,E6XUE2,E6XUF2,E8Z3P7,E8Z4Y8,E8Z4Z0,F0TTA7,F0TTB8,F0TTC9,F0TTE0,F0TTF1,F0TTG2,F0TTH3,F0TTI4,F0TTJ5,F0TTK6,F0TTL7,F0TTM8,F0TTN9,F0TTQ0,F0TTR1,F0TTS2,F0TTT3,F0TTU4,F0TTV5,F0TTW6,F0TTX7,F0TTY8,F0TTZ9,F0TU10,F0TU21,F0TU32,F0TU43,F0TU54,F0TU65,F0TU76,F2P1A3,F2P1B4,F4MDL2,F5CGM8,F5CGN9,F5CGQ0,F5CU09,F6GLF7,G0KR79,G0KTU8,G0KTX4,G0KU08,G2TU06,G7WW33,G7WW47,G7X3X3,G7X407,G7X431,G7X486,G8JBY2,H2KIX8,H2KIZ8,H2KJ09,H6QNR4,H8PHK7,H8XZS5,H8XZT1,H8XZV5,H8XZW5,H9XI03,H9XJP7,I6S4N8,I6S507,I6S561,I6S5I7,I6S5K2,I6S5R7,I6S699,I6S6S7,I6S8B7,I6S8Z3,I6S927,I6S938,I6SGN6,I6SH48,I6SHB2,I6SHJ5,I6SI16,I6SIC0,I6SIT8,I6SJ14,I6SJ90,I6SK95,I6SKG6,I6SUD6,I6T2Q4,I6T342,I6T3J6,I6T444,I6T513,I6T525,I6T535,I6T550,I6T6Z8,I6TAB5,I6TAG8,I6TAN1,I6TB35,I6TBJ3,I6TBT2,I6TBV0,I6TC02,I6TCC8,I6TCJ2,I6TCQ6,I6TCX4,I6TDL1,I6TDV0,I6TE19,I6TEC5,I6TEG7,I6TEL7,I6TEZ1,I6TF77,I6TFJ0,I6TFV0,I6TG01,I6TG75,I6TGD2,I6TGJ1,I6TH83,I6THH9,I6THP0,I6THU6,I6TWM9,I7CY76,I7DBQ0,J7GXI7,K4P0X9,K4P1A0,K4P381,K4P399,M9Q862,M9Q876,M9Q888,M9Q974,M9Q982,M9QA98,M9QAA7,M9QAB7,M9QBB0,M9QBB4,M9QBB8,M9QBQ4,M9QBQ6,M9V1A0,M9V1A1,P03498,P11618,P17042,P69272,P69273,P69274,P69279,Q0A108,Q0A2W7,Q0HCS2,Q0HD44,Q0HD54,Q0PDM0,Q0R7K8,Q0R7L9,Q0R9C4,Q15ME2,Q15MF3,Q15MG4,Q194T2,Q194T3,Q1G0M3,Q1G0M5,Q1G0M6,Q1I1J9,Q1I1L0,Q1I1M1,Q1I1N2,Q1I1P3,Q1I1Q4,Q1I1R5,Q1I1S6,Q1I1T7,Q1I1U8,Q1I1V9,Q1I1X0,Q1I1Y1,Q1I1Z2,Q1I203,Q1I2B3,Q1K9K7,Q1K9P7,Q1WP03,Q1WP14,Q20MF1,Q20MG2,Q20MH3,Q20TN7,Q288T5,Q288U6,Q288V7,Q289A1,Q289B2,Q289C3,Q2IBH5,Q2Y206,Q30N15,Q4ZH89,Q67249,Q6LD08,Q6XSV8,Q6XSW8,Q6XSX2,Q6XSX4,Q6XSX6,Q6XSX8,Q6XSY2,Q6XSY4,Q6XSY6,Q6XSZ2,Q6XSZ4,Q6XTC4,Q6XTC6,Q6XTC8,Q6XTD0,Q6XTD6,Q6XTE2,Q6XTE4,Q6XTE6,Q6XTE8,Q6XTF2,Q6XTF4,Q6XTF6,Q6XTF8,Q6XTG2,Q6XTG4,Q6XTG8,Q6XTH0,Q6XTH2,Q6XTH4,Q6XTH6,Q6XTH8,Q6XTI0,Q6XTI2,Q6XTI4,Q6XTI6,Q6XTI8,Q6XTJ0,Q6XTJ2,Q6XTJ4,Q6XTJ6,Q6XTJ8,Q76MT8,Q82505,Q82506,Q84068,Q99AU3,Q9DUT8,R4PCK4,R9WJE6,R9WJT7,R9WK02,R9WKA5,R9WKG0,R9WKL2,R9WKN0,R9WKW2,R9WL34,R9WME5,R9WMK2,R9WND6,R9WNJ7,R9WNR4,S5FQH9,S5FR40,S5FRA4,S5FS10,S5FSD4,S5FSQ5,S5FT23,S5FTA2,S5FTD5,S5FTK0,S5FTR8,S5FZI2,S5G093,S5G297,S5G2D0,S5G2L6,S5G2T0,V5J5C4 ssRNA TR, other S D(29259342;23283961) N 5NT2 D(23283961;11090154;11773396) D(23093596;21085662;11090154;29782795) D(23093596;Fluorescence anisotropy), D(17376915;RNA-binding assay), D(29782795, Fluorescence anisotropy;RNA-binding assay;In Vitro Transcription) 27486731.0 Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Papillomaviridae Human papillomavirus type 116 E2 Regulatory protein E2 C7B7D5 C7B7D5_9PAPI dsDNA TR, Rep P I(14643661, 22031941, 12019268, 29142126) N N I(22210627, 7957111) I(14643661, 21482558, 7957111, 12239214) I(14643661, binding assay, DNA complex, footprinting) Fields Virology Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex. Papillomaviridae Human papillomavirus type 116 E6 Protein E6 C7B7D2 C7B7D2_9PAPI indirect/unknown TR, Other P I(15664194) N N I(31002735, 11275986, 22210627) I(11275986) N Fields Virology Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response. Papillomaviridae Human papillomavirus type 116 E7 Protein E7 C7B7D3 C7B7D3_9PAPI indirect/unknown TR, Other P I(22099967) N N I(22210627, 7933087, 9426463, 11039910) N N Fields Virology E7 protein has both transforming and trans-activating activities. Papillomaviridae Human papillomavirus type 16 E2 Regulatory protein E2 P03120 VE2_HPV16 A0A0M4B738,A0A0M5I1R5,A0A140FB34,A0A141E6C6,A0A159DYJ1,A0A220NLS7,A0A220NM82,A0A220NM85,A0A220NMY5,A0A220NNA3,A0A220NNP4,A0A220NPB2,A0A220NPJ9,A0A220NPW4,A0A220NQ18,A0A291L508,A0A291L599,A0A291L5B6,A0A2P1HAL8,A0A2P1HAX9,A0A2P1HAZ0,A0A2P1HBJ1,A0A2P1HBK7,A0A2P1HBZ1,A0A2P1HC20,A0A2P1HCQ0,A0A2P1HCR3,A0A2P1HCR4,A0A2P1HCS0,A0A2P1HCX2,A0A2P1HCY1,A0A2P1HD20,A0A2P1HD25,A0A2P1HD43,A0A2P1HDC2,A0A2P1HDD2,A0A2P1HDS5,A0A2P1HDU8,A0A2P1HDW9,A0A2P1HE27,A0A2P1HE44,A0A2P1HEL7,A0A2P1HEM6,A0A2P1HES9,A0A2P1HEX6,A0A2P1HFE1,A0A2P1HFY5,A0A2P1HGA0,A0A2P1HGC9,A0A2P1HGE1,A0A2P1HGK3,A0A2P1HGQ9,A0A2P1HGV5,A0A2P1HH37,A0A2P1HH86,A0A2P1HH94,A0A2P1HHW6,A0A2P1HI17,A0A2P1HI38,A0A2P1HI44,A0A2P1HI84,A0A2P1HI91,A0A2P1HIA7,A0A2P1HIE3,A0A2P1HII1,A0A2P1HIQ3,A0A2P1HIV5,A0A2P1HIW5,A0A2P1HIY0,A0A2P1HJ67,A0A2P1HJA3,A0A2P1HJB1,A0A2P1HJB8,A0A2P1HJD0,A0A2P1HJG6,A0A2P1HJP9,A0A2P1HJS2,A0A2P1HK00,A0A2P1HK97,A0A2P1HKD8,A0A2P1HKI2,A0A2P1HKJ9,A0A2P1HKK3,A0A2P1HKL1,A0A2P1HKR6,A0A2P1HKT0,A0A2P1HL34,A0A2P1HLC9,A0A2P1HLK0,A0A2P1HLT4,A0A2P1HMF1,A0A2P1HMJ8,A0A2P1HMK4,A0A2P1HMP5,A0A2P1HMU0,A0A2P1HN06,A0A2P1HN27,A0A2P1HNB3,A0A2P1HND5,A0A2P1HNM5,A0A2P1HNU8,A0A2P1HNV4,A0A2P1HPG1,A0A2P1HPH7,A0A2P1HPS3,A0A2P1HPV0,A0A2P1HQ06,A0A2P1HQG6,A0A2P1HQR1,A0A2P1HQZ3,A0A2P1HQZ4,A0A2P1HQZ7,A0A2P1HR91,A0A2P1HRB4,A0A2P1HRL8,A0A2P1HRN8,A0A2P1HRP5,A0A2P1HRQ9,A0A2P1HRR6,A0A2P1HS03,A0A2P1HS26,A0A2P1HS42,A0A2P1HS76,A0A2P1HSA9,A0A2P1HSF4,A0A2P1HSP3,A0A2P1HSQ0,A0A2P1HSU6,A0A2P1HSW8,A0A2P1HSX8,A0A2P1HT05,A0A2P1HT52,A0A2P1HT60,A0A2P1HT76,A0A2P1HTC1,A0A2P1HTJ7,A0A2P1HTK2,A0A2P1HTK4,A0A2P1HTL0,A0A2P1HTN5,A0A2P1HTN8,A0A2P1HTZ3,A0A2P1HU04,A0A2P1HU15,A0A2P1HU23,A0A2P1HU81,A0A2P1HUG7,A0A2P1HUL7,A0A2P1HUN7,A0A2P1HUT3,A0A2P1HUV1,A0A2P1HV08,A0A2P1HV51,A0A2P1HV63,A0A2P1HVJ4,A0A2P1HVR1,A0A2P1HVU5,A0A2P1HW33,A0A2P1HW43,A0A2P1HW55,A0A2P1HW89,A0A2P1HWD2,A0A2P1HWF5,A0A2P1HWM1,A0A2P1HWR3,A0A2P1HWT1,A0A2P1HWT5,A0A2P1HWV9,A0A2P1HWW2,A0A2P1HWY5,A0A2P1HWY9,A0A2P1HX44,A0A2P1HX57,A0A2P1HX80,A0A2P1HXB2,A0A2P1HXJ6,A0A2P1HXJ8,A0A2P1HXK9,A0A2P1HXN5,A0A2P1HXT3,A0A2P1HXY6,A0A2P1HY15,A0A2P1HY36,A0A2P1HYS7,A0A2P1HZ11,A0A2P1HZ73,A0A2P1HZ74,A0A2P1HZF4,A0A2P1HZG3,A0A2P1HZH0,A0A2P1HZL0,A0A2P1HZS0,A0A2P1I011,A0A2P1I049,A0A2P1I080,A0A2P1I0E3,A0A2P1I0E5,A0A2P1I0J1,A0A2P1I0K7,A0A2P1I0M3,A0A2P1I0V9,A0A2P1I110,A0A2P1I114,A0A2P1I148,A0A2P1I176,A0A2P1I1A9,A0A2P1I1C0,A0A2P1I1C1,A0A2P1I1E1,A0A2P1I1G4,A0A2P1I1L0,A0A2P1I1N1,A0A2P1I1P3,A0A2P1I1R3,A0A2P1I1S1,A0A2P1I1U6,A0A2P1I1V2,A0A2P1I259,A0A2P1I2C0,A0A2P1I2D5,A0A2P1I2G5,A0A2P1I2K9,A0A2P1I2U5,A0A2P1I376,A0A2P1I3A1,A0A2P1I3A8,A0A2P1I3L7,A0A2P1I3P3,A0A2P1I3R0,A0A2P1I3R2,A0A2P1I3U6,A0A2P1I443,A0A2P1I444,A0A2P1I470,A0A2P1I4I8,A0A2P1I4M6,A0A2P1I4X1,A0A2P1I5I6,A0A2P1I5J7,A0A2P1I5N9,A0A2P1I5Q3,A0A2P1I5U4,A0A2P1I634,A0A2P1I655,A0A2P1I667,A0A2P1I686,A0A2P1I698,A0A2P1I6K3,A0A2P1I6K9,A0A2P1I6Q2,A0A2P1I6T7,A0A2P1I721,A0A2P1I744,A0A2P1I769,A0A2P1I773,A0A2P1I783,A0A2P1I7A6,A0A2P1I7D4,A0A2P1I7E7,A0A2P1I7H6,A0A2P1I7K2,A0A2P1I7M2,A0A2P1I7W3,A0A2P1I811,A0A2P1I872,A0A2P1I873,A0A2P1I878,A0A2P1I890,A0A2P1I894,A0A2P1I8I0,A0A2P1I8K4,A0A2P1I8M8,A0A2P1I8P0,A0A2P1I8T3,A0A2P1I950,A0A2P1I9C4,A0A2P1I9G8,A0A2P1I9J8,A0A2P1I9T0,A0A2P1I9X7,A0A2P1I9Y9,A0A2P1IAB5,A0A2P1IAK9,A0A2P1IAM9,A0A2P1IAU5,A0A2P1IAZ6,A0A2P1IB11,A0A2P1IB34,A0A2P1IB46,A0A2P1IB60,A0A2P1IB88,A0A2P1IBA1,A0A2P1IBF1,A0A2P1IBG1,A0A2P1IBH3,A0A2P1IBQ5,A0A2P1IBR3,A0A2P1IBV0,A0A2P1IBW3,A0A2P1IBZ1,A0A2P1ICD8,A0A2P1ICK7,A0A2P1ICM7,A0A2P1ICV0,A0A2P1ICX3,A0A2P1ID26,A0A2P1ID31,A0A2P1IDB5,A0A2P1IDD2,A0A2P1IDD9,A0A2P1IDG1,A0A2P1IDI0,A0A2P1IDJ2,A0A2P1IDK6,A0A2P1IDP1,A0A2P1IDT4,A0A2P1IDU6,A0A2P1IDW1,A0A2P1IE60,A0A2P1IE69,A0A2P1IEA0,A0A2P1IEI4,A0A2P1IEP9,A0A2P1IEQ8,A0A2P1IEY0,A0A2P1IEY4,A0A2P1IF70,A0A2P1IFB7,A0A2P1IFC5,A0A2P1IFQ2,A0A2P1IFT5,A0A2P1IFU1,A0A2P1IFY2,A0A2P1IG25,A0A2P1IG93,A0A2P1IGA1,A0A2P1IGE9,A0A2P1IGM0,A0A2P1IGM4,A0A2P1IGQ2,A0A2P1IGR6,A0A2P1IH19,A0A2P1IH21,A0A2P1IH35,A0A2P1IHA3,A0A2P1IHJ0,A0A2P1IHL9,A0A2P1IHN3,A0A2P1IHT0,A0A2P1IHW5,A0A2P1II20,A0A2P1II60,A0A2P1II66,A0A2P1IIF5,A0A2P1IIK4,A0A2P1IIW4,A0A2P1IJ92,A0A2P1IJ95,A0A2P1IJA7,A0A2P1IJH6,A0A2P1IJJ5,A0A2P1IJQ4,A0A2P1IJT5,A0A2P1IJY2,A0A2P1IKD0,A0A2P1IKE1,A0A2P1IKE7,A0A2P1IKL6,A0A2P1IKL7,A0A2P1IKR7,A0A2P1IKT3,A0A2P1IKV3,A0A2P1IKW8,A0A2P1IL29,A0A2P1IL50,A0A2P1IL94,A0A2P1ILC6,A0A2P1ILH3,A0A2P1ILI6,A0A2P1ILJ1,A0A2P1ILJ5,A0A2P1ILQ4,A0A2P1ILU5,A0A2Z5ZNE4,A0A2Z5ZNI2,A0A2Z5ZNJ8,A0A2Z5ZNL6,A0A2Z5ZNR3,A0A2Z5ZNU6,A0A2Z5ZNX6,A0A2Z5ZNY7,A0A2Z5ZP42,A0A2Z5ZP70,A0A2Z5ZP86,A0A2Z5ZPA8,A0A384K9A3,A0A384KLH2,A0A384KR39,A0A384L6H3,A0A384LBT8,A0A384LCN9,A0A384LIA5,A0A384LLD3,A0A384LN04,A0A384LPS7,B1A8W7,B1A8X5,B1A8Y3,B9UPB8,C6G868,C6G876,C6G884,D7RGN0,G0XRL3,I1SUZ8,I1SV00,J3SRD7,J3T1D1,J3T1F4,J3T1J6,J3T1Y4,J3UE95,J3XCG3,J3XCM3,J3XLP7,J3XLU0,J3XMC9,J7FME7,K4F2R3,K4F666,N0CFQ0,Q07D09,Q4VRP0,Q4VRP8,Q549Q0,Q71C70,Q8B5P3,Q8JQA8,Q918T0,Q918T5,Q918T8,Q918U1,Q918U3,Q918U5,Q918U7,Q9E839,Q9E840,Q9E841,Q9E842,Q9YIV0,Q9YV72,Q9YV73,Q9YV74,Q9YV75,Q9YV76,S4W1B0,S4W1C8,S4W1D1,S4W2B8,S4W2C7,S4W2D0,S4W2D4,S4W4I9,S4W4J3,S4W4J8,S4W4K3,S4W4K7,S4W7A5,S4W7A9,S4W7B3,S4W7B7,S4W7C0,S4W7C4,S4W8C4,S4W8C8,S4W8D0,S6AWR2,S6B2P1,S6BB15,S6BB53,S6BHC8 dsDNA TR, Rep P D(14643661, 22031941, 12019268, 29142126) N 1BY9, 1DTO, 1R8P, 1ZZF, 2NNU, 2Q79, 3MI7 D(22210627, 7957111) D(14643661, 21482558, 7957111, 12239214) D(14643661, binding assay, DNA complex, footprinting) Fields Virology Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex. Papillomaviridae Human papillomavirus type 16 E6 Protein E6 P03126 VE6_HPV16 A0A059VIP8,A0A059VIQ1,A0A059VJK0,A0A059VNE0,A0A059VNE3,A0A059VNE7,A0A059VNM4,A0A059VNM8,A0A076G1E4,A0A076G284,A0A089N7R5,A0A089N7S9,A0A0C5FR62,A0A0C5FUK7,A0A0C5FUL8,A0A0C5G7Y2,A0A0C5G7Y5,A0A0D5CS67,A0A0D5ZYT6,A0A0M4AZY2,A0A0N9QU66,A0A0N9R7C8,A0A0S2E7X6,A0A0S2E831,A0A0U2QTF6,A0A0U2QTG8,A0A0U2QTK7,A0A0U2QTM0,A0A0U2YX27,A0A0U2YX58,A0A0U2ZNY5,A0A0U2ZPD7,A0A0U3AVN8,A0A0U3AVT2,A0A0U3I277,A0A0U3I8A2,A0A0U3IDX2,A0A0U3IE20,A0A0U3IE52,A0A0U3IE93,A0A0U3IEB5,A0A0U3IJH2,A0A0U3J8V8,A0A0U3J927,A0A0U3JAY8,A0A0U3JB52,A0A0U3JCG6,A0A0U3JCM7,A0A0U3JCQ7,A0A0U3JL94,A0A0U3JLC6,A0A0U3JLK2,A0A0U3JSW5,A0A0U3JWC6,A0A0U3JWG7,A0A0U3JWJ7,A0A0U3JWN1,A0A0U3K7C4,A0A0U3K7F7,A0A1B2AH91,A0A1B2AH95,A0A1B2AHB5,A0A1B2AHE3,A0A1B2AHE5,A0A1B2AHH7,A0A1C9HIX0,A0A1C9HIX9,A0A1D8V743,A0A1D8V772,A0A1D8V7D7,A0A1P8NVX0,A0A220NMJ5,A0A220NMS7,A0A220NMT0,A0A286LT27,A0A286LT38,A0A286R0Y2,A0A286R0Z6,A0A291L533,A0A291L5A1,A0A2D1LVN5,A0A2D1LVP3,A0A2D1LVP6,A0A2D1LVP7,A0A2D1LVP8,A0A2D1LVP9,A0A2D1LVQ0,A0A2D1LVQ5,A0A2D1LVQ7,A0A2D1LVR1,A0A2D1LVR3,A0A2D1LVR4,A0A2D1LVR6,A0A2D1LVR8,A0A2D1LVS2,A0A2D1LVS6,A0A2D1LVS8,A0A2D1LVT2,A0A2D1LVU2,A0A2D1LVU7,A0A2P0VG54,A0A2P0VGD5,A0A2P0VGY9,A0A2P0VHG1,A0A2P0VHX4,A0A2P0VIB7,A0A2P0VIU5,A0A2P0VIU9,A0A2P0VJB1,A0A2P0VJU1,A0A2P0VKB9,A0A2P0VKC2,A0A2P1HB01,A0A2P1HB02,A0A2P1HB15,A0A2P1HBA8,A0A2P1HBE1,A0A2P1HBH3,A0A2P1HBM3,A0A2P1HBR0,A0A2P1HBY2,A0A2P1HCG3,A0A2P1HCG9,A0A2P1HDE3,A0A2P1HE67,A0A2P1HEE5,A0A2P1HEF3,A0A2P1HEI2,A0A2P1HEJ9,A0A2P1HF36,A0A2P1HFT5,A0A2P1HFZ6,A0A2P1HG21,A0A2P1HGE7,A0A2P1HGM3,A0A2P1HGS9,A0A2P1HGX6,A0A2P1HHC8,A0A2P1HHQ0,A0A2P1HI11,A0A2P1HIG8,A0A2P1HIH1,A0A2P1HIR9,A0A2P1HJ72,A0A2P1HJF4,A0A2P1HJU7,A0A2P1HKA0,A0A2P1HKD0,A0A2P1HKP1,A0A2P1HKQ2,A0A2P1HKZ5,A0A2P1HL30,A0A2P1HL39,A0A2P1HL86,A0A2P1HLJ8,A0A2P1HLP0,A0A2P1HLP7,A0A2P1HM15,A0A2P1HM36,A0A2P1HM90,A0A2P1HME4,A0A2P1HMG4,A0A2P1HMG5,A0A2P1HMH9,A0A2P1HMJ0,A0A2P1HMQ1,A0A2P1HMT1,A0A2P1HMZ8,A0A2P1HN04,A0A2P1HN94,A0A2P1HNM9,A0A2P1HNV3,A0A2P1HNX7,A0A2P1HP96,A0A2P1HPQ3,A0A2P1HPX8,A0A2P1HQ86,A0A2P1HQE9,A0A2P1HQI1,A0A2P1HQJ9,A0A2P1HQK3,A0A2P1HQL5,A0A2P1HQL9,A0A2P1HR68,A0A2P1HRA2,A0A2P1HRC8,A0A2P1HRI0,A0A2P1HRR9,A0A2P1HS04,A0A2P1HS22,A0A2P1HS59,A0A2P1HSQ4,A0A2P1HSV1,A0A2P1HTP3,A0A2P1HTX2,A0A2P1HTZ5,A0A2P1HUS9,A0A2P1HUW9,A0A2P1HV39,A0A2P1HV98,A0A2P1HVX7,A0A2P1HW32,A0A2P1HX54,A0A2P1HXK4,A0A2P1HXQ6,A0A2P1HY06,A0A2P1HY11,A0A2P1HYJ5,A0A2P1HYN2,A0A2P1HZ06,A0A2P1HZ47,A0A2P1HZE4,A0A2P1HZX9,A0A2P1I0J5,A0A2P1I0M9,A0A2P1I102,A0A2P1I128,A0A2P1I1F2,A0A2P1I1I8,A0A2P1I1J9,A0A2P1I1X0,A0A2P1I1Z1,A0A2P1I1Z7,A0A2P1I2B1,A0A2P1I2B8,A0A2P1I2R1,A0A2P1I3F3,A0A2P1I3J7,A0A2P1I3Q5,A0A2P1I3X8,A0A2P1I3Z9,A0A2P1I419,A0A2P1I497,A0A2P1I4B0,A0A2P1I4E0,A0A2P1I4Z7,A0A2P1I4Z9,A0A2P1I543,A0A2P1I590,A0A2P1I5C9,A0A2P1I5D5,A0A2P1I5S2,A0A2P1I5X1,A0A2P1I643,A0A2P1I6U0,A0A2P1I704,A0A2P1I738,A0A2P1I741,A0A2P1I7I4,A0A2P1I7P4,A0A2P1I7P8,A0A2P1I7S1,A0A2P1I7Y6,A0A2P1I825,A0A2P1I830,A0A2P1I8M0,A0A2P1I8P9,A0A2P1I8Z1,A0A2P1I949,A0A2P1I9I0,A0A2P1I9T1,A0A2P1IA25,A0A2P1IA62,A0A2P1IA81,A0A2P1IAA7,A0A2P1IAG9,A0A2P1IB33,A0A2P1IB69,A0A2P1IBQ6,A0A2P1IBT0,A0A2P1IBW4,A0A2P1IBX1,A0A2P1IBY0,A0A2P1IC50,A0A2P1ICA0,A0A2P1ID20,A0A2P1IDC6,A0A2P1IDD8,A0A2P1IDN9,A0A2P1IDU8,A0A2P1IDV8,A0A2P1IDW3,A0A2P1IE23,A0A2P1IE68,A0A2P1IEA9,A0A2P1IEF5,A0A2P1IEX8,A0A2P1IFE8,A0A2P1IFG8,A0A2P1IFS0,A0A2P1IFV9,A0A2P1IFX6,A0A2P1IFY1,A0A2P1IG57,A0A2P1IG80,A0A2P1IG87,A0A2P1IGG0,A0A2P1IGW0,A0A2P1IGX6,A0A2P1IH24,A0A2P1IHC7,A0A2P1IHE2,A0A2P1IHI4,A0A2P1II23,A0A2P1IIF0,A0A2P1IIJ4,A0A2P1IIR6,A0A2P1IJK4,A0A2P1IJR0,A0A2P1IJR1,A0A2P1IK24,A0A2P1IK64,A0A2P1IK80,A0A2P1IK89,A0A2P1IKC0,A0A2P1IKF2,A0A2P1IKI0,A0A2P1IKJ2,A0A2P1IKU9,A0A2P1IL87,A0A2P1ILI8,A0A2P1ILK1,A0A2Z5DHD3,A0A2Z5DHF0,A0A384K9E7,A0A384K9Q3,A0A384KEH1,A0A384KKG5,A0A384KQK8,A0A384LDF5,A0A384LH07,A0A384LI46,A0A384LQE2,A0MPS4,A1YQC0,A1YT18,A1YT19,A3RM07,A3RM08,A4L2Z5,A4L2Z7,A4L313,A7LCD3,B1A8X8,B1N828,B1N831,B7T163,B7T167,B7T1G5,B7T1G7,B7T1H5,B7T1I2,B9UPB5,C0KXJ9,C0KXK0,C0KXK2,C0KXK3,C0KXK6,C0KXK7,C0KXK9,C0KXL0,C0KXL2,C0KXL4,C0KXL6,C0KXL9,C0KXM0,C0KXM1,C0KXM3,C0KXM5,C6G881,D5LNF2,D7RGM7,E1A4A4,G0WKQ5,G0WKQ6,G9HQC8,G9HQD8,G9HQE8,G9HQF1,H6VNE9,H6VNF0,H6VNF1,H6VNF2,H6VNF3,H6VNF4,H6VNF5,H6VNF6,H6VNF7,H6VNF8,H6VNF9,H6VNG0,H6VNG2,H6VNG4,H6VNG6,H6VNG7,H6VNG8,H6VNH0,H6VNH1,H6VNH2,H6VNH3,H6VNH4,H6VNH5,H6VNH7,H6VNH8,H6VNH9,H6VNI0,H6VNI2,H6VNI3,H6VNI4,H6VNI5,H6VNI6,H6VNI7,H6VNI8,H6VNI9,H6VNJ0,H6VNJ1,H6VNJ2,H6VNJ3,H6VNJ4,H6VNJ5,H6VNJ6,H6VNJ9,H6VNK0,H6VNK1,H6VNK3,H6VNK4,J3T208,J9ZYN7,J9ZYY5,J9ZZ15,J9ZZ21,K0A0D0,N0DLZ7,N0DM07,N0DRU0,N0DRU7,Q2PJN9,Q4VRN5,Q547J2,Q71BH9,Q778I6,Q77JC7,Q8JMU8,Q8QHN0,Q8QHP5,Q8QHT0,Q8QRD5,Q8QRD6,Q8QRD7,Q8QRD8,Q8QRD9,Q8QRE0,Q8QRE1,Q919A9,Q919B1,Q919C6,Q919D4,Q9QDH3,Q9QDH5,Q9QDH7,Q9QDH9,Q9W931,Q9WH13,S5TCK5,S5TDM3,S5TDR0,S5THQ0,S5THX6,S5TL73,S5TL98,S5TLA4,S5TQ97,S5U276,S5U2B7,S5U2Z7,S5U365,S5U371,S5U3B0,S5U3D5,S5U3E1,S5U7G7 indirect/unknown TR, Other P D(15664194) N 1VZN, 2FK4, 2KPL, 2LJX, 2LJY, 2LJZ, 4GIZ, 4JOP, 4XR8, 6HKS, 6SIV, 6SJA D(31002735, 11275986, 22210627) D(11275986) N Fields Virology Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway. Papillomaviridae Human papillomavirus type 16 E7 Protein E7 P03129 VE7_HPV16 A0A059PVS3,A0A059PVS5,A0A059PVS7,A0A059PVT2,A0A059PVT4,A0A059PVT6,A0A059PVU6,A0A059PVU7,A0A059PVU9,A0A059PVV2,A0A059PVW7,A0A059PVX1,A0A076G1E9,A0A076G292,A0A076G3A1,A0A076G7W8,A0A089N7T4,A0A0G2YFL8,A0A0G2YJI6,A0A0G2YL83,A0A0H4CN15,A0A0H4CQU3,A0A0M5I281,A0A159DWG2,A0A1B2AH93,A0A1B2AHI1,A0A1B2AHJ8,A0A289SF75,A0A289SFD2,A0A289SFF8,A0A289SFI7,A0A289SFR6,A0A289SFX4,A0A289SG08,A0A289SM88,A0A289SMC3,A0A289SME7,A0A289SMJ4,A0A289SMN5,A0A289SMS4,A0A289SMW3,A0A289SPS0,A0A289SPX7,A0A289SQ04,A0A289SQ43,A0A289SQA6,A0A289SQL8,A0A289SZM6,A0A289SZX7,A0A289T025,A0A289T0B9,A0A289T0E2,A0A289T0G1,A0A289TIL4,A0A289TIQ9,A0A289TIW2,A0A289TIZ2,A0A289TJ28,A0A289TJ61,A0A291S0D2,A0A291S0D3,A0A291S0D8,A0A291S0E0,A0A291S0E9,A0A291S0F0,A0A291S0F1,A0A291S0F3,A0A291S0F7,A0A291S0F8,A0A291S0G1,A0A291S0G3,A0A291S0G4,A0A291S0G5,A0A291S0G8,A0A291S0H0,A0A291S0H1,A0A291S0H3,A0A291S0H7,A0A291S0I0,A0A291S0I3,A0A2C9DJ22,A0A2C9DJ24,A0A2C9DJ25,A0A2C9DJ27,A0A2C9DJ29,A0A2C9DJ31,A0A2C9DJ33,A0A2C9DJ34,A0A2C9DJ36,A0A2C9DJ38,A0A2C9DJ40,A0A2C9DJ42,A0A2C9DJ43,A0A2C9DJ45,A0A2C9DJ47,A0A2C9DJ49,A0A2C9DJ51,A0A2C9DJ52,A0A2C9DJ54,A0A2C9DJ56,A0A2C9DJ58,A0A2C9DJ60,A0A2C9DJ61,A0A2C9DJ63,A0A2C9DJ65,A0A2C9DJ67,A0A2C9DJ69,A0A2C9DJ70,A0A2C9DJ72,A0A2C9DJ74,A0A2C9DJ76,A0A2C9DJ78,A0A2C9DJ79,A0A2C9DJ81,A0A2C9DJ83,A0A2C9DJ85,A0A2C9DJ87,A0A2C9DJ88,A0A2C9DJ90,A0A2C9DJ92,A0A2C9DJ94,A0A2C9DJ96,A0A2C9DJ97,A0A2C9DJ99,A0A2C9DJA1,A0A2C9DJA3,A0A2C9DJA5,A0A2C9DJA6,A0A2C9DJA8,A0A2C9DJB0,A0A2C9DJB2,A0A2C9DJB4,A0A2C9DJB5,A0A2C9DJB7,A0A2C9DJB9,A0A2C9DJC1,A0A2P0VGD6,A0A2P0VGD7,A0A2P0VGZ1,A0A2P0VHG2,A0A2P0VHG5,A0A2P0VHY0,A0A2P0VHY3,A0A2P0VIC2,A0A2P0VIV5,A0A2P0VJB3,A0A2P0VJU6,A0A2P0VKC6,A0A2P1HCE8,A0A2P1HF34,A0A2P1HG37,A0A2P1HIW7,A0A2P1HJR6,A0A2P1HJS5,A0A2P1HJZ9,A0A2P1HKE3,A0A2P1HKM2,A0A2P1HLI0,A0A2P1HME9,A0A2P1HMR8,A0A2P1HNA9,A0A2P1HNK2,A0A2P1HNX3,A0A2P1HPZ2,A0A2P1HRS5,A0A2P1HS38,A0A2P1HT93,A0A2P1HTU4,A0A2P1HTU6,A0A2P1HU85,A0A2P1HUE1,A0A2P1HUQ8,A0A2P1HV03,A0A2P1HV70,A0A2P1HWM3,A0A2P1HWX3,A0A2P1HXT8,A0A2P1HYA9,A0A2P1HYI5,A0A2P1HYV4,A0A2P1HZB6,A0A2P1HZJ7,A0A2P1HZQ7,A0A2P1HZY9,A0A2P1I050,A0A2P1I084,A0A2P1I1X1,A0A2P1I1Y2,A0A2P1I277,A0A2P1I2C5,A0A2P1I369,A0A2P1I3T1,A0A2P1I4H2,A0A2P1I589,A0A2P1I5V8,A0A2P1I5W2,A0A2P1I681,A0A2P1I752,A0A2P1I7N9,A0A2P1I898,A0A2P1I8U1,A0A2P1I8V3,A0A2P1I8Y6,A0A2P1I8Z6,A0A2P1I911,A0A2P1I9B3,A0A2P1I9B5,A0A2P1I9F6,A0A2P1I9K6,A0A2P1I9V6,A0A2P1IA20,A0A2P1IBS1,A0A2P1IBV2,A0A2P1ID77,A0A2P1IDR9,A0A2P1IDZ5,A0A2P1IE20,A0A2P1IE97,A0A2P1IHA0,A0A2P1IHZ3,A0A2P1II29,A0A2P1IJ05,A0A2P1IJ29,A0A2P1IJF7,A0A2P1IJW8,A0A2P1IK25,A0A2P1IKM7,A0A2P1ILF9,A0A2Z5DHM3,A0A384LCP1,A0A384LMA3,A0A384LNE6,A0MPS5,A0MPS6,A0MPS7,A1YQD4,A1YQD5,A1YQD6,A1YQD7,A1YQD8,A1YQD9,A1YQE0,A1YQE1,B7T164,B9UPB6,C0KXQ4,C0KXQ5,D7RGM8,G0WKQ8,J9Q2I8,J9Q2V6,J9Q2W0,J9Q391,J9Q3Y3,J9Q4N7,J9Q4P1,K0F2R1,K0F2S0,K0F2T0,K0F2T8,K0F2U7,K0F2V7,K0F2W6,K0F2X5,K0F2Y7,K0F300,K0F312,K0F9K7,K0F9L4,K0F9M5,K0F9N3,K0F9P2,K0F9Q2,K0F9Q8,K0F9Q9,K0F9R8,K0F9S1,K0F9S7,K0F9S9,K0F9T5,K0F9T8,K0F9U6,K0F9U7,K0F9V4,K0F9V8,K0F9W3,K0F9X1,K0F9X9,K0F9Y7,K0F9Z4,K0FA01,K0FAG8,K0FAH3,K0FAH8,K0FAI6,K0FAJ4,K0FAK5,K0FAL4,K0FAM6,K0FAN4,K0FAP2,K0FAQ5,K0FAR6,K0FFB1,K0FFC3,K0FFD3,K0FFE3,K0FFF2,K0FFG1,K0FFG8,K0FFH7,K0FFI7,K0FFJ6,K0FFK5,K0FFL4,O11650,O12337,O12338,Q2MJT4,Q547B8,Q778G4,Q778G6,Q778G8,Q778G9,Q778H1,Q778H2,Q778H3,Q778H5,Q778H7,Q778H9,Q778I0,Q778I1,Q778I3,Q778I5,Q77AI1,Q77GV7,Q8B5P6,Q8QRD2,Q8QRD3,Q8QRD4,Q8V1J0,Q9QDH2,Q9QDH4,Q9QDH6,Q9QDH8,R4UNR4,R4UNS0,R4UNS5,R4URG4,R4URH2,R4URH7,R4UZM3,R4UZM8,R4UZN4,R4V4T8,R4V4U3,R4V4U7,R4V4V0,R4V788,R4V795,R4V7A2,R9QVU4,S4S7U0,S4S7U2,S4S7U5,S4S7U9,S4S7V5,S4S7V7,S4S7V9,S4S7W1,S4S7W3,S4S7W5,S4S7W7,S4S7W9,S4S7X1,S4S7Y4,S4S868,S4S877,S4S884,S4S891,S4S895,S4S898,S4S8A1,S4S8A4,S4S8A6,S4S8A9,S4S8B1,S4S8B5,S4S8B8,S4S8M4,S4S8N2,S4S8N9,S4S8Q3,S4S8Q9,S4S8R3,S4S8R7,S4S8S1,S4S8S4,S4S8S8,S4S8T0,S4S8T4,S4S8T9,S4S8U0,S4S8U3,S4S8U4,S4S8V1,S4S8W3,S4S8X0,S4S8X6,S4S8Y0,S4S8Y3,S4S8Y7,S4S8Z1,S4S8Z4,S4S8Z7,S4S902,S4S9B2,S4S9B9,S4S9C6,S4S9D2,S4S9E0,S4S9E5,S4S9E8,S4S9F1,S4S9F4,S4S9F8,S4S9G0,S4S9G4,S4S9G8,S4S9H0,S4U723,S4U729,S4U736,S4U7T5,S4U7U0,S4U954,S4U959,S4UB75,S4UB84,S4UDF6,S4UDG0,T1R4E0,T1R4E3,T1R539 indirect/unknown TR, Other P D(22099967) N 4YOZ, 6APN D(22210627, 7933087, 9426463, 11039910) N N Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Papillomaviridae Human papillomavirus type 1a E2 Regulatory protein E2 P03118 VE2_HPV1 dsDNA TR, Rep P I(14643661, 22031941, 12019268, 29142126) N N I(22210627, 7957111) I(14643661, 21482558, 7957111, 12239214) I(14643661, binding assay, DNA complex, footprinting) Fields Virology Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex. Papillomaviridae Human papillomavirus type 1a E6 Protein E6 P06929 VE6_HPV1 indirect/unknown TR, Other P I(15664194) N N D(7933087) I(11275986) N Fields Virology Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response. Papillomaviridae Human papillomavirus type 1a E7 Protein E7 P06465 VE7_HPV1 indirect/unknown TR, Other P I(22099967) N 2B9D D(7933087) N N Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Papillomaviridae Human papillomavirus type 41 E2 Regulatory protein E2 P27552 VE2_HPV41 dsDNA TR, Rep P I(14643661, 22031941, 12019268, 29142126) N N I(22210627, 7957111) I(14643661, 21482558, 7957111, 12239214) I(14643661, binding assay, DNA complex, footprinting) Fields Virology Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex. Papillomaviridae Human papillomavirus type 41 E6 Protein E6 P27555 VE6_HPV41 indirect/unknown TR, Other P I(15664194) N N I(31002735, 11275986, 22210627) I(11275986) N Fields Virology Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response. Papillomaviridae Human papillomavirus type 41 E7 Protein E7 P27556 VE7_HPV41 indirect/unknown TR, Other P I(22099967) N N I(22210627, 7933087, 9426463, 11039910) N N Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Papillomaviridae Human papillomavirus type 5 E2 Regulatory protein E2 P06921 VE2_HPV05 P26545 dsDNA TR, Rep P I(14643661, 22031941, 12019268, 29142126) N N I(22210627, 7957111) I(14643661, 21482558, 7957111, 12239214) I(14643661, binding assay, DNA complex, footprinting) Fields Virology Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex. Papillomaviridae Human papillomavirus type 5 E6 Protein E6 P06930 VE6_HPV05 A0A221SN86,A0A221SN96,A9XCP0,A9XCP7,A9XCQ4,A9XCR8,F8RC52,F8RC53,F8RC54,P24836,P26556,Q4PZJ4,Q4PZJ5,Q4PZJ6,Q4PZJ7,Q4PZJ8,Q4PZJ9,Q4PZK0,Q6LBH6,Q76WJ7,Q80927,Q81962,Q81985,Q81986,R9QCH1 indirect/unknown TR, Other P I(15664194) N N I(31002735, 11275986, 22210627) I(11275986) N Fields Virology Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response. Papillomaviridae Human papillomavirus type 5 E7 Protein E7 P06932 VE7_HPV05 A0A075LXE0,A0A075LYA7,A0A075LYB3,A0A075LYW2,A0A0N7I701,A0A0P0E4Z9,A0A0P0EBY8,A0A0P0EGY4,A0A0P0EME8,A0A140FA98,A0A140FAA6,A0A159DZX5,A0A192YER2,A0A192YG58,C7DYE0,C7DYE2,C7DYE4,C7DYE6,C7DYE8,C7DYF0,C7DYF2,C7DYF4,C7DYF6,C7DYF8,C7DYG0,C7DYG2,C7DYG4,C7DYG6,C7DYG8,C7DYH0,C7DYH2,C7DYH4,C7DYH6,C7DYH8,C7DYI0,C7DYI2,C7DYI4,C7DYI6,C7DYI8,C7DYJ0,C7DYJ2,C7DYJ4,C7DYJ6,C7DYJ8,C7DYK0,C7DYK2,C7DYK4,C7DYK6,C7DYK8,C7DYL0,C7DYL2,D0EDB6,F1AST1,F1AST2,F8S525,F8S541,F8S581,N0DP29,N0DQQ9,P26559,P36831,Q76WJ6,Q81019,Q8B5X6,R9QBR6 indirect/unknown TR, Other P I(22099967) N N I(22210627, 7933087, 9426463, 11039910) N N Fields Virology Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). Paramyxoviridae Hendra virus Phosphoprotein Protein P, P/V/C O55778 PHOSP_HENDH indirect/unknown TR, Rep S N N 4HEO I(7491765) N N 25281398.0 Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template (By similarity). Paramyxoviridae Human parainfluenza virus 1 Phosphoprotein P, P/C, Protein P, P/V/C P32530 PHOSP_PI1HB A0A059QA57,A0A059QA62,A0A059QA70,A0A059QA80,A0A059QAA8,A0A0G2R217,A0A1B2CW80,A0A1B2CW98,J7FNR1,J7FNT1,J7FNV2,J7FNW9,J7FNZ0,J7FP15,J7FP39,J7FP63,J7FQG2,J7FQI5,J7FQK8,J7FQL3,J7FQM7,J7FQP8,J7FQS6,J7FQV6,J7FQY2,J7FQY6,J7FSL2,J7FSN8,J7FSR7,J7FSU6,J7FSX6,J7FT03,J7FT30,J7FT61,J7FV05,J7FV29,J7FV56,J7FV78,J7FVA3,J7FVD2,J7FVG2,J7FVJ3,J7FXC5,J7FXE6,J7FXJ1,J7FXL5,J7FXN8,P28054,P32531,P32532,Q8QT31,T1UCF4,T1UCG6,T1UCH5,T1UF53,T1UF64,T1UF81,T1UF92,T1UFA1,T1UFB1 indirect/unknown TR, Rep S N N N I(7491765) N N 12692097.0 This protein is probably a component of the active polymerase. It may function in template binding. Paramyxoviridae Human parainfluenza virus 2 Phosphoprotein Protein P, P/V P23056 PHOSP_PI2HT P23055 indirect/unknown TR, Rep S N N N I(7491765) N N 12692097.0 Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis. Paramyxoviridae Human parainfluenza virus 3 Phosphoprotein P, Protein P, P/V/D P06162 PHOSP_PI3H4 A0A023PFB4,A0A023PFG3,A0A023PFL0,A0A023PFQ5,A0A023PFZ5,A0A023PG51,A0A023PG69,A0A023PGA3,A0A023PGB4,A0A023PGD8,A0A023PGK3,A0A023PGS2,A0A023PGV1,A0A023PGY1,A0A023PGZ3,A0A023PH10,A0A023PH42,A0A023PH43,A0A023PH67,A0A023PH76,A0A023PH96,A0A023PHA5,A0A023PHD4,A0A023PHE7,A0A023PHF9,A0A023PHI5,A0A023PHI8,A0A023PHJ3,A0A023PHL9,A0A023PHN2,A0A023PHQ2,A0A023PHR4,A0A023PHS5,A0A023PHT7,A0A023PHX6,A0A023PI22,A0A023PI55,A0A023PI62,A0A023PI93,A0A023PIC6,A0A023PIJ5,A0A059Q9Z8,A0A059QA10,A0A059QA21,A0A059QA33,A0A059QA45,A0A059QA55,A0A059QA84,A0A059QAB7,A0A059QAB8,A0A059QAE1,A0A059QAF7,A0A059QAG4,A0A059QAH6,A0A059QAI0,A0A059QAJ6,A0A059QAM4,A0A059QBW4,A0A059QBZ1,A0A059QC16,A0A059QC39,A0A059QC70,A0A059QC91,A0A059QDV8,A0A059QDY9,A0A059QE20,A0A059QE50,A0A059QE92,A0A059QEF4,A0A0G2R241,A0A1C9FM37,A0A1C9FM46,A0A1C9FM56,A0A1C9FM77,A0A1C9FM79,A0A1C9FM80,A0A1C9FM90,A9Z0P3,B1A5Q1,B3GQS8,B8XXB5,O89234,Q81076,Q84742,R4X5Y3,T1UCU1,T1UCW0,T1UCY2,T1UD00,T1UD33,T1UD36,T1UD58,T1UD73,T1UE22,T1UE62,T1UEB9,T1UEG1,T1UFF6,T1UFJ6,T1UFQ1,U5L3E2 indirect/unknown TR, Rep S N N N I(7491765) N N 12692097.0 Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis. Paramyxoviridae Human parainfluenza virus 4a Phosphoprotein Protein P, P/V P22044 PHOSP_PI4HA indirect/unknown TR, Rep S N N N I(7491765) N N 12692097.0 Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis. Paramyxoviridae Human parainfluenza virus 4b Phosphoprotein Protein P, P/V P21738 PHOSP_PI4HB A0A097F1I3,A0A1V0E0T4,A0A1V0E1P9,A0A1V0E1R5,A0A1W6DZN5,A0A1Z1XG58,H6WF05 indirect/unknown TR, Rep S N N N I(7491765) N N 12692097.0 Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis. Paramyxoviridae Measles virus Phosphoprotein C, P, Protein P, P/V P35974 PHOSP_MEASA A0A076FF09,A0A0A7DYR3,A0A0M3TG67,A0A0M3TG73,A0A0M3TG74,A0A0M3TG86,A0A0M3TG91,A0A0M3TGB0,A0A0M3TGC6,A0A0M4MCX4,A0A0M4MD66,A0A0M4MMI7,A0A0M4MQY5,A0A0M4N184,A0A0M4NEZ8,A0A0S1LL08,A0A0S1LL25,A0A140G963,A0A158UZJ4,A0A158V0F3,A0A158V2K3,A0A161UC10,A0A1C9U7M5,A0A1Z1ED88,A0A1Z1EDF0,A0A1Z1EDF8,A0A2R4LPH0,A0A2U7XVG9,A0A343LQ65,A0A3Q8BM42,A0A3Q8GW16,A0A3Q8GW50,A0A3Q8GW72,A0A3Q8GYD4,A0A3Q8GZ35,A0A3Q8H141,A0A3S5GNX2,A4URT3,A7XPM0,A7XPM1,A7XPM2,A7XPM3,A7XPM4,A7XPM5,A7XPM6,A7XPM7,A7XPM8,A7XPM9,A7XPN0,A7XPN1,A7XPN2,A7XPN3,A7XPN4,A7XPN5,A9YTL4,A9YTM2,B1AAA8,B1GX84,B1GX85,B1GX86,B1GX87,B1GX88,B1GX89,B1GX90,B1GX91,B1GX92,B1GX93,B1GX94,B1GX95,B1GX96,B1GX97,B1GX98,B1GX99,B1GXA0,B1GXA1,B2BML3,B2KPM4,B7TB11,B8PZQ7,B9A7E8,B9A7L7,C6L654,C8CAZ2,E2I6N2,E2I9Q7,E5RS81,E7DW48,E7DW50,E7DW52,E7DW54,E7DW62,E7DW64,E7DW68,E7DW70,E7DW72,E7DW76,E7DW78,E7DW80,E7DW84,E7DW86,E7DW92,E7DW94,E7DW96,E7DW98,E7DWA2,E7DWA8,E7DWB0,E7DWB2,E7DWB6,E7DWB8,E7DWC4,E7DWC6,E7DWC8,E7DWD0,E7DWD2,E7DWD4,E7DWD6,E7DWD8,E7DWF5,E7DWG1,E7DWG3,E7DWG5,E7DWG7,E7DWG9,E7DWH2,E7DWH4,E7DWH6,E7DWH8,E7DWI0,E7DWI4,E7DWI7,E7DWI9,E7DWJ1,E7DWJ3,E7DWJ7,E7DWJ9,E7DWK1,E7DWK3,E7DWK5,E7DWK7,E7DWL7,E7DWM1,E7DWM3,E7DWM5,E7DWM9,F1BCV1,F1BCV2,F1BCV3,F1BCV4,F1BCV5,F1BCV6,F1BCV7,F1BCV9,F1BCW3,F1BCW5,F1BCW6,F1BCW7,F1BCX0,F1BD28,F1BD31,F1BD34,F1BD35,F1BD37,F1BD45,F1BD46,F1BD53,F1BD54,F1BD55,F1BD57,F1BD59,F1BD61,F1BD62,F1BD64,F1BD65,F1BD67,F1BD69,F1BD71,F1BD77,F1BD78,F1BD79,F1BD80,F1BD84,F6I820,F6I821,F6I823,F6I825,F6I826,F6I828,F6I832,F6I833,F6I834,F8U897,G4XDT2,G5DD33,G5DD41,G5DD49,G5DD57,G5DD65,G5DD73,G5DD81,G5DD89,G5DD97,K9N4J4,K9N4K5,K9N5R1,P03422,P26033,P90485,Q00793,Q04159,Q2LJ39,Q2LJ47,Q2LJ55,Q2LJ63,Q76VZ7,Q77M20,Q77M25,Q77M31,Q77M42,Q783Q7,Q83320,Q83321,Q83623,Q8JQ52,Q8JT18,Q8JT21,Q9IC38,Q9IFK7,Q9WMB4,Q9YZZ2,Q9YZZ5,W8VRE9,X5D6I5,X5D6J1,X5D6J8,X5D6K5,X5D6L1,X5D6L7,X5D6M5,X5D6N2,X5D6Q1,X5D6Q9,X5D6R4,X5D6R7,X5D6S0,X5D6S4,X5D6S8,X5D6T1,X5D6T4,X5D6T9,X5DBD8,X5DBE2,X5DBE7,X5DBF3,X5DBF8,X5DBG3,X5DBG7,X5DBI4,X5DBJ2,X5DBJ6,X5DBJ9,X5DBK3,X5DBK6,X5DBL0,X5DBL3,X5DBL6,X5DBM0,X5DBM2,X5DBZ6,X5DD01,X5DD05,X5DD11,X5DD18,X5DD25,X5DD33,X5DD39,X5DD46,X5DD65,X5DD68,X5DD72,X5DD76,X5DD80,X5DD84,X5DD88,X5DD90,X5DD96,X5DDA1,X5DST0,X5DST5,X5DSU2,X5DSV0,X5DSV8,X5DSW3,X5DSW8,X5DSX2,X5DSZ1,X5DSZ4,X5DSZ8,X5DT03,X5DT07,X5DT10,X5DT14,X5DT19,X5DT23,X5DT28,X5DT32,X5DVE4,X5DVE9,X5DVF5,X5DVF9,X5DVG3,X5DVG9,X5DVH5,X5DVI1,X5DVK0,X5DVK9,X5DVL2,X5DVL5,X5DVL8,X5DVM1,X5DVM5,X5DVM9,X5DVN1,X5DVN3 indirect/unknown TR, Rep S N N 4BHV, 4C5Q I(7491765) N D(31381607, 8578862) 25483511.0 Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis. Paramyxoviridae Nipah virus Phosphoprotein Non-structural protein V, P, Protein W, P/V/C, P/V/W/C, V protein, W protein Q4VCQ1 Q4VCQ1_NIPAV A0A1L7B8D0,A0A1L7B8D3,A0A3G1QY20,A0A3G1QY27,A0A3G1QY38,D2DEB8,E2II04,H6V847,H6V848,H6V860,H6V869,H6V870,H6V871,Q4VCP9,Q4VCQ0,Q997F2 indirect/unknown TR, Rep S N N 4N5B I(7491765) N N 30647521.0 RNA binding;RNA-directed 5'-3' RNA polymerase activity;transcription, DNA-templated;viral genome replication Parvoviridae Adeno-associated virus Rep52 Protein Rep52 Q89270 REP52_AAV2S indirect/unknown TR, NAP, Rep S N N N N D(16775308) D(12824181) 21212830.0 Plays a critical role during packaging of viral DNA into empty capsids, where they are thought to be part of the packaging motor complex. The single stranded genomic DNA is packaged in a 3' to 5' direction and requires the association between viral DNA and Rep40. Regulates host PKA activity by interacting with host PRKX as a mechanism to interfere with helper virus propagation and to promote its own replication. Parvoviridae Adeno-associated virus Rep68 Protein Rep68 P03132 REP68_AAV2S dsDNA TR, Rep S N N 1S9H, 1U0J, 4ZO0, 4ZQ9, 5DCX D(1845899) D(16775308, 15596798) D(16775308, 15596798) 21212830.0 Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factor in site-specific integration of the viral genome. Inhibits the host cell cycle G1/S and G2/M transitions. These arrests may provide essential cellular factors for viral DNA replication. Parvoviridae Adeno-associated virus Rep78 Protein Rep78 Q89268 REP78_AAV2S A9RAH9,O56136,O56138,Q670Q9,Q670R1,Q670R3,Q670R5,Q670R7 dsDNA TR, Rep S D(15596798) N 5BYG D(10531369, 1845899) D(10531369, 10666281, 16775308) N 21212830.0 Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factors in site-specific integration of the viral genome. Regulates host PKA activity by interacting with host PRKX as a mechanism of interfering with helper virus propagation and promoting its own replication. Inhibits the host cell cycle G1/S, S and G2/M transitions. These arrests may provide essential cellular factors for viral DNA replication. Parvoviridae Human parvovirus 4 NS1 Nonstructural protein, Nonstructural protein 1, Nonstructural protein 1,, Non-structural protein, ORF1 F6KS47 F6KS47_9VIRU A0A0C4L654,A0A0C4L9E0,A7J3Q4,A7J3Q8,B0YZG4,B0YZG8,B0YZI4,D0FM80,D0FM90,D1M7U5,F6KS50,H9A241,H9A247,H9A250,H9A253,J9PN41,J9PNK6,J9PNL4,J9PPZ7 dsDNA TR, Rep S N N N I(8970971) I(27809499, 24418564) I(27809499, FA), I(11853402, Dnase I footprinting) 22492853.0 F6KS47 is inferred from Adeno-associated virus protein Q89270 ATP binding,DNA replication,viral genome replication Parvoviridae Human parvovirus B19 NS1 Initiator protein NS1, NCVP1, Non-capsid protein NS-1, Non-structural protein 1, Non-structural protein NS1 Q9PZT1 NS1_PAVHV A0A076JV48,A0A076JZ43,A0A077B001,A0A097C0L5,A0A097C0M3,A0A097C0M7,A0A097C0N6,A0A0N9H666,A0A0N9H6S8,A0A0N9H8I9,A0A0N9H9D5,A0A0N9H9F8,A0A0S2Z242,A0A0S2Z256,A0A0S2Z2A0,A0A0S2Z2D7,A0A0S2Z2F9,A0A0S2Z2I2,A0A0S2Z2I4,A0A0S2Z2K1,A0A0S2Z2K5,A0A0S2Z2K8,A0A0S2Z2M3,A0A0S2Z2P9,A0A0S2Z2X0,A0A0S2Z356,A0A0X8XHP5,A0A223LL20,A0A3Q9D3C3,A0A3R5YZH1,A1A400,A1BML3,A1BML8,A3F778,B8YQ89,D2EBU8,D4AHY8,D6CHV0,E5L8C4,E5L8C6,I7BP20,J3SB70,J3SB73,J3SB76,J3SB79,J3SB82,J3SB85,J3SB88,J3SB91,J3SB94,J3SB97,J3SBA0,J3SBA3,J3SBA6,J3SET8,J3SEV0,J3SIA5,J3SIB2,J3SMR7,J3SMS1,J3SMS4,J3SMS7,J3SMT0,J3SMT3,J3SMT6,J3SMT9,J3SMU2,J3SMU5,J3SMU8,J3SMV1,J3SMV4,J3SN47,J3SN59,J3SN73,J3SN76,J3SN79,J3SN82,J3SN85,J3SN88,J3SN91,J3SN94,J3SN97,J3SNA0,J3SNA3,J7FCE3,J7FCE6,J7FCE9,J7FCF4,J7FCF7,J7FCQ7,J7FCR0,J7FCR7,J7FCS0,J7FD52,J7FD55,J7FD60,J7FD63,J7FDJ3,J7FDJ6,J7FDJ9,J7FDK2,J7FDZ9,J7FE02,J7FE05,J7FE08,J7FE11,Q206Z8,Q207A1,Q207A4,Q207A7,Q207B0,Q2I001,Q2I006,Q2MJ80,Q2MJ83,Q2MJ86,Q2PZ28,Q308H9,Q308I3,Q38IT5,Q38IU0,Q38IU5,Q38IV0,Q3KTM4,Q6DT44,Q6KBB7,Q6RCN2,Q6TV13,Q75U70,Q75U73,Q75U76,Q75U79,Q75U85,Q75U88,Q75U94,Q8JN58,Q913X2,Q9JGP9,Q9JGQ0,Q9JGS1,Q9PZT3,Q9PZT5,Q9PZT7,Q9PZT9,Q9PZU1,Q9WKM1,S5YS34,S5YS39,S5YS41,S5YS44,S5YSP7,S5YY54,S5YY89,S5YY94,S5YYA5,S5YYB0,S5YYB6,S5YYC7,S5YYD9,S5YYE2,S5YYF0,S5Z5M0,S5Z5U6,S5Z5V2,S5Z611,S5ZHB5,S5ZHF2,S5ZHP5,S5ZHQ1,S5ZHQ5,S5ZHQ9,S5ZXZ5,S5ZXZ7,S5ZY10,S5ZY14,S5ZY63,S5ZY70,S5ZY80,S5ZY87 dsDNA TR, Rep S N N N D(8970971) D(27809499, 24418564) D(27809499, FA), D(11853402, Dnase I footprinting) 22492853.0 Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter (PubMed:27809499, PubMed:24418564, PubMed:11853402). Binds the origin of replication and performs an endonucleolytic nick within a conserved sequence in the viral genome, thereby initiating the rolling circle replication (RCR) (PubMed:27809499). Participates in the transcriptional regulation the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters (PubMed:8970971, PubMed:11853402). Transactivates several host promoters some of which induce the S cell cycle phase for the production of host replicative proteins (PubMed:20890043, PubMed:15518826, PubMed:24049177). Upregulates the expression of host E2F4 and E2F5 and interacts with both these factors thereby inhibiting the host cell cycle G2/M transition (PubMed:20890043). This arrest promotes apoptosis for viral release (PubMed:20890043, PubMed:9525624). Peribunyaviridae Bunyamwera virus N Non-structural protein NS-S, NS P16494 NSS_BUNYW A0A0A7KU45,A0A0A7KY99,A0A0G2T176,A0A0G2T1F8,A0A0G2T1M9,A0A0G2T1U8,A0A0U2GIU0,G4Y821,Q8V617 indirect/unknown TR, Other P N N N D(15150262) N N 29707545.0 Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1. Peribunyaviridae Bunyavirus La Crosse N Non-structural protein NS-S, NSs P04874 NSS_BUNLC A5HC88,D3K4J5,D3K4J7,D3K4J9,D3K4K1,D3K4K3,D3K4K5,D3K4K7,D3K4K9,D3K4L1,D3K4L3,D3K4L5,D3K4L7,D3K4L9,D3K4M1,D3K4M3,D3K4M5,D3K4M7,D3K4M9,D3K4N1,D3K4N3,D3K4N5,D3K4N7,D3K4N9,D3K4P1,D3K4P3,D3K4P5,D3K4P7,D3K4P9,D3K4Q1,D3K4Q3,D3K4Q5,D3K4Q7,D3K4Q9,D3K4R1,D3K4R3,D3K4R5,D3K4R7,D3K4R9,D3K4S1,D3K4S3,D3K505,D3K507,D3K509,D3K511,D6NSL4,D6NSL8,F6JSE2,F6JSG2,F6JSH4,P09614,Q8JPQ9,Q917M9 indirect/unknown TR, Other P N N N I(15150262) N N 26375904.0 Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 (By similarity). Peribunyaviridae Bunyavirus snowshoe hare N Non-structural protein, Non-structural protein NS-S, NSs P03514 NSS_BUNSH A9YU76 indirect/unknown TR P N N N I(12133999) N N 22798366.0 P03514 is inferred from Bunyavirus La Crosse protein P16494 Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 (By similarity). Peribunyaviridae Bwamba orthobunyavirus NSs Nonstructural protein NSs, NSs protein B3U4X9 B3U4X9_9VIRU indirect/unknown TR, Other P N N N I(15150262) N N 25188437.0 B3U4X9 is inferred from Bunyavirus La Crosse protein P16494 viral process Peribunyaviridae California encephalitis orthobunyavirus NSs Nonstructural protein NSs, NSs protein Q66003 Q66003_9VIRU A0A385KLS1,Q66002 indirect/unknown TR, Other P N N N I(22345363, 15331713) N N Fields Virology Q66003 is inferred from Bunyamwera virus protein P16494 viral process Phenuiviridae Rift valley fever virus NSs Non-structural protein S P21698 NSS_RVFVZ A0A3S5XDL9,A7KBW6,A7KBW7,O72702,O73535,O73536,O73537,O73538,O73539,O73540,O73541,O73542,O73543,O73544,O73545,O73546,O73547,O73548,O73549,Q7T6F4,Q7T6F5,Q8JUF9 indirect/unknown TR, Other P N N 2N0Y, 5OOO D(22345363, 15331713) N D(15331713) 21188836.0 Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool binds to host FBXO3 to target TFIIH subunit GTF2H1 for proteasomal degradation (PubMed:19197350, PubMed:19211744, PubMed:21543505, PubMed:23063407, PubMed:26837067). Forms filaments in the nucleus that may sequester NSs binding partners, causing cell cycle arrest (PubMed:28915104, PubMed:10233964). Pneumoviridae Human metapneumovirus M2-1 Envelope-associated 22 kDa protein, M2, Matrix M2-1 Q6WB97 M21_HMPVC A0A2H4ZA70,C4B9I0,C5MRS8,F4YZY3,M9V764,M9V801,M9V8F9,M9V8I5,Q0GMS7,Q0GMT0,T1UEZ8,X4Y081,X4Y6I6,X4Y849,X4YLV7 ssRNA TR P N N 4CS9 I(22675274) I(22675274) I(11024112) 18820584.0 Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of viral mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding (By similarity). Pneumoviridae Human metapneumovirus M2-2 M2, Matrix protein M2-2 Q6WB96 M22_HMPVC A0A1C9UMW8,A0A2H4ZA68,A0A2H4ZAG0,A0A2H4ZAL7,A0A2R4KPG0,B8X6L4,C4B9I1,G3KCK1,G3KCL0,M4QFJ4,M4QFL8,M4QJH5,M4QSN4,Q0GMS9,Q6QQH9,Q6WBA5,T1UCE1,X4XYU4,X4Y8N5,X4YM65 indirect/unknown TR, Rep S N N N I(10500164) N I(10500164) 18820584.0 Mediates the regulatory switch from transcription to RNA replication. Acts late in infection by inhibiting viral transcription and up-regulating RNA replication (By similarity). Plays a major role in antagonizing the type I IFN-mediated antiviral response. Interacts with host MAVS and prevents the interaction with its upstream partner DDX58/RIG-I in the signaling pathway leading to interferon production. Pneumoviridae Human respiratory syncytial virus M2-1 Envelope-associated 22 kDa protein, M2, Matrix M2-1 O42050 M21_HRSVB A0A023R760,A0A023R9H2,A0A023RAB4,A0A023RB46,A0A059TDC1,A0A059TDD0,A0A059TDD2,A0A059TDK0,A0A059TDS3,A0A059TDT2,A0A059TE43,A0A059TE80,A0A059TE92,A0A059TEB2,A0A059TED8,A0A076FRX0,A0A076FS08,A0A0A7NQY1,A0A0A7NR76,A0A0A7NS85,A0A0A7NSD8,A0A0A7NTH8,A0A0A7NTR2,A0A0A7NWI0,A0A0A7NWV7,A0A0E3JJE6,A0A0E3LZC2,A0A0X8CVT2,A0A0X8CW62,A0A0X9WN34,A0A0X9WNF5,A0A0X9WYQ7,A0A109QCV3,A0A109QF38,A0A109QF47,A0A109QFG0,A0A109QFU4,A0A120HQL9,A0A140H350,A0A140H3H1,A0A140H3I2,A0A142MLF2,A0A142MLU4,A0A142MME4,A0A142MMF8,A0A142MML9,A0A142MMY8,A0A142MN24,A0A142MN83,A0A142MNE0,A0A142MP28,A0A142MP67,A0A142MQE4,A0A142MQL3,A0A142MS12,A0A142MTE5,A0A142MTN4,A0A1B2VRY5,A0A1B2VTF5,A0A1B2VTV8,A0A1B2VU04,A0A1B2VUC4,A0A1B2VUQ6,A0A1B2VUR2,A0A1B2VV16,A0A1C9V116,A0A1C9V131,A0A1C9V1G1,A0A1C9V236,A0A1C9V2L7,A0A1C9V2L9,A0A1S5SHT2,A0A344X9C8,A0A384ZDG5,A0A384ZEL0,A0A384ZHM7,A0A384ZI92,A0A3Q8TDD0,G8EJ00,P04545,S5ZI93,T1UDB8,V5N720,V5N732,V5N764,V5N7P0,V5N7T2,V5N863,V5N8G0,V5N8M0,V5N9G7,X4Y2X6,X4Y354,X4Y4A9,X4Y4R1,X4Y5B0,X4Y9B5,X4YAG2,X4YBX8,X4YC51,X4YCE8,X4YCG8,X4YCK1,X4YRJ3,X4YRV8,X4YSL7,X4YT50 ssRNA TR P N N N D(22675274) D(22675274) D(11024112) 27486734.0 Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA (By similarity). Pneumoviridae Human respiratory syncytial virus M2-2 M2, Matrix M2-2, Matrix protein M2-2 O42047 M22_HRSVB A0A023R862,A0A023RAK9,A0A023RAR0,A0A023RAW2,A0A059TD79,A0A059TD88,A0A059TD97,A0A059TDB9,A0A059TDL1,A0A059TDM2,A0A059TDN5,A0A059TDU3,A0A059TDW5,A0A059TE08,A0A059TE10,A0A059TE20,A0A059TE62,A0A059TE76,A0A059TE86,A0A059TEF7,A0A088S989,A0A088SBH4,A0A088STR4,A0A0A7NQN2,A0A0A7NRD7,A0A0A7NRW9,A0A0A7NRZ5,A0A0A7NSC6,A0A0A7NSS3,A0A0A7NSZ2,A0A0A7NTQ4,A0A0A7NW37,A0A0A7NWD7,A0A0C5BY14,A0A0U2X6D1,A0A0X8CUQ7,A0A0X8CV01,A0A0X8CVY3,A0A0X8CWA4,A0A0X8CWK3,A0A0X8CWL7,A0A0X8CX84,A0A0X8D1Y1,A0A0X9WEC3,A0A0X9WNJ9,A0A0X9WQ87,A0A0X9XCQ9,A0A0X9XSH9,A0A0X9XZP0,A0A109QF63,A0A120HQH2,A0A140H3H2,A0A142MLB5,A0A142MLT2,A0A142MLW9,A0A142MLZ4,A0A142MMA1,A0A142MND2,A0A142MNS2,A0A142MP32,A0A142MPS0,A0A142MQ01,A0A142MQ24,A0A142MQB9,A0A142MQQ3,A0A142MRP9,A0A142MRQ8,A0A142MRT1,A0A142MSE7,A0A142MSN4,A0A142MTD2,A0A1B2VRZ4,A0A1B2VT71,A0A1B2VTT6,A0A1C9V163,A0A1C9V1B2,A0A1C9V1B7,A0A1C9V1C5,A0A1C9V1K6,A0A1C9V273,A0A1C9V2D1,A0A1C9V2L4,A0A1C9V3M2,A0A1C9V3M4,A0A1P8L302,A0A1P8L312,A0A1P8L326,A0A1P8L340,A0A1P8L345,A0A1P8L3C1,A0A1P8L3J1,A0A1P8L3L8,A0A1P8L3L9,A0A1P8L3N1,A0A1P8L3R6,A0A1V0G3V1,A0A1V0G3V3,A0A1V0G3Y9,A0A219V069,A0A219V0B8,A0A219V1R2,A0A220QKK0,A0A240ESV1,A0A240ET90,A0A240ETA0,A0A2H4HTW4,A0A2H4WKD5,A0A2H4WKH4,A0A2H4WKI3,A0A2H4WKJ7,A0A2H4WKK7,A0A2H4WKM6,A0A2H4WKU2,A0A2H4WKZ5,A0A2H4WL43,A0A2H4WL88,A0A2H4WL89,A0A2H4WL96,A0A2H4WLC5,A0A2H4WLJ5,A0A2H4WLK0,A0A2H4WLK1,A0A2H4WLK4,A0A2H4WLR1,A0A2H4WLS0,A0A2H4WLW4,A0A2H4WM08,A0A2H4WM68,A0A2H4WM69,A0A2I6PIW0,A0A2Z4Z400,A0A344X9C9,A0A348FUX5,A0A348FUZ7,A0A348FV41,A0A384ZD99,A0A384ZDA6,A0A384ZDE7,A0A384ZDJ1,A0A384ZDP1,A0A384ZDQ6,A0A384ZE42,A0A384ZEB4,A0A384ZFD6,A0A384ZFQ7,A0A384ZGM2,A0A384ZHC5,A0A384ZIB7,A0A384ZIM0,A0A385MKF8,A0A385MKK5,A0A385MKM5,A0A385MKY3,A0A385MKY9,A0A385ML21,A0A385ML27,A0A385MLE1,A0A385MLJ5,A0A385MLV9,A0A385MLZ9,A0A385MM88,A0A385MMM9,A0A385MMY7,A0A385MNA9,A0A385MNH8,A0A385MP38,A0A385MPR2,G8EID1,G8EIF3,G8EIN0,G8EIP1,G8EIT4,G8EJ11,I1V243,I6TQU9,I6TQX6,K4G1T0,K4G1U1,K4G1X4,K4G267,K4G278,K4G291,K4G2E0,K4G2F1,K4G2G2,K4G8U6,K4G974,P88812,R9TBJ8,R9TBV7,R9TC35,R9TCE7,R9TCH9,R9TCV3,R9TD10,R9TDD3,R9TFD3,R9TGG7,R9TGM0,S5YT63,T1UDA9,T1UFV4,V5N6W9,V5N770,V5N7H4,V5N7S2,V5N7T7,V5N7T8,V5N800,V5N9B2,V5N9Q5,V9VEA7,X4Y2T5,X4Y2X0,X4Y459,X4YC44,X4YF41,X4YQG7,X4YRX7,X4YS61,X4YSE2,X4YUD1 indirect/unknown TR, Rep S N N N D(10500164) N D(10500164) 27486734.0 Mediates the regulatory switch from transcription to RNA replication. Acts late in infection by inhibiting viral transcription and up-regulating RNA replication (By similarity). Pneumoviridae Human respiratory syncytial virus NS1 1C, Non-structural protein 1, Non-structural protein 1C P0DOE9 NS1_HRSVA A0A023RAP1,A0A023RAP2,A0A059TDA4,A0A059TE30,A0A059TEA8,A0A059TEC6,A0A076FRG5,A0A076FRP0,A0A076FRZ6,A0A088S969,A0A088S9L5,A0A088S9Q0,A0A088SBF8,A0A0A7ESZ7,A0A0A7NQK8,A0A0A7NR06,A0A0A7NTB6,A0A0A7NW88,A0A0C5CHB8,A0A0E3JFY9,A0A0E3JJF0,A0A0N7AZB8,A0A0N7AZU8,A0A0N7AZW5,A0A0N7B004,A0A0X8CUX3,A0A0X8CV39,A0A0X8CV54,A0A0X8CVU3,A0A0X8D1H5,A0A0X9WFH4,A0A0X9WJP4,A0A0X9WNC3,A0A0X9YMG0,A0A109Q8Y4,A0A109QEZ3,A0A109QF81,A0A109QF99,A0A142MN86,A0A142MNL6,A0A142MR26,A0A142MR29,A0A142MS90,A0A142MSN6,A0A142MSP0,A0A142MTA9,A0A1B2VR66,A0A1B2VR76,A0A1B2VRC9,A0A1B2VRD0,A0A1B2VRG3,A0A1B2VRG9,A0A1B2VRK3,A0A1B2VRP7,A0A1B2VRQ7,A0A1B2VRV1,A0A1B2VRX1,A0A1B2VS19,A0A1B2VS39,A0A1B2VS48,A0A1B2VS52,A0A1B2VS65,A0A1B2VS80,A0A1B2VS84,A0A1B2VSA0,A0A1B2VSE3,A0A1B2VSH6,A0A1B2VSI1,A0A1B2VSM9,A0A1B2VST7,A0A1B2VSV0,A0A1B2VSV5,A0A1B2VSY0,A0A1B2VSY7,A0A1B2VT51,A0A1B2VT63,A0A1B2VT69,A0A1B2VT83,A0A1B2VT94,A0A1B2VT96,A0A1B2VTB8,A0A1B2VTC1,A0A1B2VTC4,A0A1B2VTD8,A0A1B2VTF8,A0A1B2VTG3,A0A1B2VTG4,A0A1B2VTK9,A0A1B2VTL3,A0A1B2VTM8,A0A1B2VTN0,A0A1B2VTN8,A0A1B2VTP7,A0A1B2VTQ3,A0A1B2VTS2,A0A1B2VTS4,A0A1B2VTT3,A0A1B2VTT4,A0A1B2VTV5,A0A1B2VTV9,A0A1B2VTW6,A0A1B2VU02,A0A1B2VU38,A0A1B2VU48,A0A1B2VU55,A0A1B2VU65,A0A1B2VU70,A0A1B2VU78,A0A1B2VU81,A0A1B2VU82,A0A1B2VU88,A0A1B2VU95,A0A1B2VUA4,A0A1B2VUE3,A0A1B2VUG6,A0A1B2VUJ1,A0A1B2VUJ9,A0A1B2VUK4,A0A1B2VUK6,A0A1B2VUL5,A0A1B2VUL7,A0A1B2VUM0,A0A1B2VUM4,A0A1B2VUN6,A0A1B2VUQ1,A0A1B2VUR4,A0A1B2VUS0,A0A1B2VUT2,A0A1B2VUW2,A0A1B2VUY0,A0A1B2VUZ1,A0A1B2VV04,A0A1B2VV13,A0A1B2VV32,A0A1B2VV64,A0A1C9V0V3,A0A1C9V0X8,A0A1C9V1C9,A0A1C9V1K2,A0A1C9V1N8,A0A1C9V3D2,A0A1C9V3K7,A0A1P8L3N0,A0A1P8L3T5,A0A219V0C0,A0A219V0N1,A0A219V114,A0A219V1P3,A0A220QKI1,A0A240ESZ3,A0A2H4WKM9,A0A2H4WKW4,A0A2H4WKZ0,A0A2H4WLA5,A0A2H4WLL9,A0A2H5BXT7,A0A348FUV5,A0A348FUY8,A0A384ZCX6,A0A384ZD04,A0A384ZD36,A0A384ZDB2,A0A384ZDB3,A0A384ZDI4,A0A384ZDK9,A0A384ZDY9,A0A384ZE34,A0A384ZE47,A0A384ZE63,A0A384ZE76,A0A384ZE81,A0A384ZER9,A0A384ZET1,A0A384ZEV2,A0A384ZEY9,A0A384ZF13,A0A384ZFF8,A0A384ZFM4,A0A384ZFU1,A0A384ZFW2,A0A384ZFX9,A0A384ZFY9,A0A384ZG16,A0A384ZG51,A0A384ZG82,A0A384ZGC2,A0A384ZGG9,A0A384ZGI6,A0A384ZGK2,A0A384ZGW1,A0A384ZGW2,A0A384ZH11,A0A384ZH71,A0A384ZHA1,A0A384ZHF7,A0A384ZHH1,A0A384ZHK6,A0A384ZHS5,A0A384ZHT3,A0A384ZHT8,A0A384ZI47,A0A384ZID6,A0A384ZJ47,D8L6X1,E0WLV8,E0WLW0,E0WLW8,E0WLX4,E0WLX8,E0WLZ0,E0WLZ2,E0WLZ6,E0WM00,E0WM08,E0WM12,E0WM16,E0WM18,E0WM26,E0WMQ1,G3C7U4,G8EIQ4,G8EIV8,I1V245,I6TFE5,K4G252,K4G274,K4G2M9,K4G8K1,K7QLZ3,K7QM45,K7QM88,K7QM91,K7QMA9,K7QMD7,K7QME5,K7QMZ2,K7QMZ6,O09716,O42083,P04544,P0DOE8,P24568,Q4KRX1,Q86306,R9TBY3,R9TCN8,R9TGK0,S5Z6Q7,V5N7F0,V5N7L4,V5N7V2,V5NA43,W8E1P4,X4Y4C8,X4YC42,X4YC71,X4YRG2,X4YSB5,X4YSJ2 indirect/unknown TR, Rep, Other S N D(unpublished) N D(28665409, 15827150, 30558248) N D(9445048) 27486734.0 Plays a major role in antagonizing the type I IFN-mediated antiviral response. Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF-3. Interacts with host MAVS and prevents the interaction with its upstream partner DDX58/RIG-I in the signaling pathway leading to interferon production. Mediates the proteasomal degradation of host STAT2 with elongin-cullin E3 ligase. Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth. Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication. Pneumoviridae Human respiratory syncytial virus NS2 1B, Non-structural protein 1B, Non-structural protein 2, Non-structural protein 2,Non-structural protein 1B P04543 NS2_HRSVA A0A023R830,A0A023R8E9,A0A023R8N9,A0A023R9I4,A0A023RA27,A0A023RA93,A0A059TE26,A0A059TE72,A0A059TEA2,A0A059TEF4,A0A060AG29,A0A060AHX0,A0A075D1R7,A0A075D1S8,A0A088S9K5,A0A088S9P1,A0A088SBF0,A0A088STT8,A0A0A7EB38,A0A0A7NQS6,A0A0A7NRK6,A0A0A7NRZ4,A0A0A7NT36,A0A0A7NTS5,A0A0A7NVS6,A0A0A7NVZ7,A0A0B5HHW4,A0A0B5HI09,A0A0B5HKC4,A0A0B5HPI0,A0A0E3GJT7,A0A0E3JJF2,A0A0E3LZC5,A0A0K0WTK1,A0A0N7ATI3,A0A0N7AUF0,A0A0X8CV14,A0A0X8CVP7,A0A0X8CVW4,A0A0X8CW71,A0A0X8D1A1,A0A0X9Y758,A0A0X9YM76,A0A109QA27,A0A109QF01,A0A120HQ64,A0A142MLQ4,A0A142MM12,A0A142MMA4,A0A142MNY1,A0A142MP94,A0A142MPB2,A0A142MQH2,A0A142MR38,A0A142MRB4,A0A142MRN0,A0A142MS94,A0A142MTJ5,A0A1B2VSE2,A0A1B2VUP9,A0A1B2VUS2,A0A1B2VV91,A0A1C9V187,A0A1C9V2R9,A0A1C9V385,A0A1C9V3K1,A0A1C9V3N0,A0A1P8L309,A0A1P8L388,A0A1P8L3F9,A0A1P8L3L5,A0A1V0BZ80,A0A1V0E2A8,A0A1Y0AVJ4,A0A219V0E0,A0A219V0P6,A0A219V1E6,A0A240ESZ4,A0A240ET33,A0A249Y6G1,A0A2H4N9A4,A0A2H4WKV6,A0A2H4WL58,A0A2H4WLD3,A0A2H4WLG6,A0A2H4WLM7,A0A2H4WLM8,A0A2H4WLW6,A0A2Z4Z441,A0A348FV22,A0A384ZEI2,A0A384ZEK3,A0A384ZFR9,A0A384ZG84,A0A384ZG97,A0A384ZH23,A0A384ZH48,A0A384ZHN3,A0A384ZHU2,A0A384ZHU8,A0A384ZIH2,A0A385ML73,A0A385ML91,A0A385MLX3,A0A385MMB0,A0A385MMC9,A0A385MN52,A0A385MN71,A0A385MNF0,A0A385MNM0,A0A385MNX2,A0A385MNZ9,A0A385MPD5,A0A386BXW1,A0A3G3NDU9,A0A3G3NFT1,A0A3G3NG18,A0A3Q8TDK8,A0A3Q8TEI7,C3UPA8,D8L6X2,E0WLV9,E0WLW5,E0WLW9,E0WLX5,E0WLY9,E0WLZ3,E0WLZ5,E0WM19,E0WM23,E0WMQ2,G8EIX0,G8FR15,G8FR70,I6TQX1,I6UJV8,K4G1V7,K4G272,K4G2D4,K4G905,K7QMY7,K7QMZ9,K7QN21,O12405,O42038,P24569,Q6V2F3,Q76TL1,Q86305,R9TCM6,R9TD28,R9TDF4,R9TF62,R9TFF7,R9TG22,V5N745,V5N794,V5N7E8,V5N7K8,V5N7Q9,V5N7U5,V5N858,V5N9I0,V5NA34,W8E0C3,X4Y3J0,X4Y5K9,X4Y5Y6,X4Y9H0,X4YCW8,X4YF64,X4YQI8,X4YQW8,X4YS53,X4YUK4,X5FNU1,X5FP42,X5FP72,X5FQ06,X5FQ21,X5FQ89,X5FQN9,X5FQS3 indirect/unknown TR, Other S N N N D(19193793, 15827150) N D(19193793) 27486734.0 Plays a major role in antagonizing the type I IFN-mediated antiviral response. Acts cooperatively with NS1 to repress activation and nuclear translocation of host IFN-regulatory factor IRF-3. Interacts with the host cytoplasmic sensor of viral nucleic acids DDX58/RIG-I and prevents the interaction with its downstream partner MAVS. Mediates the proteasomal degradation of host STAT2 with Elongin-Cullin E3 ligase. Induces activation of NF-kappa-B. Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth. May also inhibit viral transcription and RNA replication. Pneumoviridae Human respiratory syncytial virus Phosphoprotein P, Protein P P03421 PHOSP_HRSVA A0A023R796,A0A023R931,A0A023R9H0,A0A023R9X3,A0A023RAW9,A0A023RB54,A0A059TD78,A0A059TDA9,A0A059TDC0,A0A059TDF6,A0A059TDK1,A0A059TDN4,A0A059TDP5,A0A059TDU4,A0A059TDW6,A0A059TDX7,A0A059TEE1,A0A059TEG5,A0A0A7NRI4,A0A0A7NTQ9,A0A0B5H8J4,A0A0B5HBQ7,A0A0B5HBR0,A0A0B5HBW0,A0A0B5HP07,A0A0B5HPA9,A0A0B5HPC5,A0A0B5HPR7,A0A0K0WTK9,A0A0N7ATJ7,A0A0N7ATT1,A0A0N7ATY2,A0A0N7AUS2,A0A0N7AV14,A0A0N7AZ16,A0A0N7AZE2,A0A0N7AZH2,A0A0N7AZI8,A0A0N7B002,A0A0X8CUQ8,A0A0X8CUV1,A0A0X8CV22,A0A0X8CW06,A0A0X8CX11,A0A0X9WMU9,A0A0X9WYK0,A0A0X9XGP1,A0A0X9XZG1,A0A0X9YMD9,A0A120HQ68,A0A120HQ74,A0A120HQF5,A0A120HQJ1,A0A120HQQ2,A0A140H334,A0A140H3G6,A0A140H3I8,A0A142MLZ0,A0A142MML1,A0A142MMQ9,A0A142MNC8,A0A142MNP1,A0A142MNY4,A0A142MPT4,A0A142MQK9,A0A142MR33,A0A142MRC6,A0A142MT43,A0A142MTU1,A0A1B2VSC7,A0A1B2VSP3,A0A1B2VSX6,A0A1B2VTC9,A0A1B2VTP2,A0A1B2VU10,A0A1B2VUZ0,A0A1C9V167,A0A1C9V175,A0A1C9V195,A0A1C9V1K3,A0A1C9V1M4,A0A1C9V2B2,A0A1C9V2G9,A0A1C9V2R8,A0A1C9V340,A0A1C9V367,A0A1C9V3B2,A0A1C9V3K6,A0A1C9V3Q0,A0A1P8J9Y5,A0A1V0G3P6,A0A1V0G3R8,A0A1V0G425,A0A1W6LX83,A0A1Y0AUC6,A0A1Y0AUD1,A0A1Y0AUU0,A0A1Y0AUW1,A0A1Y0AV62,A0A1Y0AVH6,A0A219V0G5,A0A219V0Y7,A0A219V1D0,A0A219V1P9,A0A240ESU6,A0A240ET35,A0A249Y6F2,A0A249Y6G5,A0A2H4N9D3,A0A2H4WKC9,A0A2H4WKS8,A0A2H4WKT4,A0A2H4WL41,A0A2H4WL85,A0A2H4WLA8,A0A2H4WLL5,A0A2H4WLQ9,A0A2H4WLR2,A0A2H4WLX1,A0A2H5BXX0,A0A2U9NKX0,A0A2Z4Z422,A0A344X9A1,A0A344X9D4,A0A348FV24,A0A384ZCY9,A0A384ZFT9,A0A384ZGS7,A0A384ZGZ3,A0A384ZH06,A0A384ZHN0,A0A384ZHV3,A0A384ZI22,A0A384ZIF5,A0A384ZII8,A0A384ZIU7,A0A385MKH7,A0A385MKI8,A0A385MKL1,A0A385MKU3,A0A385ML22,A0A385ML33,A0A385MLR4,A0A385MLT1,A0A385MM07,A0A385MM18,A0A385MMB4,A0A385MMP1,A0A385MMT6,A0A385MN26,A0A385MN46,A0A385MNI7,A0A385MNN3,A0A385MNW5,A0A385MPH8,A0A385MPW8,A0A3G3NDI3,A0A3G3NE50,A0A3G3NEL4,A0A3G3NFT0,A0A3G3NGN2,A0A3G3NH86,A0A3G3NHD3,A0A3Q8TBM7,G3C7R7,G8EIC5,G8EIJ1,G8EIL3,G8EIM4,G8EIR7,G8EIT9,G8EIV0,G8EIW1,I1V237,I6TFI2,O09633,O09717,O42062,P12579,P14156,P24567,Q04161,Q4KRW8,Q8UYD5,Q8V218,Q8V219,Q8V221,R9TG31,V5N740,V5N775,V5N7N3,V5N7N6,V5N7S5,V5N8A3,W8E4V8,X4Y3M5,X4Y679,X4YAF6,X4YBX5,X4YCE3,X4YCJ5,X4YCP4,X4YCT2,X4YD07,X4YD13,X4YF46,X4YQU8,X4YS93,X4YSD4,X4YSL4 indirect/unknown TR, Rep S N N N D(7491765) N N 27486734.0 Acts as a cofactor that serves both to stabilize the protein L and to place the polymerase complex on the N:RNA template. Polyomaviridae BK polyomavirus Agnoprotein Agno P14998 AGNO_POVBA A0A0G4CPA0,A0A1Q1MRD3,A0A223ZI77,A0A2H4Z6N5,A1IHW3,A1IHY7,A1IHZ9,A1II17,A1II41,A1II47,A1II83,A7BGR0,A7BH00,A7BH12,B6EXG3,B6VQB6,B9X1T9,B9X1V1,B9X1V7,B9X1W3,Q0PCM8,Q0PCN9,Q0PDF1,Q0PDG9,Q1ESU1,Q1ESU7,Q2PRN3,Q2WG17,Q65614,Q6GWH9,Q6GWN3,Q6GWQ7,Q89856 dsDNA TR, DR, Rep S N N N I(11152520) I(22840425) I(6262654) 27381292.0 Alters the structure of the nuclear envelope by interacting with host CBX5 and disrupting CBX5 association with LBR. Involved in the perinuclear-nuclear localization of the capsid protein VP1 during virion assembly and maturation. Plays an important role in the release of progeny virions from infected cells and in viral propagation, probably by acting as a viral ionic channel in the host plasma membrane. Allows influx of extracellular calcium ions in the host cell. May contribute to viral genome transcription and translation of viral late proteins (By similarity). Polyomaviridae BK polyomavirus Large T antigen LT, LT-AG P03071 LT_POVBK A0A1Q1MQ55,A0A1V0QSU1,A0A1V0QSU6,A0A2H4Z6M7,A0A2H4Z6P1,A7BGN4,P14999,Q068W4,Q0PCN5,Q0PDA5,Q6GWH5,Q6GWI1,Q6GWI7,Q6GWJ9,Q6GWK5,Q6GWL1,Q6GWL7,Q6GWM3,Q6GWN5,Q6GWQ3,U5NGJ3 dsDNA TR, Rep S I(27462916; 15265983; 18642444) N N I(8709258) I(22840425) I(3003386, 168585, 6251241, 202398) 27381292.0 Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA. Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA. Participates in the modulation of cellular gene expression preceeding viral DNA replication. This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53. Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes. Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression. Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters. Initiates viral DNA replication and unwinding via interactions with the viral origin of replication. Binds two adjacent sites in the SV40 origin. The replication fork movement is facilitated by Large T antigen helicase activity. Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization. Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription (By similarity). Polyomaviridae BK polyomavirus Small T antigen Small t antigen, ST, ST-AG P15000 ST_POVBA A0A023SFN7,A0A2H4Z6N1,A0A2H4Z6P9,B2ZRH5,B2ZRI3,B2ZRI5,B2ZRI7,B2ZRJ1,B2ZRK4,B2ZRK6,B2ZRL0,B2ZRL2,B2ZRL6,B2ZRL8,B2ZRM0,B2ZRM2,B2ZRM6,B2ZRM8,B2ZRN0,B2ZRN5,B2ZRN7,B2ZRN9,B2ZRP1,B2ZRP3,B2ZRP7,B2ZRQ3,Q6GWH4,Q6GWI6,Q6GWJ8,Q6GWL0,Q6GWL6,Q6GWN4,Q6GWQ2 indirect/unknown TR, Other S I(19282432) N N I(19282432) I(19282432) I(17158797) 27381292.0 Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture. Polyomaviridae JC polyomavirus Agnoprotein Agno, Agno protein, Agnogene, Agnoprotein (Fragment), Agnoprotein (LP1), Truncated agnoprotein P03086 AGNO_POVJC A0A173G677,A0A1E1FFS4,A0A1E1FFT6,A0A286R3X0,A0A286R3Z6,A0A286R3Z8,A0ZST9,C0SQA6,C0SQF4,C0SQH8,C0SQI4,J9XN85,K7QRQ6,K7QSR0,K7QW67,K7R6U0,O42075,O55863,O55870,O55873,O57296,P88896,P90499,Q4LFQ9,Q4LFW9,Q4W708,Q5YKE2,Q5YKE8,Q5YKP1,Q5YL44,Q679M8,Q679N4,Q679P0,Q69C52,Q6EH30,Q768G9,Q768H5,Q768I1,Q783F8,Q7T3Y5,Q7TDV5,Q82946,Q8AZ44,Q8B0K8,Q8BF42,Q8BF48,Q8BF50,Q8JJJ6,Q8JJJ8,Q8JUC0,Q8JUD7,Q8JWJ0,Q8JWJ1,Q8JWJ2,Q8JWJ6,Q8JWJ7,Q8JZI8,Q8JZJ0,Q8JZJ6,Q8JZJ7,Q8JZJ8,Q8JZJ9,Q8V6G0,Q8V6G2,Q8V6G5,Q8V6H5,Q910S4,Q910S7,Q91C18,Q91C19,Q91DE4,Q91DG4,Q91DH1,Q91DH5,Q91NM9,Q91NN5,Q91NN9,Q91NP8,Q91SI4,Q98Y35,Q993Y6,Q9DH65,Q9DPC8,Q9DUG2,Q9Q1G5,Q9Q1G6,W0LSY0,W6MEN0 dsDNA TR, DR, Rep S N N N D(11152520) D(22840425) I(6262654) 27381292.0 Alters the structure of the nuclear envelope by interacting with host CBX5 and disrupting CBX5 association with LBR. Involved in the perinuclear-nuclear localization of the capsid protein VP1 during virion assembly and maturation. Plays an important role in the release of progeny virions from infected cells and in viral propagation, probably by acting as a viral ionic channel in the host plasma membrane. Allows influx of extracellular calcium ions in the host cell. May contribute to viral genome transcription and translation of viral late proteins. Polyomaviridae JC polyomavirus Large T antigen LT, LT-AG P03072 LT_POVJC A0A0A0RHI4,A0A1E1FFU6,A0A286R3U4,A0A286R403,I0B5Z5,O55871,O55875,P88898,Q0MQN6,Q5YKC6,Q5YKD8,Q5YKL9,Q5YKN1,Q5YKN7,Q679N0,Q679N6,Q69C48,Q69F69,Q6EH26,Q7TDV3,Q7TDV4,Q8JJJ0,Q8JJK3,Q8JUB1,Q8JUB6,Q8JUB9,Q8JUC2,Q8JUC5,Q8JUC9,Q8JUD0,Q8JUD1,Q8JUD5,Q8JUD8,Q8JUE1,Q8JUE2,Q8JWI7,Q8JWJ3,Q8JWJ4,Q8JWJ5,Q8JZJ2,Q8JZK0,Q8V6F7,Q8V6F8,Q8V6G1,Q8V6G3,Q8V6G6,Q8V6G7,Q8V6H1,Q8V6H4,Q910D2,Q91C15,Q91C16,Q91DE5,Q91DE6,Q91DF4,Q91DF5,Q91DF8,Q91DG2,Q91DG3,Q91DH0,Q91DH2,Q91NL2,Q91NL5,Q91NL8,Q91NM2,Q91NM6,Q91NN1,Q91NP7,Q91NP9,Q993Y2,Q993Y4,Q993Y5,Q9DPC0,Q9DPC5,Q9DPC9,Q9DUG5,Q9WM07,Q9WM08,Q9WM10 dsDNA TR, Rep S I(27462916; 15265983; 18642444) N N I(8709258) D(22840425) I(3003386, 168585, 6251241, 202398) 27381292.0 Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA. Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA. Participates in the modulation of cellular gene expression preceeding viral DNA replication. This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53. Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes. Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression. Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters. Initiates viral DNA replication and unwinding via interactions with the viral origin of replication. Binds two adjacent sites in the SV40 origin. The replication fork movement is facilitated by Large T antigen helicase activity. Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization. Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription. Polyomaviridae JC polyomavirus Small T antigen Small t antigen, ST, ST-AG P03083 ST_POVJC A0A286R3T1,A0A385NI07,A0A385NI69,O55876,Q69F68,Q8JUB5,Q8JUC1,Q8JUC8,Q8JUD4,Q8V6H0,Q8V6H3,Q910Q3,Q91DE7,Q91DE9,Q91NL4,Q91NL7,Q91NM7,Q91NN0,Q91NP3,Q9DPB9,Q9DPC4 indirect/unknown TR, Other S D(19282432) N N D(19282432) D(19282432) I(17158797) 27381292.0 Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture. Polyomaviridae KI polyomavirus Large T antigen A6YGN7 A6YGN7_9POLY A6YGP2,A6YGP7,B3FQQ5,P0DOI5,P0DOI6 dsDNA TR, Rep S I(27462916; 15265983; 18642444) N N I(8709258) I(22840425) I(3003386, 168585, 6251241, 202398) 18976572.0 A6YGN7 is inferred from JC polyomavirus protein P03083 ATP binding,DNA replication origin binding,hydrolase activity,DNA replication Polyomaviridae KI polyomavirus Small T antigen Small t antigen, ST, ST-AG P0DOI9 ST_POVK6 P0DOJ0 indirect/unknown TR, Other S I(19282432) N N I(19282432) I(19282432) I(17158797) 18976572.0 Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture. Polyomaviridae Merkel cell polyomavirus Large T antigen Large T antigen LT, Large T antigen protein, LT, T antigen B6DVW7 B6DVW7_9POLY E2IPR7,E2IPR9,E2IPS1,E2IPS3,E2IPS4,E2IPS6,E2IPS7,E2IPS9,E2IPT0,E2IPT2,E2IPT4,K4P1F8,X2G9P4 dsDNA TR, Rep S D(28461484) N N D(28461484) D(25006834) I(3003386, 168585, 6251241, 202398) 23217622.0 ATP binding,DNA replication origin binding,hydrolase activity,DNA replication Polyomaviridae Merkel cell polyomavirus Small T antigen ST, STAg U6C6B2 U6C6B2_9POLY A0A2S1LV38,B0G0V7,B6DVX0,B6DVX6,B6DVY4,B8ZX49,B8ZX51,B8ZX57,C6KKZ9,C6KL03,C6KL05,C6KL07,D6QW80,D6QW84,D6QWD2,G8EHJ4,G8FT05,I0ISA5,T2HFI7,T2HFT7,T2HFZ4,U6C643,U6C665,U6C6W7,U6C7Y2,U6C841,U6C845,X2G6N5 indirect/unknown TR, Other S I(19282432) N N D(24067965; 24109239) I(19282432) I(17158797) 23217622.0 Not annotated Polyomaviridae Simian virus 40 Large T antigen large, LT, LT-AG P03070 LT_SV40 A7XWJ9,A7XWL1,A7XWN5,Q0Z8T6,Q2I7F9,Q6QIR8,Q77PF5,Q8JMI9,Q98ZP7,Q9J7C9,Q9W8G8,Q9WND0 dsDNA TR, Rep S D(27462916; 15265983; 18642444) N 1SVM D(15265983; 18642444) D(14990710; 10438844; 10954561) D(3003386, 168585, 6251241, 202398) 9923853.0 Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA. Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA. Participates in the modulation of cellular gene expression preceeding viral DNA replication. This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53. Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes. Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression. Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters. Initiates viral DNA replication and unwinding via interactions with the viral origin of replication. Binds two adjacent sites in the SV40 origin. The replication fork movement is facilitated by Large T antigen helicase activity. Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization. Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription. May inactivate the growth-suppressing properties of the E3 ubiquitin ligase CUL7. Polyomaviridae Simian virus 40 Small T antigen small, Small t antigen, ST, ST-AG P03081 ST_SV40 Q2I7F8,Q77JR6 indirect/unknown TR, Other S N N 2PF4 D(15684382; 8917510) D(8917510) D(17158797) 9923853.0 Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host eIF4E-binding protein EIF4EBP1 leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture. Polyomaviridae WU polyomavirus Large T antigen LT, LT-AG A5HBG1 LT_POVWU A0A023IX55,A0A0F6PCE1,A0A1Z1RFH7,A0A1Z1RFJ4,A0A1Z1RFK4,A0A1Z1RGY2,A0A2S0DAE5,A0A2S0DAF7,A0A2S0DAG6,A0A2U3T9J1,A0A2U3T9M9,A0A2U3T9Q0,A0A346TQD9,A0A346TQF4,A0A346TQH9,A9YUH2,B3FQR5,B3V7B6,B3V7C1,B3V7C6,C3VQ34,C3VQ36,C3VQ41,C3VQ46,D0F055,D0F075,D0F080,D3XCG4,D3XCH4,D3XCP9,D3XCR4,D3XCT4,D3XCV4,D3XCV9,D3XCY4,D3XD04,D3XD19 dsDNA TR, Rep S I(27462916; 15265983; 18642444) N N I(8709258) I(22840425) I(3003386, 168585, 6251241, 202398) 21994565.0 A5HBG1 is inferred from JC polyomavirus protein P03083 Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA. Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA. Participates in the modulation of cellular gene expression preceeding viral DNA replication. This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53. Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes. Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression. Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters. Initiates viral DNA replication and unwinding via interactions with the viral origin of replication. Binds two adjacent sites in the SV40 origin. The replication fork movement is facilitated by Large T antigen helicase activity. Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization. Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription. Polyomaviridae WU polyomavirus Small T antigen Small t antigen, ST, ST-AG A5HBD7 ST_POVWU A0A023IWX3,A0A0F6PCF2,A0A2U3T9P7,A0A2U3T9T2,A0A346TQI0,A9YUH3,B3V7B7,B3V7C2,B3V7C7,B9VQY3,B9VQY4,C3VQ42,C3VQ47,D0F056,D0F066,D3XCF0,D3XCH0,D3XCL0,D3XCV5,D3XD10,E2FKL4,E2FKL5,E2FKL6,E2FKL7,E2FKL8,E2FKL9,E2FKM0 indirect/unknown TR, Other S I(19282432) N N I(19282432) I(19282432) I(17158797) 21994565.0 Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture. Poxviridae Bovine papular stomatitis virus NPH-1 BVTX09c1_072, Transcription termination factor NPH-I Q6TVB6 Q6TVB6_9POXV A0A0E3XAG7 dsDNA, ssDNA TR P N N N I(8230476) I(9472022) I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) 22362531.0 Inferred from Vaccinia virus NPH-1. Involved in transcription termination (27189950) ATP binding,nucleoside-triphosphatase activity,transcription, DNA-templated Poxviridae Bovine papular stomatitis virus NPH-II BVTX09c1_036, ORF036 RNA helicase NPH-II, RNA helicase NPH-II Q6TVF2 Q6TVF2_9POXV A0A0E3T6Y5 ssDNA, ssRNA TR, TNA, Rep S N N N N I(8505308) I(20110368, 2839505, 4364422) 22362531.0 helicase activity Poxviridae Bovine papular stomatitis virus ORF083 BVTX09c1_083, Early transcription factor VETFL, ORF083 early transcription factor VETFL Q6TVA5 Q6TVA5_9POXV indirect/unknown TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) 22362531.0 positive regulation of transcription, DNA-templated Poxviridae Bovine papular stomatitis virus ORF084 BVTX09c1_084, BVTX09c15_084, BVTX09c5_084, Intermediate transcription factor VITF-3, ORF084 intermediate transcription factor VITF-3 Q6TVA4 Q6TVA4_9POXV indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 22362531.0 Not annotated Poxviridae Bovine papular stomatitis virus Phosphoprotein BVTX09c1_032, DNA-binding phosphoprotein, ORF032 DNA-binding phosphoprotein, Putative DNA binding phosphoprotein V5LTE9 V5LTE9_9POXV A0A0E3XBH8,Q6TVF6,V5LUD0 ssDNA TR, Rep S N N N N I(9525612) N 22362531.0 V5LTE9 is inferred from Orf virus protein Q6TVT8. Ligand is based on prediction domains. single-stranded DNA binding Poxviridae Bovine papular stomatitis virus RAP94 BVTX09c15_060, ORF060 RNA polymerase-associated protein RAP94, RNA polymerase-associated protein RAP94 Q6TVC8 Q6TVC8_9POXV A0A0E3XBV7 ssRNA TR P N N N I(1565650) N I(11279216, 18455214, 8125977) 22362531.0 Q6TVC8 is inferred from Molluscum contagiosum virus protein Q98252 DNA-binding transcription factor activity Poxviridae Bovine papular stomatitis virus VETFs BVTX09c15_069, ORF069 early transcription factor VETFs Q6TVB9 Q6TVB9_9POXV A0A0E3XAS4 dsDNA TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) 22362531.0 integral component of membrane Poxviridae Bovine papular stomatitis virus VITF-3 BVTX09c1_100, Intermediate transcription factor VITF-3, ORF100 intermediate transcription factor VITF-3 Q6TV88 Q6TV88_9POXV indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 22362531.0 Not annotated Poxviridae Bovine papular stomatitis virus VLTF-1 BVTX09c15_045, Late transcription factor VLTF-1, ORF045 late transcription factor VLTF-1 Q6TVE3 Q6TVE3_9POXV indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) 22362531.0 regulation of transcription, DNA-templated Poxviridae Bovine papular stomatitis virus VLTF-2 BVTX09c1_076, BVTX09c15_076, BVTX09c5_076, Late transcription factor VLTF-2, ORF076 late transcription factor VLTF-2 Q6TVB2 Q6TVB2_9POXV dsDNA TR P N N N I(8371339) I(9445047) I(8371339) 22362531.0 zinc ion binding Poxviridae Bovine papular stomatitis virus VLTF-3 BVTX09c1_077, BVTX09c15_077, BVTX09c5_077, Late transcription factor VLTF-3, ORF077 late transcription factor VLTF-3 Q6TVB1 Q6TVB1_9POXV indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) 22362531.0 regulation of viral transcription Poxviridae Bovine papular stomatitis virus VLTF-4 BVTX09c15_061, ORF061 late transcription factor VLTF-4 Q6TVC7 Q6TVC7_9POXV A0A0E3XAB9 indirect/unknown TR P N N N N N I(8794318, Transcription Assay) 22362531.0 viral envelope Poxviridae Bovine papular stomatitis virus VP8 DNA-binding virion core protein VP8, ORF050 DNA-binding virion core protein VP8 Q6TVD8 Q6TVD8_9POXV A0A0E3XAB6 dsDNA, ssDNA, ssRNA, dsRNA NAP, TR S N N N N I(9321647) I(3201752, 9321647) 22362531.0 Q6TVD8 is inferred from Orf virus protein Q6TVS0 DNA binding,structural molecule activity,viral capsid Poxviridae Cowpox virus ATPase CPXV128, CPXV128 protein, CPXV_GER91_3_120, CPXV_UK2000_K2984_121, E11L, Nucleoside triphosphate phosphohydrolase-I Q0NPW0 Q0NPW0_COWPX A0A1X9T706,A0A212PN19,A0A212PXC4,A0A212Q0S7,A0A212QBP3,A0A212QF28,A0A290GQC0,A0A2R8F699,A0A2R8F8J3,G0XSL1,G0XX58,G0XXS0,Q80DX1,Q8QMV1,U5TA95,U5TH94,U5TL23 dsDNA, ssDNA TR P N N N I(8230476) N I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) Fields Virology Q0NPW0 is inferred from Bovine papular stomatitis virus protein Q6TVB6. Involved in transcription termination (27189950). ATP binding,nucleoside-triphosphatase activity,transcription, DNA-templated Poxviridae Cowpox virus CPXV082 CPXV082 CDS, CPXV082 protein, CPXV_FIN2000_MAN_077, CPXV_GER1990_2_077, CPXV_GER1998_2_077, L3L, SsDNA-binding phosphoprotein Q8QMY7 Q8QMY7_COWPX A0A1B5FLL2,A0A1X9T8A7,A0A1X9T9H7,A0A212PNL9,A0A212PWW6,A0A212Q1T2,A0A212Q3S3,A0A212QAR0,A0A290G6V1,A0A2R8F5R8,A0A3Q9TCS7,G0XSG7,G0XTD2,G0XTZ5,G0XUL0,G0XV73,G0XVT9,G0XWF3,G0XX14,G0XXM6,Q0NQ03,Q76QK8,U5T9P9,U5TAE0,U5TB25 ssDNA TR, Rep S N N N N I(9525612) N Fields Virology Q8QMY7 is inferred from Orf virus protein Q6TVT8 single-stranded DNA binding Poxviridae Cowpox virus CPXV156 CPXV156 protein, VITF3L Q8QMT0 Q8QMT0_COWPX A0A0K2YY52,A0A1X9T7M3,A0A212PR33,G0XUT1,G0XWM4 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) Fields Virology Not annotated Poxviridae Cowpox virus NPH-II CPXV_FRA2001_NANCY_082, DExH-NPH-II, L8R, RNA-helicase G0XU00 G0XU00_COWPX A0A1S5WL07,G0XSH2,G0XTD7,G0XV78,G0XVU4,G0XWF8,G0XX19,G0XXN1,Q0NPZ8 ssDNA, ssRNA TR, TNA, Rep S N N N N I(8505308) I(20110368, 2839505, 4364422) Fields Virology ATP binding,helicase activity,nucleic acid binding Poxviridae Cowpox virus RAP94 CPXV113, CPXV113 protein, CPXV_GER1990_2_107, CPXV_GER91_3_106, CPXV_NOR1994_MAN_107, J4L protein, RNA polymerase subunit RAP94 Q0NPX4 Q0NPX4_COWPX A0A1B5FLM3,A0A1S5WL33,A0A1V0FXA5,A0A1X9T7J1,A0A1X9TAC4,A0A1X9TB56,A0A212PQT9,A0A212PTE6,A0A212PU56,A0A212PWW4,A0A212Q3P6,A0A290G4Y9,A0A290G7N2,G0XSJ7,G0XTG2,G0XU25,G0XUP0,G0XVW9,G0XWI3,G0XXQ6,Q80DY0,Q8QMW3,U5TA80,U5TDQ9,U5TK54,U5TPC8 ssRNA TR P N N N I(1565650) N I(11279216, 18455214, 8125977) Fields Virology Q0NPX4 is inferred from Molluscum contagiosum virus protein Q98252 DNA-binding transcription factor activity Poxviridae Cowpox virus VETFL 82kDa large subunit of early gene transcription factor VETF, A8L, A8L protein, CPX139, CPXV139, CPXV139 protein, CPXV_GER91_3_130, CPXV_NOR1994_MAN_131, Early gene transcription factor VETF 82 kDa large subunit, Early gene transcription factor VETF 82kDa large subunit Q0NPV0 Q0NPV0_COWPX A0A1X9T7I9,A0A212PNT3,A0A212PPV0,A0A212Q0X2,A0A212Q246,A0A212Q430,A0A290GA76,A0A290GLX5,A0A2R8F5T9,A0A3Q9TBA2,G0XSM1,G0XU49,G0XUR4,G0XVC7,G0XVZ3,G0XWK7,G0XX68,Q80DW4,Q8QMU3,U5TA85,U5TD88,U5TG43,U5TGS1 dsDNA TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) Fields Virology Q0NPV0 is inferred from Bovine papular stomatitis virus protein Q6TVA5 positive regulation of transcription, DNA-templated Poxviridae Cowpox virus VETFs 70 kDa VETF transcription factor small subunit, 70kDa small subunit of early transcription initiation factor VETF, CPXV123, CPXV123 protein, CPXV_FIN2000_MAN_116, E6R, E6R protein, Early gene transcription factor VETF 70 kDa small subunit, Early gene transcription factor VETF 70kDa small subunit Q76QJ5 Q76QJ5_COWPX A0A212PQ86,A0A212Q0R7,A0A212Q433,A0A2R8F8M7,G0XSK6,G0XU34,G0XVB2,G0XVX8,G0XWJ2,Q0NPW5,Q8QMV4,U5T9K9,U5TAT0,U5TC84 dsDNA TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) Fields Virology Q76QJ5 is inferred from Bovine papular stomatitis virus protein Q6TVB9 ATP binding,DNA binding,hydrolase activity,integral component of membrane Poxviridae Cowpox virus VITF-3 32 kDa small subunit of transcription factor VITF-3, A9R, A9R protein, CPXV140 protein, Transcription factor VITF-3 32 kDa small subunit A0A0K2YTA9 A0A0K2YTA9_COWPX indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) Fields Virology Not annotated Poxviridae Cowpox virus VLTF-1 CPXV097 protein, H9R, Late gene transcription factor VLTF-1 protein Q76QK3 Q76QK3_COWPX G0XUM4 indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) Fields Virology Q76QK3 is inferred from Orf virus protein Q6TVS5 regulation of transcription, DNA-templated,integral component of membrane Poxviridae Cowpox virus VLTF-2 A1L protein, CPXV132, CPXV132 protein, Late gene transcription factor VLTF-2 protein Q0NPV7 Q0NPV7_COWPX G0XTH9,G0XVY6,G0XWK0,Q80DW9 dsDNA TR P N N N I(8371339) I(9445047) I(8371339) Fields Virology Q0NPV7 is inferred from Molluscum contagiosum virus protein Q98270 zinc ion binding Poxviridae Cowpox virus VLTF-3 A2L protein, CPXV133, CPXV133 protein, Late gene transcription factor VLTF-3 protein Q76QJ1 Q76QJ1_COWPX Q8QMU8 indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) Fields Virology Q76QJ1 is inferred from Molluscum contagiosum virus protein Q98271 regulation of viral transcription Poxviridae Cowpox virus VLTF-4 CPXV114, CPXV114 protein, CPXV_GER91_3_107, J5R, J5R protein, Morphogenesis-related substrate of B1R kinase, Substrate of B1R kinase, VLTF-4 viral late transcription factor Q0NPX3 Q0NPX3_COWPX A0A1B5FLM5,A0A1S5WL30,A0A1X9T7T5,A0A1X9T8H8,A0A212PNP9,A0A212PQU1,A0A212Q403,A0A212QEI9,A0A212RA96,G0XSJ8,G0XTG3,G0XU26,G0XUP1,G0XVA4,G0XVX0,G0XWI4,G0XX45,G0XXQ7,Q80DX9,Q8QMW2,U5TDR6,U5TJX5,U5TK75 indirect/unknown TR P N N N N N I(8794318, Transcription Assay) Fields Virology Q0NPX3 is inferred from Vaccinia virus protein Q76RC5 viral envelope Poxviridae Cowpox virus VP8 Core protein vp8, CPXV102, CPXV102 protein, CPXV_GER1980_EP4_096 G0XUM9 G0XUM9_COWPX G0XVV8,G0XX33,Q8QMX2 dsDNA, ssDNA, ssRNA, dsRNA NAP, TR S N N N N I(9321647) I(3201752, 9321647) Fields Virology G0XUM9 is inferred from Orf virus protein Q6TVS0 structural molecule activity,viral capsid Poxviridae Molluscum contagiosum virus MC046L MC046 Q98214 Q98214_MCV1 A0A3Q9NMU6 ssDNA TR, Rep S N N N N I(9525612) N 24558417.0 Q98214 is inferred from Orf virus protein Q6TVT8 single-stranded DNA binding Poxviridae Molluscum contagiosum virus MC067R Q98235 Q98235_MCV1 indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) 24558417.0 Q98235 is inferred from Orf virus protein Q6TVS5 regulation of transcription, DNA-templated Poxviridae Molluscum contagiosum virus MC073R CX4 protein Q98241 Q98241_MCV1 indirect/unknown NAP, TR S N N N N I(9321647) I(3201752, 9321647) 24558417.0 Q98241 is inferred from Orf virus protein Q6TVS0 structural molecule activity,viral capsid Poxviridae Molluscum contagiosum virus MC085L MC085 Q98252 Q98252_MCV1 A0A3Q9NM16 ssRNA TR P N N N I(1565650) N I(11279216, 18455214, 8125977) 24558417.0 Has a RAP94 domain DNA-binding transcription factor activity Poxviridae Molluscum contagiosum virus MC103L MC103 Q98270 Q98270_MCV1 indirect/unknown TR P N N N I(8371339) I(9445047) I(8371339) 24558417.0 Has a VLTF2 domain zinc ion binding Poxviridae Molluscum contagiosum virus MC104L MC104 Q98271 Q98271_MCV1 indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) 24558417.0 Has a VLTF3 domain regulation of viral transcription Poxviridae Molluscum contagiosum virus MC111R MC111 Q98278 Q98278_MCV1 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 24558417.0 Q98278 is inferred from Cowpox virus protein A0A0K2YTA9 Not annotated Poxviridae Molluscum contagiosum virus MC128R MC128 Q98295 Q98295_MCV1 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 24558417.0 Q98295 is inferred from Bovine papular stomatitis virus protein Q6TV88 Not annotated Poxviridae Molluscum contagiosum virus NPH-1 NPH1, Nucleoside triphosphatase I, Nucleoside triphosphate phosphohydrolase I Q98267 NTP1_MCV1 dsDNA, ssDNA TR P N N N I(8230476) I(9472022) I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) 24558417.0 Q98267 is inferred from Bovine papular stomatitis virus protein Q6TVB6. Involved in transcription termination (27189950). DNA-dependent ATPase required for providing the needed energy to achieve the termination of early transcripts. Acts in concert with the RAP94 subunit of the virion RNA polymerase and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex. NPH-I must bind ssDNA in order to exhibit ATPase activity (By similarity). Poxviridae Molluscum contagiosum virus NPH-II NPH2, NTPase II, Nucleoside triphosphatase II, RNA helicase NPH-II Q98218 NPH2_MCV1 ssDNA, ssRNA TR, TNA, Rep S N N N N I(8505308) I(20110368, 2839505, 4364422) 24558417.0 NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs and plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm. Required for replication and propagation of viral particles (By similarity). Poxviridae Molluscum contagiosum virus VETFL Early transcription factor 82 kDa subunit, ETF large subunit, MC110L Q98277 ETF2_MCV1 dsDNA TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) 24558417.0 Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa (RAP94) to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters (By similarity). Poxviridae Molluscum contagiosum virus VETFs ATP-dependent helicase VETFS, Early transcription factor 70 kDa subunit, Early transcription factor 70 kDa subunit , ETF small subunit, MC095R Q98262 ETF1_MCV1 dsDNA TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) 24558417.0 Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa (RAP94) to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters (By similarity). Poxviridae Monkeypox virus A9R 32 kDa small subunit of transcription factor VITF-3, 32kDa small subunit of transcription factor VITF-3 used for intermediate gene expression, Transcription factor VITF-3 32 kDa small subunit, VITF-3 34kDa subunit Q3I8P5 Q3I8P5_MONPV F1DJH2,Q3I7J8,Q5IXQ6,Q8V4W7,V9NQ18 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 29927927.0 Poxviridae Monkeypox virus E11L ATPase, Bifunctional ATPase/nucleoside triphosphate phosphohydrolase-I, NPH1 Q3I8Q6 Q3I8Q6_MONPV A0A0F6N8U0,Q5IXR7 dsDNA, ssDNA TR P N N N I(8230476) N I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) 29927927.0 Q3I8Q6 is inferred from Bovine papular stomatitis virus protein Q6TVB6. Involved in transcription termination (27189950). ATP binding,nucleoside-triphosphatase activity,transcription, DNA-templated Poxviridae Monkeypox virus I3L DNA-binding phosphoprotein, SsDNA-binding phosphoprotein Q8V516 Q8V516_MONPV F1DJB7,Q3I8V0,Q5IXW1 ssDNA TR, Rep S N N N N I(9525612) N 29927927.0 Q8V516 is inferred from Orf virus protein Q6TVT8 single-stranded DNA binding Poxviridae Monkeypox virus I8R Bifunctional DNA-RNA-helicase-DExH-NPH-II, DExH-NPH-II, RNA helicase NPH-II, RNA-helicase Q3I8U5 Q3I8U5_MONPV Q8V511 dsDNA, ssRNA TR, TNA, Rep S N N N N I(8505308) I(20110368) 29927927.0 helicase activity Poxviridae Monkeypox virus RAP94 H4L, MPXV-COP-088, MPXV_USA2003_039_099 Q3I8S0 Q3I8S0_MONPV Q3I7M3,Q5IXT1,Q8V4Z1 ssRNA TR P N N N I(1565650) N I(11279216, 18455214, 8125977) 29927927.0 Q3I8S0 is inferred from Molluscum contagiosum virus protein Q98252 DNA-binding transcription factor activity Poxviridae Monkeypox virus VETFL 82 kDa large subunit of early gene transcription factor VETF, A8L, Early gene transcription factor VETF 82 kDa large subunit, VETF-L (Early transcription factor large) Q3I8P6 Q3I8P6_MONPV Q5IXQ7,Q8V4W8 dsDNA TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) 29927927.0 Q3I8P6 is inferred from Bovine papular stomatitis virus protein Q6TVA5 positive regulation of transcription, DNA-templated Poxviridae Monkeypox virus VETFs 70 kDa small subunit of early gene transcription factor VETF, E6R, Morphogenesis, MPXV-COP-097, MPXV-SL-097, MPXV-WRAIR097, VETF2, VETF-s (Early transcription factor small) Q5IXS2 Q5IXS2_MONPV F1DIW0,Q3I8R1 dsDNA TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) 29927927.0 Q5IXS2 is inferred from Bovine papular stomatitis virus protein Q6TVB9 ATP binding,DNA binding,hydrolase activity,integral component of membrane Poxviridae Monkeypox virus VITF3L A24R, Intermediate transcription factor 3 large subunit, VITF-3 45 kDa subunit Q8V4V4 VTF3L_MONPV indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 29927927.0 Acts with RNA polymerase to initiate transcription from intermediate gene promoters. Poxviridae Monkeypox virus VLTF-1 G9R, Late gene transcription VLTF-1, Late transcription factor VLTF-1, MPXV-COP-072, MPXV-SL-072, MPXV-WRAIR072 Q5IXU7 Q5IXU7_MONPV F1DJD1,Q77HN3 indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) 29927927.0 Q5IXU7 is inferred from Orf virus protein Q6TVS5 regulation of transcription, DNA-templated,integral component of membrane Poxviridae Monkeypox virus VLTF-2 A1L, Late gene transcription factor VLTF-2, Late transcription factor VLTF-2, MPXV-COP-105, MPXV-SL-105, MPXV-WRAIR105, Viral late gene transcription factor 2 Q5IXR4 Q5IXR4_MONPV Q77HM9 dsDNA TR P N N N I(8371339) I(9445047) I(8371339) 29927927.0 Q5IXR4 is inferred from Molluscum contagiosum virus protein Q98270 zinc ion binding Poxviridae Monkeypox virus VLTF-3 A2L, Late gene transcription factor VLTF-3, Late transcription factor VLTF-3, MPXV-COP-106, MPXV-SL-106, MPXV-WRAIR106, Viral late gene transcription factor 3 Q5IXR3 Q5IXR3_MONPV Q3I8Q2,Q8V4X4 indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) 29927927.0 Q5IXR3 is inferred from Molluscum contagiosum virus protein Q98271 regulation of viral transcription Poxviridae Monkeypox virus VLTF-4 H5R, Late gene transcription factor VLTF-4, Late transcription factor VLTF-4, MPXV-COP-089, MPXV-SL-089, MPXV-WRAIR089 Q5IXT0 Q5IXT0_MONPV F1DIV2,F1DJE8,Q3I8R9 indirect/unknown TR P N N N N N I(8794318, Transcription Assay) 29927927.0 Q5IXT0 is inferred from Vaccinia virus protein Q76RC5 viral envelope Poxviridae Monkeypox virus VP8 Core protein vp8, DNA-binding virion core protein, L4R, M4R, MPXV-COP-077, MPXV-SL-077, MPXV-WRAIR077 Q5IXU2 Q5IXU2_MONPV Q8V4Z9 dsDNA, ssDNA, ssRNA, dsRNA NAP, TR S N N N N I(9321647) I(3201752, 9321647) 29927927.0 Q5IXU2 is inferred from Orf virus protein Q6TVS0 DNA binding,structural molecule activity,viral capsid Poxviridae Orf virus NPH-1 ORF072 transcription termination factor NPH-I, ORFV072, PP62, Transcription termination factor NPH-I Q6TVP8 Q6TVP8_ORFSA A0A0R8HW06,A0A0R8IAB0,F1AX80,Q2F8A3,W5U9E8 dsDNA, ssDNA TR P N N N I(8230476) I(9472022) I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) 25807056.0 Q6TVP8 is inferred from Bovine papular stomatitis virus protein Q6TVB6. Involved in transcription termination (27189950). ATP binding,nucleoside-triphosphatase activity,transcription, DNA-templated Poxviridae Orf virus ORF038 G2R-like protein, Late transcription elongation factor, ORF038 late transcription elongation factor, ORFV038, PP176 Q6TVT1 Q6TVT1_ORFSA A0A0R8IE54,F1AX11,Q2F8D6,Q80B06,W5U438 indirect/unknown TR P N N N N N N 25807056.0 Q6TVT1 is inferred from Bovine papular stomatitis virus protein Q6TVE9 translation elongation factor activity Poxviridae Orf virus ORF100 ORF100 intermediate transcription factor VITF-3 Q6TVM0 Q6TVM0_ORFSA indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 25807056.0 Not annotated Poxviridae Orf virus ORFV036 RNA helicase NPH-II A0A0R8I9X5 A0A0R8I9X5_ORFV A0A0F6N1X0,A0A0R8I802,Q6TVT4,Q6TW64 dsDNA, ssRNA TR, TNA, Rep S N N N N I(8505308) I(20110368) 25807056.0 helicase activity Poxviridae Orf virus Phosphoprotein ORF032, ORF032 DNA-binding phosphoprotein Q6TVT8 Q6TVT8_ORFSA Q6TW68 ssDNA TR, Rep S N N N N I(9525612) N 25807056.0 Ligand is based on predicted domains single-stranded DNA binding Poxviridae Orf virus RAP94 F2L, ORF060 RNA polymerase-associated protein RAP94, ORFV060, PP81, PP82, RNA polymerase-associated protein RAP94, RNA-polymerase associated protein RAP94 Q6TVR0 Q6TVR0_ORFSA A0A0R8HSC6,A0A0R8HVU7,A0A0R8HW49,A0A0R8I9E8,F1AX49,F1AX50,Q86619,W5U3P9 ssRNA TR P N N N I(1565650) N I(11279216, 18455214, 8125977) 25807056.0 Q6TVR0 is inferred from Molluscum contagiosum virus protein Q98252 DNA-binding transcription factor activity Poxviridae Orf virus VETFL Early transcription factor, Early transcription factor VETFL, ORF083 early transcription factor VETFL, ORFV083, PP53 Q6TVN7 Q6TVN7_ORFSA A0A0R8HJ22,A0A0R8I2G6,F1AXA1,Q2F892,Q6TW17,W5U3D9 dsDNA TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) 25807056.0 Q6TVN7 is inferred from Bovine papular stomatitis virus protein Q6TVA5 positive regulation of transcription, DNA-templated Poxviridae Orf virus VETFs Early transcription factor, Early transcription factor VETFs, ORF069 early transcription factor VETFs, ORFV069, PP213 Q6TVQ1 Q6TVQ1_ORFSA A0A0F6N1P6,A0A0R8HK40,A0A0R8HYN4,F1AX73,Q2F8A6,Q6TW31,W5U458 dsDNA TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) 25807056.0 Q6TVQ1 is inferred from Bovine papular stomatitis virus protein Q6TVB9 integral component of membrane Poxviridae Orf virus VITF-3 ORF084, ORF084 intermediate transcription factor VITF-3, ORFV084 Q6TVN6 Q6TVN6_ORFSA A0A0F6N1Q9,A0A0R8IA15 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 25807056.0 Not annotated Poxviridae Orf virus VLTF-1 ORF045, ORF045 late transcription factor VLTF-1 Q6TVS5 Q6TVS5_ORFSA A0A0F6N1V9 indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) 25807056.0 regulation of transcription, DNA-templated Poxviridae Orf virus VLTF-2 ORF076, ORF076 late transcription factor VLTF-2 Q6TVP4 Q6TVP4_ORFSA Q6TW24 dsDNA TR P N N N I(8371339) I(9445047) I(8371339) 25807056.0 zinc ion binding Poxviridae Orf virus VLTF-3 Late transcription factor VLTF3, Late transcription factor VLTF-3, ORF077 late transcription factor VLTF-3, ORFV077, PP57 Q6TVP3 Q6TVP3_ORFSA A0A0R8I8Z6,F1AX92,Q6TW23 indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) 25807056.0 Q6TVP3 is inferred from Molluscum contagiosum virus protein Q98271 regulation of viral transcription Poxviridae Orf virus VLTF-4 ORF061, ORF061 late transcription factor VLTF-4 Q6TVQ9 Q6TVQ9_ORFSA Q6TW39,W5U383 indirect/unknown TR P N N N N N I(8794318, Transcription Assay) 25807056.0 viral envelope Poxviridae Orf virus VP8 ORF050, ORF050 DNA-binding virion core protein VP8, ORF050/VP8 Q6TVS0 Q6TVS0_ORFSA A0A0R8HUZ3,A0A0R8I369,A0A0R8I3R6,Q6TW50,W5U3P1 dsDNA, ssDNA, ssRNA, dsRNA NAP, TR S N N N N I(9321647) I(3201752, 9321647) 25807056.0 DNA binding,structural molecule activity,viral capsid Poxviridae Pseudocowpox virus Early transcription factor D3IZN1 D3IZN1_9POXV indirect/unknown TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) 25674608.0 positive regulation of transcription, DNA-templated Poxviridae Pseudocowpox virus Intermediate transcription factor D3IZN2 D3IZN2_9POXV indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 25674608.0 Not annotated Poxviridae Pseudocowpox virus Late transcription elongation factor D3IZI6 D3IZI6_9POXV indirect/unknown TR P N N N N N N 25674608.0 translation elongation factor activity Poxviridae Pseudocowpox virus NPH-1 D3IZL9 D3IZL9_9POXV dsDNA, ssDNA TR P N N N I(8230476) I(9472022) I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) 25674608.0 D3IZL9 is inferred from Bovine papular stomatitis virus protein Q6TVB6. Involved in transcription termination (27189950). ATP binding,nucleoside-triphosphatase activity,transcription, DNA-templated Poxviridae Pseudocowpox virus NPH-II RNA helicase NPH-II D3IZI3 D3IZI3_9POXV D3IZ52 ssDNA, ssRNA TR, TNA, Rep S N N N N I(8505308) I(20110368, 2839505, 4364422) 25674608.0 helicase activity Poxviridae Pseudocowpox virus Phosphoprotein DNA-binding phosphoprotein, Putative DNA binding phosphoprotein D3IZH9 D3IZH9_9POXV V5LTE8,V5LUD5,V5LVH9 ssDNA TR, Rep S N N N N I(9525612) N 25674608.0 D3IZH9 is inferred from Orf virus protein Q6TVT8. Ligand is based on predicted domains. single-stranded DNA binding Poxviridae Pseudocowpox virus RAP94 RNA-polymerase associated RAP94 D3IZK7 D3IZK7_9POXV ssRNA TR P N N N I(1565650) N I(11279216, 18455214, 8125977) 25674608.0 D3IZK7 is inferred from Molluscum contagiosum virus protein Q98252 DNA-binding transcription factor activity Poxviridae Pseudocowpox virus VETFs Early transcription factor D3IZL6 D3IZL6_9POXV dsDNA TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) 25674608.0 integral component of membrane Poxviridae Pseudocowpox virus Virion core protein D3IZJ7 D3IZJ7_9POXV dsDNA, ssDNA, ssRNA, dsRNA NAP, TR S N N N N I(9321647) I(3201752, 9321647) 25674608.0 D3IZJ7 is inferred from Orf virus protein Q6TVS0 structural molecule activity,viral capsid Poxviridae Pseudocowpox virus VITF-3 Intermediate transcription factor VITF3 D3IZP8 D3IZP8_9POXV indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 25674608.0 Not annotated Poxviridae Pseudocowpox virus VLTF-1 Late transcription factor D3IZJ2 D3IZJ2_9POXV indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) 25674608.0 regulation of transcription, DNA-templated Poxviridae Pseudocowpox virus VLTF-2 Late transcription factor VLTF2 D3IZM4 D3IZM4_9POXV dsDNA TR P N N N I(8371339) I(9445047) I(8371339) 25674608.0 zinc ion binding Poxviridae Pseudocowpox virus VLTF-3 Late transcription factor VLTF3 D3IZ94 D3IZ94_9POXV indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) 25674608.0 regulation of viral transcription Poxviridae Pseudocowpox virus VLTF-4 Late transcription factor VLTF4 D3IZK8 D3IZK8_9POXV indirect/unknown TR P N N N N N I(8794318, Transcription Assay) 25674608.0 viral envelope Poxviridae Tanapox virus 45L SsDNA-binding phosphoprotein A7XCG4 A7XCG4_9POXV ssDNA TR, Rep S N N N N I(9525612) N 25255815.0 A7XCG4 is inferred from Orf virus protein Q6TVT8 single-stranded DNA binding Poxviridae Tanapox virus 49R Helicase A7XCG8 A7XCG8_9POXV dsDNA, ssRNA TR, TNA, Rep S N N N N I(8505308) I(20110368) 25255815.0 ATP binding,helicase activity,nucleic acid binding Poxviridae Tanapox virus 99R Intermediate transcription factor VITF-3, VITF-3 A7XCM8 A7XCM8_9POXV indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 25255815.0 Not annotated Poxviridae Tanapox virus NPH-1 88L, Transcription termination factor NPH-1 A7XCL5 A7XCL5_9POXV dsDNA, ssDNA TR P N N N I(8230476) I(9472022) I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) 25255815.0 A7XCL5 is inferred from Bovine papular stomatitis virus protein Q6TVB6. Involved in transcription termination (27189950). ATP binding,nucleoside-triphosphatase activity,transcription, DNA-templated Poxviridae Tanapox virus RAP94 75L, RNA polymerase-associated RAP94 A7XCK0 A7XCK0_9POXV ssRNA TR P N N N I(1565650) N I(11279216, 18455214, 8125977) 25255815.0 DNA-binding transcription factor activity Poxviridae Tanapox virus VETF1 98L, Early transcription factor VETF1 A7XCM7 A7XCM7_9POXV dsDNA TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) 25255815.0 positive regulation of transcription, DNA-templated Poxviridae Tanapox virus VETFs 84R, Early transcription factor VETFs A7XCL0 A7XCL0_9POXV dsDNA TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) 25255815.0 ATP binding,DNA binding,hydrolase activity,integral component of membrane Poxviridae Tanapox virus VITF-3 115R, Intermediate transcription factor VITF-3 A7XCP7 A7XCP7_9POXV indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 25255815.0 Poxviridae Tanapox virus VLTF-1 58R, Late transcription factor VLTF-1 A7XCH9 A7XCH9_9POXV indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) 25255815.0 A7XCH9 is inferred from Orf virus protein Q6TVS5 regulation of transcription, DNA-templated Poxviridae Tanapox virus VLTF-2 91L, Late transcription factor VLTF-2 A7XCL8 A7XCL8_9POXV dsDNA TR P N N N I(8371339) I(9445047) I(8371339) 25255815.0 zinc ion binding Poxviridae Tanapox virus VLTF-3 92L, Late transcription factor VLTF-3 A7XCM0 A7XCM0_9POXV indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) 25255815.0 regulation of viral transcription Poxviridae Tanapox virus VLTF-4 76R, Late transcription factor VLTF-4 A7XCK1 A7XCK1_9POXV indirect/unknown TR P N N N N N I(8794318, Transcription Assay) 25255815.0 viral envelope Poxviridae Tanapox virus VP8 63R, Core protein VP8 A7XCI6 A7XCI6_9POXV dsDNA, ssDNA, ssRNA, dsRNA NAP, TR S N N N N I(9321647) I(3201752, 9321647) 25255815.0 A7XCI6 is inferred from Orf virus protein Q6TVS0 structural molecule activity,viral capsid Poxviridae Vaccinia virus NPH1 44.1rMVA_104, ATPase, CVA122, D11L, Early gene termination factor/Nucleoside triphosphatase I, Factor X, GL151, Nucleoside triphosphatase I, Nucleoside triphosphate phosphohydrolase-I, Putative uncharacterized protein, VACV112, VACV_BRZ_SERRO2_114, VACV-DUKE-124, VACV_IOC_B388_142, W86/88-1-112 Q1PIT3 Q1PIT3_9POXV A0A0A7A5M3,A0A0M4S9W7,A0A2I2MC53,A0A2I6J1B6,A4GDH1,A9J1V1,B9U1K8,L7QJK3,O57214,P05807,P20637,Q1PIT3,V5QZL6 dsDNA, ssDNA TR P N N N D(8230476) N D(7829483) Fields Virology ATP binding,nucleoside-triphosphatase activity,transcription, DNA-templated Poxviridae Vaccinia virus I3L 30k DNA binding phosphoprotein, DNA-binding phosphoprotein, GL094, MVA064L, Protein I3, SsDNA-binding phosphoprotein, TI3L, VAC_DPP12_083, VAC_TKT3_062, VACV_BRZ_SERRO2_070, VACV_IOC_B141_098, VACWR072, W86/88-1-068 P12923 I3_VACCW A0A0A1CQQ4,A0A0A7A5D0,A0A0M4SA87,A0A0R5TUB6,A0A2I2MDT9,B9U1F0,H2DU26,O93118,P20499,Q1PIX7,Q49QJ4,Q9JFC7,V5R1E3 ssDNA TR, Rep S N N N N D(9525612) N Fields Virology Plays an essential role in viral DNA replication. Binds to ssDNA with high affinity and localizes to cytoplasmic factories where nascent viral genomes accumulate. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Poxviridae Vaccinia virus NPH-II I8R, NPH2, NTPase II, Nucleoside triphosphatase II, RNA helicase I8, RNA helicase NPH-II P12927 NPH2_VACCW ssDNA, ssRNA TR, TNA, Rep S N N N N D(8505308; 7609038) D(20110368, 2839505, 4364422) Fields Virology NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs and plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm. Required for replication and propagation of viral particles. Poxviridae Vaccinia virus RAP94 H4L, Protein H4, RNA polymerase-associated transcription-specificity factor RAP94, RPO-associated protein of 94 kDa, VACWR102 P68438 RAP94_VACCW A0A0A1CQS7,A0A0A1CRL1,A0A0A1CUE4,A0A0A7A5E7,A0A0M5M2K1,A0A2I2MDW5,A0A2I6TDW8,A9J1S4,B9U1I7,M9WEP8,M9WGZ2,P68439,Q1PIU7 ssRNA TR P N N N D(1565650) N D(11279216, 18455214, 8125977) Fields Virology DNA-directed RNA polymerase-associated factor required for the transcription of viral early genes as well as for transcription termination. Within minutes after virus entry, recruits the core RNA polymerase, the early transcription factor (ETF) and other enzymes needed for transcription initiation, elongation, and termination thereby allowing synthesis of early mRNAs which are extruded through pores in the core particle. Recruits the multifunctional J3 protein, with poly(A) polymerase-stimulatory, cap nucleoside-2'-O-methyltransferase, and transcription elongation activities. Interacts with NPH-I, a DNA-dependent ATPase required for the termination of early transcripts. Acts as a transcription termination factor by binding, together with the capping enzyme/VTF, to the termination motif 5'-UUUUUNU-3' in the nascent mRNA. Involved as well in the packaging of RNA polymerase and other components needed for early transcription in assembling virus particles. Poxviridae Vaccinia virus VETFL CVA132, Early transcription factor (VETF) large subunit A9J0Q5 A9J0Q5_VACCA dsDNA TR P N N N D(8376362) D(1869571, 8376362) D(1869571, 8428951, 2839505) Fields Virology positive regulation of transcription, DNA-templated Poxviridae Vaccinia virus VETFs ATP-dependent helicase VETFS, CVA117, D6R, Early transcription factor 70 kDa subunit, ETF small subunit, Vaccinia virus early transcription factor small subunit, VACWR111, VETF D6 subunit, VETF small subunit, VETFS P04308 ETF1_VACCW A0A160NBD6,A0A2I6J267,A9J1U1,P20634,Q9JFA3 dsDNA TR P N N N D(8376362) D(7784215, 1869571, 8350421, 8376362) D(1869571, 8428951, 2839505) Fields Virology Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa (RAP94) to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters. Poxviridae Vaccinia virus VITF3L A23R, A8R, Intermediate transcription factor 3 large subunit, VITF-3 45 kDa subunit P20998 VITF3_VACCC Q76RB3,Q77TH8,Q80HV2 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) Fields Virology Acts with RNA polymerase to initiate transcription from intermediate gene promoters. Poxviridae Vaccinia virus VITF3S A8R, Intermediate transcription factor 3 small subunit, VITF-3 32 kDa subunit, VITF-3 small subunit P20986 VTF3S_VACCC P68719,P68720 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) Fields Virology Acts with RNA polymerase to initiate transcription from intermediate gene promoters. Poxviridae Vaccinia virus VLTF-1 Late transcription factor 1, Trans-activator protein GK1, VLTF1 P68613 VLTF1_VACCW A0A2I2MC25,A0A2I6J169,A9J1P3,B9U1G8,P68612,Q1M1N3 indirect/unknown TR P N N N N N D(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) Fields Virology Associates with RNA polymerase to initiate transcription from late gene promoters. Poxviridae Vaccinia virus VLTF-2 A1L, Trans-activator protein A1, VACWR119, Viral late gene transcription factor 2, VLTF2, VLTF-X P07610 VLTF2_VACCW A0A2I2MC49,A0A2I6J298,A9J0N9,B9U1L7,M9XDS9,P20982,Q1PIT0 dsDNA TR P N N N D(8371339) D(9445047) D(8371339) Fields Virology Acts with RNA polymerase to initiate transcription from late gene promoters. Poxviridae Vaccinia virus VLTF-3 A2L, CVA126,GL161, Trans-activator protein A2, VACV_BRZ_SERRO2_118, VACV_IOC_B141_146,A2L, VACWR120, Viral late gene transcription factor 3, VLTF3 P68319 VLTF3_VACCW A0A0A7A6B8,A0A0M5M2K3,A0A2I2MC78,A0A2I6J289,A9J0P1,B9U1L8,Q76ZR2 indirect/unknown TR P N N N D(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) Fields Virology Acts with RNA polymerase to initiate transcription from late gene promoters. Poxviridae Vaccinia virus VLTF-4 H5R,GL131,VAC_DPP13_114,VACV_BRZ_SERRO2_101, late transcription factor, Late gene transcription factor VLTF-4, MVA095R Q76RC5 Q76RC5_9POXV A0A2I2MC42,A0A2I6J256,B9U1I8,H2DV26,M9WGD8,Q1PIU6 indirect/unknown TR P N N N N N D(8794318, Transcription Assay) Fields Virology viral envelope Poxviridae Vaccinia virus VP8 25 kDa major core protein, Core protein VP8, DNA-binding virion core protein VP8, F5 polypeptide, L4 core protein, L4R, P25K, VACWR091 P03295 VP8_VACCW A0A0A7A5K7,A0A2I6J178,A0A2I6J232,A0ERU0,B9U1H3,L7QJ25,P20981,Q1M1M8,Q49PP2,Q76RD0,Q77TK7 dsDNA, ssDNA, ssRNA, dsRNA NAP, TR S N N N N D(9321647) D(3201752, 9321647) Fields Virology Major core structural protein. Poxviridae Variola virus I3L K3L, L3L, L3L protein, Protein I3, SsDNA-binding phosphoprotein, VARV_BRZ66_39_061, VARV_JAP46_yam_061, VARV_SAF65_102_061, VARV_SOM77_1252_061, VARV_SUM70_228_061 P0DOP3 I3_VAR67 A0A1U8QRX5,P33000,Q0N589,Q0N8Q3,Q0NAF4,Q0NCR4,Q0NG81,Q0NLZ6 ssDNA TR, Rep S N N N N I(9525612) N Fields Virology P33000 is inferred from Orf virus protein Q6TVT8 Single-stranded DNA (ssDNA)-binding phosphoprotein which stimulates the enzymatic activity of vaccinia ribonucleotide reductase. In the absence of magnesium and at low I3 concentration, I3 forms beaded nucleosome-like structures on ssDNA. In the presence of magnesium and at high I3 concentration, I3 and DNA aggregate into large branched filamentous structures. Might be essential for viral parental DNA replication. Poxviridae Variola virus NPH-1 ATPase, ATPase nucleoside triphosphate phosphohydrolase-I, D11L, N1L, NPH1, nucleoside triphosphate phosphohydrolase-I, Nucleoside triphosphatase I, Nucleoside triphosphate phosphohydrolase I, VARV_BEN68_59_105, VARV_BRZ66_39_105, VARV_JAP46_yam_105, VARV_SAF65_102_105, VARV_UNK52_but_105, VARV-VD21-UVic-107 P0DOQ3 NTP1_VAR67 P0DOQ3,P33066,Q0N545,Q0N5Q2,Q0NBG5,Q0NCM0,Q0NG37,Q0NLV2 dsDNA, ssDNA TR P N N N I(8230476) I(9472022) I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) Fields Virology P33066 is inferred from Bovine papular stomatitis virus protein Q6TVB6. Involved in transcription termination (27189950). DNA-dependent ATPase required for providing the needed energy to achieve the termination of early transcripts. Acts in concert with the RAP94 subunit of the virion RNA polymerase and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex. NPH-I must bind ssDNA in order to exhibit ATPase activity (By similarity). Poxviridae Variola virus NPH-II I8R, NPH2, NTPase II, Nucleoside triphosphatase II, Nucleoside triphosphate phosphohydrolase II, RNA helicase I8, RNA helicase NPH-II P0DSU5 NPH2_VAR67 A0A1L6K3L4,P33051,Q0N584,Q0N5U1,Q0N848,Q0NAE9,Q0NCQ9,Q0NDB5,Q0NG76,Q0NLZ1 ssDNA, ssRNA TR, TNA, Rep S N N N N I(8505308) I(20110368, 2839505, 4364422) Fields Virology NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs and plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm. Required for replication and propagation of viral particles (By similarity). Poxviridae Variola virus RAP94 H4L, Protein H4, RNA polymerase-associated transcription-specificity factor RAP94, RPO-associated protein of 94 kDa P0DSR3 RAP94_VAR67 A0A1U8QUB4,P33067,Q0N559,Q0N823,Q0NCN4,Q0NEZ8,Q0NG51,Q0NLW6,Q0NWC1,Q89218 ssRNA TR P N N N I(1565650) N I(11279216, 18455214, 8125977) Fields Virology DNA-directed RNA polymerase-associated factor required for the transcription of viral early genes as well as for transcription termination. Within minutes after virus entry, recruits the core RNA polymerase, the early transcription factor (ETF) and other enzymes needed for transcription initiation, elongation, and termination thereby allowing synthesis of early mRNAs which are extruded through pores in the core particle. Recruits the multifunctional J3 protein, with poly(A) polymerase-stimulatory, cap nucleoside-2'-O-methyltransferase, and transcription elongation activities. Interacts with NPH-I, a DNA-dependent ATPase required for the termination of early transcripts. Acts as a transcription termination factor by binding, together with the capping enzyme/VTF, to the termination motif 5'-UUUUUNU-3' in the nascent mRNA. Involved as well in the packaging of RNA polymerase and other components needed for early transcription in assembling virus particles (By similarity). Poxviridae Variola virus VETFL A7L, Early transcription factor 82 kDa subunit, ETF large subunit, VETF A7 subunit P0DOU7 ETF2_VAR67 P33806,Q0N535,Q0N5P2,Q0N697,Q0NCL0,Q0NG27,Q0NLU2 dsDNA TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) Fields Virology Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa (RAP94) to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters (By similarity). Poxviridae Variola virus VETFs ATP-dependent helicase VETFS, D6R, Early transcription factor 70 kDa subunit, ETF small subunit, VETF D6 subunit, VETFS P0DON9 ETF1_VAR67 A0A1L6K3P8,P33056,Q0N550,Q0N5Q7,Q0N814,Q0NCM5,Q0NG42,Q0NLV7,Q0NS90 dsDNA TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) Fields Virology Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa (RAP94) to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters (By similarity). Poxviridae Variola virus VITF3L A23R, A24R, Intermediate transcription factor 3 large subunit, VITF-3 45 kDa subunit P0DSR9 VITF3_VAR67 P33846,Q0N518,Q0NCJ3,Q0NG10,Q0NLS5 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) Fields Virology Acts with RNA polymerase to initiate transcription from intermediate gene promoters. Poxviridae Variola virus VITF3S A8R, Intermediate transcription factor 3 small subunit, VITF-3 32 kDa subunit, VITF-3 small subunit P0DSP9 VTF3S_VAR67 A0A1U8QNQ5,P33834,Q0N534,Q0NCK9,Q0ND65,Q0NG26,Q0NLU1,Q89179 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) Fields Virology Acts with RNA polymerase to initiate transcription from intermediate gene promoters. Poxviridae Variola virus VLTF-1 G8R, H8R, I9R, Late transcription factor 1, Trans-activator protein GK1, VARV_BRZ66_39_075, VARV_JAP46_yam_075, VLTF1 P32990 VLTF1_VAR67 A0A1U8QUS9,Q0N575,Q0NG67,Q0NLY2,Q85380 indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) Fields Virology Associates with RNA polymerase to initiate transcription from late gene promoters. Poxviridae Variola virus VLTF-2 A1L, Trans-activator protein A1, Viral late gene transcription factor 2, VLTF2 P0DSV3 VLTF2_VAR67 A0A1L6K3Q8,A0A1U8QHI5,P33814,Q0N542,Q0NCL7,Q0NG34,Q0NJJ8,Q0NLU9 dsDNA TR P N N N I(8371339) I(9445047) I(8371339) Fields Virology Acts with RNA polymerase to initiate transcription from late gene promoters. Poxviridae Variola virus VLTF-3 A2L, Trans-activator protein A2, Viral late gene transcription factor 3, VLTF3 P0DOT5 VLTF3_VAR67 A0A1U8QTT4,P68320,Q0N541,Q0NCL6,Q0NG33,Q0NLU8 indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) Fields Virology Acts with RNA polymerase to initiate transcription from late gene promoters. Poxviridae Variola virus VLTF-4 H5R, H5R protein, I5R, J5R, Late transcription elongation factor H5, VLTF-4 viral late transcription factor P33062 H5_VAR67 A0A1L6K3P0,A0A1U8QWZ4,Q0N558,Q0N5R5,Q0N6C0,Q0N6X0,Q0N8M2,Q0NBH8,Q0NCN3,Q0ND89,Q0NG50,Q0NGQ2,Q0NLW5,Q0NU07,Q85386,Q89219 indirect/unknown TR P N N N N N I(8794318, Transcription Assay) Fields Virology P33062 is inferred from Vaccinia virus protein Q76RC5 Involved in the co-transcriptional or post-transcriptional endoribonucleolytic cleavage that generates sequence-homogeneous 3' ends during late transcription. Involved in postreplicative transcription elongation on intermediate and late genes (Probable). Also involved in DNA replication and in multiple steps of virion morphogenesis. Required both for inclusion of virosoplasm into crescents as well as for maturation of immature virions (IV) into mature virions (MV) (By similarity). Poxviridae Variola virus VP8 25 kDa major core protein, Core protein vp8, Core protein VP8, L4 core protein, L4R, N4R, P25K P0DSW9 VP8_VAR67 A0A1U8QWC9,P33039,Q0N570,Q0NCP5,Q0NEF6,Q0NG62,Q0NLX7,Q89214 dsDNA, ssDNA, ssRNA, dsRNA NAP, TR S N N N N I(9321647) I(3201752, 9321647) Fields Virology P33039 is inferred from Orf virus protein Q6TVS0 Major core structural protein. Poxviridae Yaba monkey tumor virus 115R Q6TUQ4 Q6TUQ4_YMTV5 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 14645589.0 Q6TUQ4 is inferred from Bovine papular stomatitis virus protein Q6TV88 Not annotated Poxviridae Yaba monkey tumor virus 45L Q6TUW8 Q6TUW8_YMTV5 ssDNA TR, Rep S N N N N I(9525612) N 14645589.0 Q6TUW8 is inferred from Orf virus protein Q6TVT8 single-stranded DNA binding Poxviridae Yaba monkey tumor virus 49R RNA helicase NPH-II Q6TUW4 Q6TUW4_YMTV5 dsDNA, ssRNA TR, TNA, Rep S N N N N I(8505308) I(20110368) 14645589.0 nucleoside-triphosphatase activity Poxviridae Yaba monkey tumor virus 58R Q6TUV5 Q6TUV5_YMTV5 indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) 14645589.0 Q6TUV5 is inferred from Orf virus protein Q6TVS5 regulation of transcription, DNA-templated Poxviridae Yaba monkey tumor virus 63R Q6TUV0 Q6TUV0_YMTV5 indirect/unknown NAP, TR S N N N N I(9321647) I(3201752, 9321647) 14645589.0 Q6TUV0 is inferred from Orf virus protein Q6TVS0 structural molecule activity,viral capsid Poxviridae Yaba monkey tumor virus 75L Q6TUU0 Q6TUU0_YMTV5 indirect/unknown TR P N N N I(1565650) N I(11279216, 18455214, 8125977) 14645589.0 Q6TUU0 is inferred from Molluscum contagiosum virus protein Q98252 DNA-binding transcription factor activity Poxviridae Yaba monkey tumor virus 76R Q6TUT9 Q6TUT9_YMTV5 indirect/unknown TR P N N N N N I(8794318, Transcription Assay) 14645589.0 Q6TUT9 is inferred from Vaccinia virus protein Q76RC5 viral envelope Poxviridae Yaba monkey tumor virus 91L Q6TUS7 Q6TUS7_YMTV5 indirect/unknown TR P N N N I(8371339) I(9445047) I(8371339) 14645589.0 Q6TUS7 is inferred from Molluscum contagiosum virus protein Q98270 zinc ion binding Poxviridae Yaba monkey tumor virus 92L Q6TUS6 Q6TUS6_YMTV5 indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) 14645589.0 Q6TUS6 is inferred from Molluscum contagiosum virus protein Q98271 regulation of viral transcription Poxviridae Yaba monkey tumor virus 99R Q6TUS0 Q6TUS0_YMTV5 indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 14645589.0 Q6TUS0 is inferred from Cowpox virus protein A0A0K2YTA9 Not annotated Poxviridae Yaba monkey tumor virus NPH-1 88L, B5L, NPH I, Nucleoside triphosphatase I, Nucleoside triphosphate phosphohydrolase I Q9QB93 NTP1_YMTV5 dsDNA, ssDNA TR P N N N I(8230476) I(9472022) I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) 14645589.0 Q9QB93 is inferred from Bovine papular stomatitis virus protein Q6TVB6. Involved in transcription termination (27189950). DNA-dependent ATPase required for providing the needed energy to achieve the termination of early transcripts. Acts in concert with the RAP94 subunit of the virion RNA polymerase and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex. NPH-I must bind ssDNA in order to exhibit ATPase activity (By similarity). Poxviridae Yaba monkey tumor virus VETFL 98L, B14L, Early transcription factor 82 kDa subunit, ETF large subunit Q9QB84 ETF2_YMTV5 dsDNA TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) 14645589.0 Q9QB84 is inferred from Bovine papular stomatitis virus protein Q6TVA5 Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa (RAP94) to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters (By similarity). Poxviridae Yaba monkey tumor virus VETFs 84R, ATP-dependent helicase VETFS, B1R, Early transcription factor 70 kDa subunit, VETF small subunit, VETFS Q9QB97 ETF1_YMTV5 dsDNA TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) 14645589.0 Acts with RNA polymerase to initiate transcription from early gene promoters. A DNA-dependent ATPase activity is associated with VETF. Poxviridae Yaba-like disease virus 115R 115R protein Q9DHJ8 Q9DHJ8_YLDV indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 11581398.0 Q9DHJ8 is inferred from Bovine papular stomatitis virus protein Q6TV88 Not annotated Poxviridae Yaba-like disease virus 45L 45L protein Q9DHR7 Q9DHR7_YLDV ssDNA TR, Rep S N N N N I(9525612) N 11581398.0 Q9DHR7 is inferred from Orf virus protein Q6TVT8 single-stranded DNA binding Poxviridae Yaba-like disease virus 58R 58R protein Q9DHQ5 Q9DHQ5_YLDV indirect/unknown TR P N N N N N I(15471883, Transcription Assay), I(2041091, Transcription Assay), I(2476568, Transcription Assay) 11581398.0 Q9DHQ5 is inferred from Orf virus protein Q6TVS5 regulation of transcription, DNA-templated Poxviridae Yaba-like disease virus 63R 63R protein Q9DHQ0 Q9DHQ0_YLDV indirect/unknown NAP, TR S N N N N I(9321647) I(3201752, 9321647) 11581398.0 Q9DHQ0 is inferred from Orf virus protein Q6TVS0 structural molecule activity,viral capsid Poxviridae Yaba-like disease virus 75L 75L protein Q9DHN8 Q9DHN8_YLDV indirect/unknown TR P N N N I(1565650) N I(11279216, 18455214, 8125977) 11581398.0 Q9DHN8 is inferred from Molluscum contagiosum virus protein Q98252 DNA-binding transcription factor activity Poxviridae Yaba-like disease virus 76R 76R protein Q9DHN7 Q9DHN7_YLDV indirect/unknown TR P N N N N N I(8794318, Transcription Assay) 11581398.0 Q9DHN7 is inferred from Tanapox virus protein Q76RC5 viral envelope Poxviridae Yaba-like disease virus 84R 84R protein Q9DHM9 Q9DHM9_YLDV indirect/unknown TR P N N N I(8376362) I(7784215, 1869571, 8350421, 8376362) I(1869571, 8428951) 11581398.0 Q9DHM9 is inferred from Bovine papular stomatitis virus protein Q6TVB9 ATP binding,DNA binding,hydrolase activity,integral component of membrane Poxviridae Yaba-like disease virus 88L 88L protein Q9DHM5 Q9DHM5_YLDV dsDNA, ssDNA TR P N N N I(8230476) N I(11279216, Transcription Termination Assay), I(27189950, Transcription Termination Assay), I(7829483) 11581398.0 Q9DHM5 is inferred from Bovine papular stomatitis virus protein Q6TVB6 ATP binding,nucleoside-triphosphatase activity,transcription, DNA-templated Poxviridae Yaba-like disease virus 91L 91L protein Q9DHM2 Q9DHM2_YLDV indirect/unknown TR P N N N I(8371339) I(9445047) I(8371339) 11581398.0 Q9DHM2 is inferred from Molluscum contagiosum virus protein Q98270 zinc ion binding Poxviridae Yaba-like disease virus 92L 92L protein Q9DHM1 Q9DHM1_YLDV indirect/unknown TR P N N N I(8371340) N I(8676468, Transcription Assay), I(8523544, Transcription Assay) 11581398.0 Q9DHM1 is inferred from Molluscum contagiosum virus protein Q98271 regulation of viral transcription Poxviridae Yaba-like disease virus 98L 98L protein Q9DHL5 Q9DHL5_YLDV indirect/unknown TR P N N N I(8376362) I(1869571, 8376362) I(1869571, 8428951) 11581398.0 Q9DHL5 is inferred from Bovine papular stomatitis virus protein Q6TVA5 positive regulation of transcription, DNA-templated Poxviridae Yaba-like disease virus 99R 99R protein Q9DHL4 Q9DHL4_YLDV indirect/unknown TR P N N N N N I(10077573, Transcription Assay), I(15471883, Transcription Assay) 11581398.0 Q9DHL4 is inferred from Cowpox virus protein A0A0K2YTA9 Not annotated Retroviridae Human immunodeficiency virus 1 Tat Protein tat, tat, Transactivating regulatory protein P04608 TAT_HV1H2 A0A060KS15,A0A060KV49,A0A060KVI4,A0A076FNR3,A0A076V3Q8,A0A076V8N1,A0A076V943,A0A076V970,A0A089QCW2,A0A0K1RFJ0,A0A0K1RFL6,A0A0K1RFL8,A0A0S2CBE9,A0A0S2CBF6,A0A140GML0,A0A142J5A6,A0A142J5B5,A0A159C854,A0A159C9T1,A0A159C9V0,A0A159C9Z8,A0A159CAC9,A0A159CAP8,A0A161CFV2,A0A161CGQ6,A0A161CP30,A0A161CUQ5,A0A161CUV9,A0A161CV08,A0A161CVH7,A0A161CVX6,A0A161CW94,A0A161D3W4,A0A191CA08,A0A191CAI2,A0A191CAY4,A0A191CB60,A0A1L4AMD3,A0A1L5K0P5,A0A1L5K158,A0A1L5K1D0,A0A1L7DT27,A0A1L7DT44,A0A1L7DT47,A0A1L7DT66,A0A1L7DT91,A0A1L7DT95,A0A1L7DTB6,A0A1L7DTC9,A0A1L7DTF4,A0A1L7DTH0,A0A1L7E051,A0A1L7E086,A0A1L7E087,A0A1L7E088,A0A1L7E0C8,A0A1L7E0F9,A0A1L7E0G4,A0A1L7E0H2,A0A1L7E0J8,A0A1L7E0K6,A0A1L7E0K8,A0A1V0CPR5,A0A221SER0,A0A286LFT1,A0A2H4UM10,A0A2I6U5U1,A0A2I6U5W9,A0A2I6UA56,A0A2I6UAA8,A0A2I6UAP1,A0A2I6UAW6,A0A2I6UAX8,A0A2I6UB20,A0A2I6UB53,A0A2I6UB85,A0A2I6UBB9,A0A2I6UDU7,A0A2I6UE90,A0A2I6UEL9,A0A2I6UEW4,A0A2I6UEY9,A0A2L1KVE2,A0A2L1KVH1,A0A2L1KW66,A0A2L1KWQ3,A0A2L1KWR8,A0A2L1KX14,A0A2L1KXI4,A0A2L1KXX2,A0A2L1KXY1,A0A2L1KY88,A0A2P1IPK3,A0A2S1D2B0,A0A2S1J4U4,A0A346ARF5,A0A3G5NTJ6,A0A3G5NUD8,A0A3G5NVJ6,A0A3G5NWJ1,A0A3G5NXC4,A0A3G5NXJ3,A0A3G5NYA6,A0A3G5NYE3,A0A3G5NZ85,A0A3G5NZA5,A0A3G5NZA6,A0A3G5NZL3,A0A3G5NZN1,A0A3G5P091,A0A3G5P0G4,A0A3G5P116,A0A3G5P120,A0A3G5P1B7,A0A3G5P1C4,A0A3G5P1G0,A0A3G5P1I8,A0A3G5P1Y8,A0A3G5P1Z4,A0A3G5P267,A0A3G5P2F3,A0A3G5P2I3,A0A3G5P2J5,A0A3G5P2R2,A0A3G5P2Z0,A0A3G5P389,A0A3G5P3H0,A0A3G5P3Q1,A0A3G5P4H0,A0A3G8G526,A0ZVI9,A1DQV4,A1DQW3,A1DQW5,A1DQW7,A1DQW8,A1DQW9,A1DQX7,A1DQY0,A1DQY3,A1DQY5,A1DQY9,A1XFJ7,A1YAW1,A1YAX9,A3F992,A3F9A1,A3QVS4,A6MI20,A6MI21,A6MI22,A7YJW9,A8VGQ3,A8VGY9,A8VH75,A8VH95,A8VHA7,A8VHB4,A9U9H5,A9U9M0,A9U9M9,A9U9N8,A9U9S0,A9XCI1,B4YNJ3,B4YNL1,B4YNM3,B5AEQ4,B5AEU9,B7SWF0,B7TCC4,C4N7C1,C4N7J1,C5HA95,C5HAJ4,C5HAS7,C5HB94,C5HMU5,C5HN12,C5HNI8,C5HNW1,C5HNW7,C5HP06,C5HP90,C5HPB9,C5HR51,C5HS75,C7G256,C9E906,C9E908,C9E921,C9E988,D2CPM3,D2CPN7,D2CPN9,D2CPP0,D2CPR0,D2CPR1,D2CPS1,D2CPS6,D2CPS8,D2CPS9,D2CPU3,D2CPU4,D2K3B0,D3GG08,D3XND1,D3XND2,D3XND4,D4PC16,D4PC24,D4PE12,D5KEK7,D5KIN8,D5KIP6,D5KIS0,D5KIS8,D5KIY2,D5KIZ8,D5KJ06,D5KJ38,D5L1M9,D6NSX1,D6NVS0,D6NVS1,D6NVU0,D6NVU1,D6NVV2,D6NVW0,D6NVY1,D6NVY3,D6NVY7,D6NVY9,D6NVZ5,D6NW12,D6NW21,D6NW28,D6NW43,D6NW48,D6NW73,D6NW81,D6NW87,D6NW91,D6NW95,D6NW99,D6NWA0,D6NWA9,D6NWB6,D6NWC9,D6NWD4,D6NWE4,D6NWG1,D6NWH7,D6NWI8,D6NWI9,D6NWL1,D6NWM1,D6NWN0,D6NWN1,D6NWP0,D6NWP6,D6NWQ6,D6NWQ7,D6NWQ9,D6NWR0,D6NWR9,D6NWS1,D6NWV7,D6NWW8,D6NWY1,D6NWY7,D6NWZ8,D6NX04,D6NX09,D6NX22,D6NX24,D6NX29,D6NX32,D6NX42,D6NX46,D6NX50,D6NX58,D6NX59,D6NX60,D6NX61,D6NX65,D6NX72,D6NX88,D6R020,D6R056,E0A9Z8,E0AA13,E0AA18,E2CX23,E2CX68,F1B2A1,F1B2D3,F1B2G8,F1B2J4,F2YX68,F2YXK1,F2YXW5,F2YXX3,F5BD94,F5CFB7,G1FQH9,G9IQ96,H6CVW9,H6CW09,H6CW27,H6CWA4,H6CWD8,H6CX54,H6CX96,H6CXE0,H6CXE9,H6CXL2,I6N0A1,I6N0B0,I6N0B8,I6N0C6,I6N0D5,I6N0H9,I6QQN9,I6QTV7,I6R588,I6R5M0,I6R5Z2,I6R6E2,I6RBY5,I6RC25,I6RCG3,I6RG27,I6RGA6,I6RGK4,I6ZAD6,J3QYE6,J3QYF5,J3R262,J3R280,J3R298,J3R2A7,J3R8L1,J3R8M0,J3R8N0,J3R8N9,J3R8P8,J3RA22,J3RA49,J3RA58,J3RA67,J3RA77,J3RAX7,J3RB02,J3RB14,J3RB36,K4MKX3,K4MUI9,K4MYG3,M1KBE1,M1KBR3,M1LDW1,M4N2F6,M4N4H9,M4N943,M4N949,M4N966,M4NNN7,M4NRQ0,M4NRV8,M4PFA9,M4PHN2,M4PJ36,M4PJC5,M4PQG5,O42085,O92297,O92885,O92899,O93022,O93199,P90265,Q00EI6,Q0QL80,Q0QL89,Q1HGD2,Q1HGE1,Q1M0L8,Q1M0M7,Q1PAB4,Q1PAC0,Q2NMF7,Q2NMG6,Q2NMH5,Q2NMI4,Q2NMJ3,Q2NMM8,Q2NMP6,Q2NMS3,Q2NMT2,Q2NMU1,Q2NMV9,Q2NMW8,Q2NMX7,Q2NN30,Q2NN39,Q2NN65,Q2NN73,Q30BW0,Q30BX6,Q3SA27,Q462M7,Q462N6,Q4QXE2,Q4QXF9,Q507D6,Q507F1,Q52S52,Q52S62,Q5C9W8,Q5PYM7,Q5PYN4,Q5PYP0,Q5PYP7,Q5U882,Q5U8J9,Q672T0,Q672T8,Q673V9,Q6E6V7,Q6EFM4,Q6EG43,Q6EG88,Q6H1S1,Q6Q463,Q6RJ70,Q6RJ77,Q6RJ84,Q6RJ91,Q6RJ98,Q6RJA5,Q6RJC6,Q6RJD3,Q6RJE0,Q6RJE7,Q6RJG8,Q6RJH5,Q6Y0S7,Q6Y0T6,Q6Y0U6,Q6Y0V1,Q6Y0V2,Q74087,Q74810,Q76PP9,Q76W89,Q77688,Q7ZJC3,Q8AQT3,Q8AQV1,Q8AQW0,Q900A7,Q99BV6,Q99BV7,Q99BV8,Q99BV9,Q99BW0,Q99BW1,Q9DH20,Q9DHA9,Q9DQ29,Q9W9E3,Q9WJV2,Q9WJV9,Q9WJW7,Q9YP37,R9WY72,T2CGB4,T2CGG2,T2CHT3,T2CI19,U5YPQ4,U5YT43,U6BG48,W0FUJ1 dsDNA, ssRNA TR, Rep P D(26488441) D(22073215, 26488441, 26468528) 3MI9, 3MIA, 4OR5, 5V61, 6CYT, 6MCE, 6MCF D(11909874) D(15994812, 10428378, 14981150) D(10428378) Fields Virology Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. In the absence of Tat, the RNA Pol II generates short or non-processive transcripts that terminate at approximately 60 bp from the initiation site. Tat associates with the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. This binding increases Tat's affinity for a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively to TAR RNA. The CDK9 component of P-TEFb and other Tat-activated kinases hyperphosphorylate the C-terminus of RNA Pol II that becomes stabilized and much more processive. Other factors such as HTATSF1/Tat-SF1, SUPT5H/SPT5, and HTATIP2 are also important for Tat's function. Besides its effect on RNA Pol II processivity, Tat induces chromatin remodeling of proviral genes by recruiting the histone acetyltransferases (HATs) CREBBP, EP300 and PCAF to the chromatin. This also contributes to the increase in proviral transcription rate, especially when the provirus integrates in transcriptionally silent region of the host genome. To ensure maximal activation of the LTR, Tat mediates nuclear translocation of NF-kappa-B by interacting with host RELA. Through its interaction with host TBP, Tat may also modulate transcription initiation. Tat can reactivate a latently infected cell by penetrating in it and transactivating its LTR promoter. In the cytoplasm, Tat is thought to act as a translational activator of HIV-1 mRNAs. Retroviridae Human immunodeficiency virus 1 Vpr Protein Vpr, R ORF protein, Viral protein R P05928 VPR_HV1BR A0A1L5K181,A0A1L7E075,A0A1L7E0E4,A0A1P8DFL4,A0A1P8DFQ6,A0A1S6Q1Y8,A0A1S7G5I7,A0A1V0CPS3,A0A1V0CQ70,A0A2I6U569,A0A2I6U5R3,A0A2I6U656,A0A2I6U705,A0A2I6U757,A0A2I6U762,A0A2I6U778,A0A2I6U7M6,A0A2I6U992,A0A2I6U9P4,A0A2I6UB19,A0A2I6UB27,A0A2I6UB41,A0A2I6UBA3,A0A2I6UE01,A0A2I6UEX6,A0A2L1KWL5,A0A2L1KWR7,A0A2L1KXB7,A0A2L1KXV9,A0A2L1KXY0,A0A2S1D2C4,A0A2S1J4Z9,A0A2Z2U098,A0A2Z2U294,A0A346ARF4,A0A346BLV9,A0A346BLY6,A0A3G5NS07,A0A3G5NSG1,A0A3G5P0U6,A0A3G5P2U2,A0A3G5P404,A0A3G8G4Y4,A0A3G8G516,A5YMI3,A5YMJ1,A5YML7,A5YML9,A5YMM6,A5YMN9,A5YMP1,B2CK75,B2CK78,B2CK80,O73404,O73405,O73406,O73411,O73412,O73418,O73425,O89601,O89603,O89604,O89605,O89606,O89608,O89609,O89610,O89611,O89612,O89613,O89614,O89615,O89616,O89617,O89618,O89619,O89620,O89622,O89624,O89626,O89627,O89629,O89630,O89631,O89632,O89633,O89634,O89636,O89639,O89641,O89644,O89645,O89647,O89648,O89649,O89650,O89651,O89652,O89655,O89656,O89659,O89660,O89661,O89662,O89663,O89664,O89665,O89667,O89671,O89672,O89674,O89676,O89680,O89684,O89687,O89697,Q3HP77,Q3HP85,Q3HP91,Q3HP95,Q3HPA1,Q3HPA5,Q3HPB5,Q3HPC4,Q3HPD4,Q3HPD5,Q3HPE1,Q3HPF2,Q3HPF6,Q3HPH8,Q3HPI1,Q3HPI8,Q3HPJ3,Q3HPK0,Q3HPL6,Q3HPL8,Q3HPM2,Q3HPM3,Q3HPM5,Q3HPP4,Q3HPP8,Q3HPR2,Q3HPS8,Q3HPU2,Q3HPU3,Q3HPU6,Q3HPU9,Q3HPW0,Q3HPW8,Q3HPX2,Q3HPX6,Q3HPX8,Q3HPZ0,Q3HPZ1,Q3HPZ4,Q3HPZ9,Q3HQ04,Q3HQ07,Q3HQ14,Q3HQ25,Q3HQ39,Q3HQ40,Q3HQ48,Q3HQ80,Q3HQ83,Q3HQ84,Q3HQA3,Q3HQA9,Q3HQB6,Q3HQC8,Q3HQC9,Q3HQD4,Q3HQD9,Q3HQE0,Q3HQE1,Q3HQH7,Q3HQI1,Q3HQI4,Q3HQI5,Q3HQI7,Q3HQJ1,Q3HQK4,Q3HQM8,Q3HQP6,Q3HQP7,Q3HQQ4,Q3HQR1,Q3HQR7,Q3HQR8,Q3HQS1,Q3HQS4,Q9E285,Q9E287,Q9E289,Q9E290,Q9E291,Q9E292,Q9E293,Q9E294,Q9E296,Q9E297 indirect/unknown TR, TNA, Rep S N N N D(9560267) D(29042644) D(9560267, 29042644) Fields Virology During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus. This function is crucial for viral infection of non-dividing macrophages. May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions. Retroviridae Human immunodeficiency virus 2 Tat Protein tat, Protein Tat, Transactivating regulatory protein P18098 TAT_HV2BE A0A0S3B0B1,A0A0U3VB96,A0A1L4CV17,A0A1L4CV23,A0A1L4CV30,A0A1L4CV41,A0A1L4CV44,A0A1L4CV58,A0A1L4CV62,A0A2D3HWP3,A0A2D3HWQ0,A0A2D3HWQ7,A0A2D3HWR8,A0A2D3HWS9,A0A2D3HWU1,A0A2D3HWU9,A0A2D3HWW0,A0A2D3HWW8,A0A2D3HWX9,A0A2D3HWY4,A0A2D3HWZ3,A0A2D3HX04,A0A385PLN6,A0A385PLS1,A0A385PSL7,A0A385PSQ4,B0YP97,B5TK20,B9VR79,C7G2W8,D7UPK3,D7UPL2,D7UPM1,L8AZ71,L8B2C8,L8B2J7,L8B2M8,L8B321,P88145,Q2PQT0,Q6R780,Q6R789,Q76625,Q7SNM0,Q8UTV3,Q9IBL5,Q9YTT6 dsDNA, ssRNA TR, Rep P I(26488441) I(22073215, 26488441) N I(11909874) I(15994812, 10428378, 14981150) I(10428378) Fields Virology Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. In the absence of Tat, the RNA Pol II generates short or non-processive transcripts that terminate at approximately 60 bp from the initiation site. Tat associates with the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. This binding increases Tat's affinity for a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively to TAR RNA. The CDK9 component of P-TEFb and other Tat-activated kinases hyperphosphorylate the C-terminus of RNA Pol II that becomes stabilized and much more processive (By similarity). Retroviridae Human immunodeficiency virus 2 Vpr Protein Vpr, R ORF protein, Viral protein R P18100 VPR_HV2BE A0A1L4CV18,A0A1L4CV25,A0A1L4CV28,A0A1L4CV35,A0A1L4CV43,A0A2D3HWN8,A0A2D3HWQ2,A0A2D3HWQ9,A0A2D3HWS0,A0A2D3HWT1,A0A2D3HWU2,A0A2D3HWV2,A0A2D3HWW2,A0A2D3HWX3,A0A2D3HWY8,A0A2D3HWZ9,A0A2D3HX07,A0A2D3HX19,A0A385PLN9,A0A385PM41,A0A385PMN5,A0A385PP22,Q9Q1T3 indirect/unknown TR, TNA, Rep S N N N I(9560267) I(29042644) I(9560267, 29042644) Fields Virology Stimulates gene expression driven by the HIV-2 LTR. Prevents infected cells from undergoing mitosis and proliferating, by inducing arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest creates a favorable environment for maximizing viral expression and production (By similarity). Retroviridae Human spumaretrovirus Bel-1 Protein Bel-1, Tas, Transactivator of spumavirus, Transcriptional transactivator P14353 BEL1_FOAMV Q9IHQ8,Q9IHR0,Q9QEJ6 dsDNA TR, Rep P N N N I(8356798, 8648727, 9621006) I(8648727, 9420252, 9621006) I(8648727, Footprinting), I(9420252, Footprinting) Fields Virology Transcriptional transactivator that activates the viral internal promoter (IP), thereby enhancing its own expression. This transactivation is repressed by nuclear factor I. Also transactivates the long terminal repeat (LTR) promoter, thereby inducing structural gene expression, initiating the late phase of infection. It is therefore a key regulator of viral gene expression. It directly binds to and activates DNA target sites of viral promoters and those of distinct cellular genes. Required for viral replication. Retroviridae Human T-cell leukemia virus 1; Human T-lymphotropic virus 1 HBZ HTLV-1 basic zipper factor P0C746 HBZ_HTL1A P0C747 indirect/unknown TR P D(17151132) D(30057145) N D(19064727, 12438606, 12937177, 17151132) D(17151132) N Fields Virology Contributes to the regulation of viral RNA transcription by interacting with host proteins involved in transcriptional activation such as ATF4, or CREB1, and by inhibiting their activity. Additionally, HBZ suppresses host NF-kappa-B-driven transcription mediated by host RELA as well as transcription of some classical NF-kappa-B target genes, including IL8, IL2RA, IRF4, VCAM1, and VEGFA. Retroviridae Human T-cell leukemia virus 1; Human T-lymphotropic virus 1 Tax Protein PX, Protein Tax-1, Protein X-LOR, tax, Trans-activating transcriptional regulatory protein of HTLV-1 P14079 TAX_HTL1C P03409,P0C222 indirect/unknown TR P N N N D(15367606, 11861831) D(11861831) N Fields Virology Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Also induces chromatin remodeling of proviral LTR-mediated gene expression by recruiting the histone acetyl transferases CREBBP and EP300 to the chromatin, which results in histone acetylation. Via its interaction with IKK regulatory subunit IKBKG, Tax-1 persistently stimulates I-kappa-B kinase (IKK), resulting in constitutive activation of the transcription factor NF-kappa-B. Induction of the nuclear expression of members of the NFkB family of transcription factors, which leads to up-regulated expression of many gene promoters containing NFkB motifs. These genes include those encoding IL2, IL15, IL2RA and IL15RA, leading to autocrine IL2/IL2RA and IL15/IL15RA loops. The resulting T-cell proliferation leads to malignant transformation and to the development of adult T-cell leukemia (ATL). IL13, known to be linked to leukemogenesis, is also up-regulated by Tax-1. Interaction with PDZ domain-containing proteins induce IL2-independent growth, which may be a factor in multi-step leukemogenesis. Inhibits the action of at least three cellular tumor suppressors p53/TP53, RB1 and DLG1, and suppresses their abilities to dictate apoptosis in primary cells. Required for viral replication (By similarity). Retroviridae Human T-cell leukemia virus 2 Tax Protein Tax-2, Trans-activating transcriptional regulatory protein of HTLV-2 P03410 TAX_HTLV2 A0A0U2S9I1 indirect/unknown TR P N N N D(15367606, 11861831) D(11861831) N Fields Virology Tax does not directly bind DNA, but associates through its N-terminus with the CREB protein (16155604). Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Induces T-cell transformation, although much less efficiently than HTLV-1. Required for viral replication (By similarity). Retroviridae Human T-cell leukemia virus 3 Tax Protein Tax-3, Trans-activating transcriptional regulatory protein of HTLV-3 Q0R5R1 TAX_HTL32 Q4U0X7 indirect/unknown TR P N N N I(15367606, 11861831) I(11861831) N Fields Virology Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to two 21 bp repeat elements located within the LTRs, referred to as Tax-responsive element (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Activation of NF-kappa-B leads to up-regulation of the expression of gene promoters containing NFkB motifs like IL8 or BCL2L1. Inhibits the action of p53/TP53 and MYCB. All these functions could lead to the possible occurrence of lymphoproliferative disorders. Required for viral replication (By similarity). Retroviridae Human T-cell leukemia virus 3 Uncharacterized protein Q6LDW4 Q6LDW4_HTLV3 ssRNA TR, Rep P I(26488441) I(22073215, 26488441) N I(11909874) I(15994812, 10428378, 14981150) I(10428378) Fields Virology Q6LDW4 is inferred from Human immunodeficiency virus 1 protein P04608 RNA-binding transcription regulator activity,positive regulation of viral transcription,host cell nucleus Retroviridae Human T-lymphotropic virus 4 Tax Tax protein A0A193H3A4 A0A193H3A4_9DELA B8LHM2,Q50E57 indirect/unknown TR P N N N I(15367606, 11861831) I(11861831) N Fields Virology 2 iron, 2 sulfur cluster binding,oxidoreductase activity,positive regulation of transcription, DNA-templated Retroviridae Simian foamy virus Bel-1 bel1, Protein Bel-1, Taf, Tas, Transactivator of spumavirus, Transcriptional transactivator Q87042 BEL1_SFVCP A0A1E1EMK5,A0A2H4PMA7,A0A2Z5HTX8,H6V7J1,K7YKU4,K7YKV0,K7YKV5,Q7SIS4,R9RVK5 dsDNA TR, Rep P N N N D(8356798, 8648727, 9621006) D(8648727, 9420252, 9621006) I(8648727, Footprinting), I(9420252, Footprinting) 26446599.0 Transcriptional transactivator that activates the viral internal promoter (IP), thereby enhancing its own expression. This transactivation is repressed by nuclear factor I. Also transactivates the long terminal repeat (LTR) promoter, thereby inducing structural gene expression, initiating the late phase of infection. It is therefore a key regulator of viral gene expression. It directly binds to and activates DNA target sites of viral promoters and those of distinct cellular genes. Required for viral replication (By similarity). Rhabdoviridae Australian bat lyssavirus P Phosphoprotein, Protein M1, Protein P Q9QSP3 PHOSP_ABLVB A0A088NJK8,A0A0S2VHH1,Q91RE3,Q91RE4,Q91RE5,Q91RE6,Q91RE7,Q9YZ23 indirect/unknown TR, Rep S N N N I(26647356; 22740405; 27384657; 16973555) N I(19369340), I(8676480, in vitro Transcription Assay), I(1309893, in vitro Transcription Assay) 24556791.0 RNA polymerase cofactor Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity). Rhabdoviridae Duvenhage lyssavirus N NP, Nucleocapsid protein, Nucleoprotein, Protein N Q66453 NCAP_DUVV A0A0F6MWF3,B2XXZ9,D2CRL8,D2CRM5,I3W9E2 ssRNA TR, Rep S N N N I(11799201; 27384657; 31434934) I(15557246) I(26957093; 9603315) 17326954.0 Encapsidates the genome, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). Rhabdoviridae Duvenhage lyssavirus P Isoform P2 of Phosphoprotein, Isoform P4 of Phosphoprotein, Phosphoprotein, Phosphoprotein Phosphoprotein, Protein M1, Protein P B2XY05 B2XY05_DUVV B2XY00,D2CRL7,I3W9E3 indirect/unknown TR, Rep S N N N D(26647356) N I(1848304, in vitro Transcription Assay), I(8676480, in vitro Transcription Assay), I(1309893, in vitro Transcription Assay) 17326954.0 RNA polymerase cofactor Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Rhabdoviridae European bat lyssavirus 1 P Phosphoprotein, Protein M1, Protein P A4UHP9 PHOSP_EBLV1 indirect/unknown TR, Rep S N N N I(26647356; 22740405; 27384657; 16973555) N I(1848304, in vitro Transcription Assay), I(8676480, in vitro Transcription Assay), I(1309893, in vitro Transcription Assay) 29684025.0 RNA polymerase cofactor Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity). Rhabdoviridae European bat lyssavirus 2 P Isoform P2 of Phosphoprotein, Isoform P3 of Phosphoprotein, Isoform P5 of Phosphoprotein, Phosphoprotein, Phosphoprotein Phosphoprotein, Protein M1, Protein P A4UHQ4 PHOSP_EBLV2 indirect/unknown TR, Rep S N N N I(26647356; 22740405; 27384657; 16973555) N I(1848304, in vitro Transcription Assay), I(8676480, in vitro Transcription Assay), I(1309893, in vitro Transcription Assay) 29684025.0 RNA polymerase cofactor Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity). Rhabdoviridae Mokola lyssavirus N NP, Nucleocapsid protein, Nucleoprotein, Protein N P0C570 NCAP_MOKV B2XXY9,B2XXZ4,D6Q0P5,D6Q0P9,E4W5W4,E4W5W5,Q5VKP7,Q83544,Q86593,S5DHS6,S5DHT9 ssRNA TR, Rep S N N N D(11799201) I(15557246) I(26957093; 9603315) 28143485.0 Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). Rhabdoviridae Mokola lyssavirus P Phosphoprotein, Protein M1, Protein P P0C569 PHOSP_MOKV A0A1L2C1Z1,A0A1L2C1Z5,A0A1L2C227,B2XXZ0,B2XXZ5,O56775,O56777,Q86594,Q910M0,Q91RE0,Q91RE1,Q91RE2,R9Q7B8,R9Q7N9,R9Q7P1,S4S267,S4S2C0,S4S2C5,S5DMU3,S5DMV1,S5DMV6,S5DMW2,U5L226 indirect/unknown TR, Rep S N N 2WZL D(26647356; 22740405) N I(1848304, in vitro Transcription Assay), I(8676480, in vitro Transcription Assay), I(1309893, in vitro Transcription Assay) 28143485.0 RNA polymerase cofactor Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity). Rhabdoviridae Rabies virus N NP, Nucleoprotein, Protein N P06025 NCAP_RABVP A0A024A0B8,A0A024A0W3,A0A024A1B4,A0A059TB69,A0A059TB70,A0A059TB87,A0A059TB89,A0A059TB90,A0A059TB93,A0A059TB94,A0A059TB96,A0A059TB98,A0A059TBC0,A0A059TBC2,A0A059TBC4,A0A059TBE0,A0A059TBE1,A0A059TBE2,A0A059V8W4,A0A060N356,A0A088AXQ2,A0A089N960,A0A097P8D2,A0A097P8G3,A0A0M6VAI4,A0A0N9HLM0,A0A0R5SAT5,A0A0R5SAT8,A0A0R5SAU1,A0A0R5SAU5,A0A0R5SAU7,A0A0R5SAV4,A0A0R5SAW1,A0A0R5SAX0,A0A0R5SAX7,A0A0R7EZ21,A0A0R7EZ32,A0A0R7EZ33,A0A0R7EZ56,A0A0R7EZ74,A0A0R7EZ77,A0A0R7EZ92,A0A0R7EZB5,A0A0R7EZB6,A0A0R7EZB8,A0A0U3SBI6,A0A0U3SBL4,A0A0U3SSS1,A0A0U4BAC4,A0A0U4BIP6,A0A0U4C038,A0A0U4C066,A0A0Y0FT50,A0A109QK65,A0A125QVS9,A0A142D6R1,A0A165DA56,A0A1B0THU0,A0A1B0THU8,A0A1B4WGP6,A0A1B4WGQ5,A0A1D8BP49,A0A1D8BP50,A0A1D8BP64,A0A1D8BP68,A0A1D8BP72,A0A1D8BP73,A0A1D8BP76,A0A1D8BP83,A0A1D8BP84,A0A1D8BP85,A0A1D8BP88,A0A1D8BP93,A0A1D8BP94,A0A1D8BPA1,A0A1D8BPA2,A0A1D8BPA6,A0A1D8BPB2,A0A1D8BPB6,A0A1D8BPC0,A0A1D8BPC5,A0A1D8BPD5,A0A1D8BPD8,A0A1D8BPD9,A0A1D8BPF6,A0A1D8BPG1,A0A1D8BPG5,A0A1D8BPG8,A0A1D8BPH6,A0A1D8BPI8,A0A1D8BPJ9,A0A1D8BPK9,A0A1D8BPL0,A0A1D8BPL3,A0A1D8BPL5,A0A1D8BPL6,A0A1D8BPL7,A0A1D8BPM3,A0A1D8BPN1,A0A1D8BPN2,A0A1D8BPP9,A0A1D8BPQ0,A0A1D8BPQ7,A0A1D8BPR3,A0A1D8BPR5,A0A1D8BPR7,A0A1D8BPS1,A0A1D8BPS6,A0A1D8BPT2,A0A1D8BPT6,A0A1D8BPT9,A0A1D8BPU4,A0A1D8BPU8,A0A1D8BPV0,A0A1D8BPV2,A0A1D8BPV4,A0A1D8BPV5,A0A1D8BPV7,A0A1D8BPW0,A0A1D8BPW3,A0A1D8BPX9,A0A1D8BPY2,A0A1D8BPZ0,A0A1D8BPZ5,A0A1I9WAC1,A0A1I9WAC6,A0A1I9WAD0,A0A1I9WAD2,A0A1I9WAD3,A0A1I9WAD6,A0A1J0RF46,A0A1J0RFS2,A0A1J0RGL4,A0A1J0RGM5,A0A1J0RH62,A0A1J0RH71,A0A1J0RHB0,A0A1J0RHR8,A0A1J0RHS7,A3F5M0,A3F5Q5,A3F5T0,A4D874,A4D875,A4D881,A4D883,A4D884,A4D885,A4D888,A4D889,A4D891,A4D8A5,A4D8A6,A4D8B1,A4D8B7,A4D8C0,A4D8C1,A4D8C4,A4D8C5,A4D8C7,A4D8C8,A4D8C9,A4D8D0,A4D8D4,A4D8D6,A4D8D8,A4D8E4,A4D8E5,A4D8F5,A4D8F7,A4D8G6,A4D8G9,A4D8H0,A4D8H1,A6MF76,A7LFL9,A8CEB8,A8VR20,A9QXE5,A9Y0H9,A9Y0I5,A9Y0I6,A9Y0J1,A9Y0J3,A9Y0J4,A9Y0J5,A9Y0J6,A9Y0K5,B0EYQ3,B0FPH5,B3GQF0,B3GQF1,B3GQF2,B3GQF4,B3GQF5,B3GQF6,B3GQF7,B3GQF8,B3GQG0,B3GQG1,B3GQG2,B3GQG3,B3GQG6,B3GQG7,B3GQG8,B3GQG9,B3GQH0,B3GQH5,B3GQH7,B3GQH8,B3GQI1,B3GQI2,B3GQI3,B3GQI5,B3GQI6,B3GQI7,B3GQI8,B3GQJ0,B3GQJ1,B3GQJ2,B3GQJ3,B3GQJ4,B3GQJ6,B3GQJ7,B3GQJ8,B3GQK0,B5AAR7,B5AXD4,B5KMJ7,B5KML5,B5KMN5,B9VS70,C0IQG0,C0IQG2,C0IQG7,C0IQG9,C0IQH0,C0IQH2,C0IQH3,C0IQH4,C0IQH6,C0IQH8,C0IQI0,C0IQI1,C0IQI2,C0IQI3,C0IQI4,C0IQI5,C0IQI7,C0IQI8,C0IQJ0,C0IQJ1,C0IQJ2,C0ITH9,C0ITI1,C0ITI2,C0ITI3,C0ITI4,C0ITI8,C0ITI9,C0J5B6,C0J5B7,C0J5B9,C0J5C2,C0J5P8,C0J5Q5,C0J5S4,C0J5V0,C0J5V3,C0J5V4,C0J5V9,C0J5X2,C0J5Y3,C0J5Y5,C0JJL4,C0JJL5,C0JJL8,C0JJM0,C0JJM1,C0JJM2,C0JJM3,C0JJM5,C0JJM7,C0JJM8,C0JJN1,C0JJN2,C0JJN4,C0JJN7,C0JJN8,C0JJN9,C0JJP1,C0JJP2,C0JJP6,C0JJP7,C0JJP9,C0JJQ1,C0JJQ3,C0JJQ4,C0JJQ6,C3VID6,C4MH53,C6ZD73,C6ZD88,C7ADP4,C9WLX2,C9WLX4,C9WLX6,D2D2A8,D2D2B3,D2D2B7,D3JZP8,D4P3X7,D6Q090,D6Q0A4,D6Q0Q6,D6Q0Q8,E0X4L5,E0X4M3,E0Y5E6,E0Y5F4,E0Y5I1,E0Y5I7,E0Y5M2,E0Y5M5,E0Y5M7,E0Y5M8,E0Y5N0,E0Y5N3,E0Y5N8,E5E232,E5E233,E5E234,E5E236,E5E237,E5E238,E5E239,E5E241,E5E243,E5E245,E5E246,E5E249,E5E250,E5E252,E5E254,E5E255,E5E256,E5E257,E5E260,E5E263,E5E264,E5E265,E5E267,E5E268,E5E269,E5E271,E5E272,E5E273,E5E274,E5E275,E5E276,E5E278,E5E280,E5E281,E5E282,E5E283,E5E284,E5E285,E5E287,E5E288,E5E289,E5E290,E5E291,E5E292,E5E293,E5E294,E5E295,E5E297,E5E298,E5E299,E5E2A1,E5E2A2,E5E2A3,E5E2A4,E5E2A6,E5E2A7,E5E2A8,E5E2A9,E5E2B0,E5E2B8,E5E2C0,E5E2C2,E5E2C6,E5E2C7,E5E2C8,E5E2D0,E5E2D3,E5E2D6,E5E2D9,E5E2E2,E5E2E3,E5E2E4,E5E2E6,E5E2E7,E5E2E9,E5E2F5,E5E2F6,E5E2F8,E5E2F9,E5E2G3,E5E2G4,E5E2G5,E5E2G6,E5E2H0,E5E2H1,E5E2H2,E5E2H3,E5E2H5,E5E2H6,E5E2H7,E5E2H8,E5E2H9,E5E2I0,E5E2I2,E5E2I4,E5E2I7,E5E2I8,E5E2I9,E5E2J0,E5E2J1,E5E2J2,E5E2J3,E5E2J4,E5E2J5,E5E2J6,E5E2J7,E5E2K0,E5E2K1,E5E2K2,E5E2K5,E5E2K6,E5E2K7,E5E2K9,E5E2L0,E5E2L1,E5E2L5,E5E2L6,E5E2L7,E5E2L8,E5E2L9,E5E2M0,E5E2M1,E5E2M2,E5E2M3,E5E2M4,E5E2M7,E5E2N1,E5E2N2,E5E2N3,E5E2N4,E5E2N6,E5E2N7,E5E2N8,E5E2N9,E5E2P0,E5E2P1,E5E2P2,E5E2P3,E5E2P4,E5E2P5,E5E2P6,E5E2P7,E5E2P8,E5E2Q0,E5E2Q1,E5E2Q3,E5E2Q4,E5E2Q6,E5E2Q7,E5E2Q8,E5E2Q9,E5E2R3,E5E2R5,E5E2R6,E5E2R7,E5E2R8,E5E2R9,E5E2S0,E5E2S1,E5E2S2,E5E2S3,E5E2S5,E5E2S6,E5E2T1,E5E2T2,E5E2T3,E5E2T5,E5E2T6,E5E2T7,E5E2U1,E5E2U3,E5E2U5,E5E2U6,E5E2U8,E5E2V0,E5E2V1,E5E2V2,E5E2V6,E5E2V8,E5E2V9,E5E2W1,E5E2W5,E5E2W6,E5E2W7,F8UZL2,F8UZL5,F8UZL9,F8UZM4,F8UZM5,F8UZM6,F8UZN5,F8UZP5,G8XR30,G8XR34,H9N3Z9,H9N400,H9N402,H9N404,H9N409,H9N411,H9N412,H9N413,H9N415,H9N416,H9N418,H9N421,H9N424,H9N425,H9N426,H9N428,H9N430,H9N431,H9N432,H9N433,I4CJZ0,I6WDF0,I6WDF7,I6WDI9,I6WDM1,I6WDM7,I6WDN8,I6WDS9,I6WDT4,I6WE51,I6WEI5,I6YLU0,I7F434,J9S3H1,K9LIJ7,K9MRV2,K9MRV9,K9MRW2,K9MS20,K9MT90,K9MTA4,K9MTB5,K9MTB9,K9NVT2,M1GND6,M1H0W2,M1PLG0,M4JCU8,M4JCV1,M4JCV3,M4JCV4,M4JCW5,M4JCW7,M4JCW9,M4JCX1,M4JCX3,M4JCX6,M4JCX8,M4JCZ3,M4JCZ6,M4JD07,M4JD09,M4JD15,M4JD23,M4JD25,M4JD33,M4JD35,M4JD37,M4JD40,M4JD43,M4JD44,M4JD46,M4JD50,M4JD53,M4JD64,M4JD66,M4JD79,M4JD80,M4JDI0,M4JDI4,M4JDI6,M4JDI8,M4JDJ0,M4JDJ3,M4JDJ5,M4JDK1,M4JDK3,M4JDK6,M4JDK8,M4JDL0,M4JDL4,M4JDL9,M4JDM0,M4JDM4,M4JDM5,M4JDM6,M4JE89,M4JE95,M4JE96,M4JEA4,M4JEA6,M4JEA9,M4JEB1,M4JEB7,M4JEC1,M4JEC4,M4JEC6,M4JED8,M4JEE1,M4JEF1,M4JEF2,M4JEF6,M4JEF9,M4JEG5,M4JF52,M4JF54,M4JF56,M4JF62,M4JF65,M4JF68,M4JF72,M4JF75,M4JF78,M4JF81,M4JFB3,M4JFC5,P15197,P16285,Q0PE64,Q0PE66,Q0PE68,Q0PE72,Q0PE74,Q0PNB8,Q0Q0C4,Q0Q0D4,Q0Q0D7,Q0QDH5,Q19NZ2,Q4F904,Q52YR0,Q52YR4,Q52YR8,Q52YS3,Q52YS5,Q52YS6,Q52YT7,Q52YV1,Q52YV4,Q52YW3,Q52YW5,Q52YW9,Q52YX4,Q52YX9,Q5L4F8,Q66T65,Q69DB2,Q86410,Q86411,Q86426,Q86430,Q86431,Q86438,Q86453,Q8B6J9,Q8JXF6,Q8UYC3,Q8V0H0,Q8V0H3,Q8V0H5,Q8V415,Q8V416,Q8V417,Q8V419,Q8V420,Q8V424,Q8V426,Q8V427,Q8V428,Q91SM2,Q91SM3,Q91SM4,Q91SM5,Q91SM7,Q91SN1,Q91SN3,Q91SU2,Q91SU7,Q91SU9,Q91SV0,Q91SV1,Q91SV4,Q91SV7,Q91SW1,Q91SW5,Q91SW7,Q91SW9,Q91SX2,Q9WJY7,Q9WLM8,S5FP98,S5FQI9,S6BCW3,T2DL99,U5KJ83,U5S5Z2,U5S8N2,W6JI73 ssRNA TR, Rep S N N N D(27384657; 31434934) D(15557246) D(26957093; 9603315) 23602163.0 Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). Rhabdoviridae Rabies virus P Phosphoprotein, Protein M1, Protein P P06747 PHOSP_RABVP A3F5R6,P15198,P16286,P22363,P69479,P69480,Q0GBX8,Q0GBY3,Q8B6J8,Q9IPJ8 indirect/unknown TR, Rep S N N 3OA1 D(27384657; 26647356) N D(26957093) 23602163.0 RNA polymerase cofactor Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity). Rhabdoviridae Vesicular stomatitis Indiana virus P P Protein, Phosphoprotein, Protein M1 P03520 PHOSP_VSIVA A0A140DCD4,A0A140DCD9,A0A3G1VCW6,P04879,P04880,Q89487,Q8B0H3,Q8B0H8,Q8B0I3,Q9IG72,Q9IG73,Q9IG74,Q9IG75,Q9IG76,Q9IG77,Q9IG78,Q9IG79,Q9IG80,Q9IG81,Q9IG82,W5U2W7 indirect/unknown TR, Rep S N N 2K47 D(16973555) N D(3032453, in vitro Transcription Assay), D(1848304, in vitro Transcription Assay), D(8676480, in vitro Transcription Assay), D(1309893, in vitro Transcription Assay) 2845825.0 RNA polymerase cofactor Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template. May act as a chaperone for newly synthesized free N protein, so-called N(0). Plays a role in virion assembly.